JPWO2013129482A1 - 経時安定性を有するw/o/w型エマルションおよびその製造方法 - Google Patents
経時安定性を有するw/o/w型エマルションおよびその製造方法 Download PDFInfo
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Abstract
Description
(1)内水相に水溶性有効成分を含むW/O/W型エマルションであって、油相に固形油性成分およびシリコーン系界面活性剤を含有し、外水相に水溶性高分子を含有する、上記W/O/W型エマルション。
(2)前記シリコーン系界面活性剤が、ポリエーテル基およびアルキル基を持つシリコーン系界面活性剤である、(1)に記載のW/O/W型エマルション。
(3)前記ポリエーテル基およびアルキル基を持つシリコーン系界面活性剤が、ラウリルPEG−9ポリジメチルシロキシエチルジメチコンまたはセチルPEG/PPG−10/1ジメチコンである、(2)に記載のW/O/W型エマルション。
(4)前記シリコーン系界面活性剤のHLB値が7以下である、(1)〜(3)のいずれかに記載のW/O/W型エマルション。
(5)前記固形油性成分の含有量が、0.7重量%以上である、(1)〜(4)のいずれかに記載のW/O/W型エマルション。
(6)前記固形油性成分がワックスである、(1)〜(5)のいずれかに記載のW/O/W型エマルション。
(7)前記水溶性高分子がアクリル酸メタクリル酸アルキル共重合体またはキサンタンガムである、(1)〜(6)のいずれかに記載のW/O/W型エマルション。
(8)前記内水相に、金属塩をさらに含有する、(1)〜(7)のいずれかに記載のW/O/W型エマルション。
(9)前記水溶性有効成分がアスコルビン酸誘導体である、(1)〜(8)のいずれかに記載のW/O/W型エマルション。
(10)前記内水相と前記油相が、内水相/油相=10/90〜90/10の重量比である、(1)〜(9)のいずれかに記載のW/O/W型エマルション。
(11)前記油相に、油溶性有効成分をさらに含有する、(1)〜(10)のいずれかに記載のW/O/W型エマルション。
(12)前記油溶性有効成分が、トコフェロール誘導体である、(1)〜(11)のいずれかに記載のW/O/W型エマルション。
(13)皮膚外用剤である、(1)〜(12)のいずれかに記載のW/O/W型エマルション。
(14)水溶性有効成分を含有する内水相と、固形油性成分およびシリコーン系界面活性剤を含有する油相を混合し、乳化させることでW/O型エマルションを調製する工程と、
調製したW/O型エマルションと、水溶性高分子を含有する外水相とを混合し、乳化させる工程と、
を含む、W/O/W型エマルションの製造方法。
(15)前記内水相と前記油相を、内水相/油相=10/90〜90/10の重量比で混合する、(14)に記載のW/O/W型エマルションの製造方法。
W/O/W型エマルション
本発明のW/O/W型エマルションは、内水相に水溶性有効成分を含むW/O/W型エマルションであって、油相に固形油性成分およびシリコーン系界面活性剤、外水相に水溶性高分子を含有することを特徴とする。本発明のW/O/W型エマルション安定性に優れ、長期保存安定を有することから、化粧品などの分野で特に有用である。
〈内水相成分〉
内水相成分としては、各種水溶性有効成分を含有することができ、これらは特に限定されない。水溶性有効成分の中には、アスコルビン酸誘導体等のように粘度を低下させる作用を有するものが存在し、そのような成分はW/O/W型エマルションを一般的に不安定にするが、本発明においてはW/O/W型エマルションを安定化させる技術を複数採用していることから、有効成分の種類にかかわらず保存安定性を維持することができる。
〈油相成分〉
油相成分として固形油性成分を含有することで、油相の粘度を高め、内水相の流動性を下げることができる。固形油性成分は特に限定されないが、固形油脂類、ロウ類、炭化水素類、高級脂肪酸類、高級アルコール類、エステル類、シリコーン類等から選択され、特に、固体油脂類やロウ類が好ましい。固体油脂としては、カカオ脂、ヤシ油、パーム油、パーム核油、硬化油、硬化ヒマシ油、モクロウ、シアバター等が挙げられ、ロウ類としては、マイクロクリスタリンワックス、ミツロウ、カルナウバロウ、キャンデリラロウ、ラノリン、ホホバ油等が挙げられるが、特に、マイクロクリスタリンワックスが好ましい。
