NL8500352A - Verbeterde capsulemembraanvormingstechniek. - Google Patents
Verbeterde capsulemembraanvormingstechniek. Download PDFInfo
- Publication number
- NL8500352A NL8500352A NL8500352A NL8500352A NL8500352A NL 8500352 A NL8500352 A NL 8500352A NL 8500352 A NL8500352 A NL 8500352A NL 8500352 A NL8500352 A NL 8500352A NL 8500352 A NL8500352 A NL 8500352A
- Authority
- NL
- Netherlands
- Prior art keywords
- membrane
- capsules
- polymer
- gelled
- masses
- Prior art date
Links
- 239000012528 membrane Substances 0.000 title claims description 98
- 239000002775 capsule Substances 0.000 title claims description 74
- 238000000034 method Methods 0.000 title claims description 53
- 230000015572 biosynthetic process Effects 0.000 title claims description 16
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 35
- 229920002851 polycationic polymer Polymers 0.000 claims description 21
- 239000011162 core material Substances 0.000 claims description 16
- 125000002091 cationic group Chemical group 0.000 claims description 13
- 239000002738 chelating agent Substances 0.000 claims description 13
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 12
- 238000006243 chemical reaction Methods 0.000 claims description 12
- 229920000447 polyanionic polymer Polymers 0.000 claims description 12
- 150000001768 cations Chemical class 0.000 claims description 10
- 108010039918 Polylysine Proteins 0.000 claims description 7
- 229920000656 polylysine Polymers 0.000 claims description 7
- 150000003839 salts Chemical class 0.000 claims description 7
- 230000008569 process Effects 0.000 claims description 6
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical class O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 5
- 108010055896 polyornithine Proteins 0.000 claims description 4
- 229920002714 polyornithine Polymers 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- GXVUZYLYWKWJIM-UHFFFAOYSA-N 2-(2-aminoethoxy)ethanamine Chemical compound NCCOCCN GXVUZYLYWKWJIM-UHFFFAOYSA-N 0.000 claims description 3
- 229920001284 acidic polysaccharide Polymers 0.000 claims description 3
- 150000004805 acidic polysaccharides Chemical class 0.000 claims description 3
- 125000000129 anionic group Chemical group 0.000 claims description 3
- 108010040003 polyglutamine Proteins 0.000 claims description 3
- 229920000155 polyglutamine Polymers 0.000 claims description 3
- 229920001184 polypeptide Polymers 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 229920006318 anionic polymer Polymers 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 229920001282 polysaccharide Polymers 0.000 claims description 2
- 239000005017 polysaccharide Substances 0.000 claims description 2
- 150000004804 polysaccharides Chemical class 0.000 claims description 2
- 244000089409 Erythrina poeppigiana Species 0.000 claims 1
- 229920002873 Polyethylenimine Polymers 0.000 claims 1
- 235000009776 Rathbunia alamosensis Nutrition 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 229920000831 ionic polymer Polymers 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 36
- 239000011780 sodium chloride Substances 0.000 description 27
- 239000000243 solution Substances 0.000 description 26
- 239000000499 gel Substances 0.000 description 23
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 20
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 13
- 230000035699 permeability Effects 0.000 description 12
- 239000011148 porous material Substances 0.000 description 12
- 210000004408 hybridoma Anatomy 0.000 description 11
- 239000000126 substance Substances 0.000 description 11
- 238000007654 immersion Methods 0.000 description 10
- 229920000642 polymer Polymers 0.000 description 10
- 239000001110 calcium chloride Substances 0.000 description 9
- 229910001628 calcium chloride Inorganic materials 0.000 description 9
- 239000001509 sodium citrate Substances 0.000 description 8
