JP7824080B2 - オリゴヌクレオチドの収束液相合成 - Google Patents

オリゴヌクレオチドの収束液相合成

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Publication number
JP7824080B2
JP7824080B2 JP2021565931A JP2021565931A JP7824080B2 JP 7824080 B2 JP7824080 B2 JP 7824080B2 JP 2021565931 A JP2021565931 A JP 2021565931A JP 2021565931 A JP2021565931 A JP 2021565931A JP 7824080 B2 JP7824080 B2 JP 7824080B2
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compound
formula
salt
mmol
mixture
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Japanese (ja)
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JP2022531876A5 (https=
JP2022531876A (ja
Inventor
シアンリン シ，
ウィリアム エフ． キースマン，
フィローズ アンティア，
ヤニック フィロン，
シュアン ジョウ，
ウーミン ヤン，
ホン ジアン，
ヒエン グエン，
ロバート エス． グロンケ，
泰介 市丸
卓也 濱垣
大輔 高橋
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Biogen MA Inc
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Biogen MA Inc
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Publication of JP2022531876A publication Critical patent/JP2022531876A/ja
Publication of JP2022531876A5 publication Critical patent/JP2022531876A5/ja
Priority to JP2025113743A priority Critical patent/JP2025138846A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2021565931A 2019-05-08 2020-05-08 オリゴヌクレオチドの収束液相合成 Active JP7824080B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025113743A JP2025138846A (ja) 2019-05-08 2025-07-04 オリゴヌクレオチドの収束液相合成

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962845160P 2019-05-08 2019-05-08
US62/845,160 2019-05-08
PCT/US2020/032070 WO2020227618A2 (en) 2019-05-08 2020-05-08 Convergent liquid phase syntheses of oligonucleotides

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025113743A Division JP2025138846A (ja) 2019-05-08 2025-07-04 オリゴヌクレオチドの収束液相合成

Publications (3)

Publication Number Publication Date
JP2022531876A JP2022531876A (ja) 2022-07-12
JP2022531876A5 JP2022531876A5 (https=) 2023-05-16
JP7824080B2 true JP7824080B2 (ja) 2026-03-04

Family

ID=70919104

Family Applications (2)

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JP2021565931A Active JP7824080B2 (ja) 2019-05-08 2020-05-08 オリゴヌクレオチドの収束液相合成
JP2025113743A Pending JP2025138846A (ja) 2019-05-08 2025-07-04 オリゴヌクレオチドの収束液相合成

Family Applications After (1)

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JP2025113743A Pending JP2025138846A (ja) 2019-05-08 2025-07-04 オリゴヌクレオチドの収束液相合成

Country Status (13)

Country Link
US (1) US12378276B2 (https=)
EP (1) EP3966219A2 (https=)
JP (2) JP7824080B2 (https=)
KR (1) KR20220007104A (https=)
CN (3) CN119143828A (https=)
AU (1) AU2020268415B2 (https=)
BR (1) BR112021022219A2 (https=)
CA (1) CA3139545A1 (https=)
EA (1) EA202193010A1 (https=)
IL (2) IL287798B2 (https=)
MA (1) MA55891A (https=)
MX (1) MX2021013587A (https=)
WO (1) WO2020227618A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2831232A4 (en) 2012-03-30 2015-11-04 Univ Washington METHOD FOR MODULATING TAU EXPRESSION TO REDUCE PROBLEMS AND MODIFY A NEURODEGENERATIVE SYNDROME
TW202246503A (zh) 2013-07-19 2022-12-01 美商百健Ｍａ公司 用於調節τ蛋白表現之組合物
KR20230106665A (ko) 2020-11-11 2023-07-13 바이오젠 엠에이 인코포레이티드 올리고뉴클레오티드, 시약, 및 그의 제조 방법
TW202310854A (zh) * 2021-07-23 2023-03-16 美商百健Ｍａ公司 用於減少ｔａｕ表現之方法
WO2024083746A1 (en) 2022-10-17 2024-04-25 Bachem Holding Ag Method and composition for oligonucleotide synthesis
WO2024089953A1 (ja) * 2022-10-27 2024-05-02 住友化学株式会社 オリゴヌクレオチドの製造方法
JPWO2024185775A1 (https=) 2023-03-06 2024-09-12
GB202305283D0 (en) * 2023-04-11 2023-05-24 Exactmer Ltd Liquid-phase process for preparing oligonucleotides
JP7433684B1 (ja) * 2023-05-24 2024-02-20 塩野フィネス株式会社 疑似固相保護基、それを用いたヌクレオシド保護体又はオリゴヌクレオチド保護体、オリゴアミダイト前駆体の製造方法
EP4695265A1 (en) 2023-10-16 2026-02-18 Bachem Holding AG Method and composition for oligonucleotide synthesis
US20250206769A1 (en) * 2023-12-22 2025-06-26 Imec Vzw Synthesizing a Nucleic Acid or Nucleic Acid Analogue
WO2025235761A1 (en) 2024-05-09 2025-11-13 Biogen Ma Inc. Reagents and processes for preparing oligonucleotides
WO2026085433A2 (en) 2024-10-17 2026-04-23 Biogen Ma Inc. Methods for preparing oligonucleotide conjugates

Citations (5)

