KR0131084B1 - 약리학적 활성 화합물과 약학적 부형제를 위한 가용화제로서의 수용성 모노에스테르 - Google Patents

약리학적 활성 화합물과 약학적 부형제를 위한 가용화제로서의 수용성 모노에스테르

Info

Publication number
KR0131084B1
KR0131084B1 KR1019880011874A KR880011874A KR0131084B1 KR 0131084 B1 KR0131084 B1 KR 0131084B1 KR 1019880011874 A KR1019880011874 A KR 1019880011874A KR 880011874 A KR880011874 A KR 880011874A KR 0131084 B1 KR0131084 B1 KR 0131084B1
Authority
KR
South Korea
Prior art keywords
pharmaceutical composition
acid
cyclosporin
composition according
water
Prior art date
Application number
KR1019880011874A
Other languages
English (en)
Korean (ko)
Other versions
KR890004694A (ko
Inventor
한 로렌쯔
Original Assignee
예안 크라메르, 한스 루돌프 하우스
산도즈 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 예안 크라메르, 한스 루돌프 하우스, 산도즈 리미티드 filed Critical 예안 크라메르, 한스 루돌프 하우스
Publication of KR890004694A publication Critical patent/KR890004694A/ko
Application granted granted Critical
Publication of KR0131084B1 publication Critical patent/KR0131084B1/ko

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019880011874A 1987-09-15 1988-09-14 약리학적 활성 화합물과 약학적 부형제를 위한 가용화제로서의 수용성 모노에스테르 KR0131084B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DEP3730909.9 1987-09-15
DE3730909 1987-09-15
DEP3802355.5 1988-01-27
DE3802355 1988-01-27

Publications (2)

Publication Number Publication Date
KR890004694A KR890004694A (ko) 1989-05-09
KR0131084B1 true KR0131084B1 (ko) 1998-04-17

Family

ID=25859774

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880011874A KR0131084B1 (ko) 1987-09-15 1988-09-14 약리학적 활성 화합물과 약학적 부형제를 위한 가용화제로서의 수용성 모노에스테르

Country Status (24)

Country Link
JP (1) JP3090666B2 (fi)
KR (1) KR0131084B1 (fi)
AT (1) AT395819B (fi)
AU (1) AU628787B2 (fi)
BE (1) BE1001204A5 (fi)
CA (1) CA1338775C (fi)
CH (1) CH683672A5 (fi)
DK (1) DK175132B1 (fi)
ES (1) ES2012118A6 (fi)
FI (1) FI94837C (fi)
FR (1) FR2620336B1 (fi)
GB (1) GB2209671B (fi)
GR (1) GR1002243B (fi)
HU (1) HU205010B (fi)
IE (1) IE61195B1 (fi)
IL (1) IL87746A (fi)
IT (1) IT1224886B (fi)
LU (1) LU87335A1 (fi)
MY (1) MY103769A (fi)
NL (1) NL195094C (fi)
NO (1) NO179434C (fi)
NZ (1) NZ226163A (fi)
PT (1) PT88492B (fi)
SE (1) SE503279C2 (fi)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100456992B1 (ko) * 1996-07-01 2005-01-27 미쓰비시 가가꾸 푸즈 가부시끼가이샤 항균제

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6007840A (en) * 1988-09-16 1999-12-28 Novartis Ag Pharmaceutical compositions comprising cyclosporins
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
GR1000466B (el) * 1989-01-28 1992-07-30 Sandoz Ag Μεθοδος παρασκευης νεων φαρμακευτικων μορφων κυκλοσπορινης.
BE1003009A5 (fr) * 1989-02-09 1991-10-22 Sandoz Sa Nouvelles compositions pharmaceutiques a base de cyclosporines.
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
US6262022B1 (en) 1992-06-25 2001-07-17 Novartis Ag Pharmaceutical compositions containing cyclosporin as the active agent
ATE147619T1 (de) 1992-05-13 1997-02-15 Sandoz Ag Opthalmische zusammensetzungen enthaltend ein cyclosporin
ES2168271T3 (es) 1992-09-25 2002-06-16 Novartis Ag Composiciones farmaceuticas que contienen ciclosporinas.
SI1033128T2 (sl) * 1993-09-28 2012-02-29 Scherer Gmbh R P Izdelava mehke Ĺľelatinaste kapsule
ATE218359T1 (de) 1994-11-03 2002-06-15 Novartis Erfind Verwalt Gmbh Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
US5834017A (en) * 1995-08-25 1998-11-10 Sangstat Medical Corporation Oral cyclopsporin formulations
US5766629A (en) 1995-08-25 1998-06-16 Sangstat Medical Corporation Oral cyclosporin formulations
US5827822A (en) * 1996-03-25 1998-10-27 Sangstat Medical Corporation Cyclosporin a formulations as nanoparticles
US5962019A (en) * 1995-08-25 1999-10-05 Sangstat Medical Corporation Oral cyclosporin formulations
DE19549852B4 (de) 1995-11-29 2009-06-04 Novartis Ag Cyclosporin enthaltende Präparate
TR199901686T2 (xx) 1997-01-30 1999-09-21 Norvartis Ag Esasen ya�s�z farmakolojik kompozisyonlar� i�eren sert jelatin kaps�ller.
GB2326337A (en) * 1997-06-20 1998-12-23 Phares Pharma Holland Homogeneous lipid compositions for drug delivery
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
EP1558215A4 (en) * 2003-10-14 2007-09-12 Wockhardt Ltd STERILE GELIFYING AGENTS
JP5422871B2 (ja) * 2006-10-24 2014-02-19 不二製油株式会社 イソフラボン類組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE624258A (fi) * 1961-10-31
GB1134878A (en) * 1966-05-12 1968-11-27 Suga Kazuo Improvements in and relating to oryzanol solutions and compositions
FR5986M (fi) * 1966-11-22 1968-06-21
BE787842A (fr) * 1971-08-25 1972-12-18 Sumito Chemical Cy Ltd Procede de preparation d'une suspension aqueuse de cristaux stables du type non beta d'esters d'acides gras superieurs du chloramphenicol
JPS53107408A (en) * 1977-02-28 1978-09-19 Yamanouchi Pharmaceut Co Ltd Micellar preparation for rectal infusion
FI65914C (fi) * 1978-03-07 1984-08-10 Sandoz Ag Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a
JPS57128634A (en) * 1981-02-03 1982-08-10 Eisai Co Ltd Elastase-containing compound increasing absorption
EP0179583A1 (en) * 1984-10-04 1986-04-30 Merck & Co. Inc. A system for enhancing the water dissolution rate and solubility of poorly soluble drugs
JPS61280435A (ja) * 1985-04-04 1986-12-11 Kanji Takada サイクロスポリン類のリンパ指向性製剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100456992B1 (ko) * 1996-07-01 2005-01-27 미쓰비시 가가꾸 푸즈 가부시끼가이샤 항균제

