ES2161713T3 - Derivado de metotrexato. - Google Patents

Derivado de metotrexato.

Info

Publication number
ES2161713T3
ES2161713T3 ES93902536T ES93902536T ES2161713T3 ES 2161713 T3 ES2161713 T3 ES 2161713T3 ES 93902536 T ES93902536 T ES 93902536T ES 93902536 T ES93902536 T ES 93902536T ES 2161713 T3 ES2161713 T3 ES 2161713T3
Authority
ES
Spain
Prior art keywords
metotrexate
derivative
antirheumatic
chem
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93902536T
Other languages
English (en)
Spanish (es)
Inventor
Hiroharu Matsuoka
Hiroshi Suzuki
Nobuaki Kato
Keiichiro Tsuji
Toshio Kuroki
Noriaki Maruyama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2161713T3 publication Critical patent/ES2161713T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ES93902536T 1992-01-27 1993-01-27 Derivado de metotrexato. Expired - Lifetime ES2161713T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP5305192 1992-01-27
JP7510692 1992-02-13
JP10832092 1992-03-16
JP11512692 1992-03-24

Publications (1)

Publication Number Publication Date
ES2161713T3 true ES2161713T3 (es) 2001-12-16

Family

ID=27462860

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93902536T Expired - Lifetime ES2161713T3 (es) 1992-01-27 1993-01-27 Derivado de metotrexato.

Country Status (10)

Country Link
US (2) US6559149B1 (enExample)
EP (1) EP0632038B1 (enExample)
KR (1) KR100248324B1 (enExample)
AT (1) ATE204576T1 (enExample)
AU (1) AU3367693A (enExample)
CA (1) CA2128205C (enExample)
DE (1) DE69330639T2 (enExample)
ES (1) ES2161713T3 (enExample)
TW (1) TW223637B (enExample)
WO (1) WO1993015077A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2128205C (en) * 1992-01-27 2004-03-30 Hiroharu Matsuoka Methotrexate derivatives
KR100259742B1 (ko) * 1992-12-25 2000-07-01 나가야마 오사무 메토트렉세이트 유도체
KR100400509B1 (ko) * 1995-03-27 2004-04-03 쥬가이 세이야쿠 가부시키가이샤 메토트렉세이트유도체를함유하는약제
US7276506B2 (en) * 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
EP1283199A4 (en) * 2000-05-16 2003-12-17 Takeda Chemical Industries Ltd MELANINE CONCENTRATING HORMONE ANTAGONISTS
US20070032477A1 (en) * 2003-10-17 2007-02-08 Waer Mark J A Pteridine derivatives useful for making pharmaceutical compositions
US20060039985A1 (en) * 2004-04-27 2006-02-23 Bennett David B Methotrexate compositions
US7601834B2 (en) * 2005-02-22 2009-10-13 Savvipharm Inc Compositions and methods of reducing side effects and toxicity of methotrexate when given as orotate derivatives
WO2007062403A2 (en) 2005-11-28 2007-05-31 Vernon D Rowe Compositions useful for reducing nephrotoxicity and methods of use thereof
WO2007098089A2 (en) * 2006-02-17 2007-08-30 Novacea, Inc. Treatment of hyperproliferative diseases with methotrexate n-oxide and analogs
WO2008009078A2 (en) 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
WO2008009079A2 (en) * 2006-07-20 2008-01-24 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
TR201901010T4 (tr) 2007-04-11 2019-02-21 Merck & Cie 18F etiketli folatlar.
CN102215812B (zh) 2008-11-19 2014-09-10 宝丽化成工业有限公司 抗皱剂
SG11201606876RA (en) 2015-03-04 2016-10-28 Gilead Sciences Inc Toll like receptor modulator compounds
SI3507276T1 (sl) 2016-09-02 2022-01-31 Gilead Sciences, Inc. Spojine modulatorja toličnih receptorjev
WO2018045150A1 (en) 2016-09-02 2018-03-08 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
TWI751517B (zh) 2019-04-17 2022-01-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TWI879779B (zh) 2019-06-28 2025-04-11 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI812775L (fi) * 1980-09-12 1982-03-13 Farmos Oy Foerfarande foer framstaellning av n-/4-/(2,4-diamino-6-pteridinyl)-metyl/metylamino/benzoyl/glutaminsyra och derivat daerav
US4490529A (en) 1983-09-06 1984-12-25 Dana-Farber Cancer Institute, Inc. Cysteic acid and homocysteic acid analogues of methotrexate and aminopterin
SG49917A1 (en) * 1990-08-14 1998-06-15 Chugai Pharmaceutical Co Ltd Novel methotrexate derivatives
JP3124592B2 (ja) * 1990-08-14 2001-01-15 中外製薬株式会社 新規メトトレキセート誘導体
CA2128205C (en) * 1992-01-27 2004-03-30 Hiroharu Matsuoka Methotrexate derivatives
JP3207285B2 (ja) * 1992-01-27 2001-09-10 中外製薬株式会社 新規メトトレキセート誘導体
JP3274532B2 (ja) * 1992-03-24 2002-04-15 中外製薬株式会社 抗リウマチ剤

Also Published As

Publication number Publication date
EP0632038B1 (en) 2001-08-22
CA2128205A1 (en) 1993-08-05
ATE204576T1 (de) 2001-09-15
KR100248324B1 (ko) 2000-04-01
US6559149B1 (en) 2003-05-06
DE69330639D1 (de) 2001-09-27
EP0632038A1 (en) 1995-01-04
US20030171376A1 (en) 2003-09-11
WO1993015077A1 (fr) 1993-08-05
EP0632038A4 (en) 1995-02-22
TW223637B (enExample) 1994-05-11
AU3367693A (en) 1993-09-01
DE69330639T2 (de) 2002-07-04
CA2128205C (en) 2004-03-30

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