TW202345777A - 含肌醇之w/o/w型乳液及其製造方法 - Google Patents
含肌醇之w/o/w型乳液及其製造方法 Download PDFInfo
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Abstract
本發明係以提供一種含有肌醇,且經時穩定性良好之W/O/W型乳液及其製造方法為目的。
本發明係有關於W/O/W型乳液等,其係包含內水相、油相與外水相之W/O/W型乳液,於內水相含有肌醇。
Description
本發明係有關於W/O/W型乳液及其製造方法等。更詳而言之,本發明係有關於含有肌醇,且經時穩定性良好之W/O/W型乳液及其製造方法等。
W/O/W型(水中油中水型)乳液係使油中水型(W/O型)乳液進一步乳化分散於水相(外水相)中而得的多相乳液。W/O/W型乳液,已知作為與其他乳液型相比更可提高有效成分之經皮吸收性的製劑技術(非專利文獻1),而可望應用於化妝品、食品、醫藥品等各種用途。
另一方面,週知肌醇具有保濕作用、調整皮脂分泌量之作用等。專利文獻1中記載一種外用醫藥組成物,其含有肌醇,且為水中油型乳化形態。
[先前技術文獻]
[專利文獻]
[專利文獻1] 日本特開2019-218319號公報
[非專利文獻]
[非專利文獻1] Fragrance Journal, 1989年, 4號, p.88~93
[發明所欲解決之課題]
專利文獻1中記載,若於水中油型乳化形態之乳膏劑的水相中摻混肌醇,得以提升乳化穩定性。然而,專利文獻1中卻未記載含肌醇之W/O/W型乳液。水中油型乳液的水相,於W/O/W型乳液中係相當於外水相。
肌醇由於如上述具有保濕作用、調整皮脂分泌量之作用等,摻有肌醇之W/O/W型乳液係有用於例如化妝品領域。因此,本案發明人等針對含肌醇之W/O/W型乳液進行探討。由於化妝品在流通階段或消費者使用階段常會處於嚴格的條件下,而要求經時穩定性良好。然而,已知若使W/O/W型乳液含有肌醇,則W/O/W型乳液的穩定性會降低,而更容易發生分離(相分離)。W/O/W型乳液,一旦發生分離的話便無法回復到原本的乳液。
本發明係以提供一種含有肌醇,且經時穩定性良好之W/O/W型乳液及其製造方法為目的。
[解決課題之手段]
本案發明人等為了獲得含有肌醇,且經時穩定性良好之W/O/W型乳液而重複多次研究的結果發現,藉由使W/O/W型乳液的內水相含有肌醇,可使W/O/W型乳液呈穩定。
亦即,本發明並非限定於此等,而有關於以下W/O/W型乳液及其製造方法。
[1] 一種W/O/W型乳液,其係包含內水相、油相與外水相之W/O/W型乳液,於內水相含有肌醇。
[2] 如上述[1]之W/O/W型乳液,其中外水相不含肌醇。
[3] 如上述[1]或[2]之W/O/W型乳液,其中肌醇的含量為0.01~1.4重量%。
[4] 如上述[1]~[3]中任一項之W/O/W型乳液,其中油相含有固態油性成分及聚矽氧系界面活性劑,且外水相含有水溶性高分子。
[5] 如上述[4]之W/O/W型乳液,其中上述聚矽氧系界面活性劑的HLB值為7以下。
[6] 如上述[4]或[5]之W/O/W型乳液,其中上述聚矽氧系界面活性劑為具有聚醚基及烷基之聚矽氧系界面活性劑。
[7] 如上述[6]之W/O/W型乳液,其中上述具有聚醚基及烷基之聚矽氧系界面活性劑為鯨蠟基PEG/PPG-10/1聚二甲基矽氧烷或月桂基PEG-9聚二甲基矽氧基乙基聚二甲基矽氧烷。
[8] 如上述[4]~[7]中任一項之W/O/W型乳液,其中上述固態油性成分的含量為0.5重量%以上。
[9] 如上述[4]~[8]中任一項之W/O/W型乳液,其中上述固態油性成分為蠟。
[10] 如上述[4]~[9]中任一項之W/O/W型乳液,其中上述水溶性高分子為丙烯酸甲基丙烯酸烷基酯共聚物。
[11] 如上述[1]~[10]中任一項之W/O/W型乳液,其係於上述內水相進一步含有金屬鹽。
[12] 如上述[1]~[11]中任一項之W/O/W型乳液,其中上述內水相與上述油相係內水相/油相=10/90~90/10之重量比。
[13] 如上述[1]~[12]中任一項之W/O/W型乳液,其為外用劑。
[14] 如上述[1]~[13]中任一項之W/O/W型乳液,其為皮膚外用劑。
