KR100248324B1 - 메토트렉세이트 유도체 - Google Patents

메토트렉세이트 유도체 Download PDF

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Publication number
KR100248324B1
KR100248324B1 KR1019940702559A KR19940702559A KR100248324B1 KR 100248324 B1 KR100248324 B1 KR 100248324B1 KR 1019940702559 A KR1019940702559 A KR 1019940702559A KR 19940702559 A KR19940702559 A KR 19940702559A KR 100248324 B1 KR100248324 B1 KR 100248324B1
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KR
South Korea
Prior art keywords
compound
general formula
solution
added
lower alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019940702559A
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English (en)
Korean (ko)
Inventor
히로하루 마쓰오까
히로시 스즈끼
노부아끼 가또
게이이찌로 쓰지
도시오 구로끼
노리아끼 마루야마
가즈야 나까고미
Original Assignee
나가야마 오사무
쥬가이 세이야쿠 가부시키가이샤
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Application granted granted Critical
Publication of KR100248324B1 publication Critical patent/KR100248324B1/ko
Anticipated expiration legal-status Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1019940702559A 1992-01-27 1993-01-27 메토트렉세이트 유도체 Expired - Fee Related KR100248324B1 (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP5305192 1992-01-27
JP92-53051 1992-01-27
JP7510692 1992-02-13
JP92-75106 1992-02-13
JP92-108320 1992-03-16
JP10832092 1992-03-16
JP11512692 1992-03-24
JP92-115126 1992-03-24
PCT/JP1993/000096 WO1993015077A1 (fr) 1992-01-27 1993-01-27 Derive de methotrexate

Publications (1)

Publication Number Publication Date
KR100248324B1 true KR100248324B1 (ko) 2000-04-01

Family

ID=27462860

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940702559A Expired - Fee Related KR100248324B1 (ko) 1992-01-27 1993-01-27 메토트렉세이트 유도체

Country Status (10)

Country Link
US (2) US6559149B1 (enExample)
EP (1) EP0632038B1 (enExample)
KR (1) KR100248324B1 (enExample)
AT (1) ATE204576T1 (enExample)
AU (1) AU3367693A (enExample)
CA (1) CA2128205C (enExample)
DE (1) DE69330639T2 (enExample)
ES (1) ES2161713T3 (enExample)
TW (1) TW223637B (enExample)
WO (1) WO1993015077A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3367693A (en) * 1992-01-27 1993-09-01 Chugai Seiyaku Kabushiki Kaisha Methotrexate derivative
CN1037771C (zh) * 1992-12-25 1998-03-18 中外制药株式会社 甲氨喋呤衍生物
EP0818199A4 (en) * 1995-03-27 2002-08-14 Chugai Pharmaceutical Co Ltd MEDICINE CONTAINING METHOTREXATE DERIVATIVE
US7276506B2 (en) * 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
CA2408913A1 (en) 2000-05-16 2001-11-22 Takeda Chemical Industries, Ltd. Melanin-concentrating hormone antagonist
US20070032477A1 (en) * 2003-10-17 2007-02-08 Waer Mark J A Pteridine derivatives useful for making pharmaceutical compositions
US20060039985A1 (en) * 2004-04-27 2006-02-23 Bennett David B Methotrexate compositions
US7601834B2 (en) * 2005-02-22 2009-10-13 Savvipharm Inc Compositions and methods of reducing side effects and toxicity of methotrexate when given as orotate derivatives
CA2631014C (en) 2005-11-28 2015-04-28 Vernon D. Rowe Compositions useful for reducing nephrotoxicity and methods of use thereof
WO2007098089A2 (en) * 2006-02-17 2007-08-30 Novacea, Inc. Treatment of hyperproliferative diseases with methotrexate n-oxide and analogs
US9259426B2 (en) 2006-07-20 2016-02-16 Gilead Sciences, Inc. 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
US10144736B2 (en) * 2006-07-20 2018-12-04 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
JP5693950B2 (ja) 2007-04-11 2015-04-01 メルク エ カンパニー １８ｆ標識葉酸
KR101657323B1 (ko) 2008-11-19 2016-09-13 포라 가세이 고교 가부시키가이샤 주름 개선제
PL3097102T3 (pl) 2015-03-04 2018-04-30 Gilead Sciences Inc Związki 4,6-diamino-pirydo[3,2-d]pirymidyny modulujące działanie receptora toll-podobnego
KR102268448B1 (ko) 2016-09-02 2021-06-22 길리애드 사이언시즈, 인코포레이티드 톨 유사 수용체 조정제 화합물
ES2826748T3 (es) 2016-09-02 2021-05-19 Gilead Sciences Inc Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4490529A (en) * 1983-09-06 1984-12-25 Dana-Farber Cancer Institute, Inc. Cysteic acid and homocysteic acid analogues of methotrexate and aminopterin

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI812775A7 (fi) 1980-09-12 1982-03-13 Farmos Oy Menetelmä N-/4-/(2,4-diamino-6- pteridinyyli)-metyyli/- metyyliamino/bentsoyyli/glutamiinihapon ja senjohdannaisten valmistamiseksi.
JP3124592B2 (ja) * 1990-08-14 2001-01-15 中外製薬株式会社 新規メトトレキセート誘導体
ATE187455T1 (de) * 1990-08-14 1999-12-15 Chugai Pharmaceutical Co Ltd Methotrexatderivate mit antirheumatischer aktivität
AU3367693A (en) * 1992-01-27 1993-09-01 Chugai Seiyaku Kabushiki Kaisha Methotrexate derivative
JP3207285B2 (ja) * 1992-01-27 2001-09-10 中外製薬株式会社 新規メトトレキセート誘導体
JP3274532B2 (ja) * 1992-03-24 2002-04-15 中外製薬株式会社 抗リウマチ剤

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4490529A (en) * 1983-09-06 1984-12-25 Dana-Farber Cancer Institute, Inc. Cysteic acid and homocysteic acid analogues of methotrexate and aminopterin

Also Published As

Publication number Publication date
AU3367693A (en) 1993-09-01
EP0632038A4 (en) 1995-02-22
EP0632038A1 (en) 1995-01-04
CA2128205A1 (en) 1993-08-05
US6559149B1 (en) 2003-05-06
TW223637B (enExample) 1994-05-11
US20030171376A1 (en) 2003-09-11
WO1993015077A1 (fr) 1993-08-05
ATE204576T1 (de) 2001-09-15
DE69330639T2 (de) 2002-07-04
EP0632038B1 (en) 2001-08-22
CA2128205C (en) 2004-03-30
DE69330639D1 (de) 2001-09-27
ES2161713T3 (es) 2001-12-16

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