JPS60190229A - カプセル化方法 - Google Patents

カプセル化方法

Info

Publication number
JPS60190229A
JPS60190229A JP60026135A JP2613585A JPS60190229A JP S60190229 A JPS60190229 A JP S60190229A JP 60026135 A JP60026135 A JP 60026135A JP 2613585 A JP2613585 A JP 2613585A JP S60190229 A JPS60190229 A JP S60190229A
Authority
JP
Japan
Prior art keywords
membrane
capsule
polymer
gelled mass
molecular weight
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP60026135A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0150454B2 (show.php
Inventor
ウエン‐ギー・ツアン
アン・ダブリユー・シヤイー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Biotech Inc
Original Assignee
Damon Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Damon Biotech Inc filed Critical Damon Biotech Inc
Publication of JPS60190229A publication Critical patent/JPS60190229A/ja
Publication of JPH0150454B2 publication Critical patent/JPH0150454B2/ja
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012—Cell encapsulation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/74—Alginate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
JP60026135A 1984-02-13 1985-02-13 カプセル化方法 Granted JPS60190229A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/579,494 US4663286A (en) 1984-02-13 1984-02-13 Encapsulation of materials
US579494 1995-12-27

Publications (2)

Publication Number Publication Date
JPS60190229A true JPS60190229A (ja) 1985-09-27
JPH0150454B2 JPH0150454B2 (show.php) 1989-10-30

Family

ID=24317126

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60026135A Granted JPS60190229A (ja) 1984-02-13 1985-02-13 カプセル化方法

Country Status (14)

Country Link
US (1) US4663286A (show.php)
JP (1) JPS60190229A (show.php)
AU (1) AU572609B2 (show.php)
BE (1) BE901704A (show.php)
CA (1) CA1238273A (show.php)
CH (1) CH665137A5 (show.php)
DE (1) DE3504724C2 (show.php)
DK (1) DK65285A (show.php)
FR (1) FR2559502B1 (show.php)
GB (1) GB2153780B (show.php)
IT (1) IT1184885B (show.php)
NL (1) NL8500352A (show.php)
NO (1) NO850535L (show.php)
SE (1) SE8500623L (show.php)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6434436A (en) * 1987-07-28 1989-02-03 Sanyo Chemical Ind Ltd Gel cellular beads and manufacture thereof
JP2002506719A (ja) * 1998-03-19 2002-03-05 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ 層状の高分子電解質自己集合によるナノカプセルおよびマイクロカプセルの製造
JP2002520151A (ja) * 1998-07-15 2002-07-09 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ 生物学的テンプレート上の高分子電解質
JP2003522621A (ja) * 1998-03-19 2003-07-29 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ 分解性コロイド原型上のナノ複合多層の静電的自己集成体による多層被覆粒子及び中空シェルの製造
US8092836B2 (en) 1998-03-19 2012-01-10 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly

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* Cited by examiner, † Cited by third party
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EP0127989A3 (en) * 1983-06-01 1986-03-26 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4680174A (en) * 1984-05-24 1987-07-14 Damon Biotech, Inc. Induction of immune response by immunization with encapsulated antigen-producing cells
SE8405105L (sv) * 1984-05-24 1985-11-25 Damon Biotech Inc Sett for screening av celler
US4871671A (en) * 1985-04-29 1989-10-03 Minnesota Mining And Manufacturing Company Immobilization of biological cells in polytetrafluoroethylene matrix
IL79052A0 (en) * 1986-06-06 1986-11-30 Univ Ramot Device and process for production of alginate-shell beads containing biologically active material
US4923645A (en) * 1987-11-16 1990-05-08 Damon Biotech, Inc. Sustained release of encapsulated molecules
US5605835A (en) * 1988-05-23 1997-02-25 Regents Of The University Of Minnesota Bioreactor device with application as a bioartificial liver
US5389532A (en) * 1988-07-07 1995-02-14 Champagne Moet & Chandon Process of producing a dehydrated polysaccharide gel containing microorganisms for preparing fermented drinks
IL92966A (en) * 1989-01-12 1995-07-31 Pfizer Dispensing devices powered by hydrogel
JPH04505701A (ja) * 1989-02-21 1992-10-08 バイオシス 虫生線虫をパッケージ化するための方法および媒体
DE3908997A1 (de) * 1989-03-18 1990-09-20 Huels Chemische Werke Ag Verfahren zur herstellung immobilisierter hefen fuer die sektgaerung
WO1991001720A1 (en) * 1989-08-07 1991-02-21 Herman Wade Schlameus Composition and method of promoting hard tissue healing
US5101814A (en) * 1989-08-11 1992-04-07 Palti Yoram Prof System for monitoring and controlling blood glucose
US5190041A (en) * 1989-08-11 1993-03-02 Palti Yoram Prof System for monitoring and controlling blood glucose
US5459054A (en) * 1989-12-05 1995-10-17 Neocrin Company Cells encapsulated in alginate containing a high content of a- l- guluronic acid
JPH05502863A (ja) * 1989-12-05 1993-05-20 トランセル・コーポレイション 生体内適用および埋め込み用コーティング組成物同種グルロン酸―アルギン酸塩およびその使用方法
WO1991009119A1 (en) * 1989-12-13 1991-06-27 Trancel Corporation Improved alginate microcapsules, methods of making and using same
US5084350A (en) * 1990-02-16 1992-01-28 The Royal Institution For The Advance Of Learning (Mcgill University) Method for encapsulating biologically active material including cells
EP0454044B1 (de) * 1990-04-25 1995-12-06 Hoechst Aktiengesellschaft Pharmakologische Zubereitung, enthaltend Polyelektrolytkomplexe in mikropartikulärer Form und mindestens einen Wirkstoff
US5227298A (en) * 1990-08-17 1993-07-13 The Trustees Of Columbia University In The City Of New York Method for microencapuslation of cells or tissue
US5380536A (en) * 1990-10-15 1995-01-10 The Board Of Regents, The University Of Texas System Biocompatible microcapsules
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
FR2673122B1 (fr) * 1991-02-25 1994-09-09 Moet & Chandon Gel ionotrope deficient en entite ionique de gelification, procede de preparation d'un tel gel et utilisation de celui-ci notamment dans un procede d'elaboration de vin effervescent.
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
ES2107537T3 (es) * 1991-04-25 1997-12-01 Univ Brown Res Found Vehiculo inmunoaislante biocompatible implantable para suministrar productos terapeuticos seleccionados.
US5545423A (en) * 1991-11-25 1996-08-13 Vivorx, Inc. Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials
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WO1994015589A1 (en) * 1992-12-30 1994-07-21 Clover Consolidated, Limited Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials
US5170744A (en) * 1991-12-13 1992-12-15 Biosys Corporation Long-term storage of infective juvenile nematodes in pseudoplastic layers
EP0627911B1 (en) 1992-02-28 2000-10-25 Board Of Regents The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
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US5578442A (en) * 1992-03-23 1996-11-26 Vivorx, Inc. Graft copolymers of polycationic species and water-soluble polymers, and use therefor
US5334640A (en) * 1992-04-08 1994-08-02 Clover Consolidated, Ltd. Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
DE69330640T2 (de) * 1992-05-29 2002-07-04 Vivorx, Inc. Mikroverkapselung von zellen
US5578314A (en) * 1992-05-29 1996-11-26 The Regents Of The University Of California Multiple layer alginate coatings of biological tissue for transplantation
US5643594A (en) * 1992-05-29 1997-07-01 The Regents Of The University Of California Spin encapsulation apparatus and method of use
US5429821A (en) * 1992-05-29 1995-07-04 The Regents Of The University Of California Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use
