JPWO2021261444A5 - - Google Patents

Info

Publication number

JPWO2021261444A5

JPWO2021261444A5 JP2022531976A JP2022531976A JPWO2021261444A5 JP WO2021261444 A5 JPWO2021261444 A5 JP WO2021261444A5 JP 2022531976 A JP2022531976 A JP 2022531976A JP 2022531976 A JP2022531976 A JP 2022531976A JP WO2021261444 A5 JPWO2021261444 A5 JP WO2021261444A5

Authority

JP

Japan

Prior art keywords

tetradecanoyl

oxy

pharma

acceptable salt

decanoyloxy

Prior art date

2021-06-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
• Global Dossier
• Discuss

• 150000003839 salts Chemical class 0.000 claims 18
• 150000001875 compounds Chemical class 0.000 claims 16
• 125000001419 myristoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 14
• 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 11
• 125000003118 aryl group Chemical group 0.000 claims 11
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 11
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 9
• 239000008194 pharmaceutical composition Substances 0.000 claims 9
• 125000000217 alkyl group Chemical group 0.000 claims 7
• 239000000427 antigen Substances 0.000 claims 7
• 102000036639 antigens Human genes 0.000 claims 7
• 108091007433 antigens Proteins 0.000 claims 7
• XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 7
• 235000019260 propionic acid Nutrition 0.000 claims 7
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
• 125000001424 substituent group Chemical group 0.000 claims 5
• 125000003545 alkoxy group Chemical group 0.000 claims 4
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
• 125000004093 cyano group Chemical group *C#N 0.000 claims 4
• 229910052736 halogen Inorganic materials 0.000 claims 4
• 150000002367 halogens Chemical class 0.000 claims 4
• 238000009472 formulation Methods 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• 244000052769 pathogen Species 0.000 claims 3
• 230000001717 pathogenic effect Effects 0.000 claims 3
• 239000012646 vaccine adjuvant Substances 0.000 claims 3
• 229940124931 vaccine adjuvant Drugs 0.000 claims 3
• 208000035473 Communicable disease Diseases 0.000 claims 2
• 208000015181 infectious disease Diseases 0.000 claims 2
• -1 inorganic acid salts Chemical class 0.000 claims 2
• 150000002632 lipids Chemical class 0.000 claims 2
• 125000000896 monocarboxylic acid group Chemical group 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 150000003904 phospholipids Chemical class 0.000 claims 2
• CITHEXJVPOWHKC-UUWRZZSWSA-N 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC CITHEXJVPOWHKC-UUWRZZSWSA-N 0.000 claims 1
• 102000002322 Egg Proteins Human genes 0.000 claims 1
• 108010000912 Egg Proteins Proteins 0.000 claims 1
• ATBOMIWRCZXYSZ-XZBBILGWSA-N [1-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-3-hexadecanoyloxypropan-2-yl] (9e,12e)-octadeca-9,12-dienoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(COP(O)(=O)OCC(O)CO)OC(=O)CCCCCCC\C=C\C\C=C\CCCCC ATBOMIWRCZXYSZ-XZBBILGWSA-N 0.000 claims 1
• 239000000654 additive Substances 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
• 239000003963 antioxidant agent Substances 0.000 claims 1
• 239000000872 buffer Substances 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 235000013345 egg yolk Nutrition 0.000 claims 1
• 210000002969 egg yolk Anatomy 0.000 claims 1
• 229910052739 hydrogen Inorganic materials 0.000 claims 1
• 239000001257 hydrogen Substances 0.000 claims 1
• 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 1
• 239000002502 liposome Substances 0.000 claims 1
• 150000007522 mineralic acids Chemical class 0.000 claims 1
• 150000007524 organic acids Chemical class 0.000 claims 1
• 235000005985 organic acids Nutrition 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 230000000069 prophylactic effect Effects 0.000 claims 1
• 235000000346 sugar Nutrition 0.000 claims 1
• 150000008163 sugars Chemical class 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 229960005486 vaccine Drugs 0.000 claims 1