JPWO2021146487A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2021146487A5
JPWO2021146487A5 JP2022542908A JP2022542908A JPWO2021146487A5 JP WO2021146487 A5 JPWO2021146487 A5 JP WO2021146487A5 JP 2022542908 A JP2022542908 A JP 2022542908A JP 2022542908 A JP2022542908 A JP 2022542908A JP WO2021146487 A5 JPWO2021146487 A5 JP WO2021146487A5
Authority
JP
Japan
Prior art keywords
orthogonal
car
human
polypeptide
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022542908A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023511274A5 (https=
JP2023511274A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/013521 external-priority patent/WO2021146487A2/en
Publication of JP2023511274A publication Critical patent/JP2023511274A/ja
Publication of JP2023511274A5 publication Critical patent/JP2023511274A5/ja
Publication of JPWO2021146487A5 publication Critical patent/JPWO2021146487A5/ja
Priority to JP2025217897A priority Critical patent/JP2026041861A/ja
Pending legal-status Critical Current

Links

JP2022542908A 2020-01-14 2021-01-14 Il2オルソログおよび使用法 Pending JP2023511274A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025217897A JP2026041861A (ja) 2020-01-14 2025-12-02 Il2オルソログおよび使用法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202062961200P 2020-01-14 2020-01-14
US62/961,200 2020-01-14
US202063015476P 2020-04-24 2020-04-24
US63/015,476 2020-04-24
US202063016256P 2020-04-27 2020-04-27
US63/016,256 2020-04-27
PCT/US2021/013521 WO2021146487A2 (en) 2020-01-14 2021-01-14 Il2 orthologs and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025217897A Division JP2026041861A (ja) 2020-01-14 2025-12-02 Il2オルソログおよび使用法

Publications (3)

Publication Number Publication Date
JP2023511274A JP2023511274A (ja) 2023-03-17
JP2023511274A5 JP2023511274A5 (https=) 2024-04-26
JPWO2021146487A5 true JPWO2021146487A5 (https=) 2024-04-26

Family

ID=76864710

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022542908A Pending JP2023511274A (ja) 2020-01-14 2021-01-14 Il2オルソログおよび使用法
JP2025217897A Pending JP2026041861A (ja) 2020-01-14 2025-12-02 Il2オルソログおよび使用法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025217897A Pending JP2026041861A (ja) 2020-01-14 2025-12-02 Il2オルソログおよび使用法

Country Status (10)

Country Link
US (1) US20230076768A1 (https=)
EP (1) EP4090383A4 (https=)
JP (2) JP2023511274A (https=)
KR (1) KR20220141299A (https=)
CN (1) CN115315273A (https=)
AU (1) AU2021207901A1 (https=)
CA (1) CA3166420A1 (https=)
IL (1) IL294388A (https=)
MX (1) MX2022008772A (https=)
WO (1) WO2021146487A2 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115038453A (zh) * 2020-01-14 2022-09-09 辛德凯因股份有限公司 具有改变的icd stat信号转导的cd122
WO2023172916A2 (en) * 2022-03-08 2023-09-14 Synthekine, Inc. Orthogonal gpc3 chimeric antigen receptor t cells
EP4293040A1 (en) 2022-06-19 2023-12-20 ETH Zurich Cell line for engineering cytokine receptors