Also Published As

Publication number Publication date
GR1002243B (en) 1996-04-22
FI884192A (fi) 1989-03-16
HU205010B (en) 1992-03-30
GB2209671A (en) 1989-05-24
NO179434C (no) 1996-10-09
FI94837B (fi) 1995-07-31
PT88492B (pt) 1993-03-31
BE1001204A5 (fr) 1989-08-16
GR880100602A (el) 1989-06-22
SE503279C2 (sv) 1996-05-13
GB2209671B (en) 1991-11-13
JPH01151526A (ja) 1989-06-14
AU628787B2 (en) 1992-09-24
DK511188D0 (da) 1988-09-14
KR890004694A (ko) 1989-05-09
IE61195B1 (en) 1994-10-19
NL195094C (nl) 2003-12-17
SE8803221D0 (sv) 1988-09-13
ATA224988A (de) 1992-08-15
IL87746A0 (en) 1989-02-28
MY103769A (en) 1993-09-30
DK175132B1 (da) 2004-06-14
ES2012118A6 (es) 1990-03-01
FR2620336B1 (fr) 1991-10-25
AU2217288A (en) 1989-04-27
NL8802275A (nl) 1989-04-03
HUT49494A (en) 1989-10-30
FR2620336A1 (fr) 1989-03-17
NO179434B (no) 1996-07-01
AT395819B (de) 1993-03-25
IL87746A (en) 1992-07-15
LU87335A1 (fr) 1989-04-06
IT1224886B (it) 1990-10-24
NZ226163A (en) 1991-08-27
IT8848349A0 (it) 1988-09-14
NO884052L (no) 1989-03-16
PT88492A (pt) 1988-10-01
CH683672A5 (de) 1994-04-29
FI94837C (fi) 1995-11-10
JP3090666B2 (ja) 2000-09-25
SE8803221L (sv) 1989-03-16
GB8821443D0 (en) 1988-10-12
CA1338775C (en) 1996-12-10
DK511188A (da) 1989-03-16
NO884052D0 (no) 1988-09-13
FI884192A0 (fi) 1988-09-13
IE882772L (en) 1989-03-15

Similar Documents

Publication Publication Date Title
KR0131084B1 (ko) 약리학적 활성 화합물과 약학적 부형제를 위한 가용화제로서의 수용성 모노에스테르
US5756450A (en) Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients and novel cyclosporin galenic forms
JP4073503B2 (ja) サイクロスポリンを含有する液体製剤とその調製方法
US7060672B2 (en) Cyclosporin analog formulations
KR0137674B1 (ko) 정맥주사용 약학적 조성물 및 이를 제조하는 방법
KR0170769B1 (ko) 신규한 사이클로스포린 갈렌 제제
EP1156782B1 (en) Echinocandin pharmaceutical formulations containing micelle-forming surfactants
KR100894130B1 (ko) 사이클로스포린을 함유하는 약학 조성물
KR100188305B1 (ko) 신규의 시클로스포린 결정 형태, 이것의 제조 방법 및 이것을 함유한 약학 조성물 및 그 용도
JP2003534265A (ja) 生物学的に活性な親水性化合物を非経口的に投与するための徐放性薬剤組成物
US6187747B1 (en) Pharmaceutical composition comprising cyclosporin
EP0982035B1 (en) Cyclosporin composition comprising an hydrophilic carrier
EP1151755B1 (en) Pharmaceutical compositions comprising cyclosporin as active ingredient
DE3830494B4 (de) Wasserlösliche Monoester als Solubilisatoren für pharmakologische Wirkstoffe und pharmazeutische Hilfsstoffe
KR0173349B1 (ko) 사이클로스포린-함유 고체 분산체 조성물
KR100256007B1 (ko) 사이클로스포린을 함유하는 약학 조성물
KR100267149B1 (ko) 사이클로스포린을 함유하는 약학 조성물
JP2005060377A (ja) インターロイキン−１１含有凍結乾燥製剤

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20111101

Year of fee payment: 15

EXPY Expiration of term