GB2209671B - Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients - Google Patents
Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipientsInfo
- Publication number
- GB2209671B GB2209671B GB8821443A GB8821443A GB2209671B GB 2209671 B GB2209671 B GB 2209671B GB 8821443 A GB8821443 A GB 8821443A GB 8821443 A GB8821443 A GB 8821443A GB 2209671 B GB2209671 B GB 2209671B
- Authority
- GB
- United Kingdom
- Prior art keywords
- solubilisers
- water soluble
- active compounds
- pharmacologically active
- pharmaceutical excipients
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3730909 | 1987-09-15 | ||
DE3802355 | 1988-01-27 |
Publications (3)
Publication Number | Publication Date |
---|---|
GB8821443D0 GB8821443D0 (en) | 1988-10-12 |
GB2209671A GB2209671A (en) | 1989-05-24 |
GB2209671B true GB2209671B (en) | 1991-11-13 |
Family
ID=25859774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8821443A Expired - Lifetime GB2209671B (en) | 1987-09-15 | 1988-09-13 | Water soluble monoesters as solubilisers for pharmacologically active compounds and pharmaceutical excipients |
Country Status (24)
Country | Link |
---|---|
JP (1) | JP3090666B2 (fi) |
KR (1) | KR0131084B1 (fi) |
AT (1) | AT395819B (fi) |
AU (1) | AU628787B2 (fi) |
BE (1) | BE1001204A5 (fi) |
CA (1) | CA1338775C (fi) |
CH (1) | CH683672A5 (fi) |
DK (1) | DK175132B1 (fi) |
ES (1) | ES2012118A6 (fi) |
FI (1) | FI94837C (fi) |
FR (1) | FR2620336B1 (fi) |
GB (1) | GB2209671B (fi) |
GR (1) | GR1002243B (fi) |
HU (1) | HU205010B (fi) |
IE (1) | IE61195B1 (fi) |
IL (1) | IL87746A (fi) |
IT (1) | IT1224886B (fi) |
LU (1) | LU87335A1 (fi) |
MY (1) | MY103769A (fi) |
NL (1) | NL195094C (fi) |
NO (1) | NO179434C (fi) |
NZ (1) | NZ226163A (fi) |
PT (1) | PT88492B (fi) |
SE (1) | SE503279C2 (fi) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6007840A (en) * | 1988-09-16 | 1999-12-28 | Novartis Ag | Pharmaceutical compositions comprising cyclosporins |
GB2222770B (en) * | 1988-09-16 | 1992-07-29 | Sandoz Ltd | Pharmaceutical compositions containing cyclosporins |
GR1000466B (el) * | 1989-01-28 | 1992-07-30 | Sandoz Ag | Μεθοδος παρασκευης νεων φαρμακευτικων μορφων κυκλοσπορινης. |
BE1003009A5 (fr) * | 1989-02-09 | 1991-10-22 | Sandoz Sa | Nouvelles compositions pharmaceutiques a base de cyclosporines. |
GB8916901D0 (en) | 1989-07-24 | 1989-09-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
US6262022B1 (en) | 1992-06-25 | 2001-07-17 | Novartis Ag | Pharmaceutical compositions containing cyclosporin as the active agent |
ES2098739T3 (es) | 1992-05-13 | 1997-05-01 | Sandoz Ltd | Composiciones oftalmicas conteniendo una cyclosporin. |
EP0589843B1 (en) | 1992-09-25 | 2001-11-28 | Novartis AG | Pharmaceutical compositions containing cyclosporins |
ATE398448T1 (de) * | 1993-09-28 | 2008-07-15 | Scherer Gmbh R P | Herstellung von weichgelatinekapseln |
RU2158601C2 (ru) | 1994-11-03 | 2000-11-10 | Новартис Аг | Новые лекарственные формы циклоспорина для орального применения с простым составом и высокой биодоступностью и способ их получения |
US5827822A (en) * | 1996-03-25 | 1998-10-27 | Sangstat Medical Corporation | Cyclosporin a formulations as nanoparticles |
US5962019A (en) * | 1995-08-25 | 1999-10-05 | Sangstat Medical Corporation | Oral cyclosporin formulations |
US5766629A (en) * | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
US5834017A (en) * | 1995-08-25 | 1998-11-10 | Sangstat Medical Corporation | Oral cyclopsporin formulations |
DE19544507B4 (de) | 1995-11-29 | 2007-11-15 | Novartis Ag | Cyclosporin enthaltende Präparate |
TW414696B (en) * | 1996-07-01 | 2000-12-11 | Mitsubishi Kagaku Foods Kk | Anti-bacteria agent |
NZ336900A (en) | 1997-01-30 | 2001-06-29 | Novartis Ag | Hard gelatine capsules containing pharmaceutical compositions comprising cyclosporin A and being substantially free of any oil |
