|
US4820834A
(en)
|
1984-06-26 |
1989-04-11 |
Merck & Co., Inc. |
Benzodiazepine analogs
|
|
US4735941A
(en)
|
1986-12-23 |
1988-04-05 |
Merck & Co., Inc. |
1,4-benzodiazepines with 5- and 6-membered heterocyclic rings, useful as gastrointestinal and CNS agents
|
|
EP0304223A3
(en)
|
1987-08-17 |
1990-10-24 |
Merck & Co. Inc. |
Beta-carbolines as cholecy-stokinin and gastrin antagonist
|
|
US5166151A
(en)
|
1988-03-25 |
1992-11-24 |
Merck & Co., Inc. |
2-Benzazepines with 5- and 6-membered heterocyclic rings, compositions and medical methods of use thereof
|
|
US5032604A
(en)
|
1989-12-08 |
1991-07-16 |
Merck & Co., Inc. |
Class III antiarrhythmic agents
|
|
CA2032427A1
(en)
|
1989-12-18 |
1991-06-19 |
Mark G. Bock |
Benzodiazepines analogs
|
|
CA2032226A1
(en)
|
1989-12-18 |
1991-06-19 |
Mark G. Bock |
Benzodiazepine analogs
|
|
US5324726A
(en)
|
1989-12-18 |
1994-06-28 |
Merck & Co., Inc. |
Benzodiazepine analogs
|
|
US5041453A
(en)
|
1990-05-30 |
1991-08-20 |
Rhone-Poulenc Rorer Pharmaceuticals Inc. |
Quinolinyl-benzoheterobicyclic derivatives as antagonists of leukotriene D4
|
|
US5095031A
(en)
|
1990-08-20 |
1992-03-10 |
Abbott Laboratories |
Indole derivatives which inhibit leukotriene biosynthesis
|
|
CA2056809A1
(en)
|
1990-12-07 |
1992-06-08 |
Mark G. Bock |
Benzodiazepine analogs
|
|
US5206237A
(en)
|
1991-05-14 |
1993-04-27 |
Merck & Co., Inc. |
Benzodiazepine analogs
|
|
US5185331A
(en)
|
1991-05-14 |
1993-02-09 |
Merck & Co., Inc. |
Triazolobenzodiazepines
|
|
EP0518484A3
(en)
|
1991-05-14 |
1993-03-17 |
Merck & Co. Inc. |
1,4-benzodiazepines condesed with 5- and 6-membered heterocyclic rings to treat anxiety, pain, pupil constriction, withdrawal-syndrome or oncologic disorders
|
|
US5210082A
(en)
|
1991-05-16 |
1993-05-11 |
Merck & Co., Inc. |
2-benzazepines with 5- and 6-membered heterocyclic rings to treat pain and anxiety disorders
|
|
CA2071092A1
(en)
|
1991-06-14 |
1992-12-15 |
Roger M. Freidinger |
1,4-benzodiazepines with 5-membered heterocyclic rings
|
|
EP0523845A3
(en)
|
1991-06-14 |
1993-11-18 |
Merck & Co Inc |
New benzodiazepine analogs
|
|
US5177071A
(en)
|
1991-06-17 |
1993-01-05 |
Merck & Co., Inc. |
1,4-benzodiazepines with 6-membered heterocyclic rings to treat panic and anxiety disorder
|
|
MY110227A
(en)
|
1991-08-12 |
1998-03-31 |
Ciba Geigy Ag |
1-acylpiperindine compounds.
|
|
GB9117852D0
(en)
|
1991-08-19 |
1991-10-09 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
KR970011390B1
(ko)
|
1992-01-23 |
1997-07-10 |
도레이 가부시키가이샤 |
모르피난 유도체와 약리학적으로 허용되는 이의 산 부가염 및 이를 함유하는 약제학적 조성물
|
|
WO1993024458A1
(en)
|
1992-05-28 |
1993-12-09 |
Pfizer Inc. |
New n-aryl and n-heteroarylurea derivatives as inhibitors of acyl coenzyme a:cholesterol acyl transferase (acat)
|
|
US5559127A
(en)
|
1992-10-14 |
1996-09-24 |
Merck & Co., Inc. |
Fibrinogen receptor antagonists
|
|
AU686203B2
(en)
|
1993-07-23 |
1998-02-05 |
Toray Industries, Inc. |
Morphinan derivative and medicinal use
|
|
WO1995009159A1
(en)
|
1993-09-28 |
1995-04-06 |
Otsuka Pharmaceutical Company, Limited |
Quinoxaline derivative as antidiabetic agent
|
|
GB9408577D0
(en)
|
1994-04-29 |
1994-06-22 |
Fujisawa Pharmaceutical Co |
New compound
|
|
FR2725985B1
(fr)
|
1994-10-21 |
1996-11-15 |
Adir |
Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
FR2734814B1
(fr)
|
1995-05-31 |
1997-07-04 |
Adir |
Nouveaux composes alkoxy-aryles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
WO1997014418A1
(en)
|
1995-10-19 |
1997-04-24 |
Merck & Co., Inc. |
16-substituted-6-aza-steroid 5-alpha-reductase inhibitors
|
|
US5821261A
(en)
|
1995-12-08 |
1998-10-13 |
Merck & Co., Inc. |
Substituted saturated aza heterocycles as inhibitors of nitric oxide synthase
|
|
ES2236630T3
(es)
|
1996-11-25 |
2005-07-16 |
Toray Industries, Inc. |
Agente antipruritico.
|
|
WO1998049150A1
(en)
|
1997-04-25 |
1998-11-05 |
Takeda Chemical Industries, Ltd. |
Triazine derivatives, their production and agrochemical composition
|
|
KR100514963B1
(ko)
|
1997-07-11 |
2005-09-15 |
도레이 가부시끼가이샤 |
4,5-에폭시모르피난 유도체를 함유하는 안정한 의약품 조성물
|
|
AU6117298A
(en)
|
1997-07-25 |
1999-02-16 |
Toray Industries, Inc. |
Hyponatremia remedies
|
|
US6583151B2
(en)
|
1997-09-02 |
2003-06-24 |
Toray Industries, Inc. |
Remedies for drug addiction
|
|
FR2778662B1
(fr)
|
1998-05-12 |
2000-06-16 |
Adir |
Nouveaux composes cycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
WO1999059586A1
(en)
|
1998-05-19 |
1999-11-25 |
Regents Of The University Of California |
Thiazolidine and oxazolidine derivatives for the treatment of acute myocardial infarction and inhibition of cardiomyocyte apoptosis
|
|
JP2000053572A
(ja)
|
1998-08-11 |
2000-02-22 |
Toray Ind Inc |
ORL1(opioid orphan)受容体拮抗薬
|
|
JP2003524598A
(ja)
|
1998-09-04 |
2003-08-19 |
アルタナ ファルマ アクチエンゲゼルシャフト |
新規ピラノセン
|
|
EP1115707B1
(en)
|
1998-09-25 |
2003-11-12 |
AstraZeneca AB |
Benzamide derivatives and ther use as cytokine inhibitors
|
|
JP2002532427A
(ja)
|
1998-12-18 |
2002-10-02 |
デュポン ファーマシューティカルズ カンパニー |
ケモカイン受容体活性のモジュレーターとしてのn−ウレイドアルキルピペリジン
|
|
WO2000038683A1
(en)
|
1998-12-23 |
2000-07-06 |
Du Pont Pharmaceuticals Company |
THROMBIN OR FACTOR Xa INHIBITORS
|
|
NZ515086A
(en)
|
1999-04-28 |
2003-10-31 |
Aventis Pharma Gmbh |
Di-aryl acid derivatives as PPAR receptor ligands
|
|
CN1204139C
(zh)
|
1999-08-24 |
2005-06-01 |
东丽株式会社 |
神经性疼痛治疗剂
|
|
JP2001163784A
(ja)
|
1999-12-06 |
2001-06-19 |
Toray Ind Inc |
角膜または結膜用止痒剤
|
|
WO2001051456A2
(en)
|
2000-01-13 |
2001-07-19 |
Tularik Inc. |
Antibacterial agents
|
|
WO2002000651A2
(en)
|
2000-06-27 |
2002-01-03 |
Bristol-Myers Squibb Pharma Company |
Factor xa inhibitors
|
|
US6545152B1
(en)
|
2000-07-18 |
2003-04-08 |
Parker Hughes Institute |
R-isomers of nonnucleoside inhibitors
|
|
US8338442B2
(en)
|
2001-03-30 |
2012-12-25 |
Toray Industries, Inc. |
Remedies for psychoneurosis
|
|
WO2002089845A1
(fr)
|
2001-05-08 |
2002-11-14 |
Toray Industries, Inc. |
Remedes contre la sepsie
|
|
SE0101978D0
(sv)
|
2001-06-01 |
2001-06-01 |
Astrazeneca Ab |
New compounds
|
|
MY130373A
(en)
|
2001-10-29 |
2007-06-29 |
Malesci Sas |
Linear basic compounds having nk-2 antagonist activity and formulations thereof
|
|
EP1500652A4
(en)
|
2002-04-26 |
2006-05-03 |
Nippon Shinyaku Co Ltd |
DERIVATIVE AND MEDICINAL PRODUCT OF QUINAZOLINE
|
|
US20050203084A1
(en)
|
2002-05-22 |
2005-09-15 |
Jeong Jae U. |
Protease inhibitors
|
|
AU2003251828A1
(en)
|
2002-07-12 |
2004-02-02 |
Janssen Pharmaceutica N.V. |
Naphthol, quinoline and isoquinoline-derivatives as modulators of vanilloid vr1 receptor
|
|
JP2004083511A
(ja)
|
2002-08-28 |
2004-03-18 |
Yamanouchi Pharmaceut Co Ltd |
アクリルアミド誘導体
|
|
WO2004022535A1
(ja)
|
2002-08-28 |
2004-03-18 |
Yamanouchi Pharmaceutical Co., Ltd. |
アクリルアミド誘導体
|
|
MXPA05012894A
(es)
*
|
2003-06-05 |
2006-02-22 |
Warner Lambert Co |
Benzofuranos 3-sustituidos como agentes terapeuticos.
|
|
US7393873B2
(en)
|
2003-07-02 |
2008-07-01 |
Merck & Co., Inc. |
Arylsulfonamide derivatives
|
|
GB0324498D0
(en)
|
2003-07-21 |
2003-11-26 |
Aventis Pharma Inc |
Heterocyclic compounds as P2X7 ion channel blockers
|
|
AU2004267094A1
(en)
|
2003-08-20 |
2005-03-03 |
Vertex Pharmaceuticals Incorporated |
(4 -amino -1,2, 5-oxadiazol-4-yl) -hetxiroaromatic compounds useful as protein kinase inhibitors
|
|
EP1723126A2
(en)
|
2003-10-22 |
2006-11-22 |
Eli Lilly And Company |
Novel mch receptor antagonists
|
|
EP1678145A2
(en)
|
2003-10-28 |
2006-07-12 |
Vertex Pharmaceuticals Incorporated |
Benzimidazoles useful as modulators of ion channels
|
|
WO2005051938A1
(en)
|
2003-11-20 |
2005-06-09 |
Eli Lilly And Company |
Vitamin d receptor modulators
|
|
UA89035C2
(ru)
|
2003-12-03 |
2009-12-25 |
Лео Фарма А/С |
Эфиры гидроксамовых кислот и их фармацевтическое применение
|
|
TW200600494A
(en)
|
2004-03-08 |
2006-01-01 |
Chugai Pharmaceutical Co Ltd |
Bisphenyl compounds useful as vitamin d3 receptor agonists
|
|
US7531556B2
(en)
|
2004-04-28 |
2009-05-12 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of rock and other protein kinases
|
|
ES2400287T3
(es)
|
2005-03-14 |
2013-04-08 |
High Point Pharmaceuticals, Llc |
Derivados de benzazol, composiciones y procedimientos de uso como inhibidores de beta-secretasa
|
|
ES2351665T3
(es)
|
2005-03-24 |
2011-02-09 |
Rottapharm S.P.A. |
Derivados de benzamidina para el tratamiento y la prevención de mucositis.
|
|
MX2007015726A
(es)
|
2005-06-09 |
2008-03-04 |
Vertex Pharma |
Derivados de indano como moduladores de canales ionicos.
|
|
WO2007026720A1
(ja)
|
2005-08-31 |
2007-03-08 |
Taisho Pharmaceutical Co., Ltd. |
縮環ピラゾール誘導体
|
|
US7897766B2
(en)
|
2005-09-23 |
2011-03-01 |
Abbott Laboratories |
Amino-aza-adamantane derivatives and methods of use
|
|
RU2008118350A
(ru)
|
2005-10-12 |
2009-11-20 |
Вертекс Фармасьютикалз Инкорпорейтед (Us) |
Бифенильные производные в качестве модуляторов потенциалзависимых ионных каналов
|
|
NZ593074A
(en)
|
2005-12-21 |
2012-04-27 |
Vertex Pharma |
sulfonamide-pyrrolidone derivatives as Modulators of Ion Channels
|
|
JP2009530389A
(ja)
|
2006-03-21 |
2009-08-27 |
エピックス デラウェア, インコーポレイテッド |
S1p受容体調節化合物及びその使用
|
|
TW200815351A
(en)
|
2006-05-02 |
2008-04-01 |
Astrazeneca Ab |
Novel compounds
|
|
WO2008013963A2
(en)
|
2006-07-28 |
2008-01-31 |
University Of Connecticut |
Fatty acid amide hydrolase inhibitors
|
|
JP2010502618A
(ja)
|
2006-08-31 |
2010-01-28 |
アリーナ ファーマシューティカルズ, インコーポレイテッド |
セロトニン5−ht2a受容体のモジュレータとしてのベンゾフラン誘導体
|
|
AR063311A1
(es)
|
2006-10-18 |
2009-01-21 |
Novartis Ag |
Compuestos organicos
|
|
ES2418104T3
(es)
|
2007-04-24 |
2013-08-12 |
Toray Industries, Inc. |
Agente terapéutico o profiláctico para la discinesia
|
|
MX2009011554A
(es)
|
2007-04-26 |
2010-01-25 |
Toray Industries |
Preparacion solida estable conteniendo un derivado de 4,5-epoximorfinano.
|
|
JP5539864B2
(ja)
|
2007-06-12 |
2014-07-02 |
アカオゲン,インコーポレーテッド |
抗菌剤
|
|
US8765802B2
(en)
|
2007-06-12 |
2014-07-01 |
Provid Pharmaceuticals, Inc. |
Kinase inhibitors, compositions thereof, and methods of use therewith
|
|
CN101848714B
(zh)
|
2007-10-05 |
2014-08-20 |
东丽株式会社 |
以吗啡喃衍生物或其药理学上允许的酸加成盐为有效成分的皮肤性状改善治疗药
|
|
CN101412692B
(zh)
|
2007-10-18 |
2012-10-17 |
中国科学院上海药物研究所 |
1-(3-氨基丙基)哌啶-4-氨基酰胺类化合物、其药物组合物及其制备方法和用途
|
|
CN101965189A
(zh)
|
2008-01-11 |
2011-02-02 |
加利福尼亚大学董事会 |
处决胱冬酶原3、6和7的激活剂
|
|
WO2009112445A1
(en)
|
2008-03-10 |
2009-09-17 |
Novartis Ag |
Method of increasing cellular phosphatidyl choline by dgat1 inhibition
|
|
TW201000107A
(en)
|
2008-04-09 |
2010-01-01 |
Infinity Pharmaceuticals Inc |
Inhibitors of fatty acid amide hydrolase
|
|
EP2300427A1
(en)
|
2008-05-05 |
2011-03-30 |
Amgen Inc. |
Urea compounds as gamma secretase modulators
|
|
US7906553B2
(en)
|
2008-08-27 |
2011-03-15 |
Calcimedica, Inc. |
Substituted thiophene modulators of intracellular calcium
|
|
CN101712679B
(zh)
|
2008-10-08 |
2013-04-10 |
中国科学院上海药物研究所 |
一种酰胺类化合物、其药物组合物及其制备方法和用途
|
|
US8829019B2
(en)
|
2008-10-24 |
2014-09-09 |
Toray Industries, Inc. |
Stable tablet containing 4,5-epoxymorphinan derivative
|
|
JP5535931B2
(ja)
|
2008-10-27 |
2014-07-02 |
武田薬品工業株式会社 |
二環性化合物
|
|
GB0821913D0
(en)
|
2008-12-02 |
2009-01-07 |
Price & Co |
Antibacterial compounds
|
|
WO2010065668A1
(en)
|
2008-12-03 |
2010-06-10 |
Presidio Pharmaceuticals, Inc. |
Inhibitors of hcv ns5a
|
|
WO2010088574A1
(en)
|
2009-01-30 |
2010-08-05 |
Sirtris Pharmaceuticals, Inc. |
Azabenzimidazoles and related analogs as sirtuin modulators
|
|
SG174883A1
(en)
|
2009-03-27 |
2011-11-28 |
Presidio Pharmaceuticals Inc |
Fused ring inhibitors of hepatitis c
|
|
CN102066372B
(zh)
|
2009-08-24 |
2014-09-17 |
苏州爱斯鹏药物研发有限责任公司 |
含脲基的5,6元杂芳双环化合物作为激酶抑制剂
|
|
CN103221047B
(zh)
|
2010-01-13 |
2014-12-17 |
坦颇罗制药股份有限公司 |
化合物和方法
|
|
AU2011211223B2
(en)
|
2010-01-29 |
2014-10-23 |
Toray Industries, Inc. |
Therapeutic or prophylactic agent for biliary diseases
|
|
CN103080109A
(zh)
|
2010-09-01 |
2013-05-01 |
苏州爱斯鹏药物研发有限责任公司 |
氘代杂环化合物激酶抑制剂
|
|
WO2012050918A2
(en)
|
2010-09-29 |
2012-04-19 |
Presidio Pharmaceutical, Inc. |
Tricyclic fused ring inhibitors of hepatitis c
|
|
ES2586655T3
(es)
|
2011-01-31 |
2016-10-18 |
Toray Industries, Inc. |
(-)-17-(ciclopropilmetil)-3,14beta-dihidroxi-4,5alfa-epoxi-6beta-[N-metil-trans-3-(3-furil)acrilamido]morfinano para su utilización en el tratamiento o prevención de la caquexia por cáncer
|
|
BR112013020270A2
(pt)
|
2011-02-10 |
2016-07-12 |
Syngenta Participations Ag |
derivados de pirazol microbicidas
|
|
WO2012129562A2
(en)
|
2011-03-24 |
2012-09-27 |
The Scripps Research Institute |
Compounds and methods for inducing chondrogenesis
|
|
US9282738B2
(en)
|
2011-07-11 |
2016-03-15 |
Wisconsin Alumni Research Foundation |
Antimicrobial compositions and methods of use thereof
|
|
WO2013009810A1
(en)
|
2011-07-13 |
2013-01-17 |
Tempero Pharmaceuticals, Inc. |
Methods of treatment
|
|
WO2013009830A1
(en)
|
2011-07-13 |
2013-01-17 |
Tempero Pharmaceuticals, Inc. |
Methods of treatment
|
|
MX2014007732A
(es)
|
2011-12-23 |
2015-01-12 |
Novartis Ag |
Compuestos para inhibir la interaccion de bcl2 con los mismos componentes de enlace.
