JPS609516B2 - セフエム骨格の環化製法 - Google Patents

セフエム骨格の環化製法

Info

Publication number
JPS609516B2
JPS609516B2 JP50028452A JP2845275A JPS609516B2 JP S609516 B2 JPS609516 B2 JP S609516B2 JP 50028452 A JP50028452 A JP 50028452A JP 2845275 A JP2845275 A JP 2845275A JP S609516 B2 JPS609516 B2 JP S609516B2
Authority
JP
Japan
Prior art keywords
group
acid
groups
parts
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP50028452A
Other languages
English (en)
Japanese (ja)
Other versions
JPS51105088A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html
Inventor
照二 辻
好男 浜島
昌幸 成定
美鶴 吉岡
太一郎 米野
博 谷田
亘 永田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Shionogi and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd
Priority to JP50028452A priority Critical patent/JPS609516B2/ja
Priority to CA000245317A priority patent/CA1136132A/en
Priority to SE7601715A priority patent/SE421691B/xx
Priority to DK061976A priority patent/DK156575C/da
Priority to PT64806A priority patent/PT64806B/pt
Priority to IL57541A priority patent/IL57541A/xx
Priority to IL49048A priority patent/IL49048A/xx
Priority to GB6187/76A priority patent/GB1548641A/en
Priority to RO7694586A priority patent/RO75006A/ro
Priority to NZ184637A priority patent/NZ184637A/xx
Priority to RO7684836A priority patent/RO68460A/ro
Priority to US05/658,665 priority patent/US4079181A/en
Priority to BG034108A priority patent/BG25076A3/xx
Priority to GB41074/78A priority patent/GB1548643A/en
Priority to BG034105A priority patent/BG24949A3/xx
Priority to MX890676U priority patent/MX6599E/es
Priority to DD7600195997A priority patent/DD127901A5/xx
Priority to MX890576U priority patent/MX6578E/es
Priority to DD191283A priority patent/DD124986A5/xx
Priority to NZ184638A priority patent/NZ184638A/xx
Priority to NZ184639A priority patent/NZ184639A/xx
Priority to CH191876A priority patent/CH627160A5/de
Priority to BG034107A priority patent/BG27557A4/xx
Priority to PL1976212108A priority patent/PL114624B1/pl
Priority to MX890776U priority patent/MX6579E/es
Priority to BG034106A priority patent/BG25216A3/xx
Priority to IE313/76A priority patent/IE42479B1/en
Priority to AR262283A priority patent/AR225878A1/es
Priority to DD7600195998A priority patent/DD127902A5/xx
Priority to NL7601613A priority patent/NL190721C/xx
Priority to DD7600195993A priority patent/DD127899A5/xx
Priority to ES445250A priority patent/ES445250A1/es
Priority to BE164401A priority patent/BE838656A/xx
Priority to NZ184640A priority patent/NZ184640A/xx
Priority to RO7694587A priority patent/RO74958A/ro
Priority to MX76898U priority patent/MX3818E/es
Priority to AU11181/76A priority patent/AU508160B2/en
Priority to NZ184641A priority patent/NZ184641A/xx
Priority to DE19762606278 priority patent/DE2606278A1/de
Priority to MX890376U priority patent/MX6598E/es
Priority to FR7604318A priority patent/FR2334669A1/fr
Priority to GR50078A priority patent/GR60437B/el
Priority to YU384/76A priority patent/YU40272B/xx
Priority to NZ180037A priority patent/NZ180037A/xx
Priority to GB41073/78A priority patent/GB1548642A/en
Priority to PL1976212107A priority patent/PL114457B1/pl
Priority to DD7600195995A priority patent/DD127900A5/xx
Priority to BG032385A priority patent/BG24948A3/xx
Priority to PH18164A priority patent/PH18022A/en
Priority to SU762331355A priority patent/SU1187717A3/ru
Priority to RO197694535A priority patent/RO74936A/ro
Publication of JPS51105088A publication Critical patent/JPS51105088A/ja
Priority to FR7701590A priority patent/FR2334684A1/fr
Priority to FR7701587A priority patent/FR2334686A1/fr
Priority to SU772446154A priority patent/SU795463A4/ru
Priority to SU772442946A priority patent/SU791247A3/ru
Priority to US05/856,806 priority patent/US4160085A/en
Priority to CS78970A priority patent/CS207654B2/cs
Priority to AT417178A priority patent/AT351044B/de
Priority to AT417078A priority patent/AT361120B/de
Priority to IL56050A priority patent/IL56050A0/xx
Priority to IL56049A priority patent/IL56049A0/xx
Priority to IL57418A priority patent/IL57418A0/xx
Priority to IL57541A priority patent/IL57541A0/xx
Priority to SE7907811A priority patent/SE444811B/sv
Priority to SE7907813A priority patent/SE434637B/sv
Priority to SE7907812A priority patent/SE434950B/sv
Priority to CA000337974A priority patent/CA1077936A/en
Priority to CA000337973A priority patent/CA1144924A/en
Priority to CA000337975A priority patent/CA1095026A/en
Priority to CA000338132A priority patent/CA1132547A/en
Priority to CH75080A priority patent/CH628030A5/de
Priority to CH74880A priority patent/CH630074A5/de
Priority to CH75180A priority patent/CH628031A5/de
Priority to CH74980A priority patent/CH634579A5/de
Priority to US06/125,232 priority patent/US4332722A/en
Priority to US06/125,233 priority patent/US4346218A/en
Priority to AT0286880A priority patent/AT363598B/de
Priority to US06/338,651 priority patent/US4440683A/en
Priority to DK76882A priority patent/DK76882A/da
Priority to YU1738/82A priority patent/YU40411B/xx
Priority to YU1742/82A priority patent/YU40414B/xx
Priority to YU1739/82A priority patent/YU40412B/xx
Priority to YU1741/82A priority patent/YU40413B/xx
Publication of JPS609516B2 publication Critical patent/JPS609516B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP50028452A 1975-02-17 1975-03-07 セフエム骨格の環化製法 Expired JPS609516B2 (ja)

Priority Applications (83)

Application Number Priority Date Filing Date Title
JP50028452A JPS609516B2 (ja) 1975-03-07 1975-03-07 セフエム骨格の環化製法
CA000245317A CA1136132A (en) 1975-02-17 1976-02-09 Cyclization to form cephem ring and intermediates therefor
SE7601715A SE421691B (sv) 1975-02-17 1976-02-16 Nya azetidinforening till anvendning som mellanprodukter for framstellning av 3-cefemforeningar
DK061976A DK156575C (da) 1975-02-17 1976-02-16 Fremgangsmaade til fremstilling af 3-hydroxy-3-cephem- eller 3-oxo-cepham-carboxylsyrederivater
PT64806A PT64806B (en) 1975-02-17 1976-02-16 Process of cyclization to form cephem ring and intermediate products for same
IL57541A IL57541A (en) 1975-02-17 1976-02-16 7-oxo-alpha-4-thia-2,6-diazabicyclo(3,2,0)heptene derivatives,process for their preparation and their cyclization to form cephem compounds and pharmaceutical compositions comprising said cephem compounds
IL49048A IL49048A (en) 1975-02-17 1976-02-16 Cyclization process to form a cephem ring and intermediates therefor
GB6187/76A GB1548641A (en) 1975-02-17 1976-02-17 Cyclization to form a cephem ring and intermediates therefor
RO7694586A RO75006A (ro) 1975-02-17 1976-02-17 Procedeu pentru prepararea unor mercaptoazetidinone
NZ184637A NZ184637A (en) 1975-02-17 1976-02-17 Method of cleaving a thiazoline ring
RO7684836A RO68460A (ro) 1975-02-17 1976-02-17 Procedeu pentru prepararea unor derivati de azetidinona
US05/658,665 US4079181A (en) 1975-02-17 1976-02-17 Certain 7-oxo-4-thio-2,6-diazabicyclo-3,2,0-hept-2-ene compounds
BG034108A BG25076A3 (en) 1975-02-17 1976-02-17 A method of obtaining mercapto-azetidine derivatives
GB41074/78A GB1548643A (en) 1975-02-17 1976-02-17 Thiazoline ring cleavage
BG034105A BG24949A3 (en) 1975-02-17 1976-02-17 A method of obtaining mercaptoazetidine derivatives
MX890676U MX6599E (es) 1975-03-07 1976-02-17 Procedimiento para la preparacion de compuestos de mercaptoacetidina
DD7600195997A DD127901A5 (de) 1975-02-17 1976-02-17 Verfahren zur herstellung von mercaptoazetidin-derivaten
MX890576U MX6578E (es) 1975-02-21 1976-02-17 Procedimiento para preparar derivados de 4-mercaptoacetidinona
DD191283A DD124986A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1975-02-17 1976-02-17
NZ184638A NZ184638A (en) 1975-02-17 1976-02-17 Derivatives of 7-oxo-4-thia-2,6-diazobicylic-hept-2-enes
NZ184639A NZ184639A (en) 1975-02-17 1976-02-17 Azetidinones, intermediates for cephem compounds
CH191876A CH627160A5 (en) 1975-02-17 1976-02-17 Process for preparing halogenated azetidinone or thiazolinoazetidinone derivatives
BG034107A BG27557A4 (en) 1975-02-17 1976-02-17 Method of obtaining of cephemic compounds
PL1976212108A PL114624B1 (en) 1975-03-07 1976-02-17 Process for preparing novel cephem derivatives
MX890776U MX6579E (es) 1975-03-07 1976-02-17 Procedimiento para la preparacion de un compuesto de 3-oxocefem
BG034106A BG25216A3 (en) 1975-02-17 1976-02-17 A method of obtaining mercaptoazetidyne derivatives
IE313/76A IE42479B1 (en) 1975-02-17 1976-02-17 Cyclization to form a cephem ring and intermediates therefor