Family Cites Families (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1706096A (en) 1924-01-28 1929-03-19 Monogram Lens Corp Lamp focusing apparatus
US4401756A (en) 1981-04-14 1983-08-30 Immunex Corporation Process for preparing human interleukin 2
US4593002A (en) 1982-01-11 1986-06-03 Salk Institute Biotechnology/Industrial Associates, Inc. Viruses with recombinant surface proteins
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US7198919B1 (en) 1983-04-25 2007-04-03 Genentech, Inc. Use of alpha factor sequences in yeast expression systems
US4512584A (en) 1983-06-24 1985-04-23 Western Publishing Company, Inc. Improved game board with pieces cooperating for rotation
US4604377A (en) 1984-03-28 1986-08-05 Cetus Corporation Pharmaceutical compositions of microbially produced interleukin-2
DE3583880D1 (de) 1984-04-09 1991-10-02 Takeda Chemical Industries Ltd Stabile interleukin-2-zusammensetzung.
US4569794A (en) 1984-12-05 1986-02-11 Eli Lilly And Company Process for purifying proteins and compounds useful in such process
US4752585A (en) 1985-12-17 1988-06-21 Cetus Corporation Oxidation-resistant muteins
US5116943A (en) 1985-01-18 1992-05-26 Cetus Corporation Oxidation-resistant muteins of Il-2 and other protein
US5206344A (en) 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
DE3676670D1 (de) * 1985-06-26 1991-02-07 Cetus Corp Solubilisierung von proteinen fuer pharmazeutische zusammensetzungen mittels polymerkonjugierung.
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US4931544A (en) 1986-09-04 1990-06-05 Cetus Corporation Succinylated interleukin-2 for pharmaceutical compositions
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US6534055B1 (en) 1988-11-23 2003-03-18 Genetics Institute, Inc. Methods for selectively stimulating proliferation of T cells
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US5858358A (en) 1992-04-07 1999-01-12 The United States Of America As Represented By The Secretary Of The Navy Methods for selectively stimulating proliferation of T cells
US6905680B2 (en) 1988-11-23 2005-06-14 Genetics Institute, Inc. Methods of treating HIV infected subjects
US5126132A (en) 1989-08-21 1992-06-30 The United States Of America As Represented By The Department Of Health And Human Services Tumor infiltrating lymphocytes as a treatment modality for human cancer
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
WO1991010737A1 (en) 1990-01-11 1991-07-25 Molecular Affinities Corporation Production of antibodies using gene libraries
US5279833A (en) 1990-04-04 1994-01-18 Yale University Liposomal transfection of nucleic acids into animal cells
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6916605B1 (en) 1990-07-10 2005-07-12 Medical Research Council Methods for producing members of specific binding pairs
CA2405246A1 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with alterred binding properties
JPH06509578A (ja) 1991-07-26 1994-10-27 ユニバーシティ・オブ・ロチェスター 悪性細胞利用による癌治療法
US5283185A (en) 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
US5858784A (en) 1991-12-17 1999-01-12 The Regents Of The University Of California Expression of cloned genes in the lung by aerosol- and liposome-based delivery
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
IL104570A0 (en) 1992-03-18 1993-05-13 Yeda Res & Dev Chimeric genes and cells transformed therewith
US5320663A (en) 1992-07-02 1994-06-14 E. I. Du Pont De Nemours And Company Method of obtaining lead and organolead from contaminated media using metal accumulating plants
US5334761A (en) 1992-08-28 1994-08-02 Life Technologies, Inc. Cationic lipids
WO1995002698A1 (en) 1993-07-12 1995-01-26 Life Technologies, Inc. Composition and methods for transfecting eukaryotic cells
US5631236A (en) 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
US5698443A (en) 1995-06-27 1997-12-16 Calydon, Inc. Tissue specific viral vectors
US7175843B2 (en) 1994-06-03 2007-02-13 Genetics Institute, Llc Methods for selectively stimulating proliferation of T cells
US5650234A (en) 1994-09-09 1997-07-22 Surface Engineering Technologies, Division Of Innerdyne, Inc. Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US6692964B1 (en) 1995-05-04 2004-02-17 The United States Of America As Represented By The Secretary Of The Navy Methods for transfecting T cells
US7067318B2 (en) 1995-06-07 2006-06-27 The Regents Of The University Of Michigan Methods for transfecting T cells
US6696248B1 (en) 1995-08-18 2004-02-24 Morphosys Ag Protein/(poly)peptide libraries
JP4793971B2 (ja) 1999-08-09 2011-10-12 メルク パテント ゲーエムベーハー 複合サイトカイン−抗体複合体
US7572631B2 (en) 2000-02-24 2009-08-11 Invitrogen Corporation Activation and expansion of T cells
US6867041B2 (en) 2000-02-24 2005-03-15 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
CA2406864A1 (en) 2000-02-24 2001-08-30 Life Technologies Corporation Simultaneous stimulation and concentration of cells
US6797514B2 (en) 2000-02-24 2004-09-28 Xcyte Therapies, Inc. Simultaneous stimulation and concentration of cells
US20040259247A1 (en) 2000-12-01 2004-12-23 Thomas Tuschl Rna interference mediating small rna molecules
