KR100430312B1 - 스테로이드유도체케탈의제조방법 - Google Patents

스테로이드유도체케탈의제조방법 Download PDF

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Publication number
KR100430312B1
KR100430312B1 KR1019960057104A KR19960057104A KR100430312B1 KR 100430312 B1 KR100430312 B1 KR 100430312B1 KR 1019960057104 A KR1019960057104 A KR 1019960057104A KR 19960057104 A KR19960057104 A KR 19960057104A KR 100430312 B1 KR100430312 B1 KR 100430312B1
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KR
South Korea
Prior art keywords
formula
compound
ketal
orthoester
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019960057104A
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English (en)
Korean (ko)
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KR970027102A (ko
Inventor
브리요프 피터
테오도루스 레오나르두스 브랜즈 프란시스쿠스
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악조 노벨 엔.브이.
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Application filed by 악조 노벨 엔.브이. filed Critical 악조 노벨 엔.브이.
Publication of KR970027102A publication Critical patent/KR970027102A/ko
Application granted granted Critical
Publication of KR100430312B1 publication Critical patent/KR100430312B1/ko
Anticipated expiration legal-status Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • C07J75/005—Preparation of steroids by cyclization of non-steroid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
KR1019960057104A 1995-11-30 1996-11-25 스테로이드유도체케탈의제조방법 Expired - Fee Related KR100430312B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1001787 1995-11-30
NL1001787 1995-11-30

Publications (2)

Publication Number Publication Date
KR970027102A KR970027102A (ko) 1997-06-24
KR100430312B1 true KR100430312B1 (ko) 2004-07-30

Family

ID=19761947

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960057104A Expired - Fee Related KR100430312B1 (ko) 1995-11-30 1996-11-25 스테로이드유도체케탈의제조방법

Country Status (25)

Country Link
US (2) US5955622A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0776904B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP3984315B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR100430312B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN1152847C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AR (1) AR004813A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE190314T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU713688B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2191397C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CZ (1) CZ293396B6 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE69606957T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK0776904T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2145971T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3033527T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HUP9603296A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL119649A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN182807B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX9605981A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO307887B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ299836A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (1) PL185112B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT776904E (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
RU (1) RU2165430C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
TR (1) TR199600944A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA969778B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

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TW200611909A (en) * 2004-08-04 2006-04-16 Akzo Nobel Nv Process for the preparation 2-substituted-derivatives of estrone and estradiol
TW200613316A (en) 2004-08-26 2006-05-01 Akzo Nobel Nv Process for the preparation of estrone and/or estradiol-derivates
HUP0501132A2 (en) 2005-12-05 2007-06-28 Richter Gedeon Nyrt 17-alpha-cyanomethyl-17betha-hydroxyestra-4,9-diene-3-one of high purity and process for its production
ITMI20062504A1 (it) 2006-12-22 2008-06-23 Antibioticos Spa Procedimento per la preparazione di 17alfa-cianometil-17beta-idrossi steroidi
US8673968B2 (en) * 2009-04-06 2014-03-18 Evestra, Inc. Progesterone antagonists
US20130041166A1 (en) 2010-04-20 2013-02-14 Lupin Limited Process for the preparation of dienogest substantially free of impurities
CN101863947A (zh) * 2010-06-29 2010-10-20 沈阳药科大学 一种地诺孕素的合成方法
CN102718828A (zh) * 2011-03-30 2012-10-10 西藏海思科药业集团股份有限公司 一种地诺孕素的制备方法
US9096641B2 (en) 2013-06-05 2015-08-04 Evestra, Inc. Imidazolyl progesterone antagonists
CN104497088B (zh) * 2014-12-30 2016-08-24 湖南新合新生物医药有限公司 19-去甲-4-雄甾烯-3,17-二酮的制备方法
CN108997463B (zh) * 2018-08-09 2021-05-14 四川理工学院 一种雌甾-4，9-二烯-3，17-二酮制备方法
CN112409434B (zh) * 2020-11-27 2021-10-26 厦门欧瑞捷生物科技有限公司 一种去氢孕酮的合成方法
CN113861158B (zh) * 2021-11-22 2023-02-10 湖南新合新生物医药有限公司 一种合成甲基双烯双酮关键中间体的方法
CN114409717B (zh) * 2021-12-17 2023-03-17 湖南科益新生物医药有限公司 替勃龙中间体醚化物和替勃龙的制备方法
CN114456223B (zh) * 2022-01-24 2023-07-21 湖南科益新生物医药有限公司 3-缩酮的合成方法
CN117304244B (zh) * 2023-08-14 2024-09-20 江西君业生物制药有限公司 一种19-去甲-4-雄烯二酮的制备方法