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JP2010275254A (ja) 2009-05-29 2010-12-09 Tokyo Univ Of Agriculture & Technology 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法
JP2012111728A (ja) 2010-11-26 2012-06-14 Nokodai Tlo Kk 高分散性液相支持体を用いたオリゴヌクレオチド合成法
WO2012157723A1 (ja) 2011-05-17 2012-11-22 味の素株式会社 オリゴヌクレオチドの製造方法
WO2013179412A1 (ja) 2012-05-30 2013-12-05 北海道システム・サイエンス株式会社 高分散性液相支持体を用いたオリゴヌクレオチド合成法
WO2017104836A1 (ja) 2015-12-16 2017-06-22 味の素株式会社 オリゴヌクレオチドの製造方法、およびヌクレオシド、ヌクレオチドまたはオリゴヌクレオチド

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CA2096658A1 (en) 1990-11-20 1992-05-21 Sankyo Company, Limited Anti-sense nucleic acid derivative
US5510476A (en) 1994-07-07 1996-04-23 Isis Pharmaceuticals, Inc. Carbocation scavenging during oligonucleotide synthesis
AU738032B2 (en) 1995-10-19 2001-09-06 Proligo Llc Method for solution phase synthesis of oligonucleotides
EP1386925A1 (en) * 2002-07-31 2004-02-04 Girindus AG Method for preparing oligonucleotides
EP3470072A1 (en) 2005-06-23 2019-04-17 Biogen MA Inc. Compositions and methods for modulation of smn2 splicing
CN102282155B (zh) 2008-12-02 2017-06-09 日本波涛生命科学公司 磷原子修饰的核酸的合成方法
ES2699827T3 (es) 2009-06-17 2019-02-13 Biogen Ma Inc Composiciones y métodos para la modulación de corte y empalme de SMN2 en un sujeto
US20120184724A1 (en) * 2009-09-22 2012-07-19 Agilent Technologies, Inc. Protected monomers and methods of deprotection for rna synthesis
US8846885B2 (en) 2012-02-17 2014-09-30 Ajinomoto Co., Inc. Oligonucleotide with protected base
EP2816053B1 (en) 2012-02-17 2021-03-24 Ajinomoto Co., Inc. Base-protected oligonucleotide
US10214555B2 (en) * 2012-11-14 2019-02-26 Takeda Pharmaceutical Company Limitjed Method for liquid-phase synthesis of nucleic acid
HUE050704T2 (hu) 2014-04-01 2020-12-28 Biogen Ma Inc Összetételek a SOD-1 expressziójának modulálására
CN113717239B (zh) 2015-01-21 2024-12-24 味之素株式会社 沉淀促进剂以及使用其的沉淀方法
WO2017111137A1 (ja) * 2015-12-22 2017-06-29 味の素株式会社 オリゴヌクレオチドの製造方法
AU2016381992B2 (en) 2015-12-28 2024-01-04 Chugai Seiyaku Kabushiki Kaisha Method for promoting efficiency of purification of Fc region-containing polypeptide
TW201906855A (zh) 2017-05-02 2019-02-16 日商日產化學工業股份有限公司 寡核苷酸之製造方法

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Publication number Priority date Publication date Assignee Title
JP2010275254A (ja) 2009-05-29 2010-12-09 Tokyo Univ Of Agriculture & Technology 疎水性基結合ヌクレオシド、疎水性基結合ヌクレオシド溶液、及び疎水性基結合オリゴヌクレオチド合成方法
JP2012111728A (ja) 2010-11-26 2012-06-14 Nokodai Tlo Kk 高分散性液相支持体を用いたオリゴヌクレオチド合成法
WO2012157723A1 (ja) 2011-05-17 2012-11-22 味の素株式会社 オリゴヌクレオチドの製造方法
WO2013179412A1 (ja) 2012-05-30 2013-12-05 北海道システム・サイエンス株式会社 高分散性液相支持体を用いたオリゴヌクレオチド合成法
WO2017104836A1 (ja) 2015-12-16 2017-06-22 味の素株式会社 オリゴヌクレオチドの製造方法、およびヌクレオシド、ヌクレオチドまたはオリゴヌクレオチド

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Chemistry - A European Journal，2013年，Vol.19(26)，p.8615-8620
和光純薬時報，2018年，Vol.86, No.1，p.14-15
和光純薬時報，2018年，Vol.86, No.2，p.22-23
和光純薬時報，2018年，Vol.86, No.3，p.18-19
和光純薬時報，2018年，Vol.86, No.4，p.12-13

Also Published As

Publication number Publication date
US12378276B2 (en) 2025-08-05
WO2020227618A2 (en) 2020-11-12
AU2020268415A8 (en) 2022-01-20
IL287798A (en) 2022-01-01
JP2025138846A (ja) 2025-09-25
AU2020268415A1 (en) 2021-12-23
MA55891A (fr) 2022-03-16
EA202193010A1 (ru) 2022-03-18
CN114206897B (zh) 2024-09-20
CN114206897A (zh) 2022-03-18
IL287798B2 (en) 2025-09-01
IL319933A (en) 2025-05-01
BR112021022219A2 (pt) 2022-03-22
CN119462804A (zh) 2025-02-18
WO2020227618A8 (en) 2020-12-24
IL287798B1 (en) 2025-05-01
CA3139545A1 (en) 2020-11-12
KR20220007104A (ko) 2022-01-18
WO2020227618A3 (en) 2021-01-14
AU2020268415B2 (en) 2026-04-23
EP3966219A2 (en) 2022-03-16
US20220348602A1 (en) 2022-11-03
MX2021013587A (es) 2022-02-11
CN119143828A (zh) 2024-12-17
JP2022531876A (ja) 2022-07-12

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