KR20220007104A - 올리고뉴클레오타이드의 수렴형 액상 합성 - Google Patents

올리고뉴클레오타이드의 수렴형 액상 합성 Download PDF

Info

Publication number
KR20220007104A
KR20220007104A KR1020217039894A KR20217039894A KR20220007104A KR 20220007104 A KR20220007104 A KR 20220007104A KR 1020217039894 A KR1020217039894 A KR 1020217039894A KR 20217039894 A KR20217039894 A KR 20217039894A KR 20220007104 A KR20220007104 A KR 20220007104A
Authority
KR
South Korea
Prior art keywords
formula
salt
oligonucleotide
compound
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020217039894A
Other languages
English (en)
Korean (ko)
Inventor
시앙린 스
윌리엄 에프. 키스만
피로츠 안티아
얀니크 필론
쉬앤 조우
유밍 얀
홍 지앙
히엔 응우옌
로버트 에스. 그론케
다이스케 이치마루
타쿠야 하마가키
다이스케 타카하시
Original Assignee
바이오젠 엠에이 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 바이오젠 엠에이 인코포레이티드 filed Critical 바이오젠 엠에이 인코포레이티드
Publication of KR20220007104A publication Critical patent/KR20220007104A/ko
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020217039894A 2019-05-08 2020-05-08 올리고뉴클레오타이드의 수렴형 액상 합성 Pending KR20220007104A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962845160P 2019-05-08 2019-05-08
US62/845,160 2019-05-08
PCT/US2020/032070 WO2020227618A2 (en) 2019-05-08 2020-05-08 Convergent liquid phase syntheses of oligonucleotides

Publications (1)

Publication Number Publication Date
KR20220007104A true KR20220007104A (ko) 2022-01-18

Family

ID=70919104

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217039894A Pending KR20220007104A (ko) 2019-05-08 2020-05-08 올리고뉴클레오타이드의 수렴형 액상 합성

Country Status (13)

Country Link
US (1) US12378276B2 (https=)
EP (1) EP3966219A2 (https=)
JP (2) JP7824080B2 (https=)
KR (1) KR20220007104A (https=)
CN (3) CN119462804A (https=)
AU (1) AU2020268415B2 (https=)
BR (1) BR112021022219A2 (https=)
CA (1) CA3139545A1 (https=)
EA (1) EA202193010A1 (https=)
IL (2) IL287798B2 (https=)
MA (1) MA55891A (https=)
MX (1) MX2021013587A (https=)
WO (1) WO2020227618A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013203395A1 (en) 2012-03-30 2013-10-17 Isis Pharmaceuticals, Inc. Compositions and methods for modulating TAU expression for reducing seizure and modifying a neurodegenerative syndrome
TWI772856B (zh) 2013-07-19 2022-08-01 美商百健Ｍａ公司 用於調節τ蛋白表現之組合物
AU2021377229A1 (en) 2020-11-11 2023-06-29 Biogen Ma Inc. Oligonucleotides, reagents and preparation thereof
PE20240648A1 (es) * 2021-07-23 2024-04-04 Biogen Ma Inc Metodos para reducir la expresion de tau
WO2024083746A1 (en) 2022-10-17 2024-04-25 Bachem Holding Ag Method and composition for oligonucleotide synthesis
JP7825064B2 (ja) * 2022-10-27 2026-03-05 住友化学株式会社 オリゴヌクレオチドの製造方法
CN120813558A (zh) 2023-03-06 2025-10-17 斯佩拉制药株式会社 长链烯氧基取代的苯甲酰衍生物及使用该衍生物的寡核苷酸合成方法
GB202305283D0 (en) * 2023-04-11 2023-05-24 Exactmer Ltd Liquid-phase process for preparing oligonucleotides
JP7433684B1 (ja) * 2023-05-24 2024-02-20 塩野フィネス株式会社 疑似固相保護基、それを用いたヌクレオシド保護体又はオリゴヌクレオチド保護体、オリゴアミダイト前駆体の製造方法
EP4695265A1 (en) 2023-10-16 2026-02-18 Bachem Holding AG Method and composition for oligonucleotide synthesis
US20250206769A1 (en) * 2023-12-22 2025-06-26 Imec Vzw Synthesizing a Nucleic Acid or Nucleic Acid Analogue
WO2025235761A1 (en) 2024-05-09 2025-11-13 Biogen Ma Inc. Reagents and processes for preparing oligonucleotides

