KR100505527B1 - 트라마돌의라세미체를분리하는방법 - Google Patents

트라마돌의라세미체를분리하는방법 Download PDF

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Publication number
KR100505527B1
KR100505527B1 KR1019970001203A KR19970001203A KR100505527B1 KR 100505527 B1 KR100505527 B1 KR 100505527B1 KR 1019970001203 A KR1019970001203 A KR 1019970001203A KR 19970001203 A KR19970001203 A KR 19970001203A KR 100505527 B1 KR100505527 B1 KR 100505527B1
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KR
South Korea
Prior art keywords
tramadol
enantiomer
salt
tartaric acid
base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019970001203A
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English (en)
Korean (ko)
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KR970059155A (ko
Inventor
헬무트 부슈만
베르너 빈터
이파르스 그라우둠스
페터 얀젠
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그뤼넨탈 게엠베하
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Publication of KR970059155A publication Critical patent/KR970059155A/ko
Application granted granted Critical
Publication of KR100505527B1 publication Critical patent/KR100505527B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1019970001203A 1996-01-19 1997-01-17 트라마돌의라세미체를분리하는방법 Expired - Fee Related KR100505527B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19601745.9 1996-01-19
DE19601745A DE19601745C1 (de) 1996-01-19 1996-01-19 Verfahren zur Racematspaltung von Tramadol

Publications (2)

Publication Number Publication Date
KR970059155A KR970059155A (ko) 1997-08-12
KR100505527B1 true KR100505527B1 (ko) 2005-10-19

Family

ID=7783112

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019970001203A Expired - Fee Related KR100505527B1 (ko) 1996-01-19 1997-01-17 트라마돌의라세미체를분리하는방법

Country Status (31)

Country Link
US (1) US5723668A (en:Method)
EP (1) EP0787715B1 (en:Method)
JP (1) JPH09216858A (en:Method)
KR (1) KR100505527B1 (en:Method)
CN (1) CN1131203C (en:Method)
AR (1) AR005391A1 (en:Method)
AT (1) ATE189205T1 (en:Method)
AU (1) AU711750B2 (en:Method)
BR (1) BR9700094A (en:Method)
CA (1) CA2195370C (en:Method)
CO (1) CO4520185A1 (en:Method)
CZ (1) CZ291775B6 (en:Method)
DE (2) DE19601745C1 (en:Method)
DK (1) DK0787715T3 (en:Method)
ES (1) ES2145373T3 (en:Method)
GR (1) GR3032489T3 (en:Method)
HU (1) HU223067B1 (en:Method)
IL (1) IL120028A (en:Method)
IN (1) IN182218B (en:Method)
MY (1) MY116583A (en:Method)
NO (1) NO306059B1 (en:Method)
NZ (1) NZ299999A (en:Method)
PE (1) PE29898A1 (en:Method)
PL (1) PL187403B1 (en:Method)
PT (1) PT787715E (en:Method)
RU (1) RU2192407C2 (en:Method)
SI (1) SI0787715T1 (en:Method)
SK (1) SK281612B6 (en:Method)
UA (1) UA45343C2 (en:Method)
UY (1) UY24439A1 (en:Method)
ZA (1) ZA97369B (en:Method)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2130079B1 (es) 1997-07-10 2000-01-16 Esteve Labor Dr Resolucion de aminas
EP0996613B1 (en) * 1997-07-15 2002-10-30 Russinsky Limited Pure cis-tramadol hydrochloride production
DE19821039A1 (de) * 1998-05-11 1999-11-18 Bayer Ag Verfahren zur Herstellung von (S,S)-Benzyl-2,8-diazabicyclo[4.3.0]nonan
GB9826540D0 (en) 1998-12-02 1999-01-27 Darwin Discovery Ltd Process
KR100342919B1 (ko) * 1999-10-21 2002-07-04 박노중 트랜스체 염산 트라마돌의 분리 제조방법
US20020143065A1 (en) * 2000-10-03 2002-10-03 Lirong Liu Developing a delivery system for multi-pharmaceutical active materials at various release rates
DE10108122A1 (de) 2001-02-21 2002-10-02 Gruenenthal Gmbh Arzneimittel auf Basis von Tramadol
JP4377585B2 (ja) 2001-03-16 2009-12-02 ディーエムアイ バイオサイエンシズ インコーポレイテッド 射精遅延の方法
US6649783B2 (en) * 2001-10-03 2003-11-18 Euro-Celtique, S.A. Synthesis of (+/-)-2-((dimethylamino)methyl)-1-(aryl)cyclohexanols
US6780891B2 (en) 2001-11-30 2004-08-24 Sepracor Inc. Tramadol analogs and uses thereof
US20040248979A1 (en) * 2003-06-03 2004-12-09 Dynogen Pharmaceuticals, Inc. Method of treating lower urinary tract disorders
JP5042039B2 (ja) 2005-01-26 2012-10-03 アラーガン、インコーポレイテッド 鎮痛活性および／または免疫賦活活性を有する３−アリール−３−ヒドロキシ−２−アミノ−プロピオン酸アミド、３−ヘテロアリール−３−ヒドロキシ−２−アミノ−プロピオン酸アミドおよび関連化合物
EP1785412A1 (en) 2005-11-14 2007-05-16 IPCA Laboratories Limited Tramadol recovery process
CN101657101B (zh) * 2007-02-12 2013-12-11 Dmi生物科学公司 并存早泄和勃起功能障碍的治疗
CA2677691C (en) 2007-02-12 2012-07-31 David Bar-Or Reducing side effects of tramadol
DE102013009114A1 (de) 2013-05-29 2014-12-04 Franz Gerstheimer Pharmazeutische Zusammensetzung zur Überwindung von Metabolisierungsproblemen
KR102136004B1 (ko) 2018-06-18 2020-07-22 (주)센텍코리아 감지부의 잔존 수명을 추정할 수 있는 음주측정기

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06122686A (ja) * 1992-10-12 1994-05-06 Fujisawa Pharmaceut Co Ltd ラセミ体の光学分割法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2528267A (en) * 1950-10-31 Eobeet j
US3652589A (en) * 1967-07-27 1972-03-28 Gruenenthal Chemie 1-(m-substituted phenyl)-2-aminomethyl cyclohexanols
IL50080A (en) * 1975-07-29 1979-07-25 Beecham Group Ltd 4-oxa-1-azabicyclo(3.2.0)heptan-7-one-2-car boxylic acid derivatives and their preparation
GB9017390D0 (en) * 1990-08-08 1990-09-19 Norgine Ltd Improvements in or relating to propylamine derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06122686A (ja) * 1992-10-12 1994-05-06 Fujisawa Pharmaceut Co Ltd ラセミ体の光学分割法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Arzneim.-Forsch., 28(I), 114-121 (1978) *
타르타르산이 광학분할제로 사용된 1997년 이전의 문헌에 관한 Chemical Abstracts 검색 결과 30건 *

Also Published As

Publication number Publication date
EP0787715B1 (de) 2000-01-26
JPH09216858A (ja) 1997-08-19
PT787715E (pt) 2000-06-30
HU223067B1 (hu) 2004-03-01
DK0787715T3 (da) 2000-04-25
PL318003A1 (en) 1997-07-21
SI0787715T1 (en) 2000-04-30
US5723668A (en) 1998-03-03
ATE189205T1 (de) 2000-02-15
HUP9700141A3 (en) 2000-03-28
AU711750B2 (en) 1999-10-21
NO970211D0 (no) 1997-01-17
EP0787715A1 (de) 1997-08-06
KR970059155A (ko) 1997-08-12
NO970211L (no) 1997-07-21
ZA97369B (en) 1997-07-29
PE29898A1 (es) 1998-08-08
CN1131203C (zh) 2003-12-17
NO306059B1 (no) 1999-09-13
NZ299999A (en) 1998-01-26
CO4520185A1 (es) 1997-10-15
CZ291775B6 (cs) 2003-05-14
MX9700483A (es) 1997-07-31
IL120028A (en) 1999-12-22
DE19601745C1 (de) 1997-10-09
CN1161957A (zh) 1997-10-15
CZ15697A3 (cs) 1998-05-13
AU1223297A (en) 1997-07-24
DE59604295D1 (de) 2000-03-02
IL120028A0 (en) 1997-04-15
CA2195370C (en) 2005-07-12
RU2192407C2 (ru) 2002-11-10
SK6897A3 (en) 1997-08-06
ES2145373T3 (es) 2000-07-01
HUP9700141A2 (hu) 1998-01-28
CA2195370A1 (en) 1997-07-20
GR3032489T3 (en) 2000-05-31
SK281612B6 (sk) 2001-05-10
IN182218B (en:Method) 1999-02-06
BR9700094A (pt) 1998-09-22
MY116583A (en) 2004-02-28
PL187403B1 (pl) 2004-07-30
AR005391A1 (es) 1999-04-28
UA45343C2 (uk) 2002-04-15
HU9700141D0 (en) 1997-03-28
UY24439A1 (es) 1997-01-30

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