JP2022531876A5 - - Google Patents

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Publication number
JP2022531876A5
JP2022531876A5 JP2021565931A JP2021565931A JP2022531876A5 JP 2022531876 A5 JP2022531876 A5 JP 2022531876A5 JP 2021565931 A JP2021565931 A JP 2021565931A JP 2021565931 A JP2021565931 A JP 2021565931A JP 2022531876 A5 JP2022531876 A5 JP 2022531876A5
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Japan
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formula
salt
independently
group
compound
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JP2021565931A
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Japanese (ja)
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JP7824080B2 (ja
JP2022531876A (ja
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Priority claimed from PCT/US2020/032070 external-priority patent/WO2020227618A2/en
Publication of JP2022531876A publication Critical patent/JP2022531876A/ja
Publication of JP2022531876A5 publication Critical patent/JP2022531876A5/ja
Priority to JP2025113743A priority Critical patent/JP2025138846A/ja
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Publication of JP7824080B2 publication Critical patent/JP7824080B2/ja
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JP2021565931A 2019-05-08 2020-05-08 オリゴヌクレオチドの収束液相合成 Active JP7824080B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025113743A JP2025138846A (ja) 2019-05-08 2025-07-04 オリゴヌクレオチドの収束液相合成

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962845160P 2019-05-08 2019-05-08
US62/845,160 2019-05-08
PCT/US2020/032070 WO2020227618A2 (en) 2019-05-08 2020-05-08 Convergent liquid phase syntheses of oligonucleotides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025113743A Division JP2025138846A (ja) 2019-05-08 2025-07-04 オリゴヌクレオチドの収束液相合成

Publications (3)

Publication Number Publication Date
JP2022531876A JP2022531876A (ja) 2022-07-12
JP2022531876A5 true JP2022531876A5 (https=) 2023-05-16
JP7824080B2 JP7824080B2 (ja) 2026-03-04

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ID=70919104

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JP2021565931A Active JP7824080B2 (ja) 2019-05-08 2020-05-08 オリゴヌクレオチドの収束液相合成
JP2025113743A Pending JP2025138846A (ja) 2019-05-08 2025-07-04 オリゴヌクレオチドの収束液相合成

Family Applications After (1)

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JP2025113743A Pending JP2025138846A (ja) 2019-05-08 2025-07-04 オリゴヌクレオチドの収束液相合成

Country Status (13)

Country Link
US (1) US12378276B2 (https=)
EP (1) EP3966219A2 (https=)
JP (2) JP7824080B2 (https=)
KR (1) KR20220007104A (https=)
CN (3) CN119143828A (https=)
AU (1) AU2020268415B2 (https=)
BR (1) BR112021022219A2 (https=)
CA (1) CA3139545A1 (https=)
EA (1) EA202193010A1 (https=)
IL (2) IL287798B2 (https=)
MA (1) MA55891A (https=)
MX (1) MX2021013587A (https=)
WO (1) WO2020227618A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2831232A4 (en) 2012-03-30 2015-11-04 Univ Washington METHOD FOR MODULATING TAU EXPRESSION TO REDUCE PROBLEMS AND MODIFY A NEURODEGENERATIVE SYNDROME
TW202246503A (zh) 2013-07-19 2022-12-01 美商百健Ｍａ公司 用於調節τ蛋白表現之組合物
KR20230106665A (ko) 2020-11-11 2023-07-13 바이오젠 엠에이 인코포레이티드 올리고뉴클레오티드, 시약, 및 그의 제조 방법
TW202310854A (zh) * 2021-07-23 2023-03-16 美商百健Ｍａ公司 用於減少ｔａｕ表現之方法
WO2024083746A1 (en) 2022-10-17 2024-04-25 Bachem Holding Ag Method and composition for oligonucleotide synthesis
WO2024089953A1 (ja) * 2022-10-27 2024-05-02 住友化学株式会社 オリゴヌクレオチドの製造方法
JPWO2024185775A1 (https=) 2023-03-06 2024-09-12
GB202305283D0 (en) * 2023-04-11 2023-05-24 Exactmer Ltd Liquid-phase process for preparing oligonucleotides
JP7433684B1 (ja) * 2023-05-24 2024-02-20 塩野フィネス株式会社 疑似固相保護基、それを用いたヌクレオシド保護体又はオリゴヌクレオチド保護体、オリゴアミダイト前駆体の製造方法
EP4695265A1 (en) 2023-10-16 2026-02-18 Bachem Holding AG Method and composition for oligonucleotide synthesis
US20250206769A1 (en) * 2023-12-22 2025-06-26 Imec Vzw Synthesizing a Nucleic Acid or Nucleic Acid Analogue
WO2025235761A1 (en) 2024-05-09 2025-11-13 Biogen Ma Inc. Reagents and processes for preparing oligonucleotides
WO2026085433A2 (en) 2024-10-17 2026-04-23 Biogen Ma Inc. Methods for preparing oligonucleotide conjugates