|
|
DK2803662T3
(en)
|
2012-01-13 |
2017-05-01 |
Nippon Chemiphar Co |
P2X4 receptor antagonist
|
|
DE102012103405A1
(de)
|
2012-04-18 |
2013-10-24 |
Heinrich-Pette-Institut |
Desoxyhypusin-Synthase-Inhibitoren
|
|
US20140200215A1
(en)
|
2013-01-15 |
2014-07-17 |
Intermune, Inc. |
Lysophosphatidic acid receptor antagonists
|
|
SG11201605757SA
(en)
|
2013-12-20 |
2016-08-30 |
Inst Drug Discovery |
Substituted amino triazoles, and methods using same
|
|
KR20150136294A
(ko)
|
2014-05-27 |
2015-12-07 |
주식회사 레고켐 바이오사이언스 |
인자 XIa 억제 활성을 가지는 신규한 화합물
|
|
EP2993174A1
(en)
|
2014-09-08 |
2016-03-09 |
Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH |
Pyrazolopyridine derivatives and their use in therapy
|
|
CA2965467A1
(en)
|
2014-10-24 |
2016-04-28 |
Ono Pharmaceutical Co., Ltd. |
Kcnq2-5 channel activator
|
|
JP6765681B2
(ja)
|
2015-04-21 |
2020-10-07 |
オールジェネシス バイオセラピューティクス インコーポレイテッド |
Bace1阻害剤としての化合物およびそれらの使用
|
|
WO2017039318A1
(en)
|
2015-09-01 |
2017-03-09 |
Kainos Medicine, Inc. |
Benzimidazole derivatives for dna methylation inhibitors
|
|
WO2017117447A1
(en)
|
2015-12-31 |
2017-07-06 |
Karyopharm Therapeutics Inc. |
Multicyclic compounds and uses thereof
|
|
EP3447045B9
(en)
|
2016-04-22 |
2021-07-21 |
ONO Pharmaceutical Co., Ltd. |
1-(1-hydroxy-2,3-dihydro-1h-inden-5-yl)-urea derivatives and related compounds kcnq 2-5 channel activators for treating dysuria
|
|
CN109311882B
(zh)
|
2016-05-04 |
2022-02-11 |
Bci制药公司 |
作为蛋白激酶抑制剂的腺嘌呤衍生物
|
|
WO2018165501A1
(en)
|
2017-03-10 |
2018-09-13 |
Lycera Corporation |
INDOLINYL SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORγ AND THE TREATMENT OF DISEASE
|
|
EP3621962A4
(en)
|
2017-05-10 |
2020-12-09 |
Forge Therapeutics, Inc. |
ANTIBACTERIAL COMPOUNDS
|
|
WO2019111225A1
(en)
|
2017-12-08 |
2019-06-13 |
Avaliv Therapeutics |
Compounds and methods for the treatment of non‑alcoholic steatohepatitis
|
|
GB201809050D0
(en)
|
2018-06-01 |
2018-07-18 |
E Therapeutics Plc |
Modulators of tryptophan catabolism
|
|
WO2020028515A1
(en)
|
2018-07-31 |
2020-02-06 |
University Of Pittsburgh-Of The Commonwealth System Of Higher Education |
Neuroprotective disruption of kv2.1/syntaxin interaction by small molecules
|
|
TW202021956A
(zh)
|
2018-08-09 |
2020-06-16 |
美商奇尼塔公司 |
視黃酸誘導基因"rig-i"途徑之活化劑及其使用方法
|
|
WO2020041684A1
(en)
|
2018-08-23 |
2020-02-27 |
Memorial Sloan-Kettering Cancer Center |
Biomarkers for determining responsiveness of a cancer to pi3k inhibitors
|
|
EP3848051A4
(en)
|
2018-09-03 |
2022-06-08 |
Nippon Chemiphar Co., Ltd. |
DRUG TARGETING DIABETIC PERIPHERAL NEUROPATHY
|
|
CN111039942B
(zh)
|
2018-10-12 |
2023-04-14 |
上海长森药业有限公司 |
含氮杂环类化合物,及其制备方法、药物组合物和应用
|
|
CA3136151A1
(en)
|
2019-04-12 |
2020-10-15 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
D3 receptor agonist compounds; methods of preparation; intermediates thereof; and methods of use thereof
|
|
BR112021022536A2
(pt)
|
2019-05-10 |
2021-12-28 |
Shanghai Haiyan Pharmaceutical Tech Co Ltd |
Derivado de fenilpropenilpiridina substituída e método de preparação do mesmo e uso médico do mesmo
|
|
WO2022265993A1
(en)
|
2021-06-14 |
2022-12-22 |
Scorpion Therapeutics, Inc. |
Urea derivatives which can be used to treat cancer
|