MX2021013587A - Sintesis de fases liquidas convergentes de oligonucleotidos. - Google Patents
Sintesis de fases liquidas convergentes de oligonucleotidos.Info
- Publication number
- MX2021013587A MX2021013587A MX2021013587A MX2021013587A MX2021013587A MX 2021013587 A MX2021013587 A MX 2021013587A MX 2021013587 A MX2021013587 A MX 2021013587A MX 2021013587 A MX2021013587 A MX 2021013587A MX 2021013587 A MX2021013587 A MX 2021013587A
- Authority
- MX
- Mexico
- Prior art keywords
- oligonucleotides
- synthesis
- liquid phases
- convergent
- convergent liquid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962845160P | 2019-05-08 | 2019-05-08 | |
| PCT/US2020/032070 WO2020227618A2 (en) | 2019-05-08 | 2020-05-08 | Convergent liquid phase syntheses of oligonucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2021013587A true MX2021013587A (es) | 2022-02-11 |
Family
ID=70919104
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021013587A MX2021013587A (es) | 2019-05-08 | 2020-05-08 | Sintesis de fases liquidas convergentes de oligonucleotidos. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12378276B2 (https=) |
| EP (1) | EP3966219A2 (https=) |
| JP (2) | JP7824080B2 (https=) |
| KR (1) | KR20220007104A (https=) |
| CN (3) | CN119143828A (https=) |
| AU (1) | AU2020268415B2 (https=) |
| BR (1) | BR112021022219A2 (https=) |
| CA (1) | CA3139545A1 (https=) |
| EA (1) | EA202193010A1 (https=) |
| IL (2) | IL287798B2 (https=) |
| MA (1) | MA55891A (https=) |
| MX (1) | MX2021013587A (https=) |
| WO (1) | WO2020227618A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2831232A4 (en) | 2012-03-30 | 2015-11-04 | Univ Washington | METHOD FOR MODULATING TAU EXPRESSION TO REDUCE PROBLEMS AND MODIFY A NEURODEGENERATIVE SYNDROME |
| TW202246503A (zh) | 2013-07-19 | 2022-12-01 | 美商百健Ｍａ公司 | 用於調節τ蛋白表現之組合物 |
| KR20230106665A (ko) | 2020-11-11 | 2023-07-13 | 바이오젠 엠에이 인코포레이티드 | 올리고뉴클레오티드, 시약, 및 그의 제조 방법 |
| TW202310854A (zh) * | 2021-07-23 | 2023-03-16 | 美商百健Ｍａ公司 | 用於減少ｔａｕ表現之方法 |
| WO2024083746A1 (en) | 2022-10-17 | 2024-04-25 | Bachem Holding Ag | Method and composition for oligonucleotide synthesis |
| WO2024089953A1 (ja) * | 2022-10-27 | 2024-05-02 | 住友化学株式会社 | オリゴヌクレオチドの製造方法 |
| JPWO2024185775A1 (https=) | 2023-03-06 | 2024-09-12 | ||
| GB202305283D0 (en) * | 2023-04-11 | 2023-05-24 | Exactmer Ltd | Liquid-phase process for preparing oligonucleotides |
| JP7433684B1 (ja) * | 2023-05-24 | 2024-02-20 | 塩野フィネス株式会社 | 疑似固相保護基、それを用いたヌクレオシド保護体又はオリゴヌクレオチド保護体、オリゴアミダイト前駆体の製造方法 |
| EP4695265A1 (en) | 2023-10-16 | 2026-02-18 | Bachem Holding AG | Method and composition for oligonucleotide synthesis |
| US20250206769A1 (en) * | 2023-12-22 | 2025-06-26 | Imec Vzw | Synthesizing a Nucleic Acid or Nucleic Acid Analogue |
| WO2025235761A1 (en) | 2024-05-09 | 2025-11-13 | Biogen Ma Inc. | Reagents and processes for preparing oligonucleotides |
| WO2026085433A2 (en) | 2024-10-17 | 2026-04-23 | Biogen Ma Inc. | Methods for preparing oligonucleotide conjugates |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2096658A1 (en) | 1990-11-20 | 1992-05-21 | Sankyo Company, Limited | Anti-sense nucleic acid derivative |
| US5510476A (en) | 1994-07-07 | 1996-04-23 | Isis Pharmaceuticals, Inc. | Carbocation scavenging during oligonucleotide synthesis |
| AU738032B2 (en) | 1995-10-19 | 2001-09-06 | Proligo Llc | Method for solution phase synthesis of oligonucleotides |
| EP1386925A1 (en) * | 2002-07-31 | 2004-02-04 | Girindus AG | Method for preparing oligonucleotides |
| EP3470072A1 (en) | 2005-06-23 | 2019-04-17 | Biogen MA Inc. | Compositions and methods for modulation of smn2 splicing |
| CN102282155B (zh) | 2008-12-02 | 2017-06-09 | 日本波涛生命科学公司 | 磷原子修饰的核酸的合成方法 |
| JP5548852B2 (ja) | 2009-05-29 | 2014-07-16 | 国立大学法人東京農工大学 | 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法 |
| ES2699827T3 (es) | 2009-06-17 | 2019-02-13 | Biogen Ma Inc | Composiciones y métodos para la modulación de corte y empalme de SMN2 en un sujeto |
| US20120184724A1 (en) * | 2009-09-22 | 2012-07-19 | Agilent Technologies, Inc. | Protected monomers and methods of deprotection for rna synthesis |
| JP5705512B2 (ja) | 2010-11-26 | 2015-04-22 | 農工大ティー・エル・オー株式会社 | 高分散性液相支持体を用いたオリゴヌクレオチド合成法 |
| DK2711370T3 (en) * | 2011-05-17 | 2018-02-26 | Ajinomoto Kk | PROCEDURE FOR THE PREPARATION OF OLIGONUCLEOTIDES |
| US8846885B2 (en) | 2012-02-17 | 2014-09-30 | Ajinomoto Co., Inc. | Oligonucleotide with protected base |
| EP2816053B1 (en) | 2012-02-17 | 2021-03-24 | Ajinomoto Co., Inc. | Base-protected oligonucleotide |
| US9284344B2 (en) * | 2012-05-30 | 2016-03-15 | Hokkaido System Science Co., Ltd. | Oligonucleotide synthesis method using highly dispersible liquid-phase support |
| US10214555B2 (en) * | 2012-11-14 | 2019-02-26 | Takeda Pharmaceutical Company Limitjed | Method for liquid-phase synthesis of nucleic acid |
| HUE050704T2 (hu) | 2014-04-01 | 2020-12-28 | Biogen Ma Inc | Összetételek a SOD-1 expressziójának modulálására |
| CN113717239B (zh) | 2015-01-21 | 2024-12-24 | 味之素株式会社 | 沉淀促进剂以及使用其的沉淀方法 |
| CN116063365A (zh) | 2015-12-16 | 2023-05-05 | 味之素株式会社 | 寡核苷酸的制备方法以及核苷、核苷酸或寡核苷酸 |
| WO2017111137A1 (ja) * | 2015-12-22 | 2017-06-29 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| AU2016381992B2 (en) | 2015-12-28 | 2024-01-04 | Chugai Seiyaku Kabushiki Kaisha | Method for promoting efficiency of purification of Fc region-containing polypeptide |
| TW201906855A (zh) | 2017-05-02 | 2019-02-16 | 日商日產化學工業股份有限公司 | 寡核苷酸之製造方法 |
-
2020
- 2020-05-08 CN CN202411234221.5A patent/CN119143828A/zh active Pending
- 2020-05-08 EP EP20729413.3A patent/EP3966219A2/en active Pending
- 2020-05-08 BR BR112021022219A patent/BR112021022219A2/pt unknown
- 2020-05-08 WO PCT/US2020/032070 patent/WO2020227618A2/en not_active Ceased
- 2020-05-08 EA EA202193010A patent/EA202193010A1/ru unknown
- 2020-05-08 JP JP2021565931A patent/JP7824080B2/ja active Active
- 2020-05-08 AU AU2020268415A patent/AU2020268415B2/en active Active
- 2020-05-08 CN CN202080044020.2A patent/CN114206897B/zh active Active
- 2020-05-08 CN CN202411234328.XA patent/CN119462804A/zh active Pending
- 2020-05-08 MA MA055891A patent/MA55891A/fr unknown
- 2020-05-08 MX MX2021013587A patent/MX2021013587A/es unknown
- 2020-05-08 CA CA3139545A patent/CA3139545A1/en active Pending
- 2020-05-08 IL IL287798A patent/IL287798B2/en unknown
- 2020-05-08 US US17/608,802 patent/US12378276B2/en active Active
- 2020-05-08 KR KR1020217039894A patent/KR20220007104A/ko active Pending
- 2020-05-08 IL IL319933A patent/IL319933A/en unknown
-
2025
- 2025-07-04 JP JP2025113743A patent/JP2025138846A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US12378276B2 (en) | 2025-08-05 |
| WO2020227618A2 (en) | 2020-11-12 |
| AU2020268415A8 (en) | 2022-01-20 |
| IL287798A (en) | 2022-01-01 |
| JP2025138846A (ja) | 2025-09-25 |
| AU2020268415A1 (en) | 2021-12-23 |
| MA55891A (fr) | 2022-03-16 |
| EA202193010A1 (ru) | 2022-03-18 |
| CN114206897B (zh) | 2024-09-20 |
| CN114206897A (zh) | 2022-03-18 |
| IL287798B2 (en) | 2025-09-01 |
| IL319933A (en) | 2025-05-01 |
| BR112021022219A2 (pt) | 2022-03-22 |
