SE503174C2 - Ciclosporinkristallformer, förfarande för dess framställning, farmaceutiska kompositioner innehållande densamma samt dess användning - Google Patents
Ciclosporinkristallformer, förfarande för dess framställning, farmaceutiska kompositioner innehållande densamma samt dess användningInfo
- Publication number
- SE503174C2 SE503174C2 SE8804570A SE8804570A SE503174C2 SE 503174 C2 SE503174 C2 SE 503174C2 SE 8804570 A SE8804570 A SE 8804570A SE 8804570 A SE8804570 A SE 8804570A SE 503174 C2 SE503174 C2 SE 503174C2
- Authority
- SE
- Sweden
- Prior art keywords
- ciclosporin
- iii
- crystal form
- orthorhombic
- particle size
- Prior art date
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13623087A | 1987-12-21 | 1987-12-21 | |
| US17261388A | 1988-03-24 | 1988-03-24 | |
| US21254888A | 1988-06-28 | 1988-06-28 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8804570D0 SE8804570D0 (sv) | 1988-12-19 |
| SE8804570L SE8804570L (sv) | 1989-06-22 |
| SE503174C2 true SE503174C2 (sv) | 1996-04-15 |
Family
ID=27384838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8804570A SE503174C2 (sv) | 1987-12-21 | 1988-12-19 | Ciclosporinkristallformer, förfarande för dess framställning, farmaceutiska kompositioner innehållande densamma samt dess användning |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPH0791316B2 (de) |
| KR (1) | KR100188305B1 (de) |
| AT (1) | AT403163B (de) |
| AU (1) | AU626274B2 (de) |
| BE (1) | BE1002665A4 (de) |
| CA (1) | CA1341396C (de) |
| CH (1) | CH677926A5 (de) |
| CY (1) | CY1799A (de) |
| DE (1) | DE3843054C2 (de) |
| DK (1) | DK175220B1 (de) |
| ES (1) | ES2012580A6 (de) |
| FI (1) | FI89065C (de) |
| FR (1) | FR2624863B1 (de) |
| GB (1) | GB2211848B (de) |
| GR (1) | GR1002486B (de) |
| HK (1) | HK102894A (de) |
| HU (1) | HU203564B (de) |
| IE (1) | IE62006B1 (de) |
| IL (1) | IL88719A0 (de) |
| IT (1) | IT1235356B (de) |
| LU (1) | LU87409A1 (de) |
| MY (1) | MY103943A (de) |
| NL (1) | NL195096C (de) |
| NO (1) | NO177228C (de) |
| NZ (1) | NZ227384A (de) |
| SE (1) | SE503174C2 (de) |
| SG (1) | SG99494G (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639724A (en) * | 1984-07-24 | 1997-06-17 | Sandoz Ltd. | Cyclosporin galenic forms |
| US6007840A (en) * | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
| GB2222770B (en) | 1988-09-16 | 1992-07-29 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporins |
| US7081445B2 (en) | 1989-02-20 | 2006-07-25 | Novartis Ag | Cyclosporin galenic forms |
| US5294604A (en) * | 1989-12-20 | 1994-03-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating ocular diseases by periocular administration of cyclosporine A or G |
| GB9105705D0 (en) * | 1991-03-18 | 1991-05-01 | Sandoz Ltd | Improvements in or relating to organic compounds |
| US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
| EP0642332B1 (de) * | 1992-05-13 | 1997-01-15 | Sandoz Ltd. | Opthalmische zusammensetzungen enthaltend ein cyclosporin |
| ES2168271T3 (es) | 1992-09-25 | 2002-06-16 | Novartis Ag | Composiciones farmaceuticas que contienen ciclosporinas. |
| PT789580E (pt) | 1994-11-03 | 2002-09-30 | Novartis Ag | Formulacoes de ciclosporina para administracao oral com composicao simples e alta biodisponibilidade e processo para a sua producao |
| US5962019A (en) * | 1995-08-25 | 1999-10-05 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| US5766629A (en) | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
| DE19549852B4 (de) | 1995-11-29 | 2009-06-04 | Novartis Ag | Cyclosporin enthaltende Präparate |
| US6262054B1 (en) * | 1996-02-01 | 2001-07-17 | Sloan-Kettering Institute Of Cancer Research | Combination therapy method for treating breast cancer using edatrexate |