US6001387A (en) * 1992-05-29 1999-12-14 The Reguents Of The University Of California Spin disk encapsulation apparatus and method of use
WO1993024076A1 (en) * 1992-05-29 1993-12-09 The Regents Of The University Of California Coated transplant and method for making same
US5521079A (en) * 1994-01-24 1996-05-28 The Regents Of The University Of California Microcapsule generating system containing an air knife and method of encapsulating
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DE4312970A1 (de) * 1993-04-21 1994-10-27 Juergen Dr Schrezenmeir Mikrokapsel sowie Verfahren und Vorrichtung zu ihrer Herstellung
ATE183078T1 (de) * 1993-08-10 1999-08-15 Gore & Ass Zelleinkapselungsvorrichtung
US5965149A (en) * 1993-08-13 1999-10-12 Thermo Trilogy Corporation Granular formulation of biological entities with improved storage stability
USRE39542E1 (en) * 1994-01-13 2007-04-03 The Rogosin Institute Preparation of agarose coated, solid agarose-collagen beads containing secretory cells
EP1418228B1 (en) * 1994-01-13 2006-03-15 The Rogosin Institute Macroencapsulated secretory cells
US5876742A (en) * 1994-01-24 1999-03-02 The Regents Of The University Of California Biological tissue transplant coated with stabilized multilayer alginate coating suitable for transplantation and method of preparation thereof
US5514377A (en) * 1994-03-08 1996-05-07 The Regents Of The University Of California In situ dissolution of alginate coatings of biological tissue transplants
US5651980A (en) * 1994-04-15 1997-07-29 Biohybrid Technologies, Inc. Methods of use of uncoated gel particles
US5916790A (en) * 1995-03-03 1999-06-29 Metabolex, Inc. Encapsulation compositions, and methods
CA2214088A1 (en) * 1995-03-03 1996-09-12 Metabolex Inc. Novel encapsulation process by a gelling polymer
JP3265918B2 (ja) * 1995-06-15 2002-03-18 矢崎総業株式会社 乾燥したゲル被覆種子の復元方法
US6096344A (en) 1995-07-28 2000-08-01 Advanced Polymer Systems, Inc. Bioerodible porous compositions
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US7041634B2 (en) 1995-09-27 2006-05-09 Emory University Method of inhibiting immune system destruction of transplanted viable cells
US7297331B2 (en) * 1996-04-03 2007-11-20 The Rogosin Institute Beads containing restricted cancer cells producing material suppressing cancer cell proliferation
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US5888497A (en) * 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
US6033887A (en) * 1997-05-05 2000-03-07 Champagne Moet & Chandon Dehydrated polysaccharide gel containing microorganisms, a sugar and a polyol for producing fermented drinks
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US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
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DE102004055729A1 (de) * 2004-11-18 2006-05-24 Cellmed Ag Herstellung von zwei-oder mehrschichtig aufgebauten Mikrokapseln
CA2602029C (en) 2005-03-11 2014-07-15 Wake Forest University Health Sciences Tissue engineered blood vessels
JP2007082485A (ja) * 2005-09-22 2007-04-05 Hitachi Plant Technologies Ltd 包括固定化担体、その製造方法、及び保管・輸送方法
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6434436A (en) * 1987-07-28 1989-02-03 Sanyo Chemical Ind Ltd Gel cellular beads and manufacture thereof
JP2002506719A (ja) * 1998-03-19 2002-03-05 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ 層状の高分子電解質自己集合によるナノカプセルおよびマイクロカプセルの製造
JP2003522621A (ja) * 1998-03-19 2003-07-29 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ 分解性コロイド原型上のナノ複合多層の静電的自己集成体による多層被覆粒子及び中空シェルの製造
US8092836B2 (en) 1998-03-19 2012-01-10 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly
US8168226B2 (en) 1998-03-19 2012-05-01 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly
JP2002520151A (ja) * 1998-07-15 2002-07-09 マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ 生物学的テンプレート上の高分子電解質

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CH665137A5 (de) 1988-04-29
AU3857285A (en) 1985-08-22
CA1238273A (en) 1988-06-21
BE901704A (fr) 1985-05-29
GB8503247D0 (en) 1985-03-13
FR2559502B1 (fr) 1988-08-26
SE8500623L (sv) 1985-08-14
NL8500352A (nl) 1985-09-02
IT8567142A0 (it) 1985-02-12
DK65285D0 (da) 1985-02-12
DE3504724C2 (de) 1987-03-26
AU572609B2 (en) 1988-05-12
DK65285A (da) 1985-08-14
IT1184885B (it) 1987-10-28
GB2153780A (en) 1985-08-29
FR2559502A1 (fr) 1985-08-16
DE3504724A1 (de) 1985-09-05
IT8567142A1 (it) 1986-08-12
GB2153780B (en) 1987-10-21
JPH0150454B2 (show.php) 1989-10-30
NO850535L (no) 1985-08-14
US4663286A (en) 1987-05-05
SE8500623D0 (sv) 1985-02-12

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