KR100188305B1 - 신규의 시클로스포린 결정 형태, 이것의 제조 방법 및 이것을 함유한 약학 조성물 및 그 용도 - Google Patents

신규의 시클로스포린 결정 형태, 이것의 제조 방법 및 이것을 함유한 약학 조성물 및 그 용도 Download PDF

Info

Publication number
KR100188305B1
KR100188305B1 KR1019880017194A KR880017194A KR100188305B1 KR 100188305 B1 KR100188305 B1 KR 100188305B1 KR 1019880017194 A KR1019880017194 A KR 1019880017194A KR 880017194 A KR880017194 A KR 880017194A KR 100188305 B1 KR100188305 B1 KR 100188305B1
Authority
KR
South Korea
Prior art keywords
cyclosporin
cyclosporine
iii
treatment
composition
Prior art date
Application number
KR1019880017194A
Other languages
English (en)
Korean (ko)
Other versions
KR890009975A (ko
Inventor
지롱 다니엘르
리스트 마틴
리흐터 프리드리흐
야수이우키 우이케
페터베버 한스
Original Assignee
더블류. 하링, 지. 보이롤
노바르티스 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 더블류. 하링, 지. 보이롤, 노바르티스 아게 filed Critical 더블류. 하링, 지. 보이롤
Publication of KR890009975A publication Critical patent/KR890009975A/ko
Application granted granted Critical
Publication of KR100188305B1 publication Critical patent/KR100188305B1/ko

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
KR1019880017194A 1987-12-21 1988-12-20 신규의 시클로스포린 결정 형태, 이것의 제조 방법 및 이것을 함유한 약학 조성물 및 그 용도 KR100188305B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US13623087A 1987-12-21 1987-12-21
US136230 1987-12-21
US17261388A 1988-03-24 1988-03-24
US172613 1988-03-24
US21254888A 1988-06-28 1988-06-28
US212548 1988-06-28

Publications (2)

Publication Number Publication Date
KR890009975A KR890009975A (ko) 1989-08-05
KR100188305B1 true KR100188305B1 (ko) 1999-06-01

Family

ID=27384838

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880017194A KR100188305B1 (ko) 1987-12-21 1988-12-20 신규의 시클로스포린 결정 형태, 이것의 제조 방법 및 이것을 함유한 약학 조성물 및 그 용도

Country Status (27)

Country Link
JP (1) JPH0791316B2 (de)
KR (1) KR100188305B1 (de)
AT (1) AT403163B (de)
AU (1) AU626274B2 (de)
BE (1) BE1002665A4 (de)
CA (1) CA1341396C (de)
CH (1) CH677926A5 (de)
CY (1) CY1799A (de)
DE (1) DE3843054C2 (de)
DK (1) DK175220B1 (de)
ES (1) ES2012580A6 (de)
FI (1) FI89065C (de)
FR (1) FR2624863B1 (de)
GB (1) GB2211848B (de)
GR (1) GR1002486B (de)
HK (1) HK102894A (de)
HU (1) HU203564B (de)
IE (1) IE62006B1 (de)
IL (1) IL88719A0 (de)
IT (1) IT1235356B (de)
LU (1) LU87409A1 (de)
MY (1) MY103943A (de)
NL (1) NL195096C (de)
NO (1) NO177228C (de)
NZ (1) NZ227384A (de)
SE (1) SE503174C2 (de)
SG (1) SG99494G (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140047054A (ko) * 2011-05-27 2014-04-21 알러간, 인코포레이티드 사이클로스포린 a의 결정형, 이의 제조 방법 및 이의 사용 방법
KR20140100966A (ko) * 2011-11-15 2014-08-18 알러간, 인코포레이티드 사이클로스포린 제2형의 지속 작용 제형

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
US7081445B2 (en) 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US5294604A (en) * 1989-12-20 1994-03-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating ocular diseases by periocular administration of cyclosporine A or G
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
ATE147619T1 (de) * 1992-05-13 1997-02-15 Sandoz Ag Opthalmische zusammensetzungen enthaltend ein cyclosporin
ES2168271T3 (es) 1992-09-25 2002-06-16 Novartis Ag Composiciones farmaceuticas que contienen ciclosporinas.
CA2231404C (en) 1994-11-03 2009-02-17 Arzneimittelwerk Dresden Gmbh Novel cyclosporine preparation forms for oral administration of simple composition and high bio-availability, and process for producing them
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
DE19544507B4 (de) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin enthaltende Präparate
US6262054B1 (en) 1996-02-01 2001-07-17 Sloan-Kettering Institute Of Cancer Research Combination therapy method for treating breast cancer using edatrexate
DE29824679U1 (de) 1997-01-30 2002-03-28 Novartis Ag Pharmazeutische Zusammensetzungen
TW581681B (en) 1998-02-20 2004-04-01 Nektar Therapeutics Liquid crystal forms of cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
AU2005209201B2 (en) 2004-01-20 2010-06-03 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
CN1763084B (zh) * 2005-10-11 2010-04-21 山东新时代药业有限公司 高纯度环孢菌素a的制备方法
JP6368244B2 (ja) * 2011-11-15 2018-08-01 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ オートクレーブ可能なシクロスポリンａ２型の懸濁剤
EP2780358B1 (de) * 2011-11-15 2016-03-23 Allergan, Inc. Cyclosporin-2 im form 2 und verfahren zu deren herstellung
ES2791751T3 (es) 2011-11-15 2020-11-05 Allergan Inc Suspensiones de forma 2 de ciclosporina A

