BE1002665A4 - NOVEL CRYSTALLINE FORM OF CICLOSPORIN, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT. - Google Patents

NOVEL CRYSTALLINE FORM OF CICLOSPORIN, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT. Download PDF

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Publication number
BE1002665A4
BE1002665A4 BE8801421A BE8801421A BE1002665A4 BE 1002665 A4 BE1002665 A4 BE 1002665A4 BE 8801421 A BE8801421 A BE 8801421A BE 8801421 A BE8801421 A BE 8801421A BE 1002665 A4 BE1002665 A4 BE 1002665A4
Authority
BE
Belgium
Prior art keywords
ciclosporin
crystalline form
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
BE8801421A
Other languages
French (fr)
Original Assignee
Sandoz Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Sa filed Critical Sandoz Sa
Application granted granted Critical
Publication of BE1002665A4 publication Critical patent/BE1002665A4/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La présente invention a pour objet de nouvelles compositions pharmaceutiques, en particulier sous forme topique, par exemple pour une utilisation dermique ou une application topique sur l'oeil, et des formes injectables, par exemple pour une injection dans la lésion ou intra-articulaire, comprenant la Ciclosporine comme substance active sous forme cristalline orthorhombique. La Ciclosporine sous forme cristalline orthorhombique non solvatée est préférée pour une utilisation dans les compositions de l'invention, est nouvelle et fait également partie de l'invention ainsi que son utilisation et ses procédés de préparation.The subject of the present invention is new pharmaceutical compositions, in particular in topical form, for example for dermal use or topical application to the eye, and injectable forms, for example for injection into the lesion or intra-articular, comprising Ciclosporin as active substance in orthorhombic crystalline form. Ciclosporin in non-solvated orthorhombic crystalline form is preferred for use in the compositions of the invention, is new and also forms part of the invention as well as its use and its methods of preparation.

BE8801421A 1987-12-21 1988-12-20 NOVEL CRYSTALLINE FORM OF CICLOSPORIN, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT. BE1002665A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13623087A 1987-12-21 1987-12-21
US17261388A 1988-03-24 1988-03-24
US21254888A 1988-06-28 1988-06-28

Publications (1)

Publication Number Publication Date
BE1002665A4 true BE1002665A4 (en) 1991-04-30

Family

ID=27384838

Family Applications (1)

Application Number Title Priority Date Filing Date
BE8801421A BE1002665A4 (en) 1987-12-21 1988-12-20 NOVEL CRYSTALLINE FORM OF CICLOSPORIN, ITS PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING IT.

Country Status (27)

Country Link
JP (1) JPH0791316B2 (en)
KR (1) KR100188305B1 (en)
AT (1) AT403163B (en)
AU (1) AU626274B2 (en)
BE (1) BE1002665A4 (en)
CA (1) CA1341396C (en)
CH (1) CH677926A5 (en)
CY (1) CY1799A (en)
DE (1) DE3843054C2 (en)
DK (1) DK175220B1 (en)
ES (1) ES2012580A6 (en)
FI (1) FI89065C (en)
FR (1) FR2624863B1 (en)
GB (1) GB2211848B (en)
GR (1) GR1002486B (en)
HK (1) HK102894A (en)
HU (1) HU203564B (en)
IE (1) IE62006B1 (en)
IL (1) IL88719A0 (en)
IT (1) IT1235356B (en)
LU (1) LU87409A1 (en)
MY (1) MY103943A (en)
NL (1) NL195096C (en)
NO (1) NO177228C (en)
NZ (1) NZ227384A (en)
SE (1) SE503174C2 (en)
SG (1) SG99494G (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639724A (en) 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
KR0148748B1 (en) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 A multiphase cyclosporin composition
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
US7081445B2 (en) 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US5294604A (en) * 1989-12-20 1994-03-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating ocular diseases by periocular administration of cyclosporine A or G
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
EP0642332B1 (en) 1992-05-13 1997-01-15 Sandoz Ltd. Ophthalmic compositions containing a cyclosporin
DK0589843T3 (en) 1992-09-25 2002-04-02 Novartis Ag Cyclosporin-containing pharmaceutical preparations
PT789580E (en) 1994-11-03 2002-09-30 Novartis Ag CYCLOSPORINE FORMULATIONS FOR ORAL ADMINISTRATION WITH SIMPLE COMPOSITION AND HIGH BIODISPONIBILITY AND PROCESS FOR ITS PRODUCTION
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
DE19544507B4 (en) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin containing preparations
US6262054B1 (en) * 1996-02-01 2001-07-17 Sloan-Kettering Institute Of Cancer Research Combination therapy method for treating breast cancer using edatrexate
IL130797A0 (en) 1997-01-30 2001-01-28 Novartis Ag Hard gelatine capsules containing pharmaceutical compositions substantially free of any oil
TW581681B (en) 1998-02-20 2004-04-01 Nektar Therapeutics Liquid crystal forms of cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
AU2005209201B2 (en) 2004-01-20 2010-06-03 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
CN1763084B (en) * 2005-10-11 2010-04-21 山东新时代药业有限公司 High purity cyclosporin A preparation method
UA113627C2 (en) * 2011-05-27 2017-02-27 CRYSTAL FORM OF CYCLOSPORIN A, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT
RU2639393C2 (en) * 2011-11-15 2017-12-21 Аллерган, Инк. Composition of prolonged action of cyclosporin of form 2
EP2780358B1 (en) * 2011-11-15 2016-03-23 Allergan, Inc. Cyclosporine a form 2 and method of making same
EP2779993B1 (en) * 2011-11-15 2018-04-04 Allergan, Inc. Autoclavable suspensions of cyclosporin a form 2
CA2856057C (en) 2011-11-15 2017-01-03 Allergan, Inc. Suspensions of cyclosporin a form 2