AR262283A AR225878A1 (es) 1975-02-17 1976-02-17 Nuevos derivados de 3-amino-2-azetidinon-1-((2-halo-acetil o 2-haloetiliden))-acetico,procedimiento para prepararlos y procedimiento para obtener compuestos 3-cefem a partir de dichos derivados
DD7600195998A DD127902A5 (de) 1975-02-17 1976-02-17 Verfahren zur herstellung von mercaptoazetidin-derivaten
NL7601613A NL190721C (nl) 1975-02-17 1976-02-17 Werkwijze voor het bereiden van 3-hydroxy-cephem derivaten.
DD7600195993A DD127899A5 (de) 1975-02-17 1976-02-17 Verfahren zur herstellung von cephem-verbindungen
ES445250A ES445250A1 (es) 1975-02-17 1976-02-17 Un procedimiento para halogenar productos intermedios para la obtencion de anillos de cefem.
BE164401A BE838656A (fr) 1975-02-17 1976-02-17 Procede de cyclisation menant au cycle de cepheme et intermediaires pour son execution
NZ184640A NZ184640A (en) 1975-02-17 1976-02-17 Derivatives of 7-oxo-4-thia-2,6-diazo-bicyclic-hept-2-enes
RO7694587A RO74958A (ro) 1975-02-17 1976-02-17 Procedeu de preparare a unor cefalosporine
MX76898U MX3818E (es) 1975-02-17 1976-02-17 Procedimiento para la preparacion de enaminas de compuestos hidroxi-3-cefem
AU11181/76A AU508160B2 (en) 1975-02-17 1976-02-17 Cyclization
NZ184641A NZ184641A (en) 1975-02-17 1976-02-17 Mercaptoazetidines, intermediates for cephem ring compounds
DE19762606278 DE2606278A1 (de) 1975-02-17 1976-02-17 Azetidin-derivate und verfahren zu ihrer herstellung
MX890376U MX6598E (es) 1975-03-07 1976-02-17 Procedimiento para la preparacaion de enaminas de compuestos 3-hidroxi-3-cefem
FR7604318A FR2334669A1 (fr) 1975-02-17 1976-02-17 Procede de cyclisation pour former un noyau de cephem et nouveaux produits ainsi obtenus
GR50078A GR60437B (en) 1975-02-17 1976-02-17 Process for cyclization to form cephem ring and intermediates therefor
YU384/76A YU40272B (en) 1975-02-17 1976-02-17 Process for producing beta-lactamine compounds
NZ180037A NZ180037A (en) 1975-02-17 1976-02-17 Derivetives of2-azetidinone and cyclisation to form cephemring
GB41073/78A GB1548642A (en) 1975-02-17 1976-02-17 2-oxo-azetidine acetic acids
PL1976212107A PL114457B1 (en) 1975-03-07 1976-02-17 Process for preparing novel derivatives of mercaptoazetidine
DD7600195995A DD127900A5 (de) 1975-02-17 1976-02-17 Verfahren zur herstellung von mercaptoazetidin-derivaten
BG032385A BG24948A3 (en) 1975-02-17 1976-02-17 A method of obtaining beta-lactam compounds
PH18164A PH18022A (en) 1975-02-17 1976-03-03 Cyclization to form cephem ring and intermediate thereof
SU762331355A SU1187717A3 (ru) 1975-03-07 1976-03-05 "cпocoб пoлучehия 2-okco-aзetидиhobыx coeдиhehий"
RO197694535A RO74936A (fr) 1975-02-17 1976-07-17 Procede pour la preparation des mercaptoazetidiones
FR7701590A FR2334684A1 (fr) 1975-03-07 1977-01-20 Procede de cyclisation d'halocetones ou d'halogenols pour former un noyau de cephem et nouveaux produits ainsi obtenus
FR7701587A FR2334686A1 (fr) 1975-02-21 1977-01-20 Procede de preparation de sulfonates d'enolesters, ainsi que d'enamines non halogenes et nouveaux produits ainsi obtenus
SU772446154A SU795463A4 (ru) 1975-03-07 1977-01-26 Способ получени 2-оксо-3-ацилами-HO-4-МЕРКАпТОАзЕТидиНОВ
SU772442946A SU791247A3 (ru) 1975-03-07 1977-01-26 Способ получени производных 3-окси-3-цефем-4-карбоновой кислоты или соответствующей 3-оксоцефам-4-карбоновой кислоты