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH614931A5 (de) * 1975-11-04 1979-12-28 Sandoz Ag
CH640519A5 (en) * 1976-04-09 1984-01-13 Sandoz Ag Process for preparing a modified form of the antibiotic S 7481/F-1
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
CH637124A5 (en) * 1978-10-18 1983-07-15 Sandoz Ag Antibiotic, its preparation and use

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20140047054A (ko) * 2011-05-27 2014-04-21 알러간, 인코포레이티드 사이클로스포린 a의 결정형, 이의 제조 방법 및 이의 사용 방법
KR102079402B1 (ko) * 2011-05-27 2020-02-19 알러간, 인코포레이티드 사이클로스포린 a의 결정형, 이의 제조 방법 및 이의 사용 방법
KR20140100966A (ko) * 2011-11-15 2014-08-18 알러간, 인코포레이티드 사이클로스포린 제2형의 지속 작용 제형
KR102029513B1 (ko) * 2011-11-15 2019-10-07 알러간, 인코포레이티드 사이클로스포린 제2형의 지속 작용 제형

Also Published As

Publication number Publication date
DK705488A (da) 1989-06-22
FR2624863A1 (fr) 1989-06-23
IE62006B1 (en) 1994-12-14
JPH01211598A (ja) 1989-08-24
AU626274B2 (en) 1992-07-30
HK102894A (en) 1994-09-30
JPH0791316B2 (ja) 1995-10-04
DE3843054A1 (de) 1989-07-27
NO177228C (no) 1995-08-09
GB2211848A (en) 1989-07-12
CA1341396C (en) 2002-11-05
MY103943A (en) 1993-10-30
NO885625D0 (no) 1988-12-19
NO177228B (no) 1995-05-02
CY1799A (en) 1995-02-17
GR1002486B (el) 1996-12-09
KR890009975A (ko) 1989-08-05
DK175220B1 (da) 2004-07-12
AT403163B (de) 1997-11-25
ATA309588A (de) 1997-04-15
FI885869A (fi) 1989-06-22
SE8804570L (sv) 1989-06-22
FI885869A0 (fi) 1988-12-19
DK705488D0 (da) 1988-12-19
SE8804570D0 (sv) 1988-12-19
CH677926A5 (de) 1991-07-15
FI89065C (fi) 1993-09-30
HU203564B (en) 1991-08-28
IL88719A0 (en) 1989-07-31
DE3843054C2 (de) 2003-08-21
IE883779L (en) 1989-06-21
ES2012580A6 (es) 1990-04-01
IT8848690A0 (it) 1988-12-20
NL195096C (nl) 2004-02-09
GR880100850A (el) 1994-03-31
SG99494G (en) 1994-10-28
GB8829556D0 (en) 1989-02-08
FI89065B (fi) 1993-04-30
FR2624863B1 (fr) 1991-04-26
GB2211848B (en) 1991-11-06
NL8803125A (nl) 1989-07-17
HUT49893A (en) 1989-11-28
NO885625L (no) 1989-06-22
SE503174C2 (sv) 1996-04-15
BE1002665A4 (fr) 1991-04-30
LU87409A1 (fr) 1989-07-07
AU2705588A (en) 1989-06-22
IT1235356B (it) 1992-06-30
NZ227384A (en) 1991-09-25

Similar Documents

Publication Publication Date Title
KR100188305B1 (ko) 신규의 시클로스포린 결정 형태, 이것의 제조 방법 및 이것을 함유한 약학 조성물 및 그 용도
US5756450A (en) Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
AT403435B (de) Cyclosporin enthaltende pharmazeutische zusammensetzung
JPH0611703B2 (ja) 新規シクロスポリン製剤
JP3090666B2 (ja) 薬理活性化合物および医薬賦形剤用可溶化剤としての水溶性モノエステル類
SK278320B6 (en) Process for producing of cyclosporine a
HU212727B (en) Process for producing pharmaceutical compositions in form of microemulsion-prae-concentrate or microemulsion containing cyclosporin(s) as active component
KR100267149B1 (ko) 사이클로스포린을 함유하는 약학 조성물
KR100256007B1 (ko) 사이클로스포린을 함유하는 약학 조성물

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E601 Decision to refuse application
J2X1 Appeal (before the patent court)

Free format text: APPEAL AGAINST DECISION TO DECLINE REFUSAL

Free format text: TRIAL NUMBER: 1997201002487; APPEAL AGAINST DECISION TO DECLINE REFUSAL

N231 Notification of change of applicant
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20111221

Year of fee payment: 14

FPAY Annual fee payment

Payment date: 20121226

Year of fee payment: 15

EXPY Expiration of term