| EP0988046B1 (de) | 1997-01-30 | 2004-09-15 | Novartis AG | Ölfreie pharmazeutische zusammensetzung welche cyclosporin enthält |
| TW581681B (en) | 1998-02-20 | 2004-04-01 | Nektar Therapeutics | Liquid crystal forms of cyclosporin |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| JP2007518804A (ja) | 2004-01-20 | 2007-07-12 | アラーガン、インコーポレイテッド | トリアムシノロンアセトニドおよびヒアルロン酸を好ましく含有する眼局所治療用組成物 |
| CN1763084B (zh) * | 2005-10-11 | 2010-04-21 | 山东新时代药业有限公司 | 高纯度环孢菌素a的制备方法 |
| CA2836946C (en) * | 2011-05-27 | 2017-08-01 | Allergan, Inc. | A crystalline form of cyclosporine a, methods of preparation, and methods for use thereof |
| BR112014011744A2 (pt) | 2011-11-15 | 2017-05-02 | Allergan Inc | formulação de ação sustentável da forma 2 de ciclosporina |
| RU2630970C2 (ru) | 2011-11-15 | 2017-09-15 | Аллерган, Инк. | Автоклавируемые взвеси циклоспорина а формы 2 |
| EP2779994B1 (de) * | 2011-11-15 | 2020-02-19 | Allergan, Inc. | Cyclosporin a form 2 suspensionen |
| WO2013074608A1 (en) | 2011-11-15 | 2013-05-23 | Allergan, Inc. | Cyclosporine a form 2 and method of making same |
| WO2024085235A1 (ja) * | 2022-10-20 | 2024-04-25 | 中外製薬株式会社 | 環状ペプチドの結晶の製造方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH614931A5 (de) * | 1975-11-04 | 1979-12-28 | Sandoz Ag | |
| CH640519A5 (en) * | 1976-04-09 | 1984-01-13 | Sandoz Ag | Process for preparing a modified form of the antibiotic S 7481/F-1 |
| US4117118A (en) * | 1976-04-09 | 1978-09-26 | Sandoz Ltd. | Organic compounds |
| DE2819094A1 (de) * | 1977-05-10 | 1978-11-23 | Sandoz Ag | Cyclosporin-derivate, ihre verwendung und herstellung |
| CH637124A5 (en) * | 1978-10-18 | 1983-07-15 | Sandoz Ag | Antibiotic, its preparation and use |
-
1988
- 1988-12-09 HU HU886374A patent/HU203564B/hu unknown
- 1988-12-19 FR FR888816886A patent/FR2624863B1/fr not_active Expired - Lifetime
- 1988-12-19 AU AU27055/88A patent/AU626274B2/en not_active Expired
- 1988-12-19 NZ NZ227384A patent/NZ227384A/xx unknown
- 1988-12-19 SE SE8804570A patent/SE503174C2/sv not_active IP Right Cessation
- 1988-12-19 CH CH4687/88A patent/CH677926A5/de not_active IP Right Cessation
- 1988-12-19 IE IE377988A patent/IE62006B1/en not_active IP Right Cessation
- 1988-12-19 NO NO885625A patent/NO177228C/no unknown
- 1988-12-19 FI FI885869A patent/FI89065C/fi not_active IP Right Cessation
- 1988-12-19 IL IL88719A patent/IL88719A0/xx unknown
- 1988-12-19 DK DK198807054A patent/DK175220B1/da not_active IP Right Cessation
- 1988-12-19 GB GB8829556A patent/GB2211848B/en not_active Expired - Lifetime
- 1988-12-20 AT AT0309588A patent/AT403163B/de not_active IP Right Cessation
- 1988-12-20 KR KR1019880017194A patent/KR100188305B1/ko not_active Expired - Lifetime
- 1988-12-20 IT IT8848690A patent/IT1235356B/it active
- 1988-12-20 LU LU87409A patent/LU87409A1/fr unknown
- 1988-12-20 JP JP63321857A patent/JPH0791316B2/ja not_active Expired - Lifetime
- 1988-12-20 GR GR880100850A patent/GR1002486B/el not_active IP Right Cessation
- 1988-12-20 BE BE8801421A patent/BE1002665A4/fr not_active IP Right Cessation
- 1988-12-21 NL NL8803125A patent/NL195096C/nl active Search and Examination
- 1988-12-21 CA CA000586611A patent/CA1341396C/en not_active Expired - Fee Related
- 1988-12-21 ES ES8803887A patent/ES2012580A6/es not_active Expired - Lifetime
- 1988-12-21 DE DE3843054A patent/DE3843054C2/de not_active Expired - Lifetime
- 1988-12-21 MY MYPI88001495A patent/MY103943A/en unknown
-
1994
- 1994-07-21 SG SG99494A patent/SG99494G/en unknown
- 1994-09-22 HK HK102894A patent/HK102894A/xx not_active IP Right Cessation
-
1995
- 1995-02-17 CY CY179995A patent/CY1799A/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |