JP7824080B2 - オリゴヌクレオチドの収束液相合成 - Google Patents

オリゴヌクレオチドの収束液相合成

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Publication number
JP7824080B2
JP7824080B2 JP2021565931A JP2021565931A JP7824080B2 JP 7824080 B2 JP7824080 B2 JP 7824080B2 JP 2021565931 A JP2021565931 A JP 2021565931A JP 2021565931 A JP2021565931 A JP 2021565931A JP 7824080 B2 JP7824080 B2 JP 7824080B2
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Prior art keywords
compound
formula
salt
mmol
mixture
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JP2021565931A
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English (en)
Japanese (ja)
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JP2022531876A5 (https=
JPWO2020227618A5 (https=
JP2022531876A (ja
Inventor
シアンリン シ，
ウィリアム エフ． キースマン，
フィローズ アンティア，
ヤニック フィロン，
シュアン ジョウ，
ウーミン ヤン，
ホン ジアン，
ヒエン グエン，
ロバート エス． グロンケ，
泰介 市丸
卓也 濱垣
大輔 高橋
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Biogen MA Inc
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Biogen MA Inc
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Publication of JP2022531876A publication Critical patent/JP2022531876A/ja
Publication of JP2022531876A5 publication Critical patent/JP2022531876A5/ja
Publication of JPWO2020227618A5 publication Critical patent/JPWO2020227618A5/ja
Priority to JP2025113743A priority Critical patent/JP2025138846A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2021565931A 2019-05-08 2020-05-08 オリゴヌクレオチドの収束液相合成 Active JP7824080B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025113743A JP2025138846A (ja) 2019-05-08 2025-07-04 オリゴヌクレオチドの収束液相合成

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962845160P 2019-05-08 2019-05-08
US62/845,160 2019-05-08
PCT/US2020/032070 WO2020227618A2 (en) 2019-05-08 2020-05-08 Convergent liquid phase syntheses of oligonucleotides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025113743A Division JP2025138846A (ja) 2019-05-08 2025-07-04 オリゴヌクレオチドの収束液相合成

Publications (4)

Publication Number Publication Date
JP2022531876A JP2022531876A (ja) 2022-07-12
JP2022531876A5 JP2022531876A5 (https=) 2023-05-16
JPWO2020227618A5 JPWO2020227618A5 (https=) 2023-05-16
JP7824080B2 true JP7824080B2 (ja) 2026-03-04

Family

ID=70919104

Family Applications (2)

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JP2021565931A Active JP7824080B2 (ja) 2019-05-08 2020-05-08 オリゴヌクレオチドの収束液相合成
JP2025113743A Pending JP2025138846A (ja) 2019-05-08 2025-07-04 オリゴヌクレオチドの収束液相合成

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025113743A Pending JP2025138846A (ja) 2019-05-08 2025-07-04 オリゴヌクレオチドの収束液相合成

Country Status (13)

Country Link
US (1) US12378276B2 (https=)
EP (1) EP3966219A2 (https=)
JP (2) JP7824080B2 (https=)
KR (1) KR20220007104A (https=)
CN (3) CN119462804A (https=)
AU (1) AU2020268415B2 (https=)
BR (1) BR112021022219A2 (https=)
CA (1) CA3139545A1 (https=)
EA (1) EA202193010A1 (https=)
IL (2) IL287798B2 (https=)
MA (1) MA55891A (https=)
MX (1) MX2021013587A (https=)
WO (1) WO2020227618A2 (https=)

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Publication number Priority date Publication date Assignee Title
AU2013203395A1 (en) 2012-03-30 2013-10-17 Isis Pharmaceuticals, Inc. Compositions and methods for modulating TAU expression for reducing seizure and modifying a neurodegenerative syndrome
TWI772856B (zh) 2013-07-19 2022-08-01 美商百健Ｍａ公司 用於調節τ蛋白表現之組合物
AU2021377229A1 (en) 2020-11-11 2023-06-29 Biogen Ma Inc. Oligonucleotides, reagents and preparation thereof
PE20240648A1 (es) * 2021-07-23 2024-04-04 Biogen Ma Inc Metodos para reducir la expresion de tau
WO2024083746A1 (en) 2022-10-17 2024-04-25 Bachem Holding Ag Method and composition for oligonucleotide synthesis
JP7825064B2 (ja) * 2022-10-27 2026-03-05 住友化学株式会社 オリゴヌクレオチドの製造方法
CN120813558A (zh) 2023-03-06 2025-10-17 斯佩拉制药株式会社 长链烯氧基取代的苯甲酰衍生物及使用该衍生物的寡核苷酸合成方法
GB202305283D0 (en) * 2023-04-11 2023-05-24 Exactmer Ltd Liquid-phase process for preparing oligonucleotides
JP7433684B1 (ja) * 2023-05-24 2024-02-20 塩野フィネス株式会社 疑似固相保護基、それを用いたヌクレオシド保護体又はオリゴヌクレオチド保護体、オリゴアミダイト前駆体の製造方法
EP4695265A1 (en) 2023-10-16 2026-02-18 Bachem Holding AG Method and composition for oligonucleotide synthesis
US20250206769A1 (en) * 2023-12-22 2025-06-26 Imec Vzw Synthesizing a Nucleic Acid or Nucleic Acid Analogue
WO2025235761A1 (en) 2024-05-09 2025-11-13 Biogen Ma Inc. Reagents and processes for preparing oligonucleotides

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JP2010275254A (ja) 2009-05-29 2010-12-09 Tokyo Univ Of Agriculture & Technology 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法
JP2012111728A (ja) 2010-11-26 2012-06-14 Nokodai Tlo Kk 高分散性液相支持体を用いたオリゴヌクレオチド合成法
WO2012157723A1 (ja) 2011-05-17 2012-11-22 味の素株式会社 オリゴヌクレオチドの製造方法
WO2013179412A1 (ja) 2012-05-30 2013-12-05 北海道システム・サイエンス株式会社 高分散性液相支持体を用いたオリゴヌクレオチド合成法
WO2017104836A1 (ja) 2015-12-16 2017-06-22 味の素株式会社 オリゴヌクレオチドの製造方法、およびヌクレオシド、ヌクレオチドまたはオリゴヌクレオチド

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EP0558749A1 (en) * 1990-11-20 1993-09-08 Sankyo Company Limited Antisense nucleic acid derivative
US5510476A (en) * 1994-07-07 1996-04-23 Isis Pharmaceuticals, Inc. Carbocation scavenging during oligonucleotide synthesis
AU738032B2 (en) 1995-10-19 2001-09-06 Proligo Llc Method for solution phase synthesis of oligonucleotides
EP1386925A1 (en) * 2002-07-31 2004-02-04 Girindus AG Method for preparing oligonucleotides
SI2548560T1 (sl) 2005-06-23 2015-12-31 Isis Pharmaceuticals, Inc. Sestavki in postopki za moduliranje izrezovanja smn2
RU2572826C2 (ru) 2008-12-02 2016-01-20 Чиралджен, Лтд. Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
PT3305302T (pt) 2009-06-17 2018-12-14 Biogen Ma Inc Composições e métodos de modulação de excisões de smn2 em um sujeito
US20120184724A1 (en) * 2009-09-22 2012-07-19 Agilent Technologies, Inc. Protected monomers and methods of deprotection for rna synthesis
EP2816053B1 (en) 2012-02-17 2021-03-24 Ajinomoto Co., Inc. Base-protected oligonucleotide
US8846885B2 (en) * 2012-02-17 2014-09-30 Ajinomoto Co., Inc. Oligonucleotide with protected base
EP2921499B1 (en) * 2012-11-14 2020-01-22 Takeda Pharmaceutical Company Limited Method for liquid-phase synthesis of nucleic acids
RS60707B1 (sr) 2014-04-01 2020-09-30 Biogen Ma Inc Kompozicije za modulaciju ekspresije sod-1
EP3263579B1 (en) 2015-01-21 2022-11-30 Ajinomoto Co., Inc. Precipitation promoter and precipitation method in which same is used
JPWO2017111137A1 (ja) * 2015-12-22 2018-10-18 味の素株式会社 オリゴヌクレオチドの製造方法
CN108368166B (zh) 2015-12-28 2023-03-28 中外制药株式会社 提高含fc区多肽纯化效率的方法
TW201906855A (zh) 2017-05-02 2019-02-16 日商日產化學工業股份有限公司 寡核苷酸之製造方法

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JP2010275254A (ja) 2009-05-29 2010-12-09 Tokyo Univ Of Agriculture & Technology 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法
JP2012111728A (ja) 2010-11-26 2012-06-14 Nokodai Tlo Kk 高分散性液相支持体を用いたオリゴヌクレオチド合成法
WO2012157723A1 (ja) 2011-05-17 2012-11-22 味の素株式会社 オリゴヌクレオチドの製造方法
WO2013179412A1 (ja) 2012-05-30 2013-12-05 北海道システム・サイエンス株式会社 高分散性液相支持体を用いたオリゴヌクレオチド合成法
WO2017104836A1 (ja) 2015-12-16 2017-06-22 味の素株式会社 オリゴヌクレオチドの製造方法、およびヌクレオシド、ヌクレオチドまたはオリゴヌクレオチド

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Chemistry - A European Journal，2013年，Vol.19(26)，p.8615-8620
和光純薬時報，2018年，Vol.86, No.1，p.14-15
和光純薬時報，2018年，Vol.86, No.2，p.22-23
和光純薬時報，2018年，Vol.86, No.3，p.18-19
和光純薬時報，2018年，Vol.86, No.4，p.12-13

Also Published As

Publication number Publication date
MA55891A (fr) 2022-03-16
WO2020227618A2 (en) 2020-11-12
KR20220007104A (ko) 2022-01-18
AU2020268415A1 (en) 2021-12-23
EP3966219A2 (en) 2022-03-16
CA3139545A1 (en) 2020-11-12
EA202193010A1 (ru) 2022-03-18
WO2020227618A3 (en) 2021-01-14
AU2020268415B2 (en) 2026-04-23
US12378276B2 (en) 2025-08-05
IL287798B1 (en) 2025-05-01
AU2020268415A8 (en) 2022-01-20
MX2021013587A (es) 2022-02-11
JP2025138846A (ja) 2025-09-25
CN114206897B (zh) 2024-09-20
CN114206897A (zh) 2022-03-18
IL319933A (en) 2025-05-01
JP2022531876A (ja) 2022-07-12
IL287798A (en) 2022-01-01
BR112021022219A2 (pt) 2022-03-22
CN119462804A (zh) 2025-02-18
CN119143828A (zh) 2024-12-17
WO2020227618A8 (en) 2020-12-24
US20220348602A1 (en) 2022-11-03
IL287798B2 (en) 2025-09-01

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