SE8804570L - CICLOSPORINE CRYSTAL FORM, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING ITS SAME AND ITS USE - Google Patents

CICLOSPORINE CRYSTAL FORM, PROCEDURE FOR ITS PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING ITS SAME AND ITS USE

Info

Publication number
SE8804570L
SE8804570L SE8804570A SE8804570A SE8804570L SE 8804570 L SE8804570 L SE 8804570L SE 8804570 A SE8804570 A SE 8804570A SE 8804570 A SE8804570 A SE 8804570A SE 8804570 L SE8804570 L SE 8804570L
Authority
SE
Sweden
Prior art keywords
crystal form
pharmaceutical compositions
ciclosporine
procedure
preparation
Prior art date
Application number
SE8804570A
Other languages
Unknown language ( )
Swedish (sv)
Other versions
SE8804570D0 (en
SE503174C2 (en
Inventor
D Giron
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of SE8804570D0 publication Critical patent/SE8804570D0/en
Publication of SE8804570L publication Critical patent/SE8804570L/en
Publication of SE503174C2 publication Critical patent/SE503174C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Novel pharmaceutical compositions, in particular topical forms, e.g. for intra-lesional or intra-articular injection, comprising Ciclosporin as active ingredient in orthorhombic crystal form. Ciclosporin in non-solvate orthorhombic crystal form is preferred for use in the compositions of the invention, is new and also part of the invention together with its use and processes for its production.
SE8804570A 1987-12-21 1988-12-19 Ciclosporin crystal forms, process for its preparation, pharmaceutical compositions containing the same and its use SE503174C2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13623087A 1987-12-21 1987-12-21
US17261388A 1988-03-24 1988-03-24
US21254888A 1988-06-28 1988-06-28

Publications (3)

Publication Number Publication Date
SE8804570D0 SE8804570D0 (en) 1988-12-19
SE8804570L true SE8804570L (en) 1989-06-22
SE503174C2 SE503174C2 (en) 1996-04-15

Family

ID=27384838

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8804570A SE503174C2 (en) 1987-12-21 1988-12-19 Ciclosporin crystal forms, process for its preparation, pharmaceutical compositions containing the same and its use

Country Status (27)

Country Link
JP (1) JPH0791316B2 (en)
KR (1) KR100188305B1 (en)
AT (1) AT403163B (en)
AU (1) AU626274B2 (en)
BE (1) BE1002665A4 (en)
CA (1) CA1341396C (en)
CH (1) CH677926A5 (en)
CY (1) CY1799A (en)
DE (1) DE3843054C2 (en)
DK (1) DK175220B1 (en)
ES (1) ES2012580A6 (en)
FI (1) FI89065C (en)
FR (1) FR2624863B1 (en)
GB (1) GB2211848B (en)
GR (1) GR1002486B (en)
HK (1) HK102894A (en)
HU (1) HU203564B (en)
IE (1) IE62006B1 (en)
IL (1) IL88719A0 (en)
IT (1) IT1235356B (en)
LU (1) LU87409A1 (en)
MY (1) MY103943A (en)
NL (1) NL195096C (en)
NO (1) NO177228C (en)
NZ (1) NZ227384A (en)
SE (1) SE503174C2 (en)
SG (1) SG99494G (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639724A (en) * 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
KR0148748B1 (en) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 A multiphase cyclosporin composition
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
US7081445B2 (en) 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US5294604A (en) * 1989-12-20 1994-03-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating ocular diseases by periocular administration of cyclosporine A or G
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
SG45449A1 (en) * 1992-05-13 1998-01-16 Sandoz Ltd Ophthalmic compositions
PT589843E (en) 1992-09-25 2002-04-29 Novartis Ag PHARMACEUTICAL COMPOSITIONS CONTAINING CYCLOSPORTS
PT789580E (en) 1994-11-03 2002-09-30 Novartis Ag CYCLOSPORINE FORMULATIONS FOR ORAL ADMINISTRATION WITH SIMPLE COMPOSITION AND HIGH BIODISPONIBILITY AND PROCESS FOR ITS PRODUCTION
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
DE19544507B4 (en) 1995-11-29 2007-11-15 Novartis Ag Cyclosporin containing preparations
US6262054B1 (en) * 1996-02-01 2001-07-17 Sloan-Kettering Institute Of Cancer Research Combination therapy method for treating breast cancer using edatrexate
RU2211047C2 (en) 1997-01-30 2003-08-27 Новартис Аг Gelatin capsule with solid film including oil-free pharmaceutically compositions
TW581681B (en) 1998-02-20 2004-04-01 Nektar Therapeutics Liquid crystal forms of cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
DE602005011928D1 (en) 2004-01-20 2009-02-05 Allergan Inc COMPOSITIONS FOR LOCALIZED THERAPY OF THE EYE, PREFERABLY CONTAINING TRIAMCINOLONE ACETONIDE AND HYALURONIC ACID
CN1763084B (en) * 2005-10-11 2010-04-21 山东新时代药业有限公司 High purity cyclosporin A preparation method
BR112013030554B1 (en) 2011-05-27 2020-12-15 Allergan, Inc. CRYSTALLINE FORM OF CYCLOSPORIN A, METHODS OF PREPARATION AND METHODS FOR USE OF THE SAME
CN104080442B (en) 2011-11-15 2018-01-05 阿勒根公司 The suspension of cyclosporin A form 2
KR102072252B1 (en) 2011-11-15 2020-01-31 알러간, 인코포레이티드 Cyclosporin a form 2 and method of making same
ES2675269T3 (en) * 2011-11-15 2018-07-10 Allergan, Inc. Treatable autoclavable suspensions of cyclosporin A form 2
CN108175742B (en) 2011-11-15 2021-10-22 阿勒根公司 Sustained action formulation of cyclosporin form 2