[15] 如上述[1]~[14]中任一項之W/O/W型乳液,其為乳霜或乳液。
[16] 一種W/O/W型乳液之製造方法,其係包含:藉由將含有肌醇之內水相與油相混合使其乳化而調製W/O型乳液之步驟;及將已調製之W/O型乳液與外水相混合使其乳化之步驟。
[17] 如上述[16]之製造方法,其中外水相不含肌醇。
[18] 如上述[16]或[17]之製造方法,其中油相含有固態油性成分及聚矽氧系界面活性劑,外水相含有水溶性高分子。
[19] 如上述[16]~[18]中任一項之製造方法,其係將上述內水相與上述油相以內水相/油相=10/90~90/10之重量比混合。
[發明之效果]
根據本發明,可提供一種含有肌醇,且經時穩定性良好之W/O/W型乳液及其製造方法。本發明之W/O/W型乳液係有用於作為例如化妝品等的皮膚外用劑。
[實施發明之形態]
以下例示本發明之實施形態。
(W/O/W型乳液)
本發明之W/O/W型乳液係包含內水相、油相與外水相之W/O/W型乳液,其中內水相含有肌醇。
本發明之W/O/W型乳液為通常包含:內水相;使前述內水相分散(乳化)之油相;及使前述油相分散(乳化)之外水相的W/O/W型乳液。本發明之W/O/W型乳液可為由上述內水相、油相與外水相所構成者。於W/O/W型乳液中,內水相(內水相液滴)分散(乳化)於油相之W/O型乳液係分散(乳化)於外水相。
本發明之W/O/W型乳液由於經時穩定性良好且不易發生分離,而有用於化妝品等領域。
本發明中所稱「內水相」、「油相」、「外水相」,亦可意指W/O/W型乳液之各相,及分別含有W/O/W型乳液的製造所使用之各相成分的各溶液之任一者。
(內水相成分)
本發明之W/O/W型乳液其內水相含有肌醇。當W/O/W型乳液含有肌醇時,若其內水相含有肌醇,則W/O/W型乳液的經時穩定性良好。
肌醇(1,2,3,4,5,6-環己六醇)係具有環己烷各個碳上的氫原子逐一由羥基取代之結構的化合物。根據羥基的立體配置組合,肌醇存在myo-肌醇、allo-肌醇、D-chiro-肌醇、L-chiro-肌醇、cis-肌醇、epi-肌醇、muco-肌醇、neo-肌醇、scyllo-肌醇此9種立體異構物。
於本發明中,肌醇可為上述9種中的1種或2種以上之組合。於本發明中,肌醇較佳為myo-肌醇(順-1,2,3,5-反-4,6-環己六醇)。
本發明之W/O/W型乳液中之肌醇的含量可為0.001重量%以上,較佳為0.01重量%以上,更佳為0.05重量%以上,再更佳為0.08重量%以上,特佳為0.1重量%以上。又,W/O/W型乳液中之肌醇的含量可為0.2重量%以上、0.5重量%以上或1重量%以上。又,W/O/W型乳液中之肌醇的含量較佳為2重量%以下,更佳為1.5重量%以下,再更佳為1.4重量%以下,又更佳為1重量%以下,特佳為0.5重量%以下,最佳為0.2重量%以下。又,W/O/W型乳液中之肌醇的含量可為0.1重量%以下或0.08重量%以下。肌醇的含量若為上述範圍,可進一步提升W/O/W型乳液的經時穩定性。因此,即使長期保存W/O/W型乳液,也不易發生分離,具有長期保存穩定性。
於一樣態中,W/O/W型乳液中之肌醇的含量可為0.001~2重量%,較佳為0.01~1.5重量%,更佳為0.01~1.4重量%,更佳為0.05~1.4重量%,更佳為0.08~1.4重量%,再更佳為0.1~1.4重量%,又更佳為0.1~1重量%,特佳為0.1~0.5重量%,最佳為0.1~0.2重量%。
本發明之W/O/W型乳液係以內水相含有上述量的肌醇為佳。內水相中之肌醇可利用週知方法(例如離心分離),將W/O/W型乳液的內水相、油相、外水相分離,以週知方法(例如高效液相層析(HPLC)法)來測定。
肌醇已知具有保濕作用、皮脂分泌量調整作用等。本發明之W/O/W型乳液可使用於例如獲得肌醇衍生之作用。
本發明之W/O/W型乳液係以內水相進一步含有金屬鹽為佳。內水相成分含有金屬鹽,可進一步提升W/O/W型乳液的經時穩定性。金屬鹽不特別限定,較佳為硫酸鎂、檸檬酸鈉、麩胺酸鈉等胺基酸鹽、乳酸鈉、氯化鈉,更佳為硫酸鎂。金屬鹽可使用1種或2種以上。W/O/W型乳液含有金屬鹽時,其含量不特別限定,於W/O/W型乳液中,可為例如0.001~10重量%,較佳為0.01~5重量%,更佳為0.1~2重量%。