US7371371B2 (en) 2001-08-13 2008-05-13 University Of Southern California Interleukin-2 mutants with reduced toxicity
US7435596B2 (en) 2004-11-04 2008-10-14 St. Jude Children's Research Hospital, Inc. Modified cell line and method for expansion of NK cell
US20080017377A1 (en) 2006-07-19 2008-01-24 Cowan Kenneth M Well fluid formulation and method
US20100041872A1 (en) * 2006-10-04 2010-02-18 Defrees Shawn Glycerol linked pegylated sugars and glycopeptides
FR2906808B1 (fr) 2006-10-10 2012-10-05 Univ Nantes Utilisation d'anticorps monoclonaux specifiques de la forme o-acetylee du ganglioside gd2 dans le traitement de certains cancers
US10155038B2 (en) 2007-02-02 2018-12-18 Yale University Cells prepared by transient transfection and methods of use thereof
EP2406284B9 (en) 2009-03-10 2017-03-01 Biogen MA Inc. Anti-bcma antibodies
DK3323830T3 (da) 2010-06-19 2023-09-25 Memorial Sloan Kettering Cancer Center Anti-gd2 antibodies
EP3467101A3 (en) 2010-09-08 2019-06-19 Baylor College of Medicine Immunotherapy of brain tumor using geneticially engineered gd2-specific t cells
US8289050B2 (en) 2010-09-21 2012-10-16 Micron Technology, Inc. Switching circuits, latches and methods
ES2866674T3 (es) 2010-11-12 2021-10-19 Nektar Therapeutics Conjugados de una fracción de IL-2 y un polímero
HUE029139T2 (hu) 2011-02-10 2017-02-28 Roche Glycart Ag Mutáns interleukin-2 polipeptidek
WO2012119093A1 (en) * 2011-03-03 2012-09-07 Board Of Trustees Of The Leland Stanford Junior University Superagonists and antagonists of interleukin-2
KR101815323B1 (ko) 2011-09-08 2018-01-05 삼성전자주식회사 복수의 무선 전력 수신기로부터 무선 전력 공급기에 신호를 송신하는 방법 및 장치
EP3692794A1 (en) 2011-09-16 2020-08-12 Baylor College of Medicine Targeting the tumor microenvironment using manipulated nkt cells
ITMO20110270A1 (it) 2011-10-25 2013-04-26 Sara Caldrer Una cellula effettrice modificata per il trattamento di neoplasie esprimenti il disialonganglioside gd2
WO2013074916A1 (en) 2011-11-18 2013-05-23 Board Of Regents, The University Of Texas System Car+ t cells genetically modified to eliminate expression of t- cell receptor and/or hla
US9439768B2 (en) 2011-12-08 2016-09-13 Imds Llc Glenoid vault fixation
JP6850528B2 (ja) 2012-02-13 2021-03-31 シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート 二重特異性キメラ抗原受容体およびその治療的使用
KR102437522B1 (ko) 2012-05-25 2022-08-26 셀렉티스 면역요법을 위한 동종이형 및 면역억제제 저항성인 t 세포의 조작 방법
WO2013192294A1 (en) 2012-06-20 2013-12-27 Boston 3T Biotechnologies, Inc. Cellular therapies for treating and preventing cancers and other immune system disorders
CN104140974B (zh) * 2013-05-08 2017-09-29 科济生物医药(上海)有限公司 编码gpc‑3嵌合抗原受体蛋白的核酸及表达gpc‑3嵌合抗原受体蛋白的t淋巴细胞
GB201405845D0 (en) * 2014-04-01 2014-05-14 Ucl Business Plc Signalling system
US20150315566A1 (en) 2014-04-30 2015-11-05 The Board Of Trustees Of The University Of Illinois Method for generating high affinity, bivalent binding agents
TWI750110B (zh) 2014-07-21 2021-12-21 瑞士商諾華公司 使用人類化抗-bcma嵌合抗原受體治療癌症
WO2016025385A1 (en) 2014-08-11 2016-02-18 Delinia, Inc. Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases
WO2016115168A1 (en) 2015-01-12 2016-07-21 Synthorx, Inc. Incorporation of unnatural nucleotides and methods thereof
EP3256492A4 (en) * 2015-02-09 2018-07-11 University of Florida Research Foundation, Inc. Bi-specific chimeric antigen receptor and uses thereof
ES2857998T3 (es) * 2015-02-12 2021-09-29 Univ Health Network Receptores de antígenos quiméricos
KR102011789B1 (ko) * 2015-08-05 2019-08-19 주식회사 셀랩메드 키메라 항원 수용체 및 키메라 항원 수용체가 발현된 t 세포
WO2017027422A1 (en) 2015-08-07 2017-02-16 Alexo Therapeutics Inc. Constructs having a sirp-alpha domain or variant thereof
CN106467906B (zh) * 2015-08-20 2019-09-27 北京马力喏生物科技有限公司 构建体、转基因淋巴细胞及其制备方法和用途
KR102739782B1 (ko) * 2015-09-11 2024-12-09 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 생물학적으로 관련된 직교 사이토카인/수용체 쌍
CN105331585A (zh) 2015-11-13 2016-02-17 科济生物医药(上海)有限公司 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞
MX2019004707A (es) 2016-10-26 2019-08-12 Iovance Biotherapeutics Inc Reestimulacion de linfocitos infiltrantes de tumor crioconservados.
EP4043485A1 (en) * 2017-01-26 2022-08-17 Novartis AG Cd28 compositions and methods for chimeric antigen receptor therapy
WO2019028419A1 (en) 2017-08-03 2019-02-07 Synthorx, Inc. CYTOKINE CONJUGATES FOR THE TREATMENT OF PROLIFERATIVE AND INFECTIOUS DISEASES
CN109554348A (zh) * 2017-09-27 2019-04-02 亘喜生物科技(上海)有限公司 可诱导分泌抗cd47抗体的工程化免疫细胞
KR20200075851A (ko) 2017-10-19 2020-06-26 셀렉티스 개선된 면역 세포들 치료를 위한 nk 억제제들의 타겟인 유전자 통합
US20200299349A1 (en) 2017-11-21 2020-09-24 The Board Of Trustees Of The Leland Stanford Junior University Partial agonists of interleukin-2
WO2019169290A1 (en) * 2018-03-02 2019-09-06 Allogene Therapeutics, Inc. Inducible chimeric cytokine receptors
CN108728460A (zh) * 2018-05-25 2018-11-02 上海恒润达生生物科技有限公司 靶向gd2的嵌合抗原受体及其用途
WO2019237035A1 (en) * 2018-06-08 2019-12-12 Intellia Therapeutics, Inc. Compositions and methods for immunooncology
EP3847197A1 (en) * 2018-09-05 2021-07-14 Poseida Therapeutics, Inc. Allogeneic cell compositions and methods of use

