FR2559502B1 - Procede d'encapsulation, notamment de cellules, dans des membranes semi-permeables - Google Patents

Procede d'encapsulation, notamment de cellules, dans des membranes semi-permeables

Info

Publication number
FR2559502B1
FR2559502B1 FR8501965A FR8501965A FR2559502B1 FR 2559502 B1 FR2559502 B1 FR 2559502B1 FR 8501965 A FR8501965 A FR 8501965A FR 8501965 A FR8501965 A FR 8501965A FR 2559502 B1 FR2559502 B1 FR 2559502B1
Authority
FR
France
Prior art keywords
encapsulation
semi
cells
permeable membranes
membranes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8501965A
Other languages
English (en)
Other versions
FR2559502A1 (fr
Inventor
Wen-Ghih Tsang
Ann Wen Shue Shyr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Biotech Inc
Original Assignee
Damon Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Damon Biotech Inc filed Critical Damon Biotech Inc
Publication of FR2559502A1 publication Critical patent/FR2559502A1/fr
Application granted granted Critical
Publication of FR2559502B1 publication Critical patent/FR2559502B1/fr
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/06Making microcapsules or microballoons by phase separation
    • B01J13/08Simple coacervation, i.e. addition of highly hydrophilic material
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/20After-treatment of capsule walls, e.g. hardening
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0012Cell encapsulation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • C12N5/12Fused cells, e.g. hybridomas
    • C12N5/16Animal cells
    • C12N5/163Animal cells one of the fusion partners being a B or a T lymphocyte
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/70Polysaccharides
    • C12N2533/74Alginate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
FR8501965A 1984-02-13 1985-02-12 Procede d'encapsulation, notamment de cellules, dans des membranes semi-permeables Expired FR2559502B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/579,494 US4663286A (en) 1984-02-13 1984-02-13 Encapsulation of materials

Publications (2)

Publication Number Publication Date
FR2559502A1 FR2559502A1 (fr) 1985-08-16
FR2559502B1 true FR2559502B1 (fr) 1988-08-26

Family

ID=24317126

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8501965A Expired FR2559502B1 (fr) 1984-02-13 1985-02-12 Procede d'encapsulation, notamment de cellules, dans des membranes semi-permeables

Country Status (14)

Country Link
US (1) US4663286A (fr)
JP (1) JPS60190229A (fr)
AU (1) AU572609B2 (fr)
BE (1) BE901704A (fr)
CA (1) CA1238273A (fr)
CH (1) CH665137A5 (fr)
DE (1) DE3504724A1 (fr)
DK (1) DK65285A (fr)
FR (1) FR2559502B1 (fr)
GB (1) GB2153780B (fr)
IT (1) IT1184885B (fr)
NL (1) NL8500352A (fr)
NO (1) NO850535L (fr)
SE (1) SE8500623L (fr)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127989A3 (fr) * 1983-06-01 1986-03-26 Connaught Laboratories Limited Micro-encapsulation de tissu vivant et de cellules
US4680174A (en) * 1984-05-24 1987-07-14 Damon Biotech, Inc. Induction of immune response by immunization with encapsulated antigen-producing cells
SE8405105L (sv) * 1984-05-24 1985-11-25 Damon Biotech Inc Sett for screening av celler
US4871671A (en) * 1985-04-29 1989-10-03 Minnesota Mining And Manufacturing Company Immobilization of biological cells in polytetrafluoroethylene matrix
IL79052A0 (en) * 1986-06-06 1986-11-30 Univ Ramot Device and process for production of alginate-shell beads containing biologically active material
JPS6434436A (en) * 1987-07-28 1989-02-03 Sanyo Chemical Ind Ltd Gel cellular beads and manufacture thereof
US4923645A (en) * 1987-11-16 1990-05-08 Damon Biotech, Inc. Sustained release of encapsulated molecules
US5605835A (en) * 1988-05-23 1997-02-25 Regents Of The University Of Minnesota Bioreactor device with application as a bioartificial liver
US5389532A (en) * 1988-07-07 1995-02-14 Champagne Moet & Chandon Process of producing a dehydrated polysaccharide gel containing microorganisms for preparing fermented drinks
IL92966A (en) * 1989-01-12 1995-07-31 Pfizer Hydrogel-operated release devices
WO1990010063A1 (fr) * 1989-02-21 1990-09-07 Biosys Procede et milieu d'emballage de nematodes entomogenes
DE3908997A1 (de) * 1989-03-18 1990-09-20 Huels Chemische Werke Ag Verfahren zur herstellung immobilisierter hefen fuer die sektgaerung
WO1991001720A1 (fr) * 1989-08-07 1991-02-21 Herman Wade Schlameus Composition et procede favorisant la cicatrisation de tissus durs
US5190041A (en) * 1989-08-11 1993-03-02 Palti Yoram Prof System for monitoring and controlling blood glucose
US5101814A (en) * 1989-08-11 1992-04-07 Palti Yoram Prof System for monitoring and controlling blood glucose
WO1991007951A1 (fr) * 1989-12-05 1991-06-13 Trancel Corporation Composition de revêtement a base d'alginate comprenant de l'acide guluronique homologue destinee a etre appliquee et implantee in vivo et procede d'utilisