JPS6216955B2 - - Google Patents

Info

Publication number
JPS6216955B2
JPS6216955B2 JP53069685A JP6968578A JPS6216955B2 JP S6216955 B2 JPS6216955 B2 JP S6216955B2 JP 53069685 A JP53069685 A JP 53069685A JP 6968578 A JP6968578 A JP 6968578A JP S6216955 B2 JPS6216955 B2 JP S6216955B2
Authority
JP
Japan
Prior art keywords
ethyl
naphthyridine
add
chloroform
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP53069685A
Other languages
English (en)
Japanese (ja)
Other versions
JPS54163596A (en
Inventor
Yoshiaki Tanaka
Isao Hayakawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP6968578A priority Critical patent/JPS54163596A/ja
Priority to CA000320906A priority patent/CA1114822A/en
Priority to DE2906253A priority patent/DE2906253C2/de
Priority to ZA792467A priority patent/ZA792467B/xx
Priority to PH22549A priority patent/PH15905A/en
Priority to AU47363/79A priority patent/AU520081B2/en
Priority to IL57423A priority patent/IL57423A/xx
Priority to AR276683A priority patent/AR220561A1/es
Priority to GR59242A priority patent/GR68369B/el
Priority to AT0405879A priority patent/AT373257B/de
Priority to IT49343/79A priority patent/IT1117221B/it
Priority to IN588/CAL/79A priority patent/IN150235B/en
Priority to YU1347/79A priority patent/YU41639B/xx
Priority to ES481418A priority patent/ES481418A1/es
Priority to EP79101852A priority patent/EP0008610B1/en
Priority to NZ190675A priority patent/NZ190675A/xx
Priority to DK240179A priority patent/DK156773C/da
Priority to SU792775453A priority patent/SU982544A3/ru
Priority to MX798059U priority patent/MX5725E/es
Priority to DD79213492A priority patent/DD144263A5/de
Priority to FI791839A priority patent/FI68836C/fi
Priority to PL1979216219A priority patent/PL116341B1/pl
Publication of JPS54163596A publication Critical patent/JPS54163596A/ja
Priority to US06/191,620 priority patent/US4293695A/en
Publication of JPS6216955B2 publication Critical patent/JPS6216955B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP6968578A 1978-06-09 1978-06-09 Flonaphlizine derivative Granted JPS54163596A (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
JP6968578A JPS54163596A (en) 1978-06-09 1978-06-09 Flonaphlizine derivative
CA000320906A CA1114822A (en) 1978-06-09 1979-02-06 Furonaphthyridine compounds
DE2906253A DE2906253C2 (de) 1978-06-09 1979-02-19 Furo-[3,2-b]-1,8-naphthyridinverbindungen und diese enthaltende Arzneimittel
ZA792467A ZA792467B (en) 1978-06-09 1979-05-21 Furonaphthyridine compounds
PH22549A PH15905A (en) 1978-06-09 1979-05-23 Furonaphthyridine compounds
AU47363/79A AU520081B2 (en) 1978-06-09 1979-05-23 Furonaphthyridine compounds
IL57423A IL57423A (en) 1978-06-09 1979-05-28 Furonaphthyridine compounds and their preparation
AR276683A AR220561A1 (es) 1978-06-09 1979-05-28 Procedimiento para preparar compuestos de 5,8-dihidro 3,2-b-1,8-naftiridina y sus sales
GR59242A GR68369B (en, 2012) 1978-06-09 1979-06-01
AT0405879A AT373257B (de) 1978-06-09 1979-06-06 Verfarhren zur herstellung neuer 2,3,5,8-tetrahydrofuro- bzw. 5,8-dihydrofuro-1,8-naphthyridine-verbindung
IN588/CAL/79A IN150235B (en, 2012) 1978-06-09 1979-06-07
IT49343/79A IT1117221B (it) 1978-06-09 1979-06-07 Composti antibatterici di furonaftiridina e procedimento per prepararli
YU1347/79A YU41639B (en) 1978-06-09 1979-06-07 Process for preparing 5,8 dihydrofuro (3,2-b) 1,8 naphthirridine compounds
SU792775453A SU982544A3 (ru) 1978-06-09 1979-06-08 Способ получени 5,8-дигидро-5-этил-8-оксофуро (3,2в)-1,8-нафтиридин-7-карбоновой кислоты или ее соли
EP79101852A EP0008610B1 (en) 1978-06-09 1979-06-08 Furonaphthyridine compounds, process for their preparation and pharmaceutical compositions containing them
NZ190675A NZ190675A (en) 1978-06-09 1979-06-08 Furonaphthyridines with antibacterial properties
DK240179A DK156773C (da) 1978-06-09 1979-06-08 Analogifremgangsmaade til fremstilling af furo(3,2-b)-1,8-naphthyridin-derivater
ES481418A ES481418A1 (es) 1978-06-09 1979-06-08 Un procedimiento para preparar un compuesto de 5,8-dihidro- furo 3,2-b, 1,8-naftiridina
MX798059U MX5725E (es) 1978-06-09 1979-06-08 Procedimiento para la preparacion de derivados de 5,8-dihidrofuro-(3,2-b)-1,8-naftiridina
DD79213492A DD144263A5 (de) 1978-06-09 1979-06-08 Verfahren zur herstellung von furonaphthyridinverbindungen
FI791839A FI68836C (fi) 1978-06-09 1979-06-08 Foerfarande foer framstaellning av antibakteriella 5,8-dihydro-8-oxofuro(3,2-b)-1,8-naftyridiner
PL1979216219A PL116341B1 (en) 1978-06-09 1979-06-09 Process for preparing novel 5,8-dihydrofuro/3,2-b/-1,8-naphtiridine compounds
US06/191,620 US4293695A (en) 1978-06-09 1980-09-29 Furonaphthyridine compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6968578A JPS54163596A (en) 1978-06-09 1978-06-09 Flonaphlizine derivative