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 7
- 238000004132 cross linking Methods 0.000 description 7
- 239000002609 medium Substances 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- 238000005406 washing Methods 0.000 description 7
- 230000010261 cell growth Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 5
- 239000012267 brine Substances 0.000 description 5
- 229910001424 calcium ion Inorganic materials 0.000 description 5
- 229960001484 edetic acid Drugs 0.000 description 5
- 230000012010 growth Effects 0.000 description 5
- 230000016784 immunoglobulin production Effects 0.000 description 5
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 5
- 239000008000 CHES buffer Substances 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 230000008021 deposition Effects 0.000 description 4
- 238000005538 encapsulation Methods 0.000 description 4
- 239000003094 microcapsule Substances 0.000 description 4
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 3
- MKWKNSIESPFAQN-UHFFFAOYSA-N N-cyclohexyl-2-aminoethanesulfonic acid Chemical compound OS(=O)(=O)CCNC1CCCCC1 MKWKNSIESPFAQN-UHFFFAOYSA-N 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 230000036571 hydration Effects 0.000 description 3
- 238000006703 hydration reaction Methods 0.000 description 3
- 229920000729 poly(L-lysine) polymer Polymers 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 230000000717 retained effect Effects 0.000 description 3
- 239000000661 sodium alginate Substances 0.000 description 3
- 235000010413 sodium alginate Nutrition 0.000 description 3
- 229940005550 sodium alginate Drugs 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 2
- 229940072056 alginate Drugs 0.000 description 2
- 235000010443 alginic acid Nutrition 0.000 description 2
- 229920000615 alginic acid Polymers 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 239000007640 basal medium Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 239000012894 fetal calf serum Substances 0.000 description 2
- 238000001879 gelation Methods 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 229940124452 immunizing agent Drugs 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 229940074404 sodium succinate Drugs 0.000 description 2
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 230000032258 transport Effects 0.000 description 2
- 241001549606 Capulus Species 0.000 description 1
- 239000004971 Cross linker Substances 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000012868 Overgrowth Diseases 0.000 description 1
- 239000012979 RPMI medium Substances 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000011091 antibody purification Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000007630 basic procedure Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 238000005422 blasting Methods 0.000 description 1
- 210000001601 blood-air barrier Anatomy 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229950007919 egtazic acid Drugs 0.000 description 1
- 210000003527 eukaryotic cell Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 230000003328 fibroblastic effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- -1 for example Polymers 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000011278 mitosis Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 239000002510 pyrogen Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 230000018448 secretion by cell Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229960001790 sodium citrate Drugs 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/20—After-treatment of capsule walls, e.g. hardening
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0012—Cell encapsulation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
- C12N5/16—Animal cells
- C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/70—Polysaccharides
- C12N2533/74—Alginate
