JPWO2019222055A5 - - Google Patents
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- JPWO2019222055A5 JPWO2019222055A5 JP2020563960A JP2020563960A JPWO2019222055A5 JP WO2019222055 A5 JPWO2019222055 A5 JP WO2019222055A5 JP 2020563960 A JP2020563960 A JP 2020563960A JP 2020563960 A JP2020563960 A JP 2020563960A JP WO2019222055 A5 JPWO2019222055 A5 JP WO2019222055A5
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- 201000008937 atopic dermatitis Diseases 0.000 claims description 17
- 239000003814 drug Substances 0.000 claims description 12
- 201000010099 disease Diseases 0.000 claims description 7
- 238000002560 therapeutic procedure Methods 0.000 claims description 6
- 229950003468 Dupilumab Drugs 0.000 claims description 4
- 208000003251 Pruritus Diseases 0.000 claims description 4
- 108091003598 dupilumab Proteins 0.000 claims description 4
- 230000004044 response Effects 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 48
- 102000010787 Interleukin-4 Receptors Human genes 0.000 claims 24
- 108010038486 Interleukin-4 Receptors Proteins 0.000 claims 24
- 125000003275 alpha amino acid group Chemical group 0.000 claims 22
- 239000003112 inhibitor Substances 0.000 claims 20
- 230000002401 inhibitory effect Effects 0.000 claims 20
- 206010012438 Dermatitis atopic Diseases 0.000 claims 16
- 108090001123 antibodies Proteins 0.000 claims 8
- 102000004965 antibodies Human genes 0.000 claims 8
- 239000000427 antigen Substances 0.000 claims 8
- 102000038129 antigens Human genes 0.000 claims 8
- 108091007172 antigens Proteins 0.000 claims 8
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
- 229940071643 Prefilled Syringe Drugs 0.000 claims 4
- 230000002730 additional Effects 0.000 claims 2
- 230000001387 anti-histamine Effects 0.000 claims 2
- 239000000739 antihistaminic agent Substances 0.000 claims 2
- 239000003246 corticosteroid Substances 0.000 claims 2
- 239000003974 emollient agent Substances 0.000 claims 2
- 238000009121 systemic therapy Methods 0.000 claims 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-33-[(E,1R,2R)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17 Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 208000002205 Allergic Conjunctivitis Diseases 0.000 claims 1
- 208000006673 Asthma Diseases 0.000 claims 1
- 206010010744 Conjunctivitis allergic Diseases 0.000 claims 1
- 229940064701 Corticosteroid nasal preparations for topical use Drugs 0.000 claims 1
- 229960001334 Corticosteroids Drugs 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 1
- 208000004262 Food Hypersensitivity Diseases 0.000 claims 1
- 206010057631 House dust allergy Diseases 0.000 claims 1
- 229960003444 IMMUNOSUPPRESSANTS Drugs 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 229940014456 MYCOPHENOLATE Drugs 0.000 claims 1
- 229960000951 Mycophenolic Acid Drugs 0.000 claims 1
- 208000000592 Nasal Polyps Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 206010048908 Seasonal allergy Diseases 0.000 claims 1
- 229940037128 Systemic Glucocorticoids Drugs 0.000 claims 1
- 206010046736 Urticarias Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 230000000844 anti-bacterial Effects 0.000 claims 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 1
- 230000001684 chronic Effects 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 238000002651 drug therapy Methods 0.000 claims 1
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 1
- 235000020932 food allergy Nutrition 0.000 claims 1
- 239000011521 glass Substances 0.000 claims 1
- 230000001861 immunosuppresant Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 claims 1
- 230000000414 obstructive Effects 0.000 claims 1
- 238000001126 phototherapy Methods 0.000 claims 1
- 231100000486 side effect Toxicity 0.000 claims 1
- 201000009890 sinusitis Diseases 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
- 229940083878 topical for treatment of hemorrhoids and anal fissures Corticosteroids Drugs 0.000 claims 1
- 238000005303 weighing Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 206010027654 Allergic conditions Diseases 0.000 description 1
- 206010002855 Anxiety Diseases 0.000 description 1
- 206010057666 Anxiety disease Diseases 0.000 description 1
- 208000010340 Sleep Deprivation Diseases 0.000 description 1
- 230000001058 adult Effects 0.000 description 1
- 230000000172 allergic Effects 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2024000024A JP2024038234A (ja) | 2018-05-13 | 2024-01-04 | Il-4r阻害剤を投与することによって重度のアトピー性皮膚炎を処置するための方法 |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862670824P | 2018-05-13 | 2018-05-13 | |