Publications (2)

Publication Number Publication Date
JPS54163596A JPS54163596A (en) 1979-12-26
JPS6216955B2 true JPS6216955B2 (en, 2012) 1987-04-15

Family

ID=13409962

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6968578A Granted JPS54163596A (en) 1978-06-09 1978-06-09 Flonaphlizine derivative

Country Status (23)

Country Link
US (1) US4293695A (en, 2012)
EP (1) EP0008610B1 (en, 2012)
JP (1) JPS54163596A (en, 2012)
AR (1) AR220561A1 (en, 2012)
AT (1) AT373257B (en, 2012)
AU (1) AU520081B2 (en, 2012)
CA (1) CA1114822A (en, 2012)
DD (1) DD144263A5 (en, 2012)
DE (1) DE2906253C2 (en, 2012)
DK (1) DK156773C (en, 2012)
ES (1) ES481418A1 (en, 2012)
FI (1) FI68836C (en, 2012)
GR (1) GR68369B (en, 2012)
IL (1) IL57423A (en, 2012)
IN (1) IN150235B (en, 2012)
IT (1) IT1117221B (en, 2012)
MX (1) MX5725E (en, 2012)
NZ (1) NZ190675A (en, 2012)
PH (1) PH15905A (en, 2012)
PL (1) PL116341B1 (en, 2012)
SU (1) SU982544A3 (en, 2012)
YU (1) YU41639B (en, 2012)
ZA (1) ZA792467B (en, 2012)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10954231B2 (en) 2006-10-16 2021-03-23 Bionomics Limited Anxiolytic compounds
EP2074123B1 (en) 2006-10-16 2012-12-05 Bionomics Limited Novel anxiolytic compounds
AU2012222874B2 (en) 2011-03-02 2015-04-16 Bionomics Limited Novel small-molecules as therapeutics
JP6055817B2 (ja) 2011-05-12 2016-12-27 バイオノミックス リミテッド ナフチリジンの調製方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3149104A (en) * 1961-01-03 1964-09-15 Sterling Drug Inc 4-hydroxy-7-styryl-1, 8-naphthyridine-3-carboxylic acids and esters
US3663559A (en) * 1969-12-03 1972-05-16 Union Carbide Corp Preparation of oxo-furo-pyridines from furylvinyl isocyanates
DE2030899A1 (de) * 1970-06-18 1971-12-23 Schering Ag, 1000 Berlin Und 4619 Bergkamen Chinolincarbonsäurederivate
JPS5035194A (en, 2012) * 1973-07-19 1975-04-03
US4079058A (en) * 1973-08-29 1978-03-14 Dynamit Nobel Ag Process of performing cyclization reactions using benzyl or pyridylamino malonic acid derivatives

Also Published As

Publication number Publication date
CA1114822A (en) 1981-12-22
NZ190675A (en) 1981-03-16
AU4736379A (en) 1979-12-13
ES481418A1 (es) 1980-10-01
DE2906253A1 (de) 1979-12-13
DK240179A (da) 1979-12-10
IL57423A (en) 1982-02-28
PL116341B1 (en) 1981-06-30
FI68836B (fi) 1985-07-31
AT373257B (de) 1984-01-10
IL57423A0 (en) 1979-09-30
DK156773C (da) 1990-03-19
EP0008610A1 (en) 1980-03-19
PH15905A (en) 1983-04-15
DK156773B (da) 1989-10-02
GR68369B (en, 2012) 1981-12-23
MX5725E (es) 1983-12-28
YU41639B (en) 1987-12-31
JPS54163596A (en) 1979-12-26
IN150235B (en, 2012) 1982-08-21
IT7949343A0 (it) 1979-06-07
DE2906253C2 (de) 1983-06-09
PL216219A1 (en, 2012) 1980-03-24
ZA792467B (en) 1980-07-30
AU520081B2 (en) 1982-01-14
IT1117221B (it) 1986-02-17
DD144263A5 (de) 1980-10-08
FI791839A7 (fi) 1979-12-10
US4293695A (en) 1981-10-06
SU982544A3 (ru) 1982-12-15
ATA405879A (de) 1983-05-15
EP0008610B1 (en) 1981-10-14
FI68836C (fi) 1985-11-11
AR220561A1 (es) 1980-11-14
YU134779A (en) 1983-06-30

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