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0558749A1 (en) * 1990-11-20 1993-09-08 Sankyo Company Limited Antisense nucleic acid derivative
US5510476A (en) * 1994-07-07 1996-04-23 Isis Pharmaceuticals, Inc. Carbocation scavenging during oligonucleotide synthesis
AU738032B2 (en) 1995-10-19 2001-09-06 Proligo Llc Method for solution phase synthesis of oligonucleotides
EP1386925A1 (en) * 2002-07-31 2004-02-04 Girindus AG Method for preparing oligonucleotides
SI2548560T1 (sl) 2005-06-23 2015-12-31 Isis Pharmaceuticals, Inc. Sestavki in postopki za moduliranje izrezovanja smn2
RU2572826C2 (ru) 2008-12-02 2016-01-20 Чиралджен, Лтд. Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
JP5548852B2 (ja) * 2009-05-29 2014-07-16 国立大学法人東京農工大学 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法
PT3305302T (pt) 2009-06-17 2018-12-14 Biogen Ma Inc Composições e métodos de modulação de excisões de smn2 em um sujeito
US20120184724A1 (en) * 2009-09-22 2012-07-19 Agilent Technologies, Inc. Protected monomers and methods of deprotection for rna synthesis
JP5705512B2 (ja) 2010-11-26 2015-04-22 農工大ティー・エル・オー株式会社 高分散性液相支持体を用いたオリゴヌクレオチド合成法
JP5979139B2 (ja) * 2011-05-17 2016-08-24 味の素株式会社 オリゴヌクレオチドの製造方法
EP2816053B1 (en) 2012-02-17 2021-03-24 Ajinomoto Co., Inc. Base-protected oligonucleotide
US8846885B2 (en) * 2012-02-17 2014-09-30 Ajinomoto Co., Inc. Oligonucleotide with protected base
EP2857412B1 (en) * 2012-05-30 2017-01-11 Hokkaido System Science Co., Ltd. Oligonucleotide synthesis method using highly dispersible liquid-phase support
EP2921499B1 (en) * 2012-11-14 2020-01-22 Takeda Pharmaceutical Company Limited Method for liquid-phase synthesis of nucleic acids
RS60707B1 (sr) 2014-04-01 2020-09-30 Biogen Ma Inc Kompozicije za modulaciju ekspresije sod-1
EP3263579B1 (en) 2015-01-21 2022-11-30 Ajinomoto Co., Inc. Precipitation promoter and precipitation method in which same is used
WO2017104836A1 (ja) * 2015-12-16 2017-06-22 味の素株式会社 オリゴヌクレオチドの製造方法、およびヌクレオシド、ヌクレオチドまたはオリゴヌクレオチド
JPWO2017111137A1 (ja) * 2015-12-22 2018-10-18 味の素株式会社 オリゴヌクレオチドの製造方法
CN108368166B (zh) 2015-12-28 2023-03-28 中外制药株式会社 提高含fc区多肽纯化效率的方法
TW201906855A (zh) 2017-05-02 2019-02-16 日商日產化學工業股份有限公司 寡核苷酸之製造方法

Also Published As

Publication number Publication date
MA55891A (fr) 2022-03-16
WO2020227618A2 (en) 2020-11-12
AU2020268415A1 (en) 2021-12-23
EP3966219A2 (en) 2022-03-16
CA3139545A1 (en) 2020-11-12
EA202193010A1 (ru) 2022-03-18
WO2020227618A3 (en) 2021-01-14
AU2020268415B2 (en) 2026-04-23
US12378276B2 (en) 2025-08-05
IL287798B1 (en) 2025-05-01
AU2020268415A8 (en) 2022-01-20
MX2021013587A (es) 2022-02-11
JP2025138846A (ja) 2025-09-25
CN114206897B (zh) 2024-09-20
CN114206897A (zh) 2022-03-18
IL319933A (en) 2025-05-01
JP2022531876A (ja) 2022-07-12
IL287798A (en) 2022-01-01
BR112021022219A2 (pt) 2022-03-22
CN119462804A (zh) 2025-02-18
CN119143828A (zh) 2024-12-17
WO2020227618A8 (en) 2020-12-24
US20220348602A1 (en) 2022-11-03
IL287798B2 (en) 2025-09-01
JP7824080B2 (ja) 2026-03-04

Similar Documents

Publication Publication Date Title
KR20220007104A (ko) 올리고뉴클레오타이드의 수렴형 액상 합성
CA2879023C (en) Asymmetric auxiliary group
US10882884B2 (en) Stereoselective synthesis of phosphorothioate oligoribonucleotides
US8859755B2 (en) Method for preparing ribonucleoside phosphorothioate
AU2017368283B2 (en) Novel bicyclic nucleosides and oligomers prepared therefrom
WO2000055179A1 (en) Novel phosphate and thiophosphate protecting groups
EP0836612A1 (en) Novel synthons for stereoselective oligonucleotide synthesis
JP2023551647A (ja) オリゴヌクレオチド、試薬、及びその調製
EP0983233A1 (en) Reagent useful for synthesizing sulfurized oligonucleotide analogs
WO2001002415A1 (en) C3'-methylene hydrogen phosphonate monomers and related compounds
WO2001002419A1 (en) C3'-methylene hydrogen phosphonate oligomers and related compounds
AU707093B2 (en) Compositions and methods for the synthesis of organophosphorus derivatives
US20250270179A1 (en) Tricyclo-dna nucleoside precursors and processes for preparing the same
KR102934598B1 (ko) 신규한 몰포리노 올리고뉴클레오티드 유도체
JP2002501929A (ja) オリゴヌクレオチド合成用の新規なシントン
EA046382B1 (ru) Конвергентные жидкофазные синтезы олигонуклеотидов
WO2025235761A1 (en) Reagents and processes for preparing oligonucleotides
WO2000049032A1 (en) Oligonucleotides having alkylphosphonate linkages and methods for their preparation
WO2022194924A1 (en) Chiral synthons for the synthesis of chiral phosphorothioates
HK1242331A1 (en) Asymmetric auxiliary group

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

T11 Administrative time limit extension requested

Free format text: ST27 STATUS EVENT CODE: U-3-3-T10-T11-OTH-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13 Pre-grant limitation requested

Free format text: ST27 STATUS EVENT CODE: A-2-3-E10-E13-LIM-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-NAP-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

D21 Rejection of application intended

Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D21-EXM-PE0902 (AS PROVIDED BY THE NATIONAL OFFICE)

PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902