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH614931A5 (en) * 1975-11-04 1979-12-28 Sandoz Ag
CH640519A5 (en) * 1976-04-09 1984-01-13 Sandoz Ag Process for preparing a modified form of the antibiotic S 7481/F-1
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
DE2819094A1 (en) * 1977-05-10 1978-11-23 Sandoz Ag CYCLOSPORIN DERIVATIVES, THEIR USE AND MANUFACTURING
CH637124A5 (en) * 1978-10-18 1983-07-15 Sandoz Ag Antibiotic, its preparation and use

Also Published As

Publication number Publication date
JPH0791316B2 (en) 1995-10-04
NZ227384A (en) 1991-09-25
NO177228B (en) 1995-05-02
NL8803125A (en) 1989-07-17
IL88719A0 (en) 1989-07-31
IT8848690A0 (en) 1988-12-20
DK705488D0 (en) 1988-12-19
GB2211848B (en) 1991-11-06
KR890009975A (en) 1989-08-05
IE883779L (en) 1989-06-21
GR1002486B (en) 1996-12-09
IT1235356B (en) 1992-06-30
ES2012580A6 (en) 1990-04-01
SG99494G (en) 1994-10-28
FR2624863B1 (en) 1991-04-26
KR100188305B1 (en) 1999-06-01
CY1799A (en) 1995-02-17
HK102894A (en) 1994-09-30
SE8804570D0 (en) 1988-12-19
FI885869A (en) 1989-06-22
IE62006B1 (en) 1994-12-14
CA1341396C (en) 2002-11-05
HUT49893A (en) 1989-11-28
DE3843054A1 (en) 1989-07-27
JPH01211598A (en) 1989-08-24
GB2211848A (en) 1989-07-12
NL195096C (en) 2004-02-09
AU2705588A (en) 1989-06-22
NO177228C (en) 1995-08-09
BE1002665A4 (en) 1991-04-30
LU87409A1 (en) 1989-07-07
AT403163B (en) 1997-11-25
ATA309588A (en) 1997-04-15
DK175220B1 (en) 2004-07-12
FI89065B (en) 1993-04-30
GR880100850A (en) 1994-03-31
SE503174C2 (en) 1996-04-15
CH677926A5 (en) 1991-07-15
HU203564B (en) 1991-08-28
NO885625L (en) 1989-06-22
DK705488A (en) 1989-06-22
GB8829556D0 (en) 1989-02-08
FI89065C (en) 1993-09-30
AU626274B2 (en) 1992-07-30
MY103943A (en) 1993-10-30
DE3843054C2 (en) 2003-08-21
NO885625D0 (en) 1988-12-19
FI885869A0 (en) 1988-12-19
FR2624863A1 (en) 1989-06-23

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NUG Patent has lapsed