BE1002665A4 - Nouvelle forme cristalline de la ciclosporine, sa preparation et les compositions pharmaceutiques la contenant. - Google Patents

Nouvelle forme cristalline de la ciclosporine, sa preparation et les compositions pharmaceutiques la contenant. Download PDF

Info

Publication number
BE1002665A4
BE1002665A4 BE8801421A BE8801421A BE1002665A4 BE 1002665 A4 BE1002665 A4 BE 1002665A4 BE 8801421 A BE8801421 A BE 8801421A BE 8801421 A BE8801421 A BE 8801421A BE 1002665 A4 BE1002665 A4 BE 1002665A4
Authority
BE
Belgium
Prior art keywords
ciclosporin
crystalline form
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
BE8801421A
Other languages
English (en)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Application granted granted Critical
Publication of BE1002665A4 publication Critical patent/BE1002665A4/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention a pour objet de nouvelles compositions pharmaceutiques, en particulier sous forme topique, par exemple pour une utilisation dermique ou une application topique sur l'oeil, et des formes injectables, par exemple pour une injection dans la lésion ou intra-articulaire, comprenant la Ciclosporine comme substance active sous forme cristalline orthorhombique. La Ciclosporine sous forme cristalline orthorhombique non solvatée est préférée pour une utilisation dans les compositions de l'invention, est nouvelle et fait également partie de l'invention ainsi que son utilisation et ses procédés de préparation.
BE8801421A 1987-12-21 1988-12-20 Nouvelle forme cristalline de la ciclosporine, sa preparation et les compositions pharmaceutiques la contenant. BE1002665A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13623087A 1987-12-21 1987-12-21
US17261388A 1988-03-24 1988-03-24
US21254888A 1988-06-28 1988-06-28

Publications (1)

Publication Number Publication Date
BE1002665A4 true BE1002665A4 (fr) 1991-04-30

Family

ID=27384838

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8801421A BE1002665A4 (fr) 1987-12-21 1988-12-20 Nouvelle forme cristalline de la ciclosporine, sa preparation et les compositions pharmaceutiques la contenant.

Country Status (27)

Country Link
JP (1) JPH0791316B2 (fr)
KR (1) KR100188305B1 (fr)
AT (1) AT403163B (fr)
AU (1) AU626274B2 (fr)
BE (1) BE1002665A4 (fr)
CA (1) CA1341396C (fr)
CH (1) CH677926A5 (fr)
CY (1) CY1799A (fr)
DE (1) DE3843054C2 (fr)
DK (1) DK175220B1 (fr)
ES (1) ES2012580A6 (fr)
FI (1) FI89065C (fr)
FR (1) FR2624863B1 (fr)
GB (1) GB2211848B (fr)
GR (1) GR1002486B (fr)
HK (1) HK102894A (fr)
HU (1) HU203564B (fr)
IE (1) IE62006B1 (fr)
IL (1) IL88719A0 (fr)
IT (1) IT1235356B (fr)
LU (1) LU87409A1 (fr)
MY (1) MY103943A (fr)
NL (1) NL195096C (fr)
NO (1) NO177228C (fr)
NZ (1) NZ227384A (fr)
SE (1) SE503174C2 (fr)
SG (1) SG99494G (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
US7081445B2 (en) 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US5294604A (en) * 1989-12-20 1994-03-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating ocular diseases by periocular administration of cyclosporine A or G
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
ES2098739T3 (es) * 1992-05-13 1997-05-01 Sandoz Ltd Composiciones oftalmicas conteniendo una cyclosporin.
EP0589843B1 (fr) 1992-09-25 2001-11-28 Novartis AG Compositions pharmaceutiques comprenant de la cyclosporine
RU2158601C2 (ru) 1994-11-03 2000-11-10 Новартис Аг Новые лекарственные формы циклоспорина для орального применения с простым составом и высокой биодоступностью и способ их получения
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
DE19549852B4 (de) 1995-11-29 2009-06-04 Novartis Ag Cyclosporin enthaltende Präparate
US6262054B1 (en) * 1996-02-01 2001-07-17 Sloan-Kettering Institute Of Cancer Research Combination therapy method for treating breast cancer using edatrexate
DE29824679U1 (de) 1997-01-30 2002-03-28 Novartis Ag, Basel Pharmazeutische Zusammensetzungen
TW581681B (en) 1998-02-20 2004-04-01 Nektar Therapeutics Liquid crystal forms of cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
JP2007518804A (ja) 2004-01-20 2007-07-12 アラーガン、インコーポレイテッド トリアムシノロンアセトニドおよびヒアルロン酸を好ましく含有する眼局所治療用組成物
CN1763084B (zh) * 2005-10-11 2010-04-21 山东新时代药业有限公司 高纯度环孢菌素a的制备方法
BR112013030554B1 (pt) * 2011-05-27 2020-12-15 Allergan, Inc. Forma cristalina de ciclosporina a, métodos de preparação e métodos para uso da mesma
CN104039308B (zh) 2011-11-15 2018-06-05 阿勒根公司 环孢菌素a形式2的可热压性悬浮液
AU2012339695B2 (en) 2011-11-15 2017-10-05 Allergan, Inc. Sustained action formulation of cyclosporin Form 2
WO2013074625A1 (fr) * 2011-11-15 2013-05-23 Allergan, Inc. Suspensions de forme 2 de cyclosporine a
KR102072252B1 (ko) * 2011-11-15 2020-01-31 알러간, 인코포레이티드 사이클로스포린 a 제2형 및 그의 제조방법
WO2024085235A1 (fr) * 2022-10-20 2024-04-25 中外製薬株式会社 Procédé de production de cristaux peptidiques cycliques

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH614931A5 (fr) * 1975-11-04 1979-12-28 Sandoz Ag
CH640519A5 (en) * 1976-04-09 1984-01-13 Sandoz Ag Process for preparing a modified form of the antibiotic S 7481/F-1
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
CH637124A5 (en) * 1978-10-18 1983-07-15 Sandoz Ag Antibiotic, its preparation and use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
THE MERCK INDEX, édition 10, 1983, page 396, résumé no.2748, Merck & Co., Inc., Rahway, N.J., US; "Cyclosporins" *

Also Published As

Publication number Publication date
DE3843054A1 (de) 1989-07-27
DK705488D0 (da) 1988-12-19
AU2705588A (en) 1989-06-22
KR100188305B1 (ko) 1999-06-01
IE883779L (en) 1989-06-21
CH677926A5 (fr) 1991-07-15
FR2624863A1 (fr) 1989-06-23
CY1799A (en) 1995-02-17
ES2012580A6 (es) 1990-04-01
SG99494G (en) 1994-10-28
SE8804570L (sv) 1989-06-22
HU203564B (en) 1991-08-28
NZ227384A (en) 1991-09-25
SE503174C2 (sv) 1996-04-15
GR880100850A (el) 1994-03-31
IT8848690A0 (it) 1988-12-20
FI885869A (fi) 1989-06-22
NL8803125A (nl) 1989-07-17
AT403163B (de) 1997-11-25
HUT49893A (en) 1989-11-28
HK102894A (en) 1994-09-30
AU626274B2 (en) 1992-07-30
NL195096C (nl) 2004-02-09
NO885625D0 (no) 1988-12-19
FI89065C (fi) 1993-09-30
FI885869A0 (fi) 1988-12-19
IT1235356B (it) 1992-06-30
DK175220B1 (da) 2004-07-12
GB2211848B (en) 1991-11-06
NO177228C (no) 1995-08-09
FI89065B (fi) 1993-04-30
GR1002486B (el) 1996-12-09
MY103943A (en) 1993-10-30
LU87409A1 (fr) 1989-07-07
SE8804570D0 (sv) 1988-12-19
DK705488A (da) 1989-06-22
IE62006B1 (en) 1994-12-14
NO885625L (no) 1989-06-22
FR2624863B1 (fr) 1991-04-26
IL88719A0 (en) 1989-07-31
JPH0791316B2 (ja) 1995-10-04
CA1341396C (fr) 2002-11-05
ATA309588A (de) 1997-04-15
GB8829556D0 (en) 1989-02-08
GB2211848A (en) 1989-07-12
DE3843054C2 (de) 2003-08-21
NO177228B (no) 1995-05-02
JPH01211598A (ja) 1989-08-24
KR890009975A (ko) 1989-08-05

Similar Documents

Publication Publication Date Title
BE1002665A4 (fr) Nouvelle forme cristalline de la ciclosporine, sa preparation et les compositions pharmaceutiques la contenant.
CA2185037A1 (fr) Extrait d'iridacees et compositions le contenant
FR2634376B1 (fr) Nouvelle forme unitaire, solide et poreuse comprenant des microparticules et/ou des nanoparticules, ainsi que sa preparation
FR2442054A1 (fr) Proteines purifiees, notamment interferon, procede de preparation et compositions pharmaceutiques les contenant
FR2637182A1 (fr) Compositions a base de phases lamellaires lipidiques hydratees ou de liposomes contenant un ecdysteroide, de preference l'ecdysterone, ou l'un de ses derives; et compositions cosmetiques, pharmaceutiques, notamment dermatologiques, de sericulture ou phytosanitaires l'incorporant
BE1002266A5 (fr) Compositions de cyclosporine pour application topique.
DE69727158D1 (de) Pharmazeutische zusammensetzungen enthaltend eine mischung von selbstvernetzter und nichtselbstvernetzter hyaluronsäure zur behandlung von arthropathien
HUP9903536A2 (hu) Bázikus anyaggal stabilizált gyógyászati készítmények
BE901737A (fr) Composition pharmaceutique pour le traitement de l'ischemie myocardique aigue.
FR2653336B1 (fr) Composition pharmaceutique et cosmetiques depigmentantes a base d'acide cafeique.
RU2001109436A (ru) Косметическая композиция
DE69034226D1 (de) Herstellungsverfahren von Huperzine A und deren Analogen und Verbindungen nützlich dazu
BE905558A (fr) Nouvelles compositions cosmetiques ou dermatologiques riches en acides gras essentiellement presents a la fois sous forme de triglycerides et sous forme libre ou salifiee.
IL78061A (en) Pharmaceutical compositions based on simethicone and guar gum for protection of the oesogastroduodenal mucous membrane
MA24704A1 (fr) Formulations nouvelles de paroxetine et procede pour leur preparation
BE1003125A3 (fr) Nouvelles compositions.
CA2165519A1 (fr) Utilisation d'un antagoniste de substance p pour le traitement des prurits, des algies oculaires et/ou palpebrales et des dysesthesies oculaires ou palpebrales
FR2719771B1 (fr) Compositions pharmaceutiques contenant du gemfibrozil.
KR880004810A (ko) 소화성 궤양 치료제
FR2469711A1 (fr) Immunopotentialisateur contenant de la ricine et composition therapeutique le contenant
OA09665A (fr) Esters d'aminoacides de l'hydroquinone, leur procédé de préparation et compositions pharmaceutiques ou cosmétiques les contenant
FR2567402B1 (fr) Nouvelles compositions pharmaceutiques et cosmetiques contenant comme ingredient actif la dihydroxy-1,8 phenyl-10 anthrone-9, et procede de preparation de l'ingredient actif
ATE294568T1 (de) Zusammensetzung zur behandlung von verbrennungen
FR2604903B1 (fr) Agents therapeutiques sous forme de particules submicroscopiques contre des parasitoses et compositions pharmaceutiques les contenant
ATE53004T1 (de) Pharmazeutische zusammensetzungen mit inhalt von 5-phenyl-1,3-dioxoalkenylverbindungen.

Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *NOVARTIS A.G.

Effective date: 20081220