〈外水相成分〉
外水相成分としては、増粘剤として知られる水溶性高分子を含有する。水溶性高分子が外水相の粘度を高めてW/O型エマルションの流動性を下げることから、W/O型エマルション同士の凝集を防ぐために有効である。
〈その他〉
本発明のW/O/W型エマルションは、上記成分の他に、通常の化粧品、医薬部外品、医薬品等に用いられる各種成分、例えば、水、油性成分、乳化剤、保湿剤、増粘剤、有効成分、防腐剤、顔料、粉体、pH調製剤、紫外線吸収剤、抗酸化剤、香料等を適宜含有することができる。
植物エキスとしては、例えば、アイ(藍葉)、アカブドウ、アカヤジオウ・ジオウ(地黄)、アサ(麻子仁)、アシタバ、アズキ、アセロラ、アセンヤク、アボカド、アマ、アマチャ、アマチャヅル、アルテア、アルニカ、アロエ、アロエベラ、アンズ・ホンアンズ(杏仁)、イチゴ、イチジク又はその葉、イチョウ(銀杏葉、銀杏)、イネ種子又は種皮、イラクサ、イランイラン、ウコン、ウスベニアオイ、ウスベニタチアオイ、ウツボグサ、ウメ(烏梅)又はその果肉、ウーロン茶、ウンシュウミカン(陳皮)、エゾウコギ、エゾキイチゴ、エノキタケ、エビスグサ(決明子)、エルダーベリー果実、エンジュ(槐花、槐花米)、オウギ・キバナオウギ、オウレン、オオバコ(車前子、車前草)、オオミサンザシ・サンザシ、オウヒササノユキ、オオムギ、オクラ果実、オタネニンジン・トチバニンジン(人参)、オトギリソウ・コゴメバオトギリソウ・セイヨウオトギリソウ、オドリコソウ(続断)、オニグルミ、オニユリ・ササユリ・ハカタユリ(百合)、オノニス、オヒョウ、オランダイチゴ、オランダカラシ(クレソン)、オランダゼリ、オランダミツバ、オリーブ、オレガノ、オレンジ果実又は果皮、カイケイジオウ(熟地黄)、カカオ種子、カキ又はその葉(柿蒂)、ガジュツ、カシワ(槲樹、槲葉)、カバノキ又はシダレカンバ、カボチャ、ガマ、カミツレ・ローマカミツレ、ガラナ種子、カリン、ガルシニア、カワヤナギ、カワラタケ、カワラヨモギ、カンゾウ、カンタラアサ、カントウ、カンナ、キイチゴ、キウイ果実、キク(菊花)、キササゲ、ギシギシ、キジツ、キズタ、キダチアロエ、キダチハッカ、キナ、キナノキ(シンコーナ、アカキナノキ)、キャベツ、キャベブ未熟果、キュウリ、キンカン果実、キンマ、グアバ果実、グアユーレ、クェルクス・インフェクトリア(没食子)、ククイナッツ、クコ(枸杞、枸杞子、枸杞葉、地骨皮)、クズ(葛根)、クスノキ、グースベリー果実、クチナシ、クマザサ、クマツヅラ、クララ、クランベリー果実、クリ又はその渋皮、グレープフルーツ、クロバナヒキオコシ、ゲットウ(葉)、ゲッケイジュ、ゲンチアナ、ゲンチアナ根茎/根、コウチャ、コガネバナ(黄ゴン)、コケモモ、コショウ、コーヒー豆、ゴボウ(牛蒡、牛蒡子)、ゴマ、ゴマノハグサ、ゴミシコムギ、米・米糠(赤糠、白糠)・コメ油・加水分解コメエキス、コンニャク、サクラ(オオシマザクラ、ヤマザクラ、オオヤマザクラ、エドヒガシ、マメザクラ、ミヤマザクラ、ソメイヨシノ、タカネザクラ、カスミザクラ、チョウジザクラ、コヒガン、サトザクラ、カンザクラ)の葉・花・果実・樹皮(桜皮)、サクランボ、ザクロ、サツマイモ、サトウキビ、サトウダイコン、サルビア(セージ)、サンショウ、シア(カリテ)、シイタケ、シオン、シソ・アオジソ・チリメンジソ・カタメンジソ(紫蘇葉、紫蘇子)、シナノキ、ハタケシメジ、ブナシメジ、シロタモギタケ、シモツケソウ、ジャガイモ、シャクヤク、シャクヤク根、ショウガ、ショウブ(菖蒲、菖蒲根)、シロバナイリス、シロバナツタの花、スイカ、スイカズラ(金銀花、忍冬)、ステビア、ストロベリー果実、スギナ、ステビア、スモモ果実、セイヨウアカマツの球果、セイヨウカラマツ、セイヨウキズタ、セイヨウグルミ、セイヨウサンザシ、セイヨウタンポポ、セイヨウトチノキ(マロニエ)、セイヨウナシ(果実、枝)、セイヨウナツユキソウ、セイヨウノコギリソウ(ミルフォイル)、セイヨウバラ、セイヨウハッカ・セイヨウヤマハッカ、ゼニアオイ、セリ、セロリ、センキュウ、センブリ、ソバ種実、ダイオウ、大根、大豆、ダイダイ(橙皮、枳実)、タチジャコウソウ(タイム、ワイルドタイム、百里香)、ダマスクバラ(花)、タマネギ、タムシバ(辛夷)、タラノキ又はその根皮、タンジン、タンポポ又はシロバナタンポポ・モウコタンポポ、チェリー果実、チョウセンニンジン(人参)、ツキミソウ、ツバキ、ツボクサ、ツユクサ、ツルアズキ、ツルドクダミ、デュベリー果実、トウガン(冬瓜子)、トウガラシ、トウキ、トウキンセンカ(マリーゴールド)、トウモロコシ又はトウモロコシ毛、ドクダミ、トコン(吐根)、トチュウ(杜仲、杜仲葉)、トマト、トルメンチラ、ナガイモ・ヤマノイモ、ナツミカン、ナツメ、ナンキンマメ、ナンテン(南天実)、ニクズク、ケイ・ニッケイ(桂皮)・ケイシ、ニラ、ニンニク、ノイバラ(営実)、ノコギリソウ、ノバラ、ノモモ、パーム、パイナップル果実、バジル、ハス(蓮肉、蓮子)、パセリ(オランダゼリ)、ハッカ(薄荷、薄荷葉)、ハトムギ(ヨクイニン)、バナナ、ハナハッカ、バニラビンズ、パパイヤ、パプリカ、ハマメリス(葉)、バラ、ヒオウギ、ヒキオコシ(延命草)、ヒシ(菱実)、ヒノキ、ヒマシ、ヒマワリ、ピーマン、ビワ(枇杷、枇杷葉)、ビンロウ(大服皮、檳榔子)、フキ、フキタンポポ(款冬花、款冬葉)、ブドウ果実又は果皮・種子・葉、ブナ、フユムシナツクサタケ、ブラジルカンゾウ、ブラックベリー、プラム果実、ブルーベリー(セイヨウヒメスノキ)、プルーン、ヘチマ、ベニバナ(紅花)、ベリー果実、ベルゲニアリグラタ(根)、ホウレンソウ、ホオズキ(登呂根)、ボダイジュ、ボタン(牡丹、牡丹皮)、ホップ、ホホバ、マイタケ、マオウ、マカデミアナッツ、マグワ(桑白皮、桑葉)、マヨラナ(葉)、マルベリー果実、マルメロ、マンゴー、マンゴスチン、マンダリン果実、マンネンタケ、ミドリハッカ、ミモザ、ミョウガ、ミラクルフルーツ果実、ムクロジ、ムラサキ(紫根)、ムラサキトウモロコシ、メリアアザジラクタ(葉)、メリッサ、メリロート、メロン果実、モモの葉(桃葉)・果実・種(桃仁)、モヤシ、モレロチェリー果実、モロヘイヤ、ヤグルマソウ(ヤグルマギク)、ヤグルマハッカ、ヤマヨモギ、 ユーカリ、ユキノシタ、ユズ果実、ユリ、ヨーロッパキイチゴ、ヨモギ(艾葉)、ライム果実、ライムギ、ラズベリー葉・果実、ラベンダー、リョクチャ、リンゴ果実、リンドウ、レモン果実、レモングラス、レンギョウ、レンゲソウ、ローズマリー(マンネンロウ)、ローズヒップ(ノバラ)、ワサビ、ワレモコウ等が挙げられる。植物エキスは、内水相、油相、外水相のいずれに含有させてもよいが、特に外水相に含有させることが好ましい。
皮膚外用剤
本発明でいう「皮膚外用剤」とは、皮膚に投与し得る剤形のものであって、クリーム、美容液、乳液、化粧水、パック料等の化粧料のほか、医薬部外品、医薬品、洗浄剤等の総称を表す。本発明の皮膚外用剤の用途は、エマルションを適用し得るものとして公知の用途であれば特に限定されるものではないが、化粧料が好ましく、その中でもクリームがさらに好ましい。
W/O/W型エマルションの製造方法
本発明におけるW/O/W型エマルションの製造方法については特に限定されず、公知の方法によって製造できるが、以下の製造方法により調製することで、特に経時安定性の優れたW/O/W型エマルションが得られる。
実施例1
〈W/O/W型エマルションの調製1〉
まず、各成分を表1の配合比(重量比)で混合し、油相、内水相、外水相を調製した。油相に配合されるシリコーン系界面活性剤としては、セチルPEG/PPG−10/1ジメチコンを使用した。つぎに、80℃の温度下で油相に内水相を投入して乳化させることでW/O型エマルションを調製した。その後、50℃の条件下にて外水相にW/O型エマルションを投入し、評価サンプル(1)のW/O/W型エマルション製剤を得た。
〈W/O/W型エマルションの調製2〉
表1に示される成分比以外は評価サンプル(1)と同様の条件を採用して、シリコーン系界面活性剤を含有する本発明のW/O/W型エマルションにかかる評価サンプル(8)を製造し、比較例として、シリコーン系界面活性剤に代えて各種パルミチン酸デキストリンを界面活性剤として採用した、評価サンプル(9)〜(11)を製造した。
上記方法により得られた本発明のW/O/W型エマルション(評価サンプル(1))の顕微鏡写真を図1および図2に示す。図1および図2に示す写真により、内水相、油相、外水相からなるW/O/W型エマルションが作成できていることを確認した。
〈W/O/W型エマルションの安定性評価:界面活性剤の検討〉
製造したエマルション製剤の安定性の確認は、40℃、75%RHの加速条件下で、粒子径の測定、製剤の外観・香調を指標として行った。製剤の外観および香調の経時観察については6ヶ月経過後に評価を行い、その指標には下記の評価項目を用いた。
(外観評価項目)
○:変化なし
×:変化あり(分離が生じている)
(香調評価項目)
○:変化なし
×:変化あり(油の酸化臭や基剤臭がする)
種々の界面活性剤を使用した場合の製剤の経時的安定性について検討した結果を表2に示す。表2から、比較例として、シリコーン系界面活性剤以外の界面活性剤を使用した評価サンプル(2)〜(7)の場合、安定なW/O/W型エマルションが得られないことが明らかとなった。特に、比較例として、置換度の異なるパルミチン酸デキストリンを使用した評価サンプル(9)〜(11)では、各種デキストリン脂肪酸エステルを水溶性高分子や固形油性成分と組み合わせて使用した場合であっても安定なW/O/W型エマルションは形成されなかった。これらの結果から、シリコーン系界面活性剤に加えて、水溶性高分子や固形油性成分を含有する場合にW/O/W型エマルションが安定化されることが確認された。
〈培養皮膚モデルを用いた浸透性試験〉
(評価方法)
作成したW/O/W型エマルション(評価サンプル(1))の浸透性を確認するため、培養皮膚モデルを用いた浸透性試験を実施した。尚、比較サンプルには評価サンプル(1)と同じ原料を用いたO/W型エマルションを用いた。
(評価結果)
浸透性評価結果を、図5に示す。図5の結果から明らかなように、O/W型と比較して、W/O/W型エマルションの油相に配合した有効成分(酢酸トコフェノール)の皮膚吸収性は大幅に改善された。この結果から、油相中に分散されている内水相に配合される水溶性有効成分についても同時に吸収されていると考えられるため、本発明のW/O/W型エマルションを用いることにより、内水相成分の皮膚吸収性も同様に改善されていることが推測される。
実施例2
〈W/O/W型エマルションの安定性評価:固形油性成分の含有量の検討〉
固形油性成分(マイクロクリスタリンワックス)の含有量を変更して、W/O/W型エマルションの安定性の比較検討を行った結果を表3に示す。評価サンプル(12)〜(16)は、マイクロクリスタリンワックスの含有量を変えたこと以外は実施例1の評価サンプル(1)と同様の条件を採用して調製し、実施例1の安定性評価方法と同じ方法により、エマルション製剤の安定性を外観・香調を指標として評価した。
〈W/O/W型エマルションの安定性評価:水溶性高分子の検討〉
外水相の水溶性高分子がW/O/W型エマルションの安定性に寄与するか否かについて比較検討を行った。アクリレーツ/アクリル酸アルキルクロスポリマーに代えて精製水を使用したこと以外は実施例1の評価サンプル(1)と同様の条件を採用して、評価サンプル(17)を調製した。また、異なる種類の水溶性高分子を使用した場合にもW/O/W型エマルションの安定性が維持されるか否かについて検討を行った。アクリレーツ/アクリル酸アルキルクロスポリマーに代えてキサンタンガムを使用したこと以外は実施例1の評価サンプル(1)と同様の条件を採用して、評価サンプル(18)を調製した。調製したこれらの評価サンプルをエマルション調製1ヶ月後に評価すること以外は、実施例1の安定性評価方法と同じ方法により、エマルション製剤の安定性を外観・香調を指標として評価した。
〈W/O/W型エマルションの安定性評価:シリコーン系界面活性剤の検討〉
シリコーン系界面活性剤の種類がW/O/W型エマルションの安定性に影響するか否かについて比較検討を行った。シリコーン系界面活性剤の種類変更したこと以外は実施例1の評価サンプル(1)と同様の条件を採用して、評価サンプル(19)を調製した。評価サンプル(19)には、評価サンプル(1)と同様にポリエーテル基およびアルキル基を持つシリコーン系界面活性剤であるラウリルPEG−9ポリジメチルシロキシエチルジメチコンを使用した。調製したこれらの評価サンプルをエマルション調製1ヶ月後に評価すること以外は、実施例1の安定性評価方法と同じ方法により、エマルション製剤の安定性を外観・香調を指標として評価した。
