JPWO2020227618A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2020227618A5
JPWO2020227618A5 JP2021565931A JP2021565931A JPWO2020227618A5 JP WO2020227618 A5 JPWO2020227618 A5 JP WO2020227618A5 JP 2021565931 A JP2021565931 A JP 2021565931A JP 2021565931 A JP2021565931 A JP 2021565931A JP WO2020227618 A5 JPWO2020227618 A5 JP WO2020227618A5
Authority
JP
Japan
Prior art keywords
formula
salt
independently
group
occurrence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021565931A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022531876A5 (https=
JP2022531876A (ja
JP7824080B2 (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/032070 external-priority patent/WO2020227618A2/en
Publication of JP2022531876A publication Critical patent/JP2022531876A/ja
Publication of JP2022531876A5 publication Critical patent/JP2022531876A5/ja
Publication of JPWO2020227618A5 publication Critical patent/JPWO2020227618A5/ja
Priority to JP2025113743A priority Critical patent/JP2025138846A/ja
Application granted granted Critical
Publication of JP7824080B2 publication Critical patent/JP7824080B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021565931A 2019-05-08 2020-05-08 オリゴヌクレオチドの収束液相合成 Active JP7824080B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025113743A JP2025138846A (ja) 2019-05-08 2025-07-04 オリゴヌクレオチドの収束液相合成

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962845160P 2019-05-08 2019-05-08
US62/845,160 2019-05-08
PCT/US2020/032070 WO2020227618A2 (en) 2019-05-08 2020-05-08 Convergent liquid phase syntheses of oligonucleotides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025113743A Division JP2025138846A (ja) 2019-05-08 2025-07-04 オリゴヌクレオチドの収束液相合成

Publications (4)

Publication Number Publication Date
JP2022531876A JP2022531876A (ja) 2022-07-12
JP2022531876A5 JP2022531876A5 (https=) 2023-05-16
JPWO2020227618A5 true JPWO2020227618A5 (https=) 2023-05-16
JP7824080B2 JP7824080B2 (ja) 2026-03-04

Family

ID=70919104

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021565931A Active JP7824080B2 (ja) 2019-05-08 2020-05-08 オリゴヌクレオチドの収束液相合成
JP2025113743A Pending JP2025138846A (ja) 2019-05-08 2025-07-04 オリゴヌクレオチドの収束液相合成

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025113743A Pending JP2025138846A (ja) 2019-05-08 2025-07-04 オリゴヌクレオチドの収束液相合成

Country Status (13)

Country Link
US (1) US12378276B2 (https=)
EP (1) EP3966219A2 (https=)
JP (2) JP7824080B2 (https=)
KR (1) KR20220007104A (https=)
CN (3) CN119462804A (https=)
AU (1) AU2020268415B2 (https=)
BR (1) BR112021022219A2 (https=)
CA (1) CA3139545A1 (https=)
EA (1) EA202193010A1 (https=)
IL (2) IL287798B2 (https=)
MA (1) MA55891A (https=)
MX (1) MX2021013587A (https=)
WO (1) WO2020227618A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013203395A1 (en) 2012-03-30 2013-10-17 Isis Pharmaceuticals, Inc. Compositions and methods for modulating TAU expression for reducing seizure and modifying a neurodegenerative syndrome
TWI772856B (zh) 2013-07-19 2022-08-01 美商百健Ｍａ公司 用於調節τ蛋白表現之組合物
AU2021377229A1 (en) 2020-11-11 2023-06-29 Biogen Ma Inc. Oligonucleotides, reagents and preparation thereof
PE20240648A1 (es) * 2021-07-23 2024-04-04 Biogen Ma Inc Metodos para reducir la expresion de tau
WO2024083746A1 (en) 2022-10-17 2024-04-25 Bachem Holding Ag Method and composition for oligonucleotide synthesis
JP7825064B2 (ja) * 2022-10-27 2026-03-05 住友化学株式会社 オリゴヌクレオチドの製造方法
CN120813558A (zh) 2023-03-06 2025-10-17 斯佩拉制药株式会社 长链烯氧基取代的苯甲酰衍生物及使用该衍生物的寡核苷酸合成方法
GB202305283D0 (en) * 2023-04-11 2023-05-24 Exactmer Ltd Liquid-phase process for preparing oligonucleotides
JP7433684B1 (ja) * 2023-05-24 2024-02-20 塩野フィネス株式会社 疑似固相保護基、それを用いたヌクレオシド保護体又はオリゴヌクレオチド保護体、オリゴアミダイト前駆体の製造方法
EP4695265A1 (en) 2023-10-16 2026-02-18 Bachem Holding AG Method and composition for oligonucleotide synthesis
US20250206769A1 (en) * 2023-12-22 2025-06-26 Imec Vzw Synthesizing a Nucleic Acid or Nucleic Acid Analogue
WO2025235761A1 (en) 2024-05-09 2025-11-13 Biogen Ma Inc. Reagents and processes for preparing oligonucleotides

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0558749A1 (en) * 1990-11-20 1993-09-08 Sankyo Company Limited Antisense nucleic acid derivative
US5510476A (en) * 1994-07-07 1996-04-23 Isis Pharmaceuticals, Inc. Carbocation scavenging during oligonucleotide synthesis
AU738032B2 (en) 1995-10-19 2001-09-06 Proligo Llc Method for solution phase synthesis of oligonucleotides
EP1386925A1 (en) * 2002-07-31 2004-02-04 Girindus AG Method for preparing oligonucleotides
SI2548560T1 (sl) 2005-06-23 2015-12-31 Isis Pharmaceuticals, Inc. Sestavki in postopki za moduliranje izrezovanja smn2
RU2572826C2 (ru) 2008-12-02 2016-01-20 Чиралджен, Лтд. Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
JP5548852B2 (ja) * 2009-05-29 2014-07-16 国立大学法人東京農工大学 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法
PT3305302T (pt) 2009-06-17 2018-12-14 Biogen Ma Inc Composições e métodos de modulação de excisões de smn2 em um sujeito
US20120184724A1 (en) * 2009-09-22 2012-07-19 Agilent Technologies, Inc. Protected monomers and methods of deprotection for rna synthesis
JP5705512B2 (ja) 2010-11-26 2015-04-22 農工大ティー・エル・オー株式会社 高分散性液相支持体を用いたオリゴヌクレオチド合成法
JP5979139B2 (ja) * 2011-05-17 2016-08-24 味の素株式会社 オリゴヌクレオチドの製造方法
EP2816053B1 (en) 2012-02-17 2021-03-24 Ajinomoto Co., Inc. Base-protected oligonucleotide
US8846885B2 (en) * 2012-02-17 2014-09-30 Ajinomoto Co., Inc. Oligonucleotide with protected base
EP2857412B1 (en) * 2012-05-30 2017-01-11 Hokkaido System Science Co., Ltd. Oligonucleotide synthesis method using highly dispersible liquid-phase support
EP2921499B1 (en) * 2012-11-14 2020-01-22 Takeda Pharmaceutical Company Limited Method for liquid-phase synthesis of nucleic acids
RS60707B1 (sr) 2014-04-01 2020-09-30 Biogen Ma Inc Kompozicije za modulaciju ekspresije sod-1
EP3263579B1 (en) 2015-01-21 2022-11-30 Ajinomoto Co., Inc. Precipitation promoter and precipitation method in which same is used
WO2017104836A1 (ja) * 2015-12-16 2017-06-22 味の素株式会社 オリゴヌクレオチドの製造方法、およびヌクレオシド、ヌクレオチドまたはオリゴヌクレオチド
JPWO2017111137A1 (ja) * 2015-12-22 2018-10-18 味の素株式会社 オリゴヌクレオチドの製造方法
CN108368166B (zh) 2015-12-28 2023-03-28 中外制药株式会社 提高含fc区多肽纯化效率的方法
TW201906855A (zh) 2017-05-02 2019-02-16 日商日產化學工業股份有限公司 寡核苷酸之製造方法

Similar Documents

Publication Publication Date Title
JP7484951B2 (ja) オリゴヌクレオチドの製造方法
JP7803520B2 (ja) オリゴヌクレオチド合成用セグメントおよびその製造方法、ならびにそれを用いたオリゴヌクレオチドの合成方法
JP6281599B2 (ja) 擬似固相保護基およびヌクレオチド
CN112533892B (zh) 烷氧基苯基衍生物、核苷保护体和核苷酸保护体、寡核苷酸制造方法以及取代基除去方法
JP7824080B2 (ja) オリゴヌクレオチドの収束液相合成
JPS6250479B2 (https=)
CN108473526A (zh) 寡核苷酸的制备方法以及核苷、核苷酸或寡核苷酸
JPWO2020227618A5 (https=)
JP2010275254A (ja) 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法
JP7164540B2 (ja) 立体的に規定されたホスホロチオエートオリゴヌクレオチドの調製のための直交保護基
CN110719912B (zh) 在可见光区能进行光交联的光响应性核苷酸类似物
JP7777452B2 (ja) 核酸オリゴマーの製造方法
JP7698631B2 (ja) 核酸オリゴマーの製造方法
JP7667788B2 (ja) 核酸オリゴマーの製造方法
JP7759323B2 (ja) 核酸オリゴマーの製造方法
JP7567483B2 (ja) オリゴヌクレオチドの製造方法
CN118754922A (zh) 一种烯丙基-氰乙基核苷二聚体及其制备方法和在寡核苷酸合成中的应用
EP4559925A1 (en) Production method of oligonucleotide
WO2020158687A1 (ja) 光応答性ヌクレオチドアナログの製造方法
US12492220B2 (en) Method for the preparation of oligonucleotides
JP7825064B2 (ja) オリゴヌクレオチドの製造方法
WO2024143276A1 (ja) オリゴヌクレオチドの製造方法
JP2025116757A (ja) チミン選択的光応答性ヌクレオチドアナログ
KR20250122396A (ko) 올리고뉴클레오티드 합성을 위한 개선된 방법
WO2026071145A1 (ja) 核酸オリゴマーの製造方法