Family Cites Families (21)

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Publication number Priority date Publication date Assignee Title
CA2096658A1 (en) 1990-11-20 1992-05-21 Sankyo Company, Limited Anti-sense nucleic acid derivative
US5510476A (en) 1994-07-07 1996-04-23 Isis Pharmaceuticals, Inc. Carbocation scavenging during oligonucleotide synthesis
AU738032B2 (en) 1995-10-19 2001-09-06 Proligo Llc Method for solution phase synthesis of oligonucleotides
EP1386925A1 (en) * 2002-07-31 2004-02-04 Girindus AG Method for preparing oligonucleotides
EP3470072A1 (en) 2005-06-23 2019-04-17 Biogen MA Inc. Compositions and methods for modulation of smn2 splicing
CN102282155B (zh) 2008-12-02 2017-06-09 日本波涛生命科学公司 磷原子修饰的核酸的合成方法
JP5548852B2 (ja) 2009-05-29 2014-07-16 国立大学法人東京農工大学 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法
ES2699827T3 (es) 2009-06-17 2019-02-13 Biogen Ma Inc Composiciones y métodos para la modulación de corte y empalme de SMN2 en un sujeto
US20120184724A1 (en) * 2009-09-22 2012-07-19 Agilent Technologies, Inc. Protected monomers and methods of deprotection for rna synthesis
JP5705512B2 (ja) 2010-11-26 2015-04-22 農工大ティー・エル・オー株式会社 高分散性液相支持体を用いたオリゴヌクレオチド合成法
DK2711370T3 (en) * 2011-05-17 2018-02-26 Ajinomoto Kk PROCEDURE FOR THE PREPARATION OF OLIGONUCLEOTIDES
US8846885B2 (en) 2012-02-17 2014-09-30 Ajinomoto Co., Inc. Oligonucleotide with protected base
EP2816053B1 (en) 2012-02-17 2021-03-24 Ajinomoto Co., Inc. Base-protected oligonucleotide
US9284344B2 (en) * 2012-05-30 2016-03-15 Hokkaido System Science Co., Ltd. Oligonucleotide synthesis method using highly dispersible liquid-phase support
US10214555B2 (en) * 2012-11-14 2019-02-26 Takeda Pharmaceutical Company Limitjed Method for liquid-phase synthesis of nucleic acid
HUE050704T2 (hu) 2014-04-01 2020-12-28 Biogen Ma Inc Összetételek a SOD-1 expressziójának modulálására
CN113717239B (zh) 2015-01-21 2024-12-24 味之素株式会社 沉淀促进剂以及使用其的沉淀方法
CN116063365A (zh) 2015-12-16 2023-05-05 味之素株式会社 寡核苷酸的制备方法以及核苷、核苷酸或寡核苷酸
WO2017111137A1 (ja) * 2015-12-22 2017-06-29 味の素株式会社 オリゴヌクレオチドの製造方法
AU2016381992B2 (en) 2015-12-28 2024-01-04 Chugai Seiyaku Kabushiki Kaisha Method for promoting efficiency of purification of Fc region-containing polypeptide
TW201906855A (zh) 2017-05-02 2019-02-16 日商日產化學工業股份有限公司 寡核苷酸之製造方法

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