JPWO2022040002A5 - - Google Patents
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- JPWO2022040002A5 JPWO2022040002A5 JP2023512031A JP2023512031A JPWO2022040002A5 JP WO2022040002 A5 JPWO2022040002 A5 JP WO2022040002A5 JP 2023512031 A JP2023512031 A JP 2023512031A JP 2023512031 A JP2023512031 A JP 2023512031A JP WO2022040002 A5 JPWO2022040002 A5 JP WO2022040002A5
- Authority
- JP
- Japan
- Prior art keywords
- monocyclic
- group
- membered
- alkyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000217 alkyl group Chemical group 0.000 claims 36
- 150000001875 compounds Chemical class 0.000 claims 21
- 229910052739 hydrogen Inorganic materials 0.000 claims 19
- 239000001257 hydrogen Substances 0.000 claims 19
- 229910052736 halogen Inorganic materials 0.000 claims 17
- 150000002367 halogens Chemical group 0.000 claims 17
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 15
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 14
- 229910052760 oxygen Inorganic materials 0.000 claims 12
- 125000003545 alkoxy group Chemical group 0.000 claims 11
- 229910052799 carbon Inorganic materials 0.000 claims 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 9
- 239000001301 oxygen Substances 0.000 claims 9
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 150000001721 carbon Chemical group 0.000 claims 4
- -1 cyano, hydroxy Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 208000002672 hepatitis B Diseases 0.000 claims 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063066689P | 2020-08-17 | 2020-08-17 | |
| US63/066,689 | 2020-08-17 | ||
| US202163210423P | 2021-06-14 | 2021-06-14 | |
| US63/210,423 | 2021-06-14 | ||
| PCT/US2021/045696 WO2022040002A1 (en) | 2020-08-17 | 2021-08-12 | Methods and compositions for targeting pd-l1 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023539463A JP2023539463A (ja) | 2023-09-14 |
| JPWO2022040002A5 true JPWO2022040002A5 (https=) | 2024-08-19 |
| JP2023539463A5 JP2023539463A5 (https=) | 2024-08-19 |
Family
ID=80350607
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023512031A Pending JP2023539463A (ja) | 2020-08-17 | 2021-08-12 | Ｐｄ－ｌ１を標的とするための方法及び組成物 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11760761B2 (https=) |
| EP (1) | EP4185569B1 (https=) |
| JP (1) | JP2023539463A (https=) |
| KR (1) | KR20230059801A (https=) |
| CN (1) | CN116209663A (https=) |
| AU (1) | AU2021329259A1 (https=) |
| CA (1) | CA3190154A1 (https=) |
| TW (1) | TW202227451A (https=) |
| WO (1) | WO2022040002A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3182131A1 (en) | 2020-05-22 | 2021-11-25 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
| CN115232109A (zh) * | 2021-04-25 | 2022-10-25 | 广东东阳光药业有限公司 | Pd-1/pd-l1类小分子抑制剂及其在药物中的应用 |
| BR112023026747A2 (pt) * | 2021-06-18 | 2024-03-12 | Aligos Therapeutics Inc | Métodos e composições para direcionamento de pd-l1 |
| JP2024525589A (ja) | 2021-07-09 | 2024-07-12 | アリゴス セラピューティクス インコーポレイテッド | 抗ウイルス化合物 |
| WO2023043816A1 (en) | 2021-09-17 | 2023-03-23 | Aligos Therapeutics, Inc. | Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections |
| CA3240346A1 (en) | 2021-12-16 | 2023-06-22 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
| WO2024134466A1 (en) * | 2022-12-21 | 2024-06-27 | Arbutus Biopharma Corporation | Substituted arylamine compounds, substituted heteroarylamine compounds, and methods using same |
| KR20250150141A (ko) * | 2023-02-23 | 2025-10-17 | 선샤인 레이크 파르마 컴퍼니 리미티드 | 피리도피리미딘 유도체 및 이의 용도 |
| WO2025015063A1 (en) * | 2023-07-13 | 2025-01-16 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
| WO2025171031A1 (en) * | 2024-02-07 | 2025-08-14 | Aligos Therapeutics, Inc. | Pd-l1 compounds with a bicyclic group |
| WO2025171025A1 (en) * | 2024-02-07 | 2025-08-14 | Aligos Therapeutics, Inc. | Pd-l1 compounds with a bicyclic group |
| WO2025174835A1 (en) * | 2024-02-15 | 2025-08-21 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
| WO2025199281A1 (en) * | 2024-03-22 | 2025-09-25 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
| WO2025199273A1 (en) * | 2024-03-22 | 2025-09-25 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
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| EP4100381A4 (en) * | 2020-02-03 | 2024-04-03 | Arbutus Biopharma Corporation | SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS OF USE THEREOF |
| CA3182131A1 (en) | 2020-05-22 | 2021-11-25 | Aligos Therapeutics, Inc. | Methods and compositions for targeting pd-l1 |
| BR112023026747A2 (pt) | 2021-06-18 | 2024-03-12 | Aligos Therapeutics Inc | Métodos e composições para direcionamento de pd-l1 |
-
2021
- 2021-08-12 JP JP2023512031A patent/JP2023539463A/ja active Pending
- 2021-08-12 US US17/444,947 patent/US11760761B2/en active Active
- 2021-08-12 EP EP21858851.5A patent/EP4185569B1/en active Active
- 2021-08-12 CN CN202180062965.1A patent/CN116209663A/zh active Pending
- 2021-08-12 WO PCT/US2021/045696 patent/WO2022040002A1/en not_active Ceased
- 2021-08-12 KR KR1020237008638A patent/KR20230059801A/ko not_active Ceased
- 2021-08-12 AU AU2021329259A patent/AU2021329259A1/en active Pending
- 2021-08-12 CA CA3190154A patent/CA3190154A1/en active Pending
- 2021-08-16 TW TW110130151A patent/TW202227451A/zh unknown
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