ATE204576T1 - Methotrexat-derivate - Google Patents

Methotrexat-derivate

Info

Publication number
ATE204576T1
ATE204576T1 AT93902536T AT93902536T ATE204576T1 AT E204576 T1 ATE204576 T1 AT E204576T1 AT 93902536 T AT93902536 T AT 93902536T AT 93902536 T AT93902536 T AT 93902536T AT E204576 T1 ATE204576 T1 AT E204576T1
Authority
AT
Austria
Prior art keywords
methotrexate derivatives
antirheumatic
chem
iii
image
Prior art date
Application number
AT93902536T
Other languages
German (de)
English (en)
Inventor
Hiroharu Matsuoka
Hiroshi Suzuki
Nobuaki Kato
Keiichiro Tsuji
Toshio Kuroki
Noriaki Maruyama
Kazuya Nakagomi
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE204576T1 publication Critical patent/ATE204576T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT93902536T 1992-01-27 1993-01-27 Methotrexat-derivate ATE204576T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP5305192 1992-01-27
JP7510692 1992-02-13
JP10832092 1992-03-16
JP11512692 1992-03-24
PCT/JP1993/000096 WO1993015077A1 (fr) 1992-01-27 1993-01-27 Derive de methotrexate

Publications (1)

Publication Number Publication Date
ATE204576T1 true ATE204576T1 (de) 2001-09-15

Family

ID=27462860

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93902536T ATE204576T1 (de) 1992-01-27 1993-01-27 Methotrexat-derivate

Country Status (10)

Country Link
US (2) US6559149B1 (enExample)
EP (1) EP0632038B1 (enExample)
KR (1) KR100248324B1 (enExample)
AT (1) ATE204576T1 (enExample)
AU (1) AU3367693A (enExample)
CA (1) CA2128205C (enExample)
DE (1) DE69330639T2 (enExample)
ES (1) ES2161713T3 (enExample)
TW (1) TW223637B (enExample)
WO (1) WO1993015077A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0632038B1 (en) * 1992-01-27 2001-08-22 Chugai Seiyaku Kabushiki Kaisha Methotrexate derivative
CA2152485A1 (en) * 1992-12-25 1994-07-07 Nobuhiro Ohi Methotrexate derivative
KR100400509B1 (ko) * 1995-03-27 2004-04-03 쥬가이 세이야쿠 가부시키가이샤 메토트렉세이트유도체를함유하는약제
US7276506B2 (en) * 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
US7229986B2 (en) 2000-05-16 2007-06-12 Takeda Pharmaceutical Company Ltd. Melanin-concentrating hormone antagonist
US20070032477A1 (en) * 2003-10-17 2007-02-08 Waer Mark J A Pteridine derivatives useful for making pharmaceutical compositions
US20060039985A1 (en) * 2004-04-27 2006-02-23 Bennett David B Methotrexate compositions
US7601834B2 (en) * 2005-02-22 2009-10-13 Savvipharm Inc Compositions and methods of reducing side effects and toxicity of methotrexate when given as orotate derivatives
CN101355952B (zh) 2005-11-28 2012-03-21 韦罗制药有限公司 用于减少肾毒性的组合物及其使用方法
WO2007098089A2 (en) * 2006-02-17 2007-08-30 Novacea, Inc. Treatment of hyperproliferative diseases with methotrexate n-oxide and analogs
WO2008009078A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
US10144736B2 (en) * 2006-07-20 2018-12-04 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
AU2008237934B2 (en) 2007-04-11 2014-03-27 Merck & Cie 18F-labelled folates
JP5746864B2 (ja) 2008-11-19 2015-07-08 ポーラ化成工業株式会社 シワ改善剤
KR102394917B1 (ko) 2015-03-04 2022-05-09 길리애드 사이언시즈, 인코포레이티드 톨 유사 수용체 조정제 화합물
WO2018045150A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
PT3507276T (pt) 2016-09-02 2022-01-11 Gilead Sciences Inc Compostos moduladores do recetor de tipo toll
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI812775L (fi) * 1980-09-12 1982-03-13 Farmos Oy Foerfarande foer framstaellning av n-/4-/(2,4-diamino-6-pteridinyl)-metyl/metylamino/benzoyl/glutaminsyra och derivat daerav
US4490529A (en) * 1983-09-06 1984-12-25 Dana-Farber Cancer Institute, Inc. Cysteic acid and homocysteic acid analogues of methotrexate and aminopterin
JP3124592B2 (ja) * 1990-08-14 2001-01-15 中外製薬株式会社 新規メトトレキセート誘導体
WO1992003436A1 (fr) * 1990-08-14 1992-03-05 Chugai Seiyaku Kabushiki Kaisha Nouveau derive de methotrexate
EP0632038B1 (en) * 1992-01-27 2001-08-22 Chugai Seiyaku Kabushiki Kaisha Methotrexate derivative
JP3207285B2 (ja) * 1992-01-27 2001-09-10 中外製薬株式会社 新規メトトレキセート誘導体
JP3274532B2 (ja) * 1992-03-24 2002-04-15 中外製薬株式会社 抗リウマチ剤

Also Published As

Publication number Publication date
AU3367693A (en) 1993-09-01
CA2128205A1 (en) 1993-08-05
EP0632038B1 (en) 2001-08-22
US20030171376A1 (en) 2003-09-11
TW223637B (enExample) 1994-05-11
US6559149B1 (en) 2003-05-06
CA2128205C (en) 2004-03-30
WO1993015077A1 (fr) 1993-08-05
DE69330639D1 (de) 2001-09-27
ES2161713T3 (es) 2001-12-16
KR100248324B1 (ko) 2000-04-01
EP0632038A1 (en) 1995-01-04
EP0632038A4 (en) 1995-02-22
DE69330639T2 (de) 2002-07-04

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