US05/856,806 US4160085A (en) 1975-02-17 1977-12-01 Cyclization to form cephem ring and intermediates therefor
CS78970A CS207654B2 (cs) 1975-03-07 1978-02-15 Způsob přípravy derivátů 7-acylamino-3-hydroxy-3cefem-4-karboxylové kyseliny nebo jejich oxoforem
AT417178A AT351044B (de) 1975-03-07 1978-06-08 Verfahren zur herstellung von neuen azetidin- derivaten
AT417078A AT361120B (de) 1975-03-07 1978-06-08 Verfahren zur herstellung von azetidinderivaten
IL56050A IL56050A0 (en) 1975-02-17 1978-11-26 Azetidinones
IL56049A IL56049A0 (en) 1975-02-17 1978-11-26 Thiazoline ring cleavage
IL57418A IL57418A0 (en) 1975-02-17 1979-05-28 7-oxo-4-thia-2,6-diazabicyclo(3,2,0)heptene derivatives
IL57541A IL57541A0 (en) 1975-02-17 1979-06-11 7-oxo- -4-thia-2,6-diazabicyclo(3,2,0)heptene derivatives,process for their preparation and pharmaceutical compositons comprising the same
SE7907811A SE444811B (sv) 1975-02-17 1979-09-20 Azetidinylforening for framstellning av 3-hydroxi-cefemforeningar och forfarande for dess framstellning
SE7907813A SE434637B (sv) 1975-02-17 1979-09-20 Ozoniseringsforfarande for framstellning av alfa-(azetidinyl)-alfa-(hydroxietyliden)-ettiksyraforeningar
SE7907812A SE434950B (sv) 1975-02-17 1979-09-20 Forfarande for framstellning av 3-hydroxi-cefalosporinforeningar
CA000337974A CA1077936A (en) 1975-02-17 1979-10-19 Cyclization to form cephem ring and intermediates therefor
CA000337973A CA1144924A (en) 1975-02-17 1979-10-19 Cyclization to form cephem ring and intermediates therefor
CA000337975A CA1095026A (en) 1975-02-17 1979-10-19 Cyclization to form cephem ring and intermediates therefor
CA000338132A CA1132547A (en) 1975-02-17 1979-10-22 Cyclization to form cephem ring and intermediates therefor
CH75080A CH628030A5 (en) 1975-02-17 1980-01-30 Process for the preparation of an enamine compound
CH74880A CH630074A5 (en) 1975-02-17 1980-01-30 Process for preparing an acetidinone compound
CH75180A CH628031A5 (en) 1975-02-17 1980-01-30 Process for the preparation of azetidinone compounds
CH74980A CH634579A5 (en) 1975-02-17 1980-01-30 Process for preparing cephem compounds
US06/125,232 US4332722A (en) 1975-02-17 1980-02-27 Cyclization to form cephem ring and intermediates therefor
US06/125,233 US4346218A (en) 1975-02-17 1980-02-27 Cyclization process to form cephem ring
AT0286880A AT363598B (de) 1975-03-07 1980-05-29 Verfahren zur herstellung von azetidinderivaten
US06/338,651 US4440683A (en) 1975-02-17 1982-01-11 Cyclization to form cephem ring and azetidinone intermediates therefor
DK76882A DK76882A (da) 1975-02-17 1982-02-22 Mellemprodukter til dannelse af en sephemring og fremgangsmaader til fremstilling deraf
YU1738/82A YU40411B (en) 1975-02-17 1982-08-10 Process for obtaining mrcapto azetidine compounds
YU1742/82A YU40414B (en) 1975-02-17 1982-08-10 Process for obtaining new azetidinone derivatives
YU1739/82A YU40412B (en) 1975-02-17 1982-08-10 Process for producing mercapto azetidine compounds
YU1741/82A YU40413B (en) 1975-02-17 1982-08-10 Process for obtaining cephem compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP50028452A JPS609516B2 (ja) 1975-03-07 1975-03-07 セフエム骨格の環化製法

