ATE277944T1 - Verfahren zur herstellung von substanzen zur förderung der sekretion des wachstumsharmones - Google Patents

Verfahren zur herstellung von substanzen zur förderung der sekretion des wachstumsharmones

Info

Publication number
ATE277944T1
ATE277944T1 AT00301526T AT00301526T ATE277944T1 AT E277944 T1 ATE277944 T1 AT E277944T1 AT 00301526 T AT00301526 T AT 00301526T AT 00301526 T AT00301526 T AT 00301526T AT E277944 T1 ATE277944 T1 AT E277944T1
Authority
AT
Austria
Prior art keywords
secretion
promoting
producing substances
harmone
growth
Prior art date
Application number
AT00301526T
Other languages
English (en)
Inventor
Frank Robert Busch
Charles Kwok-Fung Chiu
Clifford Nathaniel Meltz
Ronald James Post
Peter Robert Rose
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of ATE277944T1 publication Critical patent/ATE277944T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT00301526T 1999-02-26 2000-02-25 Verfahren zur herstellung von substanzen zur förderung der sekretion des wachstumsharmones ATE277944T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12274599P 1999-02-26 1999-02-26

Publications (1)

Publication Number Publication Date
ATE277944T1 true ATE277944T1 (de) 2004-10-15

Family

ID=22404505

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00301526T ATE277944T1 (de) 1999-02-26 2000-02-25 Verfahren zur herstellung von substanzen zur förderung der sekretion des wachstumsharmones

Country Status (44)

Country Link
US (2) US6541634B2 (de)
EP (2) EP1031575B1 (de)
JP (3) JP3437813B2 (de)
KR (2) KR100372063B1 (de)
CN (3) CN1515570A (de)
AP (1) AP1221A (de)
AR (2) AR029617A1 (de)
AT (1) ATE277944T1 (de)
AU (1) AU764122B2 (de)
BG (1) BG104175A (de)
BR (2) BRPI0017522B8 (de)
CA (1) CA2299495C (de)
CO (1) CO5160252A1 (de)
DE (1) DE60014212T2 (de)
DK (1) DK1031575T3 (de)
DZ (1) DZ3018A1 (de)
EA (1) EA003218B1 (de)
EE (1) EE200000193A (de)
ES (1) ES2226712T3 (de)
GT (1) GT200000018A (de)
HK (1) HK1030219A1 (de)
HN (1) HN2000000021A (de)
HR (1) HRP20000103A2 (de)
HU (1) HUP0000907A3 (de)
ID (1) ID24861A (de)
IL (2) IL134599A (de)
IN (1) IN192352B (de)
IS (1) IS5380A (de)
MA (1) MA25072A1 (de)
NO (1) NO20000965L (de)
NZ (1) NZ503062A (de)
OA (1) OA11325A (de)
PA (1) PA8491201A1 (de)
PE (1) PE20001550A1 (de)
PL (1) PL338628A1 (de)
PT (1) PT1031575E (de)
SG (1) SG90096A1 (de)
SI (1) SI1031575T1 (de)
SK (1) SK284982B6 (de)
TN (1) TNSN00035A1 (de)
TR (1) TR200000536A2 (de)
TW (2) TWI286142B (de)
UA (1) UA70306C2 (de)
ZA (1) ZA200000888B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1132388A3 (de) * 2000-03-09 2004-03-03 Pfizer Products Inc. Metaboliten von Hexahydropyrazolo[4,3-c]pyridinen
JP2003534377A (ja) 2000-05-30 2003-11-18 メルク エンド カムパニー インコーポレーテッド メラノコルチン受容体作働薬
WO2004103983A1 (en) * 2003-05-26 2004-12-02 Biocon Limited Process for the preparation of s(+)-2-ethoxy-4-[n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl]benzoic acid derivatives
WO2005027913A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue
US9117477B2 (en) 2013-05-08 2015-08-25 HGST Netherlands B.V. Perpendicular magnetic recording media having novel seed layer
US9499543B2 (en) * 2013-05-28 2016-11-22 Raqualia Pharma Inc. Polymorph forms
CN109320515A (zh) * 2018-11-22 2019-02-12 常州大学 一种Capromorelin手性中间体的不对称合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8610980D0 (en) 1986-05-06 1986-06-11 Ici America Inc Heterocyclic fused tricyclic compounds
GB8901423D0 (en) 1989-01-23 1989-03-15 Fujisawa Pharmaceutical Co Pyrazolopyridine compound and processes for preparation thereof
US5578593A (en) 1992-12-11 1996-11-26 Merck & Co., Inc. Spiro piperidines and homologs promote release of growth hormone
CA2175218A1 (en) 1993-11-09 1995-05-18 Gregori J. Morriello Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
US5609150A (en) 1995-04-18 1997-03-11 Maged; Jeffrey M. Method for dilating respiratory passages
TW432073B (en) 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
WO1997034604A1 (en) 1996-03-21 1997-09-25 Merck & Co., Inc. 4-spiroindoline piperidines promote release of growth hormone
WO1997036873A1 (en) 1996-04-03 1997-10-09 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
UA64751C2 (uk) * 1997-06-25 2004-03-15 Пфайзер Продактс Інк. Спосіб лікування інсулінової толерантності речовинами, які посилюють секрецію гормону росту (варіанти) та фармацевтична композиція (варіанти)
USRE38524E1 (en) 1997-06-25 2004-06-01 Pfizer Inc. Dipeptide derivatives as growth hormone secretagogues
UA53716C2 (uk) 1997-06-25 2003-02-17 Пфайзер Продактс Інк. Тартратна сіль заміщеного дипептиду, спосіб її одержання, проміжні сполуки та спосіб їх одержання, фармацевтична композиція (варіанти), спосіб підвищення рівнів ендогенного гормону росту та спосіб лікування або профілактики захворювань (варіанти)

Also Published As

Publication number Publication date
TWI286142B (en) 2007-09-01
HN2000000021A (es) 2001-02-02
KR20010006698A (ko) 2001-01-26
PA8491201A1 (es) 2001-04-30
BG104175A (bg) 2000-12-29
NO20000965L (no) 2000-08-28
CN1515570A (zh) 2004-07-28
US6541634B2 (en) 2003-04-01
TNSN00035A1 (fr) 2005-11-10
ES2226712T3 (es) 2005-04-01
PL338628A1 (en) 2000-08-28
TW200718702A (en) 2007-05-16
DZ3018A1 (fr) 2004-03-20
KR100372063B1 (ko) 2003-02-14
SK2302000A3 (en) 2000-11-07
EP1031575A1 (de) 2000-08-30
NZ503062A (en) 2001-07-27
HU0000907D0 (en) 2000-04-28
KR20020065455A (ko) 2002-08-13
UA70306C2 (en) 2004-10-15
CN1837205A (zh) 2006-09-27
TR200000536A2 (tr) 2000-09-21
DE60014212D1 (de) 2004-11-04
BRPI0017522B8 (pt) 2021-05-25
IL157103A (en) 2007-07-24
HK1030219A1 (en) 2001-04-27
HUP0000907A3 (en) 2001-05-28
ZA200000888B (en) 2001-08-23
PT1031575E (pt) 2004-11-30
CA2299495A1 (en) 2000-08-26
KR100361783B1 (ko) 2002-11-22
DK1031575T3 (da) 2005-01-03
SG90096A1 (en) 2002-07-23
PE20001550A1 (es) 2001-01-11
US20030158414A1 (en) 2003-08-21
JP2000247974A (ja) 2000-09-12
IL134599A0 (en) 2001-04-30
BRPI0017522A2 (de) 2009-12-22
JP3437813B2 (ja) 2003-08-18
DE60014212T2 (de) 2005-12-15
NO20000965D0 (no) 2000-02-25
JP2003327585A (ja) 2003-11-19
BRPI0000967B8 (pt) 2021-12-07
HRP20000103A2 (en) 2001-04-30
AR029617A1 (es) 2003-07-10
CO5160252A1 (es) 2002-05-30
ID24861A (id) 2000-08-31
CA2299495C (en) 2010-06-15
HUP0000907A2 (en) 2001-03-28
JP4051314B2 (ja) 2008-02-20
OA11325A (en) 2003-10-27
US20020002283A1 (en) 2002-01-03
AR053722A2 (es) 2007-05-16
BRPI0000967B1 (pt) 2012-06-12
SI1031575T1 (en) 2005-02-28
AU1947100A (en) 2000-08-31
US6673929B2 (en) 2004-01-06
MA25072A1 (fr) 2000-10-01
IL157103A0 (en) 2004-02-08
BRPI0017522B1 (pt) 2013-09-24
AP2000001754A0 (en) 2000-03-31
EE200000193A (et) 2000-10-16
EP1031575B1 (de) 2004-09-29
IN192352B (de) 2004-04-10
JP2003261565A (ja) 2003-09-19
CN1270960A (zh) 2000-10-25
AU764122B2 (en) 2003-08-07
EA003218B1 (ru) 2003-02-27
BRPI0000967A (pt) 2001-09-11
GT200000018A (es) 2001-08-16
EA200000172A3 (ru) 2000-10-30
EA200000172A2 (ru) 2000-08-28
IL134599A (en) 2006-12-10
EP1449842A1 (de) 2004-08-25
CN1137891C (zh) 2004-02-11
IS5380A (is) 2000-08-27
AP1221A (en) 2003-11-03
SK284982B6 (sk) 2006-03-02

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