ES2012580A6 - Procedimiento para la produccion de una nueva forma cristalina de ciclosporinas. - Google Patents

Procedimiento para la produccion de una nueva forma cristalina de ciclosporinas.

Info

Publication number
ES2012580A6
ES2012580A6 ES8803887A ES8803887A ES2012580A6 ES 2012580 A6 ES2012580 A6 ES 2012580A6 ES 8803887 A ES8803887 A ES 8803887A ES 8803887 A ES8803887 A ES 8803887A ES 2012580 A6 ES2012580 A6 ES 2012580A6
Authority
ES
Spain
Prior art keywords
ciclosporin
orthorhomic
intra
crystal form
crystals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8803887A
Other languages
English (en)
Inventor
Danielle Giron
Martin List
Friedrich Richter
Yasuyuki Uike
Hans Peter Weber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES2012580A6 publication Critical patent/ES2012580A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA LA PRODUCCION DE UNA NUEVA FORMA CRISTALINA DE CICLOSPORINAS. SE CRISTALIZA LA CICLOSPORINA EN UN MEDIO DISOLVENTE DANDO NACIMIENTO A LA CICLOSPORINA CRISTALINA ORTOROMBICA NO-SOLVATADA, POR EJEMPLO UN MEDIO DISOLVENTE QUE COMPRENDE UN ETER DE PESO MOLECULAR MAS ELEVADO, TAL COMO UN POLIETILENOGLICOL O POLIPROPILENOGLICOL, POR EJEMPLO DISOLVIENDO LA CICLOSPORINA EN DICHO MEDIO DISOLVENTE A UNA TEMPERATURA SUPERIOR A LOS 40GC, TRAS LO CUAL SE ENFRIA EL CITADO MEDIO Y SE RECUPERAN LOS CRISTALES ORTOROMBICOS NO-SOLVATADOS DE LA CICLOSPORINA. LA CICLOSPORINA ASI OBTENIDA PRESENTA ACTIVIDAD FARMACEUTICA.
ES8803887A 1987-12-21 1988-12-21 Procedimiento para la produccion de una nueva forma cristalina de ciclosporinas. Expired - Lifetime ES2012580A6 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13623087A 1987-12-21 1987-12-21
US17261388A 1988-03-24 1988-03-24
US21254888A 1988-06-28 1988-06-28

Publications (1)

Publication Number Publication Date
ES2012580A6 true ES2012580A6 (es) 1990-04-01

Family

ID=27384838

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8803887A Expired - Lifetime ES2012580A6 (es) 1987-12-21 1988-12-21 Procedimiento para la produccion de una nueva forma cristalina de ciclosporinas.

Country Status (27)

Country Link
JP (1) JPH0791316B2 (es)
KR (1) KR100188305B1 (es)
AT (1) AT403163B (es)
AU (1) AU626274B2 (es)
BE (1) BE1002665A4 (es)
CA (1) CA1341396C (es)
CH (1) CH677926A5 (es)
CY (1) CY1799A (es)
DE (1) DE3843054C2 (es)
DK (1) DK175220B1 (es)
ES (1) ES2012580A6 (es)
FI (1) FI89065C (es)
FR (1) FR2624863B1 (es)
GB (1) GB2211848B (es)
GR (1) GR1002486B (es)
HK (1) HK102894A (es)
HU (1) HU203564B (es)
IE (1) IE62006B1 (es)
IL (1) IL88719A0 (es)
IT (1) IT1235356B (es)
LU (1) LU87409A1 (es)
MY (1) MY103943A (es)
NL (1) NL195096C (es)
NO (1) NO177228C (es)
NZ (1) NZ227384A (es)
SE (1) SE503174C2 (es)
SG (1) SG99494G (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639724A (en) * 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
KR0148748B1 (ko) * 1988-09-16 1998-08-17 장 크라메르, 한스 루돌프 하우스 사이클로스포린을 함유하는 약학조성물
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
US7081445B2 (en) 1989-02-20 2006-07-25 Novartis Ag Cyclosporin galenic forms
US5294604A (en) * 1989-12-20 1994-03-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Method of treating ocular diseases by periocular administration of cyclosporine A or G
GB9105705D0 (en) * 1991-03-18 1991-05-01 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
EP0642332B1 (en) * 1992-05-13 1997-01-15 Sandoz Ltd. Ophthalmic compositions containing a cyclosporin
PT589843E (pt) 1992-09-25 2002-04-29 Novartis Ag Composicoes farmaceuticas contendo ciclosporinas
DK0789580T3 (da) 1994-11-03 2002-09-09 Novartis Ag Nye præparatformer for cyclosporin til oral administration med simpel sammensætning og høj biotilgængelighed, og fremgangsmåder til deres fremstilling
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
DE19549852B4 (de) 1995-11-29 2009-06-04 Novartis Ag Cyclosporin enthaltende Präparate
US6262054B1 (en) * 1996-02-01 2001-07-17 Sloan-Kettering Institute Of Cancer Research Combination therapy method for treating breast cancer using edatrexate
SG115386A1 (en) 1997-01-30 2005-10-28 Novartis Ag Hard gelatine capsules containing pharmaceutical compositions substantially free of any oil
TW581681B (en) 1998-02-20 2004-04-01 Nektar Therapeutics Liquid crystal forms of cyclosporin
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
AU2005209201B2 (en) 2004-01-20 2010-06-03 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
CN1763084B (zh) * 2005-10-11 2010-04-21 山东新时代药业有限公司 高纯度环孢菌素a的制备方法
JP6163482B2 (ja) * 2011-05-27 2017-07-12 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ シクロスポリンａの結晶形態、その調製方法、およびその使用のための方法
JP6368244B2 (ja) * 2011-11-15 2018-08-01 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ オートクレーブ可能なシクロスポリンａ２型の懸濁剤
KR102015152B1 (ko) * 2011-11-15 2019-08-27 알러간, 인코포레이티드 사이클로스포린 a 제2형의 현탁액
KR102072252B1 (ko) * 2011-11-15 2020-01-31 알러간, 인코포레이티드 사이클로스포린 a 제2형 및 그의 제조방법
AU2012339695B2 (en) 2011-11-15 2017-10-05 Allergan, Inc. Sustained action formulation of cyclosporin Form 2
WO2024085235A1 (ja) * 2022-10-20 2024-04-25 中外製薬株式会社 環状ペプチドの結晶の製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH614931A5 (es) * 1975-11-04 1979-12-28 Sandoz Ag
CH640519A5 (en) * 1976-04-09 1984-01-13 Sandoz Ag Process for preparing a modified form of the antibiotic S 7481/F-1
US4117118A (en) * 1976-04-09 1978-09-26 Sandoz Ltd. Organic compounds
DE2819094A1 (de) * 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
CH637124A5 (en) * 1978-10-18 1983-07-15 Sandoz Ag Antibiotic, its preparation and use

Also Published As

Publication number Publication date
IE62006B1 (en) 1994-12-14
SE8804570D0 (sv) 1988-12-19
AT403163B (de) 1997-11-25
DK705488D0 (da) 1988-12-19
NZ227384A (en) 1991-09-25
KR890009975A (ko) 1989-08-05
FR2624863B1 (fr) 1991-04-26
JPH01211598A (ja) 1989-08-24
FI89065C (fi) 1993-09-30
NL8803125A (nl) 1989-07-17
NO885625D0 (no) 1988-12-19
FR2624863A1 (fr) 1989-06-23
IT8848690A0 (it) 1988-12-20
LU87409A1 (fr) 1989-07-07
DK175220B1 (da) 2004-07-12
AU626274B2 (en) 1992-07-30
FI89065B (fi) 1993-04-30
GB8829556D0 (en) 1989-02-08
DE3843054A1 (de) 1989-07-27
SE503174C2 (sv) 1996-04-15
HU203564B (en) 1991-08-28
GR1002486B (el) 1996-12-09
IE883779L (en) 1989-06-21
JPH0791316B2 (ja) 1995-10-04
NO177228B (no) 1995-05-02
NO177228C (no) 1995-08-09
BE1002665A4 (fr) 1991-04-30
HK102894A (en) 1994-09-30
CA1341396C (en) 2002-11-05
CY1799A (en) 1995-02-17
GR880100850A (el) 1994-03-31
CH677926A5 (es) 1991-07-15
FI885869A (fi) 1989-06-22
GB2211848B (en) 1991-11-06
NO885625L (no) 1989-06-22
IT1235356B (it) 1992-06-30
MY103943A (en) 1993-10-30
SG99494G (en) 1994-10-28
NL195096C (nl) 2004-02-09
DK705488A (da) 1989-06-22
SE8804570L (sv) 1989-06-22
DE3843054C2 (de) 2003-08-21
FI885869A0 (fi) 1988-12-19
IL88719A0 (en) 1989-07-31
HUT49893A (en) 1989-11-28
AU2705588A (en) 1989-06-22
KR100188305B1 (ko) 1999-06-01
GB2211848A (en) 1989-07-12
ATA309588A (de) 1997-04-15

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2008-12-21

PC1A Transfer granted
FD1A Patent lapsed

Effective date: 20081222