JPWO2021206876A5 - - Google Patents
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- Publication number
- JPWO2021206876A5 JPWO2021206876A5 JP2022561396A JP2022561396A JPWO2021206876A5 JP WO2021206876 A5 JPWO2021206876 A5 JP WO2021206876A5 JP 2022561396 A JP2022561396 A JP 2022561396A JP 2022561396 A JP2022561396 A JP 2022561396A JP WO2021206876 A5 JPWO2021206876 A5 JP WO2021206876A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- alkyl
- salt
- compound
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063008183P | 2020-04-10 | 2020-04-10 | |
| US63/008,183 | 2020-04-10 | ||
| US202063027495P | 2020-05-20 | 2020-05-20 | |
| US63/027,495 | 2020-05-20 | ||
| PCT/US2021/022656 WO2021206876A1 (en) | 2020-04-10 | 2021-03-17 | Inhibitors of norovirus and coronavirus replication |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023521116A JP2023521116A (ja) | 2023-05-23 |
| JPWO2021206876A5 true JPWO2021206876A5 (https=) | 2024-03-26 |
| JP2023521116A5 JP2023521116A5 (https=) | 2024-03-26 |
| JP7721561B2 JP7721561B2 (ja) | 2025-08-12 |
Family
ID=75439538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022561396A Active JP7721561B2 (ja) | 2020-04-10 | 2021-03-17 | ノロウイルス及びコロナウイルス複製の阻害剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20230159453A1 (https=) |
| EP (1) | EP4132944A1 (https=) |
| JP (1) | JP7721561B2 (https=) |
| KR (1) | KR20230008079A (https=) |
| CN (1) | CN115698035A (https=) |
| AU (1) | AU2021254045A1 (https=) |
| BR (1) | BR112022019557A2 (https=) |
| CA (1) | CA3179697A1 (https=) |
| IL (1) | IL297069A (https=) |
| MX (1) | MX2022012714A (https=) |
| PH (1) | PH12022552486A1 (https=) |
| TW (1) | TW202204318A (https=) |
| WO (1) | WO2021206876A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4126816A4 (en) * | 2020-03-30 | 2024-07-31 | Kansas State University Research Foundation | BROAD-SPECTRUM ANTIVIRALS AGAINST CORONAVIRUS |
| US11124497B1 (en) | 2020-04-17 | 2021-09-21 | Pardes Biosciences, Inc. | Inhibitors of cysteine proteases and methods of use thereof |
| US11174231B1 (en) | 2020-06-09 | 2021-11-16 | Pardes Biosciences, Inc. | Inhibitors of cysteine proteases and methods of use thereof |
| GB2607514B (en) | 2020-07-20 | 2023-06-21 | Enanta Pharm Inc | Functionalized peptides as antiviral agents |
| US11351149B2 (en) * | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
| US11352363B1 (en) | 2020-11-23 | 2022-06-07 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US11384090B2 (en) | 2020-11-23 | 2022-07-12 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US12540141B2 (en) | 2020-11-23 | 2026-02-03 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| KR20230124583A (ko) | 2020-11-23 | 2023-08-25 | 이난타 파마슈티칼스, 인코포레이티드 | 신규한 스피로피롤리딘 유래 항바이러스제 |
| CN116685573B (zh) * | 2021-01-19 | 2025-12-12 | 中国人民解放军军事科学院军事医学研究院 | 含有n-(取代磺酰基)乙酰胺结构的病毒蛋白酶抑制剂，及其在抗病毒药物中的应用 |
| WO2022165220A1 (en) * | 2021-01-29 | 2022-08-04 | Kansas State University Research Foundation | Conformationally-constrained inhibitors of 3c or 3c-like proteases |
| WO2022235605A1 (en) | 2021-05-04 | 2022-11-10 | Enanta Pharmaceuticals, Inc. | Novel macrocyclic antiviral agents |
| US12398147B2 (en) | 2021-05-11 | 2025-08-26 | Enanta Pharmaceuticals, Inc. | Macrocyclic spiropyrrolidine derived antiviral agents |
| US11319325B1 (en) | 2021-05-11 | 2022-05-03 | Enanta Pharmaceuticals, Inc. | Macrocyclic spiropyrrolidine derived antiviral agents |
| JP2024522990A (ja) * | 2021-06-02 | 2024-06-25 | エイシア セラピューティクス， インコーポレイテッド | 抗ウイルス薬としてのプロテアーゼ阻害剤 |
| WO2022266363A1 (en) * | 2021-06-16 | 2022-12-22 | The Scripps Research Institute | Protease inhibitors for the treatment of coronavirus infections |
| US11325916B1 (en) | 2021-07-29 | 2022-05-10 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US11339170B1 (en) | 2021-07-23 | 2022-05-24 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US12479854B2 (en) | 2021-07-29 | 2025-11-25 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| JP2024530920A (ja) * | 2021-08-03 | 2024-08-27 | コクリスタル ファーマ，インコーポレイテッド | コロナウイルスに対する阻害剤 |
| WO2023086352A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
| WO2023086350A1 (en) | 2021-11-12 | 2023-05-19 | Enanta Pharmaceuticals, Inc. | Alkyne-containing antiviral agents |
| US11919910B2 (en) | 2021-11-12 | 2024-03-05 | Enanta Pharmaceuticals, Inc. | Spiropyrrolidine derived antiviral agents |
| US11993600B2 (en) | 2021-12-08 | 2024-05-28 | Enanta Pharmaceuticals, Inc. | Saturated spirocyclics as antiviral agents |
| US12145941B2 (en) | 2021-12-08 | 2024-11-19 | Enanta Pharmaceuticals, Inc. | Heterocyclic antiviral agents |