Publications (2)

Publication Number Publication Date
JPS51105088A JPS51105088A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-09-17
JPS609516B2 true JPS609516B2 (ja) 1985-03-11

Family

ID=12249046

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50028452A Expired JPS609516B2 (ja) 1975-02-17 1975-03-07 セフエム骨格の環化製法

Country Status (5)

Country Link
JP (1) JPS609516B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (2) AT361120B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR2334684A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PL (2) PL114624B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SU (2) SU1187717A3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4013651A (en) * 1975-05-12 1977-03-22 Eli Lilly And Company 3-substituted amino-cephalosporins
US4024152A (en) * 1975-09-19 1977-05-17 Eli Lilly And Company 4-Dithio-3-imido-azetidin-2-ones
CA1148938A (en) * 1979-05-08 1983-06-28 John R. Corfield Preparation of cephalosporins and intermediates employed therein
JP3195959B2 (ja) * 1991-03-13 2001-08-06 大塚化学株式会社 ３−ヒドロキシセフェム誘導体の製造法

Also Published As

Publication number Publication date
JPS51105088A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-09-17
SU1187717A3 (ru) 1985-10-23
ATA286880A (de) 1981-01-15
SU791247A3 (ru) 1980-12-23
PL114457B1 (en) 1981-01-31
AT363598B (de) 1981-08-10
FR2334684B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-03-28
FR2334684A1 (fr) 1977-07-08
PL114624B1 (en) 1981-02-28
ATA417078A (de) 1980-07-15
AT361120B (de) 1981-02-25

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