只要無損本發明之效果,則內水相亦可含有肌醇以外的水溶性有效成分。肌醇以外的水溶性有效成分可為1種或2種以上。肌醇以外的水溶性有效成分可舉出例如週知作為美白成分的抗壞血酸衍生物(維生素C衍生物)、熊果苷、洋甘菊萃取物、傳明酸、胎盤萃取物、芸香酚、氫醌等。又,可舉出下述所例示之植物萃取物、其他美容成分。
W/O/W型乳液含有肌醇以外的水溶性有效成分時,其含量不特別限定,於W/O/W型乳液中,可為例如0.0001~10重量%,較佳為0.001~5重量%,更佳為0.005~5重量%,再更佳為0.005~2重量%。於一樣態中,肌醇以外的水溶性有效成分的含量,於W/O/W型乳液中亦較佳為0.001~2重量%。
(油相成分)
油相含有油性成分。油性成分可使用液體油性成分、固態油性成分。油性成分可為1種或2種以上。
油相通常含有液體油性成分。液體油性成分只要在常溫下為液體即可。液體油性成分可舉出天然動植物油脂、烴油、酯油、聚矽氧油、高級醇、高級脂肪酸等,可使用1種或2種以上。
天然動植物油可舉出例如鱷梨油、亞麻籽油、杏仁油、橄欖油、可可油、泡桐油、小麥胚芽油、芝麻油、米胚芽油、米糠油、紅花油、大豆油、月見草油、山茶油、玉米油、菜籽油、杏桃核仁油、棕櫚油、棕櫚仁油、蓖麻油、葵花籽油、葡萄油、荷荷巴油、澳洲堅果油、貂油、棉籽油、椰子油、花生油、玫瑰果油等。
烴油可舉出α-烯烴寡聚物、角鯊烷、角鯊烯、液體石蠟等。
酯油可舉出己二酸二異丁酯、己二酸二己基癸酯、己二酸二-2-庚基十一烷基酯、異硬脂酸異硬脂酸酯、三羥甲基丙烷三異硬脂酸酯、2-乙基己酸鯨蠟酯、新戊二醇二-2-乙基己酸酯、三羥甲基丙烷三-2-乙基己酸酯、季戊四醇四-2-乙基己酸酯、辛酸鯨蠟酯、油酸油酯、油酸辛基十二烷基酯、油酸癸酯、新戊二醇二癸酸酯、琥珀酸2-乙基己酯、硬脂酸異鯨蠟酯、硬脂酸丁酯、癸二酸二異丙酯、乳酸鯨蠟酯、乳酸十四烷酯、肉荳蔻酸異丙酯、肉荳蔻酸辛基十二烷基酯、肉荳蔻酸鯨蠟酯、肉荳蔻酸肉荳蔻酯、棕櫚酸辛酯、2-棕櫚酸乙基己酯、2-棕櫚酸酯己基癸酯、2-庚基十一烷基棕櫚酸酯、植物甾醇油酸酯、二異硬脂醇蘋果酸酯、對甲氧基肉桂酸酯、季戊四醇四樹脂酸酯等。
聚矽氧油可舉出例如二甲基聚矽氧烷、高聚甲基聚矽氧烷、甲基苯基聚矽氧烷、甲基氫聚矽氧烷、八甲基環四矽氧烷、八甲基環五矽氧烷、十甲基環六矽氧烷、硬脂氧基聚矽氧等高級烷氧基改性聚矽氧、烷基改性聚矽氧、高級脂肪酸酯改性聚矽氧等。
高級醇可舉出例如辛基十二烷醇、異硬脂醇、油醇等。
高級脂肪酸可舉出例如異硬脂酸、油酸、亞油酸、亞麻酸等。
於一樣態中,液體油性成分較佳為烴油。於一樣態中,液體油性成分更佳為角鯊烷。
於本發明之W/O/W型乳液中,油相較佳含有固態油性成分及聚矽氧系界面活性劑。油相若含有固態油性成分及聚矽氧系界面活性劑,可進一步提升W/O/W型乳液的經時穩定性。又,油相係以不含肌醇為佳。
透過油相成分含有固態油性成分,可提高油相的黏度,而降低內水相的流動性。藉此,可進一步提升W/O/W型乳液的穩定性。固態油性成分不特別限定,可選自固態油脂類、蠟、烴類、高級脂肪酸類、高級醇類、酯類、聚矽氧類等,尤以固體油脂類、蠟為佳。固體油脂類可舉出可可脂、椰子油、棕櫚油、棕櫚仁油、氫化油、氫化蓖麻油、日本蠟、乳木果油等。蠟可舉出微晶蠟、蜂蠟、巴西棕櫚蠟、小燭樹蠟、羊毛脂等。其中,固態油性成分較佳為蠟,更佳為微晶蠟。
W/O/W型乳液含有固態油性成分時,固態油性成分的含量不特別限定,於W/O/W型乳液中,較佳為例如0.3重量%以上,更佳為0.5重量%以上;又較佳為10重量%以下,更佳為5重量%以下。於一樣態中,固態油性成分的含量,於W/O/W型乳液中,較佳為0.3~10重量%,更佳為0.5~5重量%。使用蠟(較佳為微晶蠟)時,蠟的含量,於W/O/W型乳液中,較佳為0.4重量%以上,更佳為0.5重量%以上;又,較佳為10重量%以下,更佳為5重量%以下。於一樣態中,W/O/W型乳液含有蠟時,就其含量,於W/O/W型乳液中,較佳為0.4~10重量%,更佳為0.5~5重量%。
聚矽氧系界面活性劑係指具有對聚矽氧導入親水性取代基之結構的界面活性劑,藉由改變此親水性取代基的種類,可獲得適於各種用途的界面活性劑。於本發明中,只要是聚矽氧系界面活性劑則不特別限定,例如較佳為取代基為聚醚之聚醚改性聚矽氧系界面活性劑,更佳為具有聚醚基及烷基之聚矽氧系界面活性劑。
又,聚矽氧系界面活性劑較佳為HLB值7以下者,HLB值更佳為6以下,再更佳為2.5~5.5。聚矽氧系界面活性劑的HLB值若為上述範圍,可獲得經時穩定性更良好的乳液。
具有聚醚基之聚矽氧系界面活性劑可舉出PEG-11甲醚聚二甲基矽氧烷、PEG/PPG-20/22丁醚聚二甲基矽氧烷、PEG-9聚二甲基矽氧烷、PEG-3聚二甲基矽氧烷、PEG-9甲醚聚二甲基矽氧烷、PEG-10聚二甲基矽氧烷、PEG-32甲醚聚二甲基矽氧烷、聚聚矽氧-13、PEG-9 聚二甲基矽氧基乙基聚二甲基矽氧烷、PEG/PPG-19/19 聚二甲基矽氧烷、(聚二甲基矽氧烷/(PEG-10/15))交叉聚合物、鯨蠟基PEG/PPG-10/1聚二甲基矽氧烷(HLB5.0)、月桂基PEG-9聚二甲基矽氧基乙基聚二甲基矽氧烷(HLB3.0)等。具有聚醚基及烷基之聚矽氧系界面活性劑可舉出月桂基或鯨蠟基聚二甲基矽氧烷共聚醇等,尤其可舉鯨蠟基PEG/PPG-10/1聚二甲基矽氧烷、月桂基PEG-9聚二甲基矽氧基乙基聚二甲基矽氧烷等作為較佳實例。上述聚矽氧系界面活性劑可單獨使用1種,亦可組合使用2種以上。
W/O/W型乳液含有聚矽氧系界面活性劑時,就其含量,於W/O/W型乳液中,可為例如0.1~15.0重量%,較佳為0.5~12.5重量%,更佳為1.0~10.0重量%。
又,作為油相成分,可任意含有油溶性有效成分,其種類不特別限定。透過進一步使其含有油溶性有效成分,可製造例如兼具肌醇衍生及油性有效成分衍生之機能的化妝品等。又,本發明之W/O/W型乳液,作為油溶性有效成分,可含有下述所例示之植物萃取物、其他美容成分。
例如透過油相含有生育酚衍生物(維生素E衍生物),可進一步附加促進血液循環作用、抗氧化作用、皮膚柔軟效果。W/O/W型乳液含有油溶性有效成分時,就其含量,於W/O/W型乳液中,可為例如0.0001~10重量%,較佳為0.0005~5重量%,再更佳為0.001~2重量%。
(外水相成分)
於本發明中,外水相亦可含有肌醇,惟較佳不含有。這是因為,外水相所含肌醇的量愈少,W/O/W型乳液的經時穩定性愈高。外水相所含肌醇的量,於W/O/W型乳液中較佳為0.5重量%以下,更佳為0.3重量%以下,再更佳為0.1重量%以下。
於本發明中,外水相較佳含有水溶性高分子。外水相若含有水溶性高分子,可進一步提升W/O/W型乳液的經時穩定性。水溶性高分子可使用週知作為增黏劑的水溶性高分子。由於水溶性高分子可提高外水相的黏度而降低W/O型乳液的流動性,對防止W/O型乳液彼此的凝聚係屬有效。
本發明之W/O/W型乳液的較佳樣態之一係內水相含有肌醇,油相含有固態油性成分及聚矽氧系界面活性劑,且外水相含有水溶性高分子的W/O/W型乳液。又,係以外水相不含肌醇為佳。
本發明所使用之水溶性高分子不特別限定,可使用週知水溶性高分子,可舉出例如天然水溶性高分子、半合成的水溶性高分子、合成的水溶性高分子等。天然水溶性高分子可舉出例如阿拉伯膠、瓜爾膠(Guar gum)、卡拉膠、果膠、寒天、榠櫨子(馬梅洛(marmelo))、澱粉(米、玉米、馬鈴薯、小麥)等植物系高分子;三仙膠、糊精、支鏈澱粉等微生物系高分子;膠原蛋白、酪蛋白、白蛋白、明膠等動物系高分子等。半合成的水溶性高分子可舉出例如羧基甲基澱粉、甲基羥基丙基澱粉等澱粉系高分子;甲基纖維素、硝基纖維素、乙基纖維素、羥基乙基纖維素、羥基丙基纖維素、羧基甲基纖維素鈉(CMC)、結晶纖維素、纖維素粉末等纖維素系高分子;褐藻酸鈉、褐藻酸丙二醇酯等褐藻酸系高分子等。合成的水溶性高分子可舉出例如聚乙烯醇、聚乙烯基甲醚、羧基乙烯基聚合物(Carbomer)等乙烯基系高分子;聚氧乙烯聚氧丙烯共聚物共聚合系高分子;聚丙烯酸鈉、聚丙烯醯胺、丙烯酸甲基丙烯酸烷基酯共聚物(丙烯酸・甲基丙烯酸烷基酯共聚物)等丙烯酸系高分子;聚乙烯亞胺、陽離子聚合物等。水溶性高分子可使用1種,亦可組合使用2種以上。水溶性高分子較佳為丙烯酸系高分子,更佳為丙烯酸甲基丙烯酸烷基酯共聚物。
本發明之W/O/W型乳液較佳含有丙烯酸甲基丙烯酸烷基酯共聚物。當W/O/W型乳液含有水溶性高分子時,就其含量,於W/O/W型乳液中為例如0.001~10重量%,較佳為0.005~5重量%,更佳為0.01~2重量%。
外水相中之其他成分不特別限定,可含有週知有助於乳液的穩定性之成分,例如可進一步含有聚氧乙烯系界面活性劑。聚氧乙烯系界面活性劑不特別限定,可使用單油酸聚氧乙烯山梨醇酐等。W/O/W型乳液含有聚氧乙烯系界面活性劑時,就其含量,於W/O/W型乳液中,可為例如0.01~20重量%,較佳為0.1~10重量%,更佳為1~5重量%。
(其他)
本發明之W/O/W型乳液,除上述成分,亦可適宜含有一般化妝品、準醫藥品、醫藥品、香妝品等所使用之各種成分,例如水、乳化劑、保濕劑、增黏劑、有效成分、防腐劑、顏料、粉體、pH值調整劑、紫外線吸收劑、抗氧化劑、香料等。
又,諸如上述,本發明之W/O/W型乳液可含有所有水溶性或油溶性之有效成分。
有效成分可舉出膠原蛋白、玻尿酸、彈力蛋白、蛋白多醣、神經醯胺、胎盤、蝦紅素、多酚、酵母、胺基酸、胜肽(乙醯基六胜肽-8等)等。
又,作為有效成分,可摻混植物萃取物,可舉出例如槐蘭植物(藍葉)、紅葡萄、生地黃・地黃、大麻(麻子仁)、明日葉、紅豆、西印度櫻桃、阿仙藥、酪梨、亞麻、土常山、絞股藍、木槿花、山金車、蘆薈、蘆薈果、杏桃・杏仁、草莓、無花果或其葉、銀杏(銀杏葉、銀杏)、稻子種子或種皮、蕁麻、香水樹、鬱金香、小蜀葵、藥用蜀葵、滁州夏枯草、烏梅或其果肉、烏龍茶、陳皮、五加皮、歐洲覆盆子、金針菇、決明子、接骨木花果實、槐(槐花、槐花米)、黃耆・蒙古黃耆、黃蓮、車前草(車前子、車前草)、歐米山蘭・山蘭(音譯)、絲龍舌蘭、大麥、秋葵果實、朝鮮人蔘・竹節人蔘(人蔘)、橡木(常綠橡木)、弟切草・小米葉弟切草・西洋弟切草、野芝麻(川續斷)、鬼胡桃、鬼百合・世百合・博多百合(百合)、刺芒柄花、厚司木(Ulmus lacinata)、荷蘭草莓、荷蘭芥末(西洋菜)、荷蘭芹、中國芹、橄欖草、花薄荷、橘子果實或果皮、熟地黃、可可亞種子、柿子或其葉子(柿蒂)、加木、槲樹(槲葉)、白樺樹或垂枝樺、南瓜、香浦、小甘菊・羅馬小甘菊、巴西可可種子、花梨、藤黃果、川柳、雲芝、菌陳嵩、重瓣萱草、龍舌蘭、蒲公英、美人蕉、木莓、奇異果實、菊花、梓樹、羊蹄、未熟橘、台灣常春藤、非洲產蘆薈、西洋山薄荷、奎寧皮、奎寧樹(肉桂、金雞納樹)、高麗菜、高麗菜未熟果、小黃瓜、橘子果實、蒟醬、芭樂果實、阿根廷銀膠菊、班槐櫟(沒食子)、夏威夷果、枸杞(枸杞、枸杞子、枸杞葉、地骨皮)、葛根、樟樹、醋栗(gooseberry)、梔子、山白竹、馬鞭草、苦蔘、蔓越莓果實、栗子或其涉皮、葡萄柚、毛果香茶菜、夏油(葉)、月桂樹、龍膽、龍膽根莖/根、紅茶、黃岑(黃蓮)、苔桃、胡椒、咖啡豆、牛蒡(牛蒡、牛蒡子)、芝麻、玄蔘、五味子、米・米糠(紅糠、白糠) ・米油・水解米萃取物、蒟蒻、櫻花(大島櫻、山櫻、大山櫻、江東櫻、豆櫻、深山櫻、染井吉野櫻、高嶺櫻、霞櫻、丁字櫻、小彼岸櫻、里櫻、寒櫻)之葉・花・果實・樹皮(櫻樹皮)、櫻桃、石榴、蕃薯、甘蔗、糖用甜菜、一串紅(鼠尾草)、山椒、乳木果、香菇、紫苑(shion)、紫蘇・青紫蘇・皺葉紫蘇・雙面雙色紫蘇(紫蘇葉・紫蘇子)、品木、荷葉傘菇、真姬菇、傘菌菇、蚊子草、馬鈴薯、芍藥、芍藥根、胡椒、菖蒲(菖蒲、菖蒲根)、香根鳶尾、白花常春藤之花、西瓜、忍冬(金銀花、忍冬)、甜菊、草莓果實、問荊、甜菊、李子果實、西洋紅松之毬果、歐洲落葉松、西洋常春藤、西洋胡桃、西洋山楂、西洋蒲公英、西洋槭樹、西洋梨(果實、枝)、西洋夏雪草、西洋耆草、西洋玫瑰、西洋薄荷・西洋山薄荷、錢葵、芹、西洋芹、川芎、日本獐牙菜、蕎麥種實、大黃、蘿蔔、大豆、橙(橙皮、枳實)、普通百里香(百里香、野生百里香)、大馬士革粉紅玫瑰(花)、洋蔥、柳葉木蘭(木筆)、日本蔥木或其根皮、丹蔘、蒲公英或白花蒲公英・蒙古蒲公英、櫻桃果實、朝鮮人蔘(人蔘)、月見草、山茶花、雷公根、鴨拓草、赤小豆、何首烏、雙莓果實、冬瓜(冬瓜子)、辣椒、當歸、金盞花(萬壽菊)、玉蜀黍或玉蜀黍鬚、魚腥草、吐根、杜仲(杜仲、杜仲葉)、蕃茄、洋委陵菜、芋頭・山芋、夏橘、大棗、南京豆、南天竹(南天實)、肉豆蔻、皮・肉桂皮(桂皮)・桂枝、韭菜、大蒜、