MA55891A - Synthèses en phase liquide convergente d'oligonucléotides - Google Patents

Synthèses en phase liquide convergente d'oligonucléotides

Info

Publication number
MA55891A
MA55891A MA055891A MA55891A MA55891A MA 55891 A MA55891 A MA 55891A MA 055891 A MA055891 A MA 055891A MA 55891 A MA55891 A MA 55891A MA 55891 A MA55891 A MA 55891A
Authority
MA
Morocco
Prior art keywords
oligonucleotides
liquid phase
phase syntheses
convergent
convergent liquid
Prior art date
Application number
MA055891A
Other languages
English (en)
French (fr)
Inventor
Firoz Antia
Yannick Fillon
Robert S Gronke
Takuya Hamagaki
Taisuke Ichimaru
Hong Jiang
William F Kiesman
Hien Nguyen
Xianglin Shi
Daisuke Takahashi
Wuming Yan
Xuan Zhou
Original Assignee
Ajinomoto Kk
Biogen Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk, Biogen Ma Inc filed Critical Ajinomoto Kk
Publication of MA55891A publication Critical patent/MA55891A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA055891A 2019-05-08 2020-05-08 Synthèses en phase liquide convergente d'oligonucléotides MA55891A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962845160P 2019-05-08 2019-05-08

Publications (1)

Publication Number Publication Date
MA55891A true MA55891A (fr) 2022-03-16

Family

ID=70919104

Family Applications (1)

Application Number Title Priority Date Filing Date
MA055891A MA55891A (fr) 2019-05-08 2020-05-08 Synthèses en phase liquide convergente d'oligonucléotides

Country Status (13)

Country Link
US (1) US12378276B2 (https=)
EP (1) EP3966219A2 (https=)
JP (2) JP7824080B2 (https=)
KR (1) KR20220007104A (https=)
CN (3) CN119462804A (https=)
AU (1) AU2020268415B2 (https=)
BR (1) BR112021022219A2 (https=)
CA (1) CA3139545A1 (https=)
EA (1) EA202193010A1 (https=)
IL (2) IL287798B2 (https=)
MA (1) MA55891A (https=)
MX (1) MX2021013587A (https=)
WO (1) WO2020227618A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013203395A1 (en) 2012-03-30 2013-10-17 Isis Pharmaceuticals, Inc. Compositions and methods for modulating TAU expression for reducing seizure and modifying a neurodegenerative syndrome
TWI772856B (zh) 2013-07-19 2022-08-01 美商百健Ｍａ公司 用於調節τ蛋白表現之組合物
AU2021377229A1 (en) 2020-11-11 2023-06-29 Biogen Ma Inc. Oligonucleotides, reagents and preparation thereof
PE20240648A1 (es) * 2021-07-23 2024-04-04 Biogen Ma Inc Metodos para reducir la expresion de tau
WO2024083746A1 (en) 2022-10-17 2024-04-25 Bachem Holding Ag Method and composition for oligonucleotide synthesis
JP7825064B2 (ja) * 2022-10-27 2026-03-05 住友化学株式会社 オリゴヌクレオチドの製造方法
CN120813558A (zh) 2023-03-06 2025-10-17 斯佩拉制药株式会社 长链烯氧基取代的苯甲酰衍生物及使用该衍生物的寡核苷酸合成方法
GB202305283D0 (en) * 2023-04-11 2023-05-24 Exactmer Ltd Liquid-phase process for preparing oligonucleotides
JP7433684B1 (ja) * 2023-05-24 2024-02-20 塩野フィネス株式会社 疑似固相保護基、それを用いたヌクレオシド保護体又はオリゴヌクレオチド保護体、オリゴアミダイト前駆体の製造方法
EP4695265A1 (en) 2023-10-16 2026-02-18 Bachem Holding AG Method and composition for oligonucleotide synthesis
US20250206769A1 (en) * 2023-12-22 2025-06-26 Imec Vzw Synthesizing a Nucleic Acid or Nucleic Acid Analogue
WO2025235761A1 (en) 2024-05-09 2025-11-13 Biogen Ma Inc. Reagents and processes for preparing oligonucleotides

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0558749A1 (en) * 1990-11-20 1993-09-08 Sankyo Company Limited Antisense nucleic acid derivative
US5510476A (en) * 1994-07-07 1996-04-23 Isis Pharmaceuticals, Inc. Carbocation scavenging during oligonucleotide synthesis
AU738032B2 (en) 1995-10-19 2001-09-06 Proligo Llc Method for solution phase synthesis of oligonucleotides
EP1386925A1 (en) * 2002-07-31 2004-02-04 Girindus AG Method for preparing oligonucleotides
SI2548560T1 (sl) 2005-06-23 2015-12-31 Isis Pharmaceuticals, Inc. Sestavki in postopki za moduliranje izrezovanja smn2
RU2572826C2 (ru) 2008-12-02 2016-01-20 Чиралджен, Лтд. Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
JP5548852B2 (ja) * 2009-05-29 2014-07-16 国立大学法人東京農工大学 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法
PT3305302T (pt) 2009-06-17 2018-12-14 Biogen Ma Inc Composições e métodos de modulação de excisões de smn2 em um sujeito
US20120184724A1 (en) * 2009-09-22 2012-07-19 Agilent Technologies, Inc. Protected monomers and methods of deprotection for rna synthesis
JP5705512B2 (ja) 2010-11-26 2015-04-22 農工大ティー・エル・オー株式会社 高分散性液相支持体を用いたオリゴヌクレオチド合成法
JP5979139B2 (ja) * 2011-05-17 2016-08-24 味の素株式会社 オリゴヌクレオチドの製造方法
EP2816053B1 (en) 2012-02-17 2021-03-24 Ajinomoto Co., Inc. Base-protected oligonucleotide
US8846885B2 (en) * 2012-02-17 2014-09-30 Ajinomoto Co., Inc. Oligonucleotide with protected base
EP2857412B1 (en) * 2012-05-30 2017-01-11 Hokkaido System Science Co., Ltd. Oligonucleotide synthesis method using highly dispersible liquid-phase support
EP2921499B1 (en) * 2012-11-14 2020-01-22 Takeda Pharmaceutical Company Limited Method for liquid-phase synthesis of nucleic acids
RS60707B1 (sr) 2014-04-01 2020-09-30 Biogen Ma Inc Kompozicije za modulaciju ekspresije sod-1
EP3263579B1 (en) 2015-01-21 2022-11-30 Ajinomoto Co., Inc. Precipitation promoter and precipitation method in which same is used
WO2017104836A1 (ja) * 2015-12-16 2017-06-22 味の素株式会社 オリゴヌクレオチドの製造方法、およびヌクレオシド、ヌクレオチドまたはオリゴヌクレオチド
JPWO2017111137A1 (ja) * 2015-12-22 2018-10-18 味の素株式会社 オリゴヌクレオチドの製造方法
CN108368166B (zh) 2015-12-28 2023-03-28 中外制药株式会社 提高含fc区多肽纯化效率的方法
TW201906855A (zh) 2017-05-02 2019-02-16 日商日產化學工業股份有限公司 寡核苷酸之製造方法

Also Published As

Publication number Publication date
WO2020227618A2 (en) 2020-11-12
KR20220007104A (ko) 2022-01-18
AU2020268415A1 (en) 2021-12-23
EP3966219A2 (en) 2022-03-16
CA3139545A1 (en) 2020-11-12
EA202193010A1 (ru) 2022-03-18
WO2020227618A3 (en) 2021-01-14
AU2020268415B2 (en) 2026-04-23
US12378276B2 (en) 2025-08-05
IL287798B1 (en) 2025-05-01
AU2020268415A8 (en) 2022-01-20
MX2021013587A (es) 2022-02-11
JP2025138846A (ja) 2025-09-25
CN114206897B (zh) 2024-09-20
CN114206897A (zh) 2022-03-18
IL319933A (en) 2025-05-01
JP2022531876A (ja) 2022-07-12
IL287798A (en) 2022-01-01
BR112021022219A2 (pt) 2022-03-22
CN119462804A (zh) 2025-02-18
CN119143828A (zh) 2024-12-17
WO2020227618A8 (en) 2020-12-24
US20220348602A1 (en) 2022-11-03
IL287798B2 (en) 2025-09-01
JP7824080B2 (ja) 2026-03-04

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