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BE632347A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) *
DE296931C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1915-11-05 1917-03-06
NL122142C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1962-03-06
NL127071C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1964-12-31
FR2201287A1 (en) * 1972-09-27 1974-04-26 Roussel Uclaf Epoxidation using hexafluoroacetone hydroperoxide - for treatment of unsatd. cyclic cpds esp steroids
DE3113053A1 (de) * 1981-04-01 1982-10-21 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung eines tricyclischen steroid-abbauprodukts
US4400524A (en) * 1981-07-28 1983-08-23 The Upjohn Company Grignard reagents prepared from 5-halopentan-2-one propylene ketals
DE3208432A1 (de) * 1982-03-09 1983-09-15 The Upjohn Co., 49001 Kalamazoo, Mich. Verfahren zur herstellung von 19-norandrostendion, zwischenprodukt des 19-norandrostendions und verfahren zu seiner herstellung
HU201091B (en) * 1985-12-26 1990-09-28 Mitsubishi Chem Ind Process for producing gonatriene derivatives and pharmaceutical compositions comprising same
DD296931A5 (de) * 1987-08-28 1991-12-19 Jenapharm Gmbh Jena,De Verfahren zur herstellung von 13 beta-alkyl-5(10),9(11)-gonadienderivaten
NZ232422A (en) * 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
CA2086919C (en) * 1990-07-09 1998-02-24 Gerhard Teichmuller Process for the production of unsaturated 17.alpha.-cyanomethyl -17.beta. hydroxy steroids
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids
CA2166332C (en) * 1993-08-04 2005-05-10 Bernardus Wynand Machijs Marie Peeters Antiglucocorticoid steroids for the treatment of anxiety disorders

Non-Patent Citations (1)

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Pharmazie Vol.33(12):792-798 (1978) *

Also Published As

Publication number Publication date
DK0776904T3 (da) 2000-07-31
KR970027102A (ko) 1997-06-24
HUP9603296A3 (en) 1998-07-28
HU9603296D0 (en) 1997-01-28
CZ350496A3 (cs) 1998-03-18
CA2191397C (en) 2006-08-01
EP0776904A3 (en) 1997-12-17
AU7404196A (en) 1997-06-05
NO965113L (no) 1997-06-02
EP0776904B1 (en) 2000-03-08
RU2165430C2 (ru) 2001-04-20
ATE190314T1 (de) 2000-03-15
CN1168876A (zh) 1997-12-31
EP0776904A2 (en) 1997-06-04
ZA969778B (en) 1997-06-17
AR004813A1 (es) 1999-03-10
TR199600944A1 (tr) 1997-06-21
PL185112B1 (pl) 2003-02-28
AU713688B2 (en) 1999-12-09
NO965113D0 (no) 1996-11-29
IL119649A0 (en) 1997-02-18
IN182807B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1999-04-24
MX9605981A (es) 1998-04-30
JP3984315B2 (ja) 2007-10-03
GR3033527T3 (en) 2000-09-29
NO307887B1 (no) 2000-06-13
US6005124A (en) 1999-12-21
DE69606957T2 (de) 2000-10-05
HUP9603296A2 (en) 1997-08-28
NZ299836A (en) 1997-11-24
JPH09183792A (ja) 1997-07-15
PL317248A1 (en) 1997-06-09
IL119649A (en) 2002-03-10
US5955622A (en) 1999-09-21
CZ293396B6 (cs) 2004-04-14
CN1152847C (zh) 2004-06-09
DE69606957D1 (de) 2000-04-13
ES2145971T3 (es) 2000-07-16
PT776904E (pt) 2000-07-31
CA2191397A1 (en) 1997-05-31

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