KR100380954B1 - 피라졸로[4,3-디]피리미딘-7-온 및 그의 중간체의 제조방법 - Google Patents

피라졸로[4,3-디]피리미딘-7-온 및 그의 중간체의 제조방법 Download PDF

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Publication number
KR100380954B1
KR100380954B1 KR10-1999-0043836A KR19990043836A KR100380954B1 KR 100380954 B1 KR100380954 B1 KR 100380954B1 KR 19990043836 A KR19990043836 A KR 19990043836A KR 100380954 B1 KR100380954 B1 KR 100380954B1
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South Korea
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formula
compound
tertiary
metal
compounds
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Expired - Fee Related
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KR10-1999-0043836A
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English (en)
Korean (ko)
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KR20000028987A (ko
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던피터제임스
레베트필립찰스
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화이자리써치앤드디벨롭먼트캄파니앤브이-에스에이
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Application filed by 화이자리써치앤드디벨롭먼트캄파니앤브이-에스에이 filed Critical 화이자리써치앤드디벨롭먼트캄파니앤브이-에스에이
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/26—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR10-1999-0043836A 1998-10-12 1999-10-11 피라졸로[4,3-디]피리미딘-7-온 및 그의 중간체의 제조방법 Expired - Fee Related KR100380954B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9822238.3A GB9822238D0 (en) 1998-10-12 1998-10-12 Process for preparation of pyrazolo[4,3-D]pyrimidin-7-ones and intermediates thereof
GB9822238.3 1998-10-12

Publications (2)

Publication Number Publication Date
KR20000028987A KR20000028987A (ko) 2000-05-25
KR100380954B1 true KR100380954B1 (ko) 2003-04-21

Family

ID=10840421

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-1999-0043836A Expired - Fee Related KR100380954B1 (ko) 1998-10-12 1999-10-11 피라졸로[4,3-디]피리미딘-7-온 및 그의 중간체의 제조방법

Country Status (48)

Country Link
US (3) US6207829B1 (https=)
EP (1) EP0994115B1 (https=)
JP (1) JP3721021B2 (https=)
KR (1) KR100380954B1 (https=)
CN (2) CN1207295C (https=)
AP (1) AP1233A (https=)
AR (1) AR019244A1 (https=)
AT (1) ATE290003T1 (https=)
AU (1) AU756463B2 (https=)
BG (1) BG63205B1 (https=)
BR (1) BR9905092A (https=)
CA (1) CA2285733C (https=)
CO (1) CO5150214A1 (https=)
CR (1) CR6118A (https=)
CU (1) CU22928A3 (https=)
CZ (1) CZ296816B6 (https=)
DE (1) DE69923906T2 (https=)
DK (1) DK0994115T3 (https=)
DZ (1) DZ2912A1 (https=)
EA (1) EA003774B1 (https=)
EE (1) EE04192B1 (https=)
EG (1) EG22630A (https=)
ES (1) ES2237049T3 (https=)
GB (1) GB9822238D0 (https=)
GE (1) GEP20022700B (https=)
GT (1) GT199900172A (https=)
HR (1) HRP990318B1 (https=)
HU (1) HU226162B1 (https=)
ID (1) ID23351A (https=)
IL (11) IL152923A (https=)
IS (1) IS1951B (https=)
MA (1) MA25007A1 (https=)
MY (1) MY124620A (https=)
NO (1) NO313700B1 (https=)
OA (1) OA11165A (https=)
PE (1) PE20001086A1 (https=)
PL (1) PL198150B1 (https=)
PT (1) PT994115E (https=)
RS (1) RS49762B (https=)
SG (1) SG118060A1 (https=)
SI (1) SI0994115T1 (https=)
SK (1) SK285215B6 (https=)
TN (1) TNSN99189A1 (https=)
TR (1) TR199902541A2 (https=)
TW (1) TW589314B (https=)
UA (1) UA66787C2 (https=)
UY (1) UY25750A1 (https=)
ZA (1) ZA996412B (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5204800A (en) * 1999-06-21 2001-01-09 Biochemical Pharmaceutical Factory of Zhuhai Sez, The Process for preparing sildenafil, and troche which comprises sildenafil and apomorphine
US6667398B2 (en) 2000-06-22 2003-12-23 Pfizer Inc Process for the preparation of pyrazolopyrimidinones
EP1292586B1 (en) * 2000-06-22 2004-08-04 Pfizer Limited Process for the preparation of pyrazolopyrimidinones
YU51701A (sh) * 2000-07-28 2003-12-31 Pfizer Inc. Postupak za dobijanje jedinjenja pirazola/4,3-d/ pirimidin-7-ona i njihovih derivata
EP1176142A1 (en) * 2000-07-28 2002-01-30 Pfizer Inc. Process for the preparation of pyrazoles
US6407259B1 (en) 2000-07-28 2002-06-18 Pfizer Inc. Process for the preparation of pyrazoles
PE20020394A1 (es) 2000-08-18 2002-06-21 Agouron Pharma Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2
DE60235198D1 (de) * 2001-12-20 2010-03-11 Merck Serono Sa Coinsins Pyrrolidin-derivatie als prostaglandin-modulatoren
US6908923B2 (en) 2001-12-21 2005-06-21 Cytokinetics, Inc. Compositions and methods for treating heart failure
SI1509525T1 (sl) 2002-05-31 2006-12-31 Schering Corp Postopek priprave inhibitorjev ksantinske fosfodiesteraze V in njihovih prekurzorjev
WO2004072079A1 (en) * 2003-02-11 2004-08-26 Pfizer Limited Hydrated and anhydrous sildenafil hemi-citrate compound
EP1605752B1 (en) * 2003-03-27 2011-09-14 Cytokinetics, Inc. Sulfonamides for the treatment of congestive heart failure, their compositions and uses.
CN100360531C (zh) * 2003-12-18 2008-01-09 中国人民解放军军事医学科学院放射与辐射医学研究所 用于预防或治疗阳萎和性冷淡的新吡唑并嘧啶类化合物
US20070010525A1 (en) * 2005-06-27 2007-01-11 Meyer Jackson Method and compositions for modulating neuropeptide hormone secretion
NL2000291C2 (nl) * 2005-11-10 2009-02-17 Pfizer Prod Inc 1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-ylamino)-1H- pyrazool(4,3-d)pyrimidine-5-yl)piperidine-4-carbonzuur en zouten daarvan.
WO2007141805A2 (en) * 2006-06-05 2007-12-13 Matrix Laboratories Limited Novel process for the preparation of sildenafil citrate
CZ308056B6 (cs) * 2015-07-20 2019-11-27 Ustav Experimentalni Botaniky Av Cr V V I 5-Substituované-7-[4-(substituované)benzyl]amino-3-isopropylpyrazolo[4,3-d]pyrimidiny, jejich použití jako antirevmatika, a farmaceutické přípravky
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN107759603B (zh) * 2016-08-18 2020-09-01 四川科伦药物研究院有限公司 一种杂环化合物的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0812845A1 (en) * 1996-06-14 1997-12-17 Pfizer Limited Process for preparing sildenafil

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3992441A (en) * 1972-12-26 1976-11-16 Pfizer Inc. Sulfamylbenzoic acids
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
US6723719B1 (en) * 1997-04-25 2004-04-20 Pfizer Inc Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3′,5′—monophosphate phosphodiesterase (cGMP PDE5) for the treatment of sexual dysfunction

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0812845A1 (en) * 1996-06-14 1997-12-17 Pfizer Limited Process for preparing sildenafil

Also Published As

Publication number Publication date
JP3721021B2 (ja) 2005-11-30
JP2000119273A (ja) 2000-04-25
IS1951B (is) 2004-10-13
PE20001086A1 (es) 2000-10-18
PT994115E (pt) 2005-06-30
NO994943L (no) 2000-04-13
US6207829B1 (en) 2001-03-27
EG22630A (en) 2003-05-31
HUP9903469A3 (en) 2000-10-30
DE69923906D1 (de) 2005-04-07
HK1027559A1 (en) 2001-01-19
IL152927A (en) 2004-06-01
IL152928A (en) 2007-07-04
IL152924A (en) 2004-02-19
GB9822238D0 (en) 1998-12-09
AP9901672A0 (en) 1999-12-31
EE04192B1 (et) 2003-12-15
NO313700B1 (no) 2002-11-18
HU9903469D0 (en) 1999-12-28
GEP20022700B (en) 2002-05-27
AU5358199A (en) 2000-04-13
IL132273A0 (en) 2001-03-19
ES2237049T3 (es) 2005-07-16
HRP990318B1 (en) 2004-06-30
MA25007A1 (fr) 2000-07-01
ZA996412B (en) 2001-04-11
HUP9903469A2 (hu) 2000-08-28
CZ296816B6 (cs) 2006-06-14
DZ2912A1 (fr) 2004-03-01
CN1255497A (zh) 2000-06-07
HRP990318A2 (en) 2000-06-30
NO994943D0 (no) 1999-10-11
CO5150214A1 (es) 2002-04-29
EP0994115A2 (en) 2000-04-19
RS49762B (sr) 2008-04-04
IS5209A (is) 2000-04-13
TW589314B (en) 2004-06-01
AP1233A (en) 2003-12-18
HU226162B1 (en) 2008-05-28
MY124620A (en) 2006-06-30
CU22928A3 (es) 2004-02-20
EA003774B1 (ru) 2003-08-28
SI0994115T1 (https=) 2005-08-31
CN1207295C (zh) 2005-06-22
SK285215B6 (sk) 2006-09-07
EE9900507A (et) 2000-06-15
CA2285733A1 (en) 2000-04-12
CR6118A (es) 2005-09-16
UY25750A1 (es) 2001-08-27
IL152926A0 (en) 2003-06-24
ATE290003T1 (de) 2005-03-15
IL152924A0 (en) 2003-06-24
IL152923A0 (en) 2003-06-24
US20030069422A1 (en) 2003-04-10
CN1473831A (zh) 2004-02-11
PL335959A1 (en) 2000-04-25
IL152927A0 (en) 2003-06-24
DE69923906T2 (de) 2006-04-06
YU48999A (sh) 2002-06-19
KR20000028987A (ko) 2000-05-25
UA66787C2 (en) 2004-06-15
TNSN99189A1 (fr) 2005-11-10
CA2285733C (en) 2004-08-24
IL152923A (en) 2004-02-08
ID23351A (id) 2000-04-13
GT199900172A (es) 2001-03-28
SG118060A1 (en) 2006-01-27
PL198150B1 (pl) 2008-05-30
BG103794A (en) 2000-09-29
EP0994115A3 (en) 2000-05-24
EP0994115B1 (en) 2005-03-02
IL152928A0 (en) 2003-06-24
EA199900822A3 (ru) 2000-08-28
BR9905092A (pt) 2000-08-08
CZ353299A3 (cs) 2000-05-17
AR019244A1 (es) 2001-12-26
OA11165A (en) 2003-04-22
AU756463B2 (en) 2003-01-16
IL152926A (en) 2004-02-19
EA199900822A2 (ru) 2000-04-24
IL132273A (en) 2004-06-20
BG63205B1 (bg) 2001-06-29
US20010009962A1 (en) 2001-07-26
DK0994115T3 (da) 2005-06-20
SK138599A3 (en) 2000-05-16
TR199902541A2 (xx) 2000-07-21

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