IE883779L - Cyclosporin crystal form - Google Patents

Cyclosporin crystal form

Info

Publication number
IE883779L
IE883779L IE883779A IE377988A IE883779L IE 883779 L IE883779 L IE 883779L IE 883779 A IE883779 A IE 883779A IE 377988 A IE377988 A IE 377988A IE 883779 L IE883779 L IE 883779L
Authority
IE
Ireland
Prior art keywords
crystal form
cyclosporin
ciclosporin
intra
orthorhombic crystal
Prior art date
Application number
IE883779A
Other versions
IE62006B1 (en
Inventor
Danielle Grion
Martin List
Friedrich Richter
Yasuyuki Uike
Hans Peter Weber
Original Assignee
Sandoz Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ltd filed Critical Sandoz Ltd
Publication of IE883779L publication Critical patent/IE883779L/en
Publication of IE62006B1 publication Critical patent/IE62006B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Novel pharmaceutical compositions, in particular topical forms, e.g. for dermal or topical ophthalmic use, and injectible forms, e.g. for intra-lesional or intra-articular injection, comprising Ciclosporin as active ingredient in orthorhombic crystal form. Ciclosporin in non-solvate orthorhombic crystal form is preferred for use in the compositions of the invention, is new and also part of the invention, together with its use and processes for its production. [CA1341396C]
IE377988A 1987-12-21 1988-12-19 "Orthorhombic ciclosporin crystal form, process for its production and pharmaceutical compositions containing it" IE62006B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13623087A 1987-12-21 1987-12-21
US17261388A 1988-03-24 1988-03-24
US21254888A 1988-06-28 1988-06-28

Publications (2)

Publication Number Publication Date
IE883779L true IE883779L (en) 1989-06-21
IE62006B1 IE62006B1 (en) 1994-12-14

Family

ID=27384838

Family Applications (1)

Application Number Title Priority Date Filing Date
IE377988A IE62006B1 (en) 1987-12-21 1988-12-19 "Orthorhombic ciclosporin crystal form, process for its production and pharmaceutical compositions containing it"

Country Status (27)

Country Link
JP (1) JPH0791316B2 (en)
KR (1) KR100188305B1 (en)
AT (1) AT403163B (en)
AU (1) AU626274B2 (en)
BE (1) BE1002665A4 (en)
CA (1) CA1341396C (en)
CH (1) CH677926A5 (en)
CY (1) CY1799A (en)
DE (1) DE3843054C2 (en)
DK (1) DK175220B1 (en)
ES (1) ES2012580A6 (en)
FI (1) FI89065C (en)
FR (1) FR2624863B1 (en)
GB (1) GB2211848B (en)
GR (1) GR1002486B (en)
HK (1) HK102894A (en)
HU (1) HU203564B (en)
IE (1) IE62006B1 (en)
IL (1) IL88719A0 (en)
IT (1) IT1235356B (en)
LU (1) LU87409A1 (en)
MY (1) MY103943A (en)
NL (1) NL195096C (en)
NO (1) NO177228C (en)
NZ (1) NZ227384A (en)
SE (1) SE503174C2 (en)
SG (1) SG99494G (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639724A (en) * 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
KR0148748B1 (en) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 A multiphase cyclosporin composition
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
US7081445B2 (en) 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US5294604A (en) * 1989-12-20 1994-03-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating ocular diseases by periocular administration of cyclosporine A or G
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
EP0642332B1 (en) * 1992-05-13 1997-01-15 Sandoz Ltd. Ophthalmic compositions containing a cyclosporin
PT589843E (en) 1992-09-25 2002-04-29 Novartis Ag PHARMACEUTICAL COMPOSITIONS CONTAINING CYCLOSPORTS
DK0789580T3 (en) 1994-11-03 2002-09-09 Novartis Ag New Formulations of Cyclosporin for Oral Administration with Simple Composition and High Bioavailability, and Methods for their Preparation
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
DE19549852B4 (en) 1995-11-29 2009-06-04 Novartis Ag Cyclosporin containing preparations
US6262054B1 (en) * 1996-02-01 2001-07-17 Sloan-Kettering Institute Of Cancer Research Combination therapy method for treating breast cancer using edatrexate
SG115386A1 (en) 1997-01-30 2005-10-28 Novartis Ag Hard gelatine capsules containing pharmaceutical compositions substantially free of any oil
TW581681B (en) 1998-02-20 2004-04-01 Nektar Therapeutics Liquid crystal forms of cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
AU2005209201B2 (en) 2004-01-20 2010-06-03 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
CN1763084B (en) * 2005-10-11 2010-04-21 山东新时代药业有限公司 High purity cyclosporin A preparation method
JP6163482B2 (en) * 2011-05-27 2017-07-12 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ Crystalline form of cyclosporin A, process for its preparation and process for its use
JP6368244B2 (en) * 2011-11-15 2018-08-01 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ Autoclavable cyclosporin A2 suspension
KR102015152B1 (en) * 2011-11-15 2019-08-27 알러간, 인코포레이티드 Suspensions of cyclosporin a form 2
KR102072252B1 (en) * 2011-11-15 2020-01-31 알러간, 인코포레이티드 Cyclosporin a form 2 and method of making same
AU2012339695B2 (en) 2011-11-15 2017-10-05 Allergan, Inc. Sustained action formulation of cyclosporin Form 2
WO2024085235A1 (en) * 2022-10-20 2024-04-25 中外製薬株式会社 Method for producing cyclic peptide crystals

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH614931A5 (en) * 1975-11-04 1979-12-28 Sandoz Ag
CH640519A5 (en) * 1976-04-09 1984-01-13 Sandoz Ag Process for preparing a modified form of the antibiotic S 7481/F-1
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
DE2819094A1 (en) * 1977-05-10 1978-11-23 Sandoz Ag CYCLOSPORIN DERIVATIVES, THEIR USE AND MANUFACTURING
CH637124A5 (en) * 1978-10-18 1983-07-15 Sandoz Ag Antibiotic, its preparation and use

Also Published As

Publication number Publication date
IE62006B1 (en) 1994-12-14
SE8804570D0 (en) 1988-12-19
AT403163B (en) 1997-11-25
DK705488D0 (en) 1988-12-19
NZ227384A (en) 1991-09-25
KR890009975A (en) 1989-08-05
FR2624863B1 (en) 1991-04-26
ES2012580A6 (en) 1990-04-01
JPH01211598A (en) 1989-08-24
FI89065C (en) 1993-09-30
NL8803125A (en) 1989-07-17
NO885625D0 (en) 1988-12-19
FR2624863A1 (en) 1989-06-23
IT8848690A0 (en) 1988-12-20
LU87409A1 (en) 1989-07-07
DK175220B1 (en) 2004-07-12
AU626274B2 (en) 1992-07-30
FI89065B (en) 1993-04-30
GB8829556D0 (en) 1989-02-08
DE3843054A1 (en) 1989-07-27
SE503174C2 (en) 1996-04-15
HU203564B (en) 1991-08-28
GR1002486B (en) 1996-12-09
JPH0791316B2 (en) 1995-10-04
NO177228B (en) 1995-05-02
NO177228C (en) 1995-08-09
BE1002665A4 (en) 1991-04-30
HK102894A (en) 1994-09-30
CA1341396C (en) 2002-11-05
CY1799A (en) 1995-02-17
GR880100850A (en) 1994-03-31
CH677926A5 (en) 1991-07-15
FI885869A (en) 1989-06-22
GB2211848B (en) 1991-11-06
NO885625L (en) 1989-06-22
IT1235356B (en) 1992-06-30
MY103943A (en) 1993-10-30
SG99494G (en) 1994-10-28
NL195096C (en) 2004-02-09
DK705488A (en) 1989-06-22
SE8804570L (en) 1989-06-22
DE3843054C2 (en) 2003-08-21
FI885869A0 (en) 1988-12-19
IL88719A0 (en) 1989-07-31
HUT49893A (en) 1989-11-28
AU2705588A (en) 1989-06-22
KR100188305B1 (en) 1999-06-01
GB2211848A (en) 1989-07-12
ATA309588A (en) 1997-04-15

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