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Immunology (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Orthopedics, Nursing, And Contraception (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57949484 | 1984-02-13 | ||
| US06/579,494 US4663286A (en) | 1984-02-13 | 1984-02-13 | Encapsulation of materials |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL8500352A true NL8500352A (nl) | 1985-09-02 |
Family
ID=24317126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL8500352A NL8500352A (nl) | 1984-02-13 | 1985-02-07 | Verbeterde capsulemembraanvormingstechniek. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4663286A (show.php) |
| JP (1) | JPS60190229A (show.php) |
| AU (1) | AU572609B2 (show.php) |
| BE (1) | BE901704A (show.php) |
| CA (1) | CA1238273A (show.php) |
| CH (1) | CH665137A5 (show.php) |
| DE (1) | DE3504724C2 (show.php) |
| DK (1) | DK65285A (show.php) |
| FR (1) | FR2559502B1 (show.php) |
| GB (1) | GB2153780B (show.php) |
| IT (1) | IT1184885B (show.php) |
| NL (1) | NL8500352A (show.php) |
| NO (1) | NO850535L (show.php) |
| SE (1) | SE8500623L (show.php) |
Families Citing this family (97)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0127989A3 (en) * | 1983-06-01 | 1986-03-26 | Connaught Laboratories Limited | Microencapsulation of living tissue and cells |
| US4680174A (en) * | 1984-05-24 | 1987-07-14 | Damon Biotech, Inc. | Induction of immune response by immunization with encapsulated antigen-producing cells |
| SE8405105L (sv) * | 1984-05-24 | 1985-11-25 | Damon Biotech Inc | Sett for screening av celler |
| US4871671A (en) * | 1985-04-29 | 1989-10-03 | Minnesota Mining And Manufacturing Company | Immobilization of biological cells in polytetrafluoroethylene matrix |
| IL79052A0 (en) * | 1986-06-06 | 1986-11-30 | Univ Ramot | Device and process for production of alginate-shell beads containing biologically active material |
| JPS6434436A (en) * | 1987-07-28 | 1989-02-03 | Sanyo Chemical Ind Ltd | Gel cellular beads and manufacture thereof |
| US4923645A (en) * | 1987-11-16 | 1990-05-08 | Damon Biotech, Inc. | Sustained release of encapsulated molecules |
| US5605835A (en) * | 1988-05-23 | 1997-02-25 | Regents Of The University Of Minnesota | Bioreactor device with application as a bioartificial liver |
| US5389532A (en) * | 1988-07-07 | 1995-02-14 | Champagne Moet & Chandon | Process of producing a dehydrated polysaccharide gel containing microorganisms for preparing fermented drinks |
| IL92966A (en) * | 1989-01-12 | 1995-07-31 | Pfizer | Dispensing devices powered by hydrogel |
| JPH04505701A (ja) * | 1989-02-21 | 1992-10-08 | バイオシス | 虫生線虫をパッケージ化するための方法および媒体 |
| DE3908997A1 (de) * | 1989-03-18 | 1990-09-20 | Huels Chemische Werke Ag | Verfahren zur herstellung immobilisierter hefen fuer die sektgaerung |
| WO1991001720A1 (en) * | 1989-08-07 | 1991-02-21 | Herman Wade Schlameus | Composition and method of promoting hard tissue healing |
| US5101814A (en) * | 1989-08-11 | 1992-04-07 | Palti Yoram Prof | System for monitoring and controlling blood glucose |
| US5190041A (en) * | 1989-08-11 | 1993-03-02 | Palti Yoram Prof | System for monitoring and controlling blood glucose |
| US5459054A (en) * | 1989-12-05 | 1995-10-17 | Neocrin Company | Cells encapsulated in alginate containing a high content of a- l- guluronic acid |
| JPH05502863A (ja) * | 1989-12-05 | 1993-05-20 | トランセル・コーポレイション | 生体内適用および埋め込み用コーティング組成物同種グルロン酸―アルギン酸塩およびその使用方法 |
| WO1991009119A1 (en) * | 1989-12-13 | 1991-06-27 | Trancel Corporation | Improved alginate microcapsules, methods of making and using same |
| US5084350A (en) * | 1990-02-16 | 1992-01-28 | The Royal Institution For The Advance Of Learning (Mcgill University) | Method for encapsulating biologically active material including cells |