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH614931A5 (en) * 1975-11-04 1979-12-28 Sandoz Ag
CH640519A5 (en) * 1976-04-09 1984-01-13 Sandoz Ag Process for preparing a modified form of the antibiotic S 7481/F-1
DE2819094A1 (en) * 1977-05-10 1978-11-23 Sandoz Ag CYCLOSPORIN DERIVATIVES, THEIR USE AND MANUFACTURING
CH637124A5 (en) * 1978-10-18 1983-07-15 Sandoz Ag Antibiotic, its preparation and use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
THE MERCK INDEX, édition 10, 1983, page 396, résumé no.2748, Merck & Co., Inc., Rahway, N.J., US; "Cyclosporins" *

Also Published As

Publication number Publication date
LU87409A1 (en) 1989-07-07
DE3843054C2 (en) 2003-08-21
GR880100850A (en) 1994-03-31
NO885625L (en) 1989-06-22
KR890009975A (en) 1989-08-05
AU2705588A (en) 1989-06-22
JPH01211598A (en) 1989-08-24
ES2012580A6 (en) 1990-04-01
CA1341396C (en) 2002-11-05
NZ227384A (en) 1991-09-25
FR2624863A1 (en) 1989-06-23
NO885625D0 (en) 1988-12-19
IE62006B1 (en) 1994-12-14
IT8848690A0 (en) 1988-12-20
CY1799A (en) 1995-02-17
SE8804570L (en) 1989-06-22
FI89065C (en) 1993-09-30
AU626274B2 (en) 1992-07-30
NL195096C (en) 2004-02-09
SE8804570D0 (en) 1988-12-19
IE883779L (en) 1989-06-21
KR100188305B1 (en) 1999-06-01
GB8829556D0 (en) 1989-02-08
NO177228B (en) 1995-05-02
NO177228C (en) 1995-08-09
HU203564B (en) 1991-08-28
GB2211848A (en) 1989-07-12
FI885869A0 (en) 1988-12-19
JPH0791316B2 (en) 1995-10-04
CH677926A5 (en) 1991-07-15
SE503174C2 (en) 1996-04-15
FI89065B (en) 1993-04-30
DK175220B1 (en) 2004-07-12
MY103943A (en) 1993-10-30
DE3843054A1 (en) 1989-07-27
SG99494G (en) 1994-10-28
GR1002486B (en) 1996-12-09
IL88719A0 (en) 1989-07-31
FI885869A (en) 1989-06-22
GB2211848B (en) 1991-11-06
DK705488A (en) 1989-06-22
FR2624863B1 (en) 1991-04-26
ATA309588A (en) 1997-04-15
IT1235356B (en) 1992-06-30
HK102894A (en) 1994-09-30
DK705488D0 (en) 1988-12-19
NL8803125A (en) 1989-07-17
AT403163B (en) 1997-11-25
HUT49893A (en) 1989-11-28

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Legal Events

Date Code Title Description
RE20 Patent expired

Owner name: *NOVARTIS A.G.

Effective date: 20081220