| CN119462804A (zh) | 2025-02-18 |
| WO2020227618A8 (en) | 2020-12-24 |
| JP7824080B2 (ja) | 2026-03-04 |
| IL287798B1 (en) | 2025-05-01 |
| CA3139545A1 (en) | 2020-11-12 |
| KR20220007104A (ko) | 2022-01-18 |
| WO2020227618A3 (en) | 2021-01-14 |
| AU2020268415B2 (en) | 2026-04-23 |
| EP3966219A2 (en) | 2022-03-16 |
| US20220348602A1 (en) | 2022-11-03 |
| CN119143828A (zh) | 2024-12-17 |
| JP2022531876A (ja) | 2022-07-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2021013587A (es) | Sintesis de fases liquidas convergentes de oligonucleotidos. | |
| CY1123289T1 (el) | Ενωσεις ολιγονουκλεοτιδιων για τη στοχευση του huntingtin mrna | |
| CL2020003028A1 (es) | Anticuerpos anti-cd33, anticuerpos bispecíficos anti-cd33/anti-cd3 y sus usos. | |
| BR112014009066B8 (pt) | molécula de ácido nucleico, método para a sintetização de uma molécula de dna de triciclo-fosforotioato e composição farmacêutica | |
| MX2019007795A (es) | Moleculas de union a antigeno biespecificas que comprenden el clon 20h4.9 anti-4-1bb. | |
| EA033012B1 (ru) | Способ и устройство для превращения сырой нефти в продукты нефтехимического синтеза, характеризующегося улучшенным выходом по этилену и бтк | |
| BR112017023308A2 (pt) | composição contendo produtos de reação e adutos de triamida n-(n-butil)-tiofosfórica | |
| WO2017079498A3 (en) | Nucleotide analogues | |
| AR088883A1 (es) | Moleculas de union para bcma y cd3 | |
| EP3995581A3 (en) | Oligonucleotide compounds for treatment of preeclampsia and other angiogenic disorders | |
| BR112016025352A2 (pt) | métodos de produção de uma biblioteca de clones de células eucarióticas, método de produção de um repertório diverso de ligantes, método de triagem para uma célula de um fenótipo desejado, método de triagem para um ligante que reconhece um alvo, biblioteca, biblioteca in vitro de clones de células eucarióticas, recipiente contendo células eucarióticas, uso de uma nuclease específica de sítio, usos da biblioteca, método para converter as populações de anticorpo de cadeia simples (scfv) em imunoglobulina (ig) ou fragmento, e método que permite a reformatação de quaisquer dois elementos de dna unidos a um vetor | |
| BR112019003314A2 (pt) | métodos para acoplamento cruzado | |
| MX2022015258A (es) | Anticuerpos anti-cxcr5 y composiciones y usos de los mismos. | |
| MX392317B (es) | Proceso para la preparación de etilenglicol a partir de azúcares. | |
| MY190981A (en) | Biomass-derived chemical intermediates | |
| MX2018002665A (es) | Combinacion que comprende oligonucleotidos inmunoestimulantes. | |
| CL2014002661A1 (es) | Compuestos derivados de tienopirimidina o sus sales, como inhibidores de la alk quinasa; su proceso de preparacion; composicion farmaceutica que los comprende, util para el tratamiento del cancer. | |
| BR112018007517A2 (pt) | métodos para tratar esclerose múltipla usando compostos de pirimidina e piridina com atividade inibidora de btk | |
| BR112016025196A2 (pt) | composições de oligonucleotídeo e métodos de fazê-las | |
| BR112015024050A2 (pt) | composto, composição farmacêutica, e, uso de um composto | |
| HK1254367A1 (zh) | 新的工艺和中间体 | |
| BR112017005856A2 (pt) | reação de carboxilação de fluxo contínuo | |
| MX2017000023A (es) | Proceso para preparar fenilalcanos sustituidos. | |
| MX2018011052A (es) | Compuestos y metodos para la sintesis de fosforamidato de 5-(n-triptamina carboxamida protegida)-2'-desoxiuridina para ser incorporados en una secuencia nucleica. | |
| CL2025000292A1 (es) | Anticuerpos tmem219 y usos terapéuticos de los mismos |