| EP0454044B1 (de) * | 1990-04-25 | 1995-12-06 | Hoechst Aktiengesellschaft | Pharmakologische Zubereitung, enthaltend Polyelektrolytkomplexe in mikropartikulärer Form und mindestens einen Wirkstoff |
| US5227298A (en) * | 1990-08-17 | 1993-07-13 | The Trustees Of Columbia University In The City Of New York | Method for microencapuslation of cells or tissue |
| US5380536A (en) * | 1990-10-15 | 1995-01-10 | The Board Of Regents, The University Of Texas System | Biocompatible microcapsules |
| US5462990A (en) * | 1990-10-15 | 1995-10-31 | Board Of Regents, The University Of Texas System | Multifunctional organic polymers |
| US5626863A (en) * | 1992-02-28 | 1997-05-06 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
| US5410016A (en) * | 1990-10-15 | 1995-04-25 | Board Of Regents, The University Of Texas System | Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers |
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|---|---|---|---|---|
| DD36655A3 (show.php) * | 1964-06-12 | 1965-11-05 | ||
| DE1917738B2 (de) * | 1969-04-05 | 1980-06-26 | Bayer Ag, 5090 Leverkusen | Verfahren zum Einbetten bzw Umhüllen von festen oder flussigen Substanzen |
| GB1302275A (show.php) * | 1970-03-26 | 1973-01-04 | ||
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| US4391909A (en) * | 1979-03-28 | 1983-07-05 | Damon Corporation | Microcapsules containing viable tissue cells |
| US4352883A (en) * | 1979-03-28 | 1982-10-05 | Damon Corporation | Encapsulation of biological material |
| NO158284C (no) * | 1981-03-13 | 1988-08-17 | Damon Biotech Inc | Fremgangsmaate for selektiv oppbrytning av en permeabel membran. |
| US4407957A (en) * | 1981-03-13 | 1983-10-04 | Damon Corporation | Reversible microencapsulation of a core material |
| US4439488A (en) * | 1982-02-26 | 1984-03-27 | The United States Of America As Represented By The Secretary Of Agriculture | Encapsulation by entrapment within polyhydroxy polymer borates |
| US4582799A (en) * | 1983-04-15 | 1986-04-15 | Damon Biotech, Inc. | Process for recovering nonsecreted substances produced by cells |
-
1984
- 1984-02-13 US US06/579,494 patent/US4663286A/en not_active Expired - Fee Related
-
1985
- 1985-02-07 NL NL8500352A patent/NL8500352A/nl not_active Application Discontinuation
- 1985-02-07 CA CA000473751A patent/CA1238273A/en not_active Expired
- 1985-02-08 GB GB08503247A patent/GB2153780B/en not_active Expired
- 1985-02-08 AU AU38572/85A patent/AU572609B2/en not_active Ceased
- 1985-02-11 BE BE0/214493A patent/BE901704A/fr not_active IP Right Cessation
- 1985-02-12 SE SE8500623A patent/SE8500623L/ not_active Application Discontinuation
- 1985-02-12 NO NO850535A patent/NO850535L/no unknown
- 1985-02-12 IT IT67142/85A patent/IT1184885B/it active
- 1985-02-12 DE DE3504724A patent/DE3504724C2/de not_active Expired
- 1985-02-12 DK DK65285A patent/DK65285A/da not_active Application Discontinuation
- 1985-02-12 CH CH642/85A patent/CH665137A5/de not_active IP Right Cessation
- 1985-02-12 FR FR8501965A patent/FR2559502B1/fr not_active Expired
- 1985-02-13 JP JP60026135A patent/JPS60190229A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| CH665137A5 (de) | 1988-04-29 |
| AU3857285A (en) | 1985-08-22 |
| CA1238273A (en) | 1988-06-21 |
| BE901704A (fr) | 1985-05-29 |
| GB8503247D0 (en) | 1985-03-13 |
| FR2559502B1 (fr) | 1988-08-26 |
| SE8500623L (sv) | 1985-08-14 |
| IT8567142A0 (it) | 1985-02-12 |
| DK65285D0 (da) | 1985-02-12 |
| DE3504724C2 (de) | 1987-03-26 |
| AU572609B2 (en) | 1988-05-12 |
| DK65285A (da) | 1985-08-14 |
| IT1184885B (it) | 1987-10-28 |
| JPS60190229A (ja) | 1985-09-27 |
| GB2153780A (en) | 1985-08-29 |
| FR2559502A1 (fr) | 1985-08-16 |
| DE3504724A1 (de) | 1985-09-05 |
| IT8567142A1 (it) | 1986-08-12 |
| GB2153780B (en) | 1987-10-21 |
| JPH0150454B2 (show.php) | 1989-10-30 |
| NO850535L (no) | 1985-08-14 |
| US4663286A (en) | 1987-05-05 |
| SE8500623D0 (sv) | 1985-02-12 |
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