機能性クリームの原料の配合量を表4に示す。
Claims (15)
- 内水相に水溶性有効成分を含むW/O/W型エマルションであって、油相に固形油性成分およびシリコーン系界面活性剤を含有し、外水相に水溶性高分子を含有する、上記W/O/W型エマルション。
- 前記シリコーン系界面活性剤が、ポリエーテル基およびアルキル基を持つシリコーン系界面活性剤である、請求項1に記載のW/O/W型エマルション。
- 前記ポリエーテル基およびアルキル基を持つシリコーン系界面活性剤が、ラウリルPEG−9ポリジメチルシロキシエチルジメチコンまたはセチルPEG/PPG−10/1ジメチコンである、請求項2に記載のW/O/W型エマルション。
- 前記シリコーン系界面活性剤のHLB値が7以下である、請求項1〜3のいずれか1項に記載のW/O/W型エマルション。
- 前記固形油性成分の含有量が、0.7重量%以上である、請求項1〜4のいずれか1項に記載のW/O/W型エマルション。
- 前記固形油性成分がワックスである、請求項1〜5のいずれか1項に記載のW/O/W型エマルション。
- 前記水溶性高分子がアクリル酸メタクリル酸アルキル共重合体またはキサンタンガムである、請求項1〜6のいずれか1項に記載のW/O/W型エマルション。
- 前記内水相に、金属塩をさらに含有する、請求項1〜7のいずれか1項に記載のW/O/W型エマルション。
- 前記水溶性有効成分がアスコルビン酸誘導体である、請求項1〜8のいずれか1項に記載のW/O/W型エマルション。
- 前記内水相と前記油相が、内水相/油相=10/90〜90/10の重量比である、請求項1〜9のいずれか1項に記載のW/O/W型エマルション。
- 前記油相に、油溶性有効成分をさらに含有する、請求項1〜10のいずれか1項に記載のW/O/W型エマルション。
- 前記油溶性有効成分が、トコフェロール誘導体である、請求項1〜11のいずれか1項に記載のW/O/W型エマルション。
- 皮膚外用剤である、請求項1〜12のいずれか1項に記載のW/O/W型エマルション。
- 水溶性有効成分を含有する内水相と、固形油性成分およびシリコーン系界面活性剤を含有する油相を混合し、乳化させることでW/O型エマルションを調製する工程と、
調製したW/O型エマルションと、水溶性高分子を含有する外水相とを混合し、乳化させる工程と、
を含む、W/O/W型エマルションの製造方法。 - 前記内水相と前記油相を、内水相/油相=10/90〜90/10の重量比で混合する、請求項14に記載のW/O/W型エマルションの製造方法。
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Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104382780A (zh) * | 2014-11-07 | 2015-03-04 | 广州市博卡利生物科技有限公司 | 一种有机果蔬面膜粉 |
CN104771349A (zh) * | 2015-03-09 | 2015-07-15 | 胡建华 | 一种含有植物提取物的护肤品及其制备方法 |
CN110868990B (zh) * | 2017-06-29 | 2023-09-08 | 株式会社资生堂 | 彩妆化妆品 |
CN108542817B (zh) * | 2018-05-03 | 2019-09-10 | 浙江艳庄化妆品有限公司 | 一种适用于敏感肌肤人群使用的栀子花型彩妆 |
CN109123570A (zh) * | 2018-07-09 | 2019-01-04 | 颐海(上海)食品有限公司 | 一种低脂火锅底料及其制备方法 |
US11617727B2 (en) | 2019-04-30 | 2023-04-04 | Bayer Healthcare Llc | Topical analgesic gel compositions |