US62/670,824 | 2018-05-13 | ||
US201962840493P | 2019-04-30 | 2019-04-30 | |
US62/840,493 | 2019-04-30 | ||
PCT/US2019/031801 WO2019222055A1 (en) | 2018-05-13 | 2019-05-10 | Methods for treating atopic dermatitis by administering an il-4r inhibitor |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2024000024A Division JP2024038234A (ja) | 2018-05-13 | 2024-01-04 | Il-4r阻害剤を投与することによって重度のアトピー性皮膚炎を処置するための方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2021523188A JP2021523188A (ja) | 2021-09-02 |
JPWO2019222055A5 true JPWO2019222055A5 (hr) | 2022-05-12 |
Family
ID=66641513
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2020563960A Pending JP2021523188A (ja) | 2018-05-13 | 2019-05-10 | Il−4r阻害剤を投与することによって重度のアトピー性皮膚炎を処置するための方法 |
JP2024000024A Pending JP2024038234A (ja) | 2018-05-13 | 2024-01-04 | Il-4r阻害剤を投与することによって重度のアトピー性皮膚炎を処置するための方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2024000024A Pending JP2024038234A (ja) | 2018-05-13 | 2024-01-04 | Il-4r阻害剤を投与することによって重度のアトピー性皮膚炎を処置するための方法 |
Country Status (12)
Country | Link |
---|---|
US (2) | US11292847B2 (hr) |
EP (1) | EP3793597A1 (hr) |
JP (2) | JP2021523188A (hr) |
KR (1) | KR20210010518A (hr) |
CN (1) | CN112153982A (hr) |
AU (1) | AU2019270940A1 (hr) |
BR (1) | BR112020020387A2 (hr) |
CA (1) | CA3099066A1 (hr) |
MA (1) | MA52624A (hr) |
MX (1) | MX2020012064A (hr) |
SG (1) | SG11202009371WA (hr) |
WO (1) | WO2019222055A1 (hr) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI633891B (zh) | 2013-06-04 | 2018-09-01 | 再生元醫藥公司 | 藉由投與il-4r抑制劑以治療過敏及增強過敏原-特異之免疫療法的方法 |
TWI634900B (zh) | 2013-07-11 | 2018-09-11 | 再生元醫藥公司 | 藉由投與il-4r抑制劑治療嗜酸性食道炎的方法 |
CA2939506C (en) | 2014-02-28 | 2022-08-23 | Regeneron Pharmaceuticals, Inc. | Methods for treating skin infection by administering an il-4r antagonist |
CN113372446A (zh) | 2016-06-08 | 2021-09-10 | 苏州康乃德生物医药有限公司 | 用于结合白细胞介素4受体的抗体 |
KR20240065318A (ko) | 2016-09-01 | 2024-05-14 | 리제너론 파아마슈티컬스, 인크. | Il-4r 길항제를 투여함에 의해 알레르기를 예방하거나 치료하기 위한 방법 |
US10485844B2 (en) | 2016-09-22 | 2019-11-26 | Regeneron Pharmaceuticals, Inc. | Methods for treating severe atopic dermatitis by administering an IL-4R inhibitor |
WO2019028367A1 (en) | 2017-08-04 | 2019-02-07 | Regeneron Pharmaceuticals, Inc. | METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES |
KR20210143246A (ko) | 2019-03-21 | 2021-11-26 | 리제너론 파아마슈티컬스, 인크. | 알레르기 치료용 il-4/il-13 경로 억제제 및 형질 세포 절제의 병용 |
CA3147113A1 (en) * | 2019-08-05 | 2021-02-11 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
BR112022000581A2 (pt) | 2019-08-05 | 2022-03-03 | Regeneron Pharma | Métodos para tratamento de alergia e intensificação de imunoterapia específica dos alergénos através da administração de um antagonista de il-4r |
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KR20210143246A (ko) | 2019-03-21 | 2021-11-26 | 리제너론 파아마슈티컬스, 인크. | 알레르기 치료용 il-4/il-13 경로 억제제 및 형질 세포 절제의 병용 |
BR112022000581A2 (pt) | 2019-08-05 | 2022-03-03 | Regeneron Pharma | Métodos para tratamento de alergia e intensificação de imunoterapia específica dos alergénos através da administração de um antagonista de il-4r |
CA3147113A1 (en) | 2019-08-05 | 2021-02-11 | Regeneron Pharmaceuticals, Inc. | Methods for treating atopic dermatitis by administering an il-4r antagonist |
JP2023527775A (ja) | 2020-05-22 | 2023-06-30 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Il-4r阻害剤の投与により好酸球性食道炎を処置する方法 |
-
2019
- 2019-05-10 MX MX2020012064A patent/MX2020012064A/es unknown
- 2019-05-10 CA CA3099066A patent/CA3099066A1/en active Pending
- 2019-05-10 SG SG11202009371WA patent/SG11202009371WA/en unknown
- 2019-05-10 KR KR1020207035859A patent/KR20210010518A/ko unknown
- 2019-05-10 JP JP2020563960A patent/JP2021523188A/ja active Pending
- 2019-05-10 EP EP19726273.6A patent/EP3793597A1/en active Pending
- 2019-05-10 WO PCT/US2019/031801 patent/WO2019222055A1/en unknown
- 2019-05-10 MA MA052624A patent/MA52624A/fr unknown
- 2019-05-10 CN CN201980032103.7A patent/CN112153982A/zh active Pending
- 2019-05-10 AU AU2019270940A patent/AU2019270940A1/en active Pending
- 2019-05-10 BR BR112020020387-4A patent/BR112020020387A2/pt unknown
- 2019-05-10 US US16/409,164 patent/US11292847B2/en active Active
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2022
- 2022-03-04 US US17/687,051 patent/US20220298250A1/en active Pending
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2024
- 2024-01-04 JP JP2024000024A patent/JP2024038234A/ja active Pending
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