GB2326337A (en) * | 1997-06-20 | 1998-12-23 | Phares Pharma Holland | Homogeneous lipid compositions for drug delivery |
EP1558215A4 (en) * | 2003-10-14 | 2007-09-12 | Wockhardt Ltd | STERILE GELIFYING AGENTS |
JP5422871B2 (ja) * | 2006-10-24 | 2014-02-19 | 不二製油株式会社 | イソフラボン類組成物 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1134878A (en) * | 1966-05-12 | 1968-11-27 | Suga Kazuo | Improvements in and relating to oryzanol solutions and compositions |
JPS61280435A (ja) * | 1985-04-04 | 1986-12-11 | Kanji Takada | サイクロスポリン類のリンパ指向性製剤 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE624258A (fi) * | 1961-10-31 | |||
FR5986M (fi) * | 1966-11-22 | 1968-06-21 | ||
BE787842A (fr) * | 1971-08-25 | 1972-12-18 | Sumito Chemical Cy Ltd | Procede de preparation d'une suspension aqueuse de cristaux stables du type non beta d'esters d'acides gras superieurs du chloramphenicol |
JPS53107408A (en) * | 1977-02-28 | 1978-09-19 | Yamanouchi Pharmaceut Co Ltd | Micellar preparation for rectal infusion |
FI65914C (fi) * | 1978-03-07 | 1984-08-10 | Sandoz Ag | Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a |
JPS57128634A (en) * | 1981-02-03 | 1982-08-10 | Eisai Co Ltd | Elastase-containing compound increasing absorption |
EP0179583A1 (en) * | 1984-10-04 | 1986-04-30 | Merck & Co. Inc. | A system for enhancing the water dissolution rate and solubility of poorly soluble drugs |
-
1988
- 1988-09-01 HU HU884518A patent/HU205010B/hu unknown
- 1988-09-12 LU LU87335A patent/LU87335A1/xx unknown
- 1988-09-12 BE BE8801044A patent/BE1001204A5/fr not_active IP Right Cessation
- 1988-09-12 FR FR888811953A patent/FR2620336B1/fr not_active Expired - Lifetime
- 1988-09-12 CH CH3398/88A patent/CH683672A5/de not_active IP Right Cessation
- 1988-09-13 NO NO884052A patent/NO179434C/no not_active IP Right Cessation
- 1988-09-13 IE IE277288A patent/IE61195B1/en not_active IP Right Cessation
- 1988-09-13 CA CA000577214A patent/CA1338775C/en not_active Expired - Lifetime
- 1988-09-13 PT PT88492A patent/PT88492B/pt not_active IP Right Cessation
- 1988-09-13 FI FI884192A patent/FI94837C/fi not_active IP Right Cessation
- 1988-09-13 NZ NZ226163A patent/NZ226163A/xx unknown
- 1988-09-13 SE SE8803221A patent/SE503279C2/sv not_active IP Right Cessation
- 1988-09-13 GB GB8821443A patent/GB2209671B/en not_active Expired - Lifetime
- 1988-09-13 AU AU22172/88A patent/AU628787B2/en not_active Expired
- 1988-09-14 GR GR880100602A patent/GR1002243B/el not_active IP Right Cessation
- 1988-09-14 IL IL87746A patent/IL87746A/xx active Protection Beyond IP Right Term
- 1988-09-14 KR KR1019880011874A patent/KR0131084B1/ko not_active IP Right Cessation
- 1988-09-14 IT IT8848349A patent/IT1224886B/it active
- 1988-09-14 MY MYPI88001027A patent/MY103769A/en unknown
- 1988-09-14 DK DK198805111A patent/DK175132B1/da not_active IP Right Cessation
- 1988-09-14 AT AT0224988A patent/AT395819B/de not_active IP Right Cessation
- 1988-09-14 JP JP63231396A patent/JP3090666B2/ja not_active Expired - Lifetime
- 1988-09-15 NL NL8802275A patent/NL195094C/nl not_active IP Right Cessation
- 1988-09-15 ES ES8802831A patent/ES2012118A6/es not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1134878A (en) * | 1966-05-12 | 1968-11-27 | Suga Kazuo | Improvements in and relating to oryzanol solutions and compositions |
JPS61280435A (ja) * | 1985-04-04 | 1986-12-11 | Kanji Takada | サイクロスポリン類のリンパ指向性製剤 |
Non-Patent Citations (1)
Title |
---|
Pharm. Res. 3(1), 48-51 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
732E | Amendments to the register in respect of changes of name or changes affecting rights (sect. 32/1977) | ||
PE20 | Patent expired after termination of 20 years |
Expiry date: 20080912 |