CN109998958B (zh) * | 2019-05-10 | 2021-11-19 | 西南大学 | 一种川芎美白w/o/w型复乳及其制备方法和应用 |
CN110812280A (zh) * | 2019-09-27 | 2020-02-21 | 方达医药技术(苏州)有限公司 | 一种固体多重自乳化载体及其制备方法 |
CN114796067A (zh) * | 2021-05-07 | 2022-07-29 | 杨庆瑞 | 一种多效植物护肤纳米乳液产品及其应用 |
KR102480538B1 (ko) * | 2021-09-28 | 2022-12-23 | 코스맥스 주식회사 | 수상 및 유상의 적절한 비율을 갖는 유중수형 고형 화장료 조성물 |
CN114588075B (zh) * | 2021-09-30 | 2023-08-29 | 中山中研化妆品有限公司 | 一种w/o/w包覆型保湿乳及其制备方法和应用 |
CN113876597B (zh) * | 2021-11-02 | 2024-01-26 | 广州科妙生物科技有限公司 | 一种润肤保湿乳霜及其制备方法 |
KR102473474B1 (ko) * | 2021-12-01 | 2022-12-02 | 한국콜마주식회사 | W/o/w 에멀젼 화장료 조성물 및 이의 제조방법 |
CN114288205A (zh) * | 2021-12-28 | 2022-04-08 | 华熙生物科技股份有限公司 | 具有改善稳定性作用的透明质酸多重乳液、制法及其应用 |
TW202345777A (zh) * | 2022-01-27 | 2023-12-01 | 日商三得利控股股份有限公司 | 含肌醇之w/o/w型乳液及其製造方法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2693466B1 (fr) * | 1992-07-09 | 1994-09-16 | Oreal | Composition cosmétique sous forme d'émulsion triple eau/huile de silicone/eau gélifiée. |
FR2693733B1 (fr) * | 1992-07-17 | 1994-09-16 | Oreal | Composition cosmétique sous forme d'émulsion triple eau/huile/eau gélifiée. |
DE4322174A1 (de) * | 1993-07-03 | 1995-01-12 | Goldschmidt Ag Th | Flüssige oder pastöse, lagerstabile, multiple Emulsion des Typs W·1·/O/W·2· |
JPH08245364A (ja) * | 1995-03-15 | 1996-09-24 | Kose Corp | W/o/w型乳化化粧料 |
FR2758719B1 (fr) * | 1997-01-24 | 1999-03-05 | Oreal | Emulsion eau-dans-huile, composition comprenant une telle emulsion et utilisation en cosmetique, en pharmacie ou en hygiene |
EP1105089A1 (en) * | 1999-06-25 | 2001-06-13 | Color Access, Inc. | Gel-based cosmetic composition |
US6290943B1 (en) * | 1999-10-22 | 2001-09-18 | Unilever Home & Personal Care Usa, Division Of Conopco, Inc. | Stable multiple emulsion composition |
