KR100540721B1 - 오메프라졸의 제약 제제 - Google Patents

오메프라졸의 제약 제제 Download PDF

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Publication number
KR100540721B1
KR100540721B1 KR1019997011083A KR19997011083A KR100540721B1 KR 100540721 B1 KR100540721 B1 KR 100540721B1 KR 1019997011083 A KR1019997011083 A KR 1019997011083A KR 19997011083 A KR19997011083 A KR 19997011083A KR 100540721 B1 KR100540721 B1 KR 100540721B1
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KR
South Korea
Prior art keywords
omeprazole
hpmc
cloud point
core material
enteric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019997011083A
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English (en)
Korean (ko)
Other versions
KR20010013104A (ko
Inventor
마그누스 에릭슨
라르스 조세프슨
Original Assignee
아스트라제네카 악티에볼라그
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20407122&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100540721(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 아스트라제네카 악티에볼라그 filed Critical 아스트라제네카 악티에볼라그
Publication of KR20010013104A publication Critical patent/KR20010013104A/ko
Application granted granted Critical
Publication of KR100540721B1 publication Critical patent/KR100540721B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

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  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1019997011083A 1997-05-28 1998-05-18 오메프라졸의 제약 제제 Expired - Fee Related KR100540721B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9702000A SE9702000D0 (sv) 1997-05-28 1997-05-28 New pharmaceutical formulation
SE9702000-2 1997-05-28
PCT/SE1998/000922 WO1998053803A1 (en) 1997-05-28 1998-05-18 Pharmaceutical formulation of omeprazole

Publications (2)

Publication Number Publication Date
KR20010013104A KR20010013104A (ko) 2001-02-26
KR100540721B1 true KR100540721B1 (ko) 2006-01-10

Family

ID=20407122

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019997011083A Expired - Fee Related KR100540721B1 (ko) 1997-05-28 1998-05-18 오메프라졸의 제약 제제

Country Status (40)

Country Link
US (1) US6090827A (enExample)
EP (1) EP0984773B1 (enExample)
JP (1) JP4649001B2 (enExample)
KR (1) KR100540721B1 (enExample)
CN (1) CN1123338C (enExample)
AR (1) AR012698A1 (enExample)
AT (1) ATE234078T1 (enExample)
AU (1) AU722879B2 (enExample)
BR (1) BR9809484A (enExample)
CA (1) CA2290531C (enExample)
CZ (1) CZ298972B6 (enExample)
DE (1) DE69812089T2 (enExample)
DK (1) DK0984773T3 (enExample)
DZ (1) DZ2494A1 (enExample)
EE (1) EE03903B1 (enExample)
EG (1) EG24044A (enExample)
ES (1) ES2195342T3 (enExample)
HR (1) HRP980260B1 (enExample)
HU (1) HU229154B1 (enExample)
ID (1) ID24654A (enExample)
IL (1) IL132895A0 (enExample)
IS (1) IS2856B (enExample)
MA (1) MA26497A1 (enExample)
MY (1) MY122298A (enExample)
NO (1) NO328100B1 (enExample)
NZ (1) NZ500886A (enExample)
PL (1) PL194634B1 (enExample)
PT (1) PT984773E (enExample)
RS (1) RS49629B (enExample)
RU (1) RU2207121C2 (enExample)
SA (1) SA98190304B1 (enExample)
SE (1) SE9702000D0 (enExample)
SI (1) SI0984773T1 (enExample)
SK (1) SK286625B6 (enExample)
TN (1) TNSN98068A1 (enExample)
TR (1) TR199902890T2 (enExample)
TW (1) TW575435B (enExample)
UA (1) UA71541C2 (enExample)
WO (1) WO1998053803A1 (enExample)
ZA (1) ZA984178B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102432084B1 (ko) 2021-11-16 2022-08-12 알리코제약(주) S-오메프라졸을 함유하는 안정성이 개선되고 소형화된 정제

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US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) * 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) * 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6174548B1 (en) * 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6096340A (en) 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US20020039597A1 (en) * 1998-04-20 2002-04-04 Koji Ukai Stabilized compositions containing benzimidazole-type compounds
SE9803772D0 (sv) * 1998-11-05 1998-11-05 Astra Ab Pharmaceutical formulation
SE9902386D0 (sv) * 1999-06-22 1999-06-22 Astra Ab New formulation
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
ES2168043B1 (es) 1999-09-13 2003-04-01 Esteve Labor Dr Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido.
TWI268779B (en) 1999-10-20 2006-12-21 Eisai Co Ltd Method for stabilizing benzimidazole-based compounds
US20040092511A1 (en) * 1999-12-10 2004-05-13 Billstein Stephan Anthony Pharmaceutical combinations and their use in treating gastrointestinal and abdominal viscera disorders
US20020192299A1 (en) * 2000-12-28 2002-12-19 Rajneesh Taneja Pharmaceutical compositions of a non-enteric coated proton pump inhibitor with a carbonate salt and bicarbonate salt combination
JP2002234842A (ja) * 2001-02-09 2002-08-23 Kyowa Yakuhin Kogyo Kk 内服腸溶性製剤
CA2472103A1 (en) * 2002-01-25 2003-08-07 Santarus, Inc. Transmucosal delivery of proton pump inhibitors
US20040082618A1 (en) * 2002-07-03 2004-04-29 Rajneesh Taneja Liquid dosage forms of acid labile drugs
FR2843121B3 (fr) 2002-08-02 2004-09-10 Rhodia Chimie Sa Agent ignifugeant, procede de preparation et l'utilisation de cet agent
US20040121004A1 (en) * 2002-12-20 2004-06-24 Rajneesh Taneja Dosage forms containing a PPI, NSAID, and buffer
US20070243251A1 (en) * 2002-12-20 2007-10-18 Rajneesh Taneja Dosage Forms Containing A PPI, NSAID, and Buffer
US20040146558A1 (en) * 2003-01-28 2004-07-29 Kyowa Pharmaceutical Co., Ltd. Oral enteric-coated preparation
AU2004208606B2 (en) 2003-01-29 2009-09-24 Takeda Pharmaceutical Company Limited Process for producing coated preparation
RU2359671C2 (ru) * 2003-01-29 2009-06-27 Такеда Фармасьютикал Компани Лимитед Способ получения препарата с покрытием
JP4567340B2 (ja) * 2003-01-29 2010-10-20 武田薬品工業株式会社 被覆製剤の製造方法
CN1761465B (zh) * 2003-01-29 2010-10-13 武田药品工业株式会社 制备被覆制剂的方法
US20040248942A1 (en) * 2003-02-20 2004-12-09 Bonnie Hepburn Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid
RU2375048C2 (ru) * 2003-07-17 2009-12-10 Д-Р Редди'С Лабораторис Инк. Фармацевтическая композиция с набухающим покрытием
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
CN1311824C (zh) * 2004-04-21 2007-04-25 常州市第四制药厂有限公司 奥美拉唑肠溶微粒制剂及制备方法
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
ATE425791T1 (de) * 2005-07-29 2009-04-15 Rottapharm Spa Kombination aus itriglumid und ppi zur behandlung von gastrointestinalen- und assozierten krankheiten
JP2009538901A (ja) * 2006-06-01 2009-11-12 デクセル ファーマ テクノロジーズ エルティーディー． 複式ユニット製薬的製剤
KR101436516B1 (ko) * 2007-07-23 2014-09-02 주식회사태평양제약 코팅된 펠렛을 함유하는 현탁정 및 이의 제조방법
AU2008304033B2 (en) * 2007-09-28 2014-05-01 Ctc Bio, Inc. Pharmaceutical composition containing esomeprazole
RU2477123C2 (ru) * 2008-03-28 2013-03-10 Феррер Интернасионал, С.А. Капсула и лекарственное средство для профилактики сердечно-сосудистых заболеваний
RU2554347C2 (ru) 2008-08-19 2015-06-27 Ксенопорт, Инк. Пролекарства метилгидрофумарата, фармацевтические композиции с ними и способы применения
US20140056973A1 (en) 2012-08-22 2014-02-27 Xenoport, Inc. Oral Dosage Forms Having a High Loading of a Methyl Hydrogen Fumarate Prodrug
US10945984B2 (en) 2012-08-22 2021-03-16 Arbor Pharmaceuticals, Llc Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
CN102961356A (zh) * 2012-12-11 2013-03-13 山西云鹏制药有限公司 一种含奥美拉唑的蓝色肠溶片剂的制备方法
WO2014160633A1 (en) 2013-03-24 2014-10-02 Xenoport, Inc. Pharmaceutical compositions of dimethyl fumarate
US9416096B2 (en) 2013-09-06 2016-08-16 Xenoport, Inc. Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use
US20150079180A1 (en) * 2013-09-18 2015-03-19 Xenoport, Inc. Nanoparticle compositions of dimethyl fumarate
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
EP3288556A4 (en) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Orally disintegrating compositions
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
JPWO2021153525A1 (enExample) 2020-01-27 2021-08-05
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102432084B1 (ko) 2021-11-16 2022-08-12 알리코제약(주) S-오메프라졸을 함유하는 안정성이 개선되고 소형화된 정제

Also Published As

Publication number Publication date
WO1998053803A1 (en) 1998-12-03
TW575435B (en) 2004-02-11
DE69812089T2 (de) 2004-03-04
SI0984773T1 (en) 2003-10-31
DE69812089D1 (de) 2003-04-17
PT984773E (pt) 2003-07-31
TNSN98068A1 (fr) 2005-03-15
HK1025744A1 (en) 2000-11-24
AU7680398A (en) 1998-12-30
ZA984178B (en) 1998-11-30
NO995809D0 (no) 1999-11-26
CZ298972B6 (cs) 2008-03-26
EE9900540A (et) 2000-06-15
UA71541C2 (uk) 2004-12-15
CA2290531C (en) 2006-12-12
CN1258217A (zh) 2000-06-28
EE03903B1 (et) 2002-12-16
DZ2494A1 (fr) 2003-01-25
YU60899A (sh) 2002-06-19
SA98190304B1 (ar) 2006-10-11
JP2002500665A (ja) 2002-01-08
EP0984773A1 (en) 2000-03-15
MA26497A1 (fr) 2004-12-20
BR9809484A (pt) 2000-06-20
IL132895A0 (en) 2001-03-19
CN1123338C (zh) 2003-10-08
SK286625B6 (sk) 2009-02-05
ES2195342T3 (es) 2003-12-01
TR199902890T2 (xx) 2000-02-21
SE9702000D0 (sv) 1997-05-28
KR20010013104A (ko) 2001-02-26
HU229154B1 (en) 2013-09-30
JP4649001B2 (ja) 2011-03-09
HRP980260A2 (en) 1999-02-28
NO328100B1 (no) 2009-12-07
AU722879B2 (en) 2000-08-10
AR012698A1 (es) 2000-11-08
ID24654A (id) 2000-07-27
US6090827A (en) 2000-07-18
HUP0002182A2 (hu) 2002-05-29
CZ420299A3 (cs) 2000-05-17
IS5245A (is) 1999-11-11
HRP980260B1 (en) 2003-10-31
ATE234078T1 (de) 2003-03-15
RS49629B (sr) 2007-08-03
MY122298A (en) 2006-04-29
EP0984773B1 (en) 2003-03-12
PL337237A1 (en) 2000-08-14
CA2290531A1 (en) 1998-12-03
PL194634B1 (pl) 2007-06-29
RU2207121C2 (ru) 2003-06-27
NZ500886A (en) 2001-11-30
DK0984773T3 (da) 2003-07-07
SK159099A3 (en) 2000-06-12
HUP0002182A3 (en) 2003-02-28
NO995809L (no) 2000-01-28
EG24044A (en) 2008-04-13
IS2856B (is) 2013-11-15

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