| EP4460508A4 (en) * | 2022-01-07 | 2025-12-24 | Merck Sharp & Dohme Llc | PROTEASE INHIBITORS TO TREAT OR PREVENT CORONAVIRUS INFECTION |
| EP4488264A4 (en) * | 2022-03-01 | 2026-03-04 | Westvac Biopharma Co Ltd | CETO AMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USE |
| WO2023196307A1 (en) | 2022-04-05 | 2023-10-12 | Enanta Pharmaceuticals, Inc. | Novel spiropyrrolidine derived antiviral agents |
| CN115260074B (zh) * | 2022-08-02 | 2024-06-21 | 爱斯特（成都）生物制药股份有限公司 | 一种口服抗病毒药物Paxlovid中间体的制备方法 |
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| US4131648A (en) | 1975-01-28 | 1978-12-26 | Alza Corporation | Structured orthoester and orthocarbonate drug delivery devices |
| US4093709A (en) | 1975-01-28 | 1978-06-06 | Alza Corporation | Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates) |
| US4180646A (en) | 1975-01-28 | 1979-12-25 | Alza Corporation | Novel orthoester polymers and orthocarbonate polymers |
| US4079038A (en) | 1976-03-05 | 1978-03-14 | Alza Corporation | Poly(carbonates) |
| GB2064336B (en) | 1979-12-06 | 1984-03-14 | Glaxo Group Ltd | Device for dispensing medicaments |
| US4304767A (en) | 1980-05-15 | 1981-12-08 | Sri International | Polymers of di- (and higher functionality) ketene acetals and polyols |
| US4353656A (en) | 1980-10-14 | 1982-10-12 | Xerox Corporation | Moving coil, multiple energy print hammer system including a closed loop servo |
| DE3274065D1 (de) | 1981-07-08 | 1986-12-11 | Draco Ab | Powder inhalator |
| DK172541B1 (da) | 1982-10-08 | 1998-12-07 | Glaxo Group Ltd | Apparat til administrering af medikamenter til patienter og en medikamentpakning til brug i apparatet |
| GB2169265B (en) | 1982-10-08 | 1987-08-12 | Glaxo Group Ltd | Pack for medicament |
| US4778054A (en) | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| US4501729A (en) | 1982-12-13 | 1985-02-26 | Research Corporation | Aerosolized amiloride treatment of retained pulmonary secretions |
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| DE3682457D1 (de) | 1985-07-30 | 1991-12-19 | Glaxo Group Ltd | Geraet zur verabreichung von medikamenten an patienten. |
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| US7462594B2 (en) * | 2003-12-31 | 2008-12-09 | Taigen Biotechnology Co., Ltd. | Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases |
| US8481571B2 (en) * | 2004-05-04 | 2013-07-09 | Academia Sinica | Anti-coronavirus compounds |
| WO2005113580A1 (en) * | 2004-05-21 | 2005-12-01 | Pfizer Inc. | Anticoronviral compounds and compositions, their pharmaceutical uses and materials for their synthesis |
| WO2006061714A2 (en) * | 2004-12-09 | 2006-06-15 | Pfizer Inc. | Anticoronaviral compounds and compositions, their pharmaceutical uses and materials for their synthesis |
| MX2013006840A (es) * | 2010-12-16 | 2014-01-31 | Vertex Pharma | Inhibidores de la replicacion de los virus de la influenza. |
| CA2850003C (en) * | 2011-09-27 | 2020-01-07 | Kansas State University Research Foundation | Broad-spectrum antivirals against 3c or 3c-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses |
| CN103145608B (zh) * | 2011-12-07 | 2015-09-02 | 南开大学 | 抗肠病毒71(ev71)己内酰胺类化合物及其制备方法和用途 |
| CN106928206B (zh) * | 2015-12-31 | 2022-02-18 | 中国科学院上海药物研究所 | 醛基类化合物及其制法和用途 |
| WO2017222935A1 (en) * | 2016-06-20 | 2017-12-28 | Kansas State University Research Foundation | Small molecule therapeutic inhibitors against picornaviruses, caliciviruses, and coronaviruses |
| CN110818691A (zh) * | 2018-08-09 | 2020-02-21 | 中国科学院上海药物研究所 | 酮酰胺类化合物及其制备方法、药物组合物和用途 |
| CN110105348A (zh) * | 2019-03-08 | 2019-08-09 | 南开大学 | 新型迈克尔受体类肠病毒71型抑制剂的制备及用途 |
-
2021
- 2021-03-17 CN CN202180027505.5A patent/CN115698035A/zh active Pending
- 2021-03-17 TW TW110109546A patent/TW202204318A/zh unknown
- 2021-03-17 US US17/912,749 patent/US20230159453A1/en active Pending
- 2021-03-17 BR BR112022019557A patent/BR112022019557A2/pt unknown
- 2021-03-17 PH PH1/2022/552486A patent/PH12022552486A1/en unknown
- 2021-03-17 MX MX2022012714A patent/MX2022012714A/es unknown
- 2021-03-17 JP JP2022561396A patent/JP7721561B2/ja active Active
- 2021-03-17 KR KR1020227039096A patent/KR20230008079A/ko active Pending
- 2021-03-17 WO PCT/US2021/022656 patent/WO2021206876A1/en not_active Ceased
- 2021-03-17 CA CA3179697A patent/CA3179697A1/en active Pending
- 2021-03-17 AU AU2021254045A patent/AU2021254045A1/en active Pending
- 2021-03-17 EP EP21717692.4A patent/EP4132944A1/en active Pending
- 2021-03-17 IL IL297069A patent/IL297069A/en unknown
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