JP2003511235A (ja) * | 1999-10-22 | 2003-03-25 | ユニリーバー・ナームローゼ・ベンノートシヤープ | 安定なマルチプルエマルジョン組成物 |
JP4601031B2 (ja) * | 2001-03-16 | 2010-12-22 | 株式会社資生堂 | W/o/w型乳化化粧料 |
US6387874B1 (en) * | 2001-06-27 | 2002-05-14 | Spartan Chemical Company, Inc. | Cleaning composition containing an organic acid and a spore forming microbial composition |
JP2003104861A (ja) * | 2001-09-28 | 2003-04-09 | Kanebo Ltd | W/o/w型複合エマルジョン |
JP4359014B2 (ja) * | 2001-09-28 | 2009-11-04 | 花王株式会社 | W/o/w型複合エマルジョン |
KR100479587B1 (ko) | 2001-12-15 | 2005-04-06 | 한국아렌디코스메틱 주식회사 | 수상/오일상/수상의 다중 리포좀 내에 안정화된 알부틴을 함유하는 미백 화장료 및 그 제조방법 |
FR2838343B1 (fr) * | 2002-04-12 | 2004-05-28 | Oreal | Composition cosmetique sous forme d'emulsion multiple comprenant un agent tenseur |
US6926886B2 (en) * | 2002-10-31 | 2005-08-09 | Johnson & Johnson Consumer Companies, Inc. | Compositions for darkening the skin and/or hair |
JP4282358B2 (ja) * | 2003-04-08 | 2009-06-17 | 日本メナード化粧品株式会社 | W/o/wエマルション皮膚外用組成物およびその製造方法 |
FR2862235B1 (fr) | 2003-11-13 | 2007-12-28 | Rhodia Chimie Sa | Emulsion pour vehiculer une matiere active hydrophobe vers un substrat en milieu aqueux |
DE202006005494U1 (de) * | 2006-04-03 | 2006-10-19 | Beiersdorf Ag | Kosmetische Selbstbräunungszubereitung |
JP5196760B2 (ja) * | 2006-10-27 | 2013-05-15 | 一般財団法人 九州医療資源財団 | W/o/w型エマルジョン組成物 |
US8691248B2 (en) * | 2008-03-11 | 2014-04-08 | Mary Kay Inc. | Stable three-phased emulsions |
KR101655346B1 (ko) | 2009-11-27 | 2016-09-08 | (주)아모레퍼시픽 | 고유상 안정화 화장료 조성물 |
ES2663826T3 (es) * | 2010-02-12 | 2018-04-17 | Shiseido Company, Ltd. | Preparado cosmético de tipo emulsión de agua en aceite |
JP5546291B2 (ja) | 2010-03-04 | 2014-07-09 | 竹本油脂株式会社 | W/o/w型ピッケリングエマルション及びその調製方法 |
WO2012059590A1 (en) * | 2010-11-05 | 2012-05-10 | Chr. Hansen A/S | Multiple emulsions for colorants |
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