Similar Documents

Publication Publication Date Title
RU2688692C2 (ru) Фармацевтическая композиция, обладающая противоопухолевым эффектом, и способ снижения ингибирующего эффекта pd-l1 на т-клетки человека
Murata et al. OX40 costimulation synergizes with GM-CSF whole-cell vaccination to overcome established CD8+ T cell tolerance to an endogenous tumor antigen
Blazar et al. Recent advances in graft‐versus‐host disease (GVHD) prevention
EP2828290B1 (en) Anti-mesothelin chimeric antigen receptors
Zhou et al. Breast cancer immunotherapy
WO2012054825A1 (en) Anti-mage-a3 t cell receptors and related materials and methods of use
US20190194340A1 (en) Methods of making bispecific anti-cd307e and anti-bcma chimeric antigen receptors and uses of the same
BR112016024972B1 (pt) Anticorpo monoclonal humanizado, polinucleotídeo isolado,plasmídeo, composições farmacêutica e de disgnóstico, usos do dito anticorpo monoclonal humanizado e método in vitro para determinar a expressão de ceacam1
AU2019370618B2 (en) Bispecific polypeptides for engagement of CAR expressing immune cells with antigen presenting cells and uses thereof
JP2022109934A (ja) 癌治療のために免疫チェックポイントを調節する単一特異性および二重特異性タンパク質
Schmitz et al. Identification of an interferon-γ-inducible carcinoembryonic antigen (CEA) CD8+ T-cell epitope, which mediates tumor killing in CEA transgenic mice
JP2023505067A (ja) Il-2タンパク質およびcd80タンパク質を含む融合タンパク質および免疫チェックポイント抑制剤を含む癌治療用医薬組成物
AU2013357239B2 (en) Novel MHC-independent tumor-associated antigens
US20230220022A1 (en) Hmgn partial peptide and cancer therapy using the same
JP2026041861A5 (https=)
EP3898665B1 (en) Cd22-specific t cell receptors and adoptive t cell therapy for treatment of b cell malignancies
CN117187185A (zh) 一种工程化免疫细胞及其用途
CN113272016A (zh) 关于治疗实体肿瘤的工程化和非工程化γδ-T细胞的组合物和方法
JPWO2021146487A5 (https=)
Mohanty et al. Anti-tumor immunity induced by an anti-idiotype antibody mimicking human Her-2/neu
JP6716801B2 (ja) 抗腫瘍剤及びその評価方法
WO2007100568A2 (en) T cell receptors and related materials and methods of use
CN110540997A (zh) 靶向bcma嵌合抗原受体、核酸序列、载体及应用
JP2005535571A (ja) 抗イディオタイプ抗cea抗体分子および癌ワクチンとしてのその使用
KR20220009428A (ko) 암 치료