KR100372063B1 - 성장 호르몬 분비촉진제의 제조 방법 - Google Patents

성장 호르몬 분비촉진제의 제조 방법 Download PDF

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Publication number
KR100372063B1
KR100372063B1 KR10-2000-0009296A KR20000009296A KR100372063B1 KR 100372063 B1 KR100372063 B1 KR 100372063B1 KR 20000009296 A KR20000009296 A KR 20000009296A KR 100372063 B1 KR100372063 B1 KR 100372063B1
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KR
South Korea
Prior art keywords
formula
compound
oxo
methyl
ethyl
Prior art date
Application number
KR10-2000-0009296A
Other languages
English (en)
Korean (ko)
Other versions
KR20010006698A (ko
Inventor
프랭크 로버트 부쉬
찰스 콕-풍 치우
클리포드 나타니엘 멜츠
로날드 제임스 포스트
피터 로버트 로즈
Original Assignee
화이자 프로덕츠 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 화이자 프로덕츠 인크. filed Critical 화이자 프로덕츠 인크.
Publication of KR20010006698A publication Critical patent/KR20010006698A/ko
Application granted granted Critical
Publication of KR100372063B1 publication Critical patent/KR100372063B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
KR10-2000-0009296A 1999-02-26 2000-02-25 성장 호르몬 분비촉진제의 제조 방법 KR100372063B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12274599P 1999-02-26 1999-02-26
US60/122,745 1999-02-26

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020020042729A Division KR100361783B1 (ko) 1999-02-26 2002-07-20 성장 호르몬 분비촉진제의 제조 방법

Publications (2)

Publication Number Publication Date
KR20010006698A KR20010006698A (ko) 2001-01-26
KR100372063B1 true KR100372063B1 (ko) 2003-02-14

Family

ID=22404505

Family Applications (2)

Application Number Title Priority Date Filing Date
KR10-2000-0009296A KR100372063B1 (ko) 1999-02-26 2000-02-25 성장 호르몬 분비촉진제의 제조 방법
KR1020020042729A KR100361783B1 (ko) 1999-02-26 2002-07-20 성장 호르몬 분비촉진제의 제조 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020020042729A KR100361783B1 (ko) 1999-02-26 2002-07-20 성장 호르몬 분비촉진제의 제조 방법

Country Status (44)

Country Link
US (2) US6541634B2 (xx)
EP (2) EP1031575B1 (xx)
JP (3) JP3437813B2 (xx)
KR (2) KR100372063B1 (xx)
CN (3) CN1837205A (xx)
AP (1) AP1221A (xx)
AR (2) AR029617A1 (xx)
AT (1) ATE277944T1 (xx)
AU (1) AU764122B2 (xx)
BG (1) BG104175A (xx)
BR (2) BRPI0017522B8 (xx)
CA (1) CA2299495C (xx)
CO (1) CO5160252A1 (xx)
DE (1) DE60014212T2 (xx)
DK (1) DK1031575T3 (xx)
DZ (1) DZ3018A1 (xx)
EA (1) EA003218B1 (xx)
EE (1) EE200000193A (xx)
ES (1) ES2226712T3 (xx)
GT (1) GT200000018A (xx)
HK (1) HK1030219A1 (xx)
HN (1) HN2000000021A (xx)
HR (1) HRP20000103A2 (xx)
HU (1) HUP0000907A3 (xx)
ID (1) ID24861A (xx)
IL (2) IL134599A (xx)
IN (1) IN192352B (xx)
IS (1) IS5380A (xx)
MA (1) MA25072A1 (xx)
NO (1) NO20000965L (xx)
NZ (1) NZ503062A (xx)
OA (1) OA11325A (xx)
PA (1) PA8491201A1 (xx)
PE (1) PE20001550A1 (xx)
PL (1) PL338628A1 (xx)
PT (1) PT1031575E (xx)
SG (1) SG90096A1 (xx)
SI (1) SI1031575T1 (xx)
SK (1) SK284982B6 (xx)
TN (1) TNSN00035A1 (xx)
TR (1) TR200000536A2 (xx)
TW (2) TWI286142B (xx)
UA (1) UA70306C2 (xx)
ZA (1) ZA200000888B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1132388A3 (en) * 2000-03-09 2004-03-03 Pfizer Products Inc. Hexahydropyrazolo[4,3-c]pyridine metabolites
CA2410597A1 (en) 2000-05-30 2001-12-06 Merck & Co., Inc. Melanocortin receptor agonists
AU2003237595A1 (en) * 2003-05-26 2004-12-13 Biocon Limited Process for the preparation of s(+)-2-ethoxy-4-(n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl)benzoic acid derivatives
WO2005027913A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue
US9117477B2 (en) 2013-05-08 2015-08-25 HGST Netherlands B.V. Perpendicular magnetic recording media having novel seed layer
RU2670978C9 (ru) * 2013-05-28 2018-11-22 Раквалиа Фарма Инк. Полиморфные формы
CN109320515A (zh) * 2018-11-22 2019-02-12 常州大学 一种Capromorelin手性中间体的不对称合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8610980D0 (en) 1986-05-06 1986-06-11 Ici America Inc Heterocyclic fused tricyclic compounds
GB8901423D0 (en) 1989-01-23 1989-03-15 Fujisawa Pharmaceutical Co Pyrazolopyridine compound and processes for preparation thereof
US5578593A (en) 1992-12-11 1996-11-26 Merck & Co., Inc. Spiro piperidines and homologs promote release of growth hormone
PL322706A1 (en) 1993-11-09 1998-02-16 Merck & Co Inc Piperidines, pyrolidines and hexahydro-1h-azepins enhancing growth hormone liberation
US5609150A (en) 1995-04-18 1997-03-11 Maged; Jeffrey M. Method for dilating respiratory passages
TW432073B (en) 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
WO1997034604A1 (en) 1996-03-21 1997-09-25 Merck & Co., Inc. 4-spiroindoline piperidines promote release of growth hormone
WO1997036873A1 (en) 1996-04-03 1997-10-09 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
AU7445498A (en) 1997-06-25 1999-01-04 Pfizer Inc. Dipeptide derivatives as growth hormone secretagogues
UA53716C2 (uk) 1997-06-25 2003-02-17 Пфайзер Продактс Інк. Тартратна сіль заміщеного дипептиду, спосіб її одержання, проміжні сполуки та спосіб їх одержання, фармацевтична композиція (варіанти), спосіб підвищення рівнів ендогенного гормону росту та спосіб лікування або профілактики захворювань (варіанти)
UA64751C2 (uk) 1997-06-25 2004-03-15 Пфайзер Продактс Інк. Спосіб лікування інсулінової толерантності речовинами, які посилюють секрецію гормону росту (варіанти) та фармацевтична композиція (варіанти)