薔薇(薔薇攀援灌木)、耆草、野薔薇、山桃、棕櫚樹、鳳梨果實、羅勒葉、蓮(蓮肉、蓮子)、香芹(歐芹)、薄荷(薄荷、薄荷葉)、薏仁、香蕉、花薄荷、香草豆、木瓜、紅甜椒、北美金縷梅(葉)、玫瑰、檜扇、香茶菜(延命草)、本菱(菱實)、杉木、蓖麻、向日葵、青椒、枇杷(枇杷、枇杷葉)、檳榔(大服皮、檳榔子)、款冬、款冬蒲公英(款冬花、款冬葉)、葡萄果實或果皮・種子・葉、山毛櫸、冬蟲夏草、巴西蠟、黑莓、李子果實、藍莓(歐洲越橘)、棗子、絲瓜、紅花、莓果實、虎耳草(根)、菠菜、阿克酸漿(登呂根)、菩提樹、牡丹(牡丹、牡丹皮)、蛇麻、荷荷巴、灰樹花、麻黃、夏威夷豆、桑樹(桑白皮、桑葉)、馬約拉那(葉)、圓形莓果實、圓形哈密瓜、芒果、山竹、橘子果實、靈芝、綠薄荷、含羞草、薑、神秘果果實、無患子、紫草(紫根)、紫玉米、印度楝(葉)、蜂花、香蜂葉、哈密瓜果實、桃葉・果實・種子(桃仁)、豆芽菜、桑葚果實、黃麻、鬼燈檠(矢車菊)、矢車薄荷、山艾、尤加利樹、虎耳草、柚子果實、百合、歐洲草莓、艾葉、萊姆果實、黑麥、覆盆子葉・果實、薰衣草、綠茶、蘋果果實、龍膽、檸檬果實、檸檬草、連翹、紫雲英、迷迭香、玫瑰果(野薔薇)、芥末、地榆等。
又,亦可摻混其他美容成分,可舉出例如酵母菌、水解貝殼多醣、水解玻尿酸、羥丙基三甲基玻尿酸鹽、水解烷基(C12-13)玻尿酸甘油酯等。
此等有效成分可考量各者之特性而判斷使其含於內水相、油相、外水相何者中。
各相中之成分相對於W/O/W型乳液之總量的含量可依據有效成分、界面活性劑的種類、固態油性成分的種類或量等適宜決定。
基於乳液的穩定性觀點,油相與內水相之重量比較佳為內水相/油相=10/90~90/10,內水相/油相之重量比更佳為20/80~80/20,再更佳為25/75~75/25。又,相對於內水相100重量份,油相較佳為10~500重量份,更佳為20~300重量份,再更佳為50~200重量份;外水相較佳為50~2000重量份,更佳為100~1500重量份,再更佳為200~1000重量份。
本發明之W/O/W型乳液的形態只要是具有經時穩定性者則不特別限定,例如內水相液滴的平均粒徑可為0.001~100μm,較佳為0.01~100μm,更佳為0.1~100μm,W/O型乳液平均粒徑可為例如0.01~100μm,較佳為0.1~100μm,更佳為0.5~100μm,再更佳為1~50μm。
本發明之W/O/W型乳液的黏度,於25℃下較佳為500~50,000mPa・s,更佳為1,000~40,000mPa・s,再更佳為2,000~30,000mPa・s。於此,前述黏度為藉由BM型黏度計(TOKI SANGYO公司製、測定條件:轉子No.4、12rpm、1分鐘)所測得的黏度。
本發明之W/O/W型乳液可使用於可應用W/O/W型乳液的各種用途。於一樣態中,本發明之W/O/W型乳液可作為外用劑(外用組成物)使用。又,於一樣態中,本發明之W/O/W型乳液可作為口服組成物(例如飲食品、口服醫藥品、口服準醫藥品等)使用。於一樣態中,本發明之W/O/W型乳液可適用於作為外用劑。
外用劑可施用於皮膚、黏膜等軀體的表面,可舉出例如化妝品、外用準醫藥品、外用醫藥品、洗淨劑、香妝品等。外用劑較佳為例如皮膚外用劑。
本發明之W/O/W型乳液可適用於作為例如皮膚外用劑。本發明中所稱「皮膚外用劑」,係指可對皮膚之劑形;除乳霜、美容液、乳液、化妝水、面膜等化妝品外,亦表示準醫藥品、醫藥品、洗淨劑、香妝品等的總稱。皮膚外用劑之形態不特別限定,較佳為乳霜或乳液。本發明之皮膚外用劑的用途,只要是週知作為可施用乳液之用途則不特別限定,較佳為化妝品,其中更佳為乳霜或乳液。
(W/O/W型乳液之製造方法)
就本發明之W/O/W型乳液之製造方法不特別限定,可藉由週知方法來製造;透過以下製造方法來調製,可獲得經時穩定性特別優異的W/O/W型乳液。
例如,W/O/W型乳液的製造可透過:藉由將含有肌醇之內水相與油相混合使其乳化,而調製W/O型乳液之步驟;及將已調製之W/O型乳液與外水相混合,使其乳化之步驟來進行。
包含:上述調製W/O型乳液之步驟;及將已調製之W/O型乳液與外水相混合,使其乳化之步驟的W/O/W型乳液之製造方亦屬本發明之一。
於本發明之製造方法中,內水相、油相及外水相之較佳樣態係與上述相同。例如油相較佳含有固態油性成分及聚矽氧系界面活性劑。外水相宜含有水溶性高分子。
W/O/W型乳液的製造較佳為可藉由下列2步驟來進行:
(1)藉由將含有肌醇之內水相與含有固態油性成分及聚矽氧系界面活性劑之油相混合使其乳化,而調製W/O型乳液之步驟;及
(2)將已調製之W/O型乳液與含有水溶性高分子之外水相混合,使其乳化之步驟。
具體而言,係對油相添加含有肌醇之內水相,且於較佳為50~100℃,更佳為60~95℃,再更佳為65~85℃的乳化溫度進行乳化來調製W/O型乳液。此時,較佳將內水相與油相,以較佳為內水相/油相=10/90~90/10,更佳為20/80~80/20,再更佳為25/75~75/25之重量比混合。
內水相亦可含有可任意使用的其他任意成分(金屬鹽等)。油相通常包含液體油性成分。油相亦可含有上述之任意成分(油溶性有效成分等)。
其次,藉由對外水相添加W/O型乳液,且於較佳為70℃以下,更佳為0~60℃,再更佳為10~50℃的乳化溫度使其乳化,來調製W/O/W型乳液。
外水相亦可含有丙烯酸甲基丙烯酸烷基酯共聚物。外水相較佳不含肌醇。
各成分的摻混量較佳為W/O/W型乳液中的含量成為上述範圍的量。
本說明書中由下限值與上限值表示之數值範圍,即「下限值~上限值」係包含該等下限值及上限值。例如由「1~2」表示之範圍係指1以上2以下,包含1及2。本說明書中,上限及下限可採任意組合所成之範圍。
[實施例]
以下基於實施例詳細說明本發明,惟本發明非限定於此等。
<實施例1~4>
茲調製含有肌醇之W/O/W型乳液。
首先,將各成分以表1之摻混比(重量%)混合,調製成油相、內水相、外水相。其次,藉由在80℃之溫度下對油相投入內水相使其乳化而調製成W/O型乳液。於W/O型乳液的調製時,係將內水相與油相混合來進行乳化。其後,於50℃之條件下對外水相投入W/O型乳液,而得到實施例1~4之W/O/W型乳液(W/O/W型乳液製劑)。更詳而言之,係將W/O型乳液與外水相混合進行乳化,而得到上述W/O/W型乳液。
以目視確認所得之W/O/W型乳液的外觀,結果為乳液狀。以光學顯微鏡觀察所得之W/O/W型乳液,確認可製得由內水相、油相、外水相所構成的W/O/W型乳液。
實施例1~3之W/O/W型乳液為內水相含有肌醇之W/O/W型乳液。實施例4之W/O/W型乳液為內水相及外水相含有肌醇之W/O/W型乳液。
表1中之數值為W/O/W型乳液(100重量%)中之各成分的摻混量(重量%)。肌醇係使用myo-肌醇(築野食品工業(股)製)。
<比較例1>
除如表1所示取各成分之配方以外,係以與實施例1同樣的方法調製成W/O/W型乳液(W/O/W型乳液製劑)。所得之W/O/W型乳液的外觀(目視)為乳液狀。
<參考例1>
除如表1所示取各成分之配方以外,係以與實施例1同樣的方法調製成W/O/W型乳液(W/O/W型乳液製劑)。所得之W/O/W型乳液的外觀(目視)為乳液狀。
比較例1中已調製之W/O/W型乳液為外水相含有肌醇之W/O/W型乳液。參考例1中已調製之W/O/W型乳液為不含肌醇之W/O/W型乳液。對於比較例1及參考例1,藉由光學顯微鏡觀察確認可製得由內水相、油相、外水相所構成的W/O/W型乳液。
表1中之成分係使用下述者。
鯨蠟基PEG/PPG-10/1聚二甲基矽氧烷:Evonik
Operations GmbH公司製,HLB5.0
角鯊烷:Nikko Chemicals(股)製
微晶蠟:NIKKO RICA(股)製
丙烯酸・甲基丙烯酸烷基酯共聚物:Lubrizol
Advanced Materials, Inc製
單油酸聚氧乙烯山梨醇酐(20E.O.):花王(股)製
<W/O/W型乳液的評定>
茲評定實施例、比較例及參考例中已調製之W/O/W型乳液的經時穩定性。
於50℃之加速條件下保存已調製之乳液製劑,以目視確認製造時(剛製造後)、保存經過1個月後、經過2個月後的製劑外觀,檢視有無分離,依下述基準加以評定。將結果示於表2。
(評定基準)
○:未看出分離
△:些微看出分離
×:看出分離
外水相中摻有肌醇的比較例1之W/O/W型乳液,保存1個月後可看出分離,經時穩定性差。
另一方面,內水相含有肌醇的實施例1~4之W/O/W型乳液其經時穩定性良好。尤以實施例1~3之W/O/W型乳液具有優良的經時穩定性,保存後亦未發生分離,外觀無變化。實施例4之W/O/W型乳液與比較例1相比,可看出經時穩定性獲改善。
<實施例5~6>
除如表3所示取各成分之配方以外,係以與實施例1同樣的方法調製成內水相含有肌醇之W/O/W型乳液(W/O/W型乳液製劑)。所得之W/O/W型乳液的外觀(目視)為乳液狀。以光學顯微鏡觀察所得之W/O/W型乳液,確認可製得由內水相、油相、外水相所構成的W/O/W型乳液。表3中之數值為W/O/W型乳液(100重量%)中之各成分的摻混量(重量%)。所用成分係與實施例1相同。
將實施例5~6中所得之W/O/W型乳液於常溫下保存6個月,以目視評定外觀。實施例5~6中所得之W/O/W型乳液,6個月後外觀未看出變化,未發生分離。確認W/O/W型乳液的經時穩定性。本發明之W/O/W型乳液可確認適用於作為例如乳液或乳霜。
可知將肌醇摻混於W/O/W型乳液時,若內水相摻有肌醇,則可穩定維持W/O/W型乳液。
[產業上可利用性]
根據本發明,可提供一種含有肌醇,且經時穩定性良好之W/O/W型乳液及其製造方法。
Claims (19)
- 一種W/O/W型乳液,其係包含內水相、油相與外水相之W/O/W型乳液,其於內水相含有肌醇。
- 如請求項1之W/O/W型乳液,其中外水相不含肌醇。
- 如請求項1或2之W/O/W型乳液,其中肌醇的含量為0.01~1.4重量%。
- 如請求項1或2之W/O/W型乳液,其中油相含有固態油性成分及聚矽氧系界面活性劑,且外水相含有水溶性高分子。
- 如請求項4之W/O/W型乳液,其中前述聚矽氧系界面活性劑的HLB值為7以下。
- 如請求項4之W/O/W型乳液,其中前述聚矽氧系界面活性劑為具有聚醚基及烷基之聚矽氧系界面活性劑。
- 如請求項6之W/O/W型乳液,其中前述具有聚醚基及烷基之聚矽氧系界面活性劑為鯨蠟基PEG/PPG-10/1聚二甲基矽氧烷或月桂基PEG-9聚二甲基矽氧基乙基聚二甲基矽氧烷。
- 如請求項4之W/O/W型乳液,其中前述固態油性成分的含量為0.5重量%以上。
- 如請求項4之W/O/W型乳液,其中前述固態油性成分為蠟。
- 如請求項4之W/O/W型乳液,其中前述水溶性高分子為丙烯酸甲基丙烯酸烷基酯共聚物。
- 如請求項1或2之W/O/W型乳液,其係於前述內水相進一步含有金屬鹽。
- 如請求項1或2之W/O/W型乳液,其中前述內水相與前述油相係內水相/油相=10/90~90/10之重量比。
- 如請求項1或2之W/O/W型乳液,其為外用劑。
- 如請求項1或2之W/O/W型乳液,其為皮膚外用劑。
- 如請求項1或2之W/O/W型乳液,其為乳霜或乳液。
- 一種W/O/W型乳液之製造方法,其係包含: 藉由將含有肌醇之內水相與油相混合使其乳化而調製W/O型乳液之步驟;及將已調製之W/O型乳液與外水相混合使其乳化之步驟。
- 如請求項16之製造方法,其中外水相不含肌醇。
- 如請求項16或17之製造方法,其中, 油相含有固態油性成分及聚矽氧系界面活性劑, 外水相含有水溶性高分子。
- 如請求項16或17之製造方法,其係將前述內水相與前述油相以內水相/油相=10/90~90/10之重量比混合。
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WO2009005032A1 (ja) * | 2007-07-02 | 2009-01-08 | The Nisshin Oillio Group, Ltd. | W/o/w型乳化組成物 |
US9642792B2 (en) * | 2012-02-28 | 2017-05-09 | Suntory Holdings Limited | W/O/W emulsion having temporal stability and method for producing the same |
JP2019218319A (ja) * | 2018-06-22 | 2019-12-26 | 小林製薬株式会社 | 外用医薬組成物 |
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