Also Published As

Publication number Publication date
AP1221A (en) 2003-11-03
BRPI0000967B8 (pt) 2021-12-07
HN2000000021A (es) 2001-02-02
CN1137891C (zh) 2004-02-11
IL134599A0 (en) 2001-04-30
TWI286142B (en) 2007-09-01
JP4051314B2 (ja) 2008-02-20
EP1449842A1 (en) 2004-08-25
IL157103A0 (en) 2004-02-08
HRP20000103A2 (en) 2001-04-30
TNSN00035A1 (fr) 2005-11-10
CA2299495A1 (en) 2000-08-26
EA200000172A3 (ru) 2000-10-30
PE20001550A1 (es) 2001-01-11
HU0000907D0 (en) 2000-04-28
EP1031575A1 (en) 2000-08-30
KR100361783B1 (ko) 2002-11-22
PA8491201A1 (es) 2001-04-30
ATE277944T1 (de) 2004-10-15
DE60014212T2 (de) 2005-12-15
JP2003261565A (ja) 2003-09-19
IS5380A (is) 2000-08-27
NZ503062A (en) 2001-07-27
AR029617A1 (es) 2003-07-10
NO20000965L (no) 2000-08-28
SI1031575T1 (en) 2005-02-28
ES2226712T3 (es) 2005-04-01
IL157103A (en) 2007-07-24
JP2003327585A (ja) 2003-11-19
KR20010006698A (ko) 2001-01-26
TR200000536A2 (tr) 2000-09-21
IN192352B (xx) 2004-04-10
JP2000247974A (ja) 2000-09-12
AR053722A2 (es) 2007-05-16
BRPI0000967A (pt) 2001-09-11
CN1270960A (zh) 2000-10-25
IL134599A (en) 2006-12-10
US6673929B2 (en) 2004-01-06
CO5160252A1 (es) 2002-05-30
BRPI0017522A2 (xx) 2009-12-22
EA003218B1 (ru) 2003-02-27
BRPI0000967B1 (pt) 2012-06-12
PT1031575E (pt) 2004-11-30
GT200000018A (es) 2001-08-16
HUP0000907A3 (en) 2001-05-28
JP3437813B2 (ja) 2003-08-18
DZ3018A1 (fr) 2004-03-20
US6541634B2 (en) 2003-04-01
AP2000001754A0 (en) 2000-03-31
CA2299495C (en) 2010-06-15
DE60014212D1 (de) 2004-11-04
MA25072A1 (fr) 2000-10-01
DK1031575T3 (da) 2005-01-03
HK1030219A1 (en) 2001-04-27
US20030158414A1 (en) 2003-08-21
EE200000193A (et) 2000-10-16
EP1031575B1 (en) 2004-09-29
PL338628A1 (en) 2000-08-28
KR20020065455A (ko) 2002-08-13
CN1515570A (zh) 2004-07-28
UA70306C2 (en) 2004-10-15
OA11325A (en) 2003-10-27
SK284982B6 (sk) 2006-03-02
BRPI0017522B1 (pt) 2013-09-24
HUP0000907A2 (en) 2001-03-28
ZA200000888B (en) 2001-08-23
ID24861A (id) 2000-08-31
NO20000965D0 (no) 2000-02-25
AU1947100A (en) 2000-08-31
US20020002283A1 (en) 2002-01-03
SG90096A1 (en) 2002-07-23
TW200718702A (en) 2007-05-16
CN1837205A (zh) 2006-09-27
BG104175A (bg) 2000-12-29
EA200000172A2 (ru) 2000-08-28
AU764122B2 (en) 2003-08-07
BRPI0017522B8 (pt) 2021-05-25
SK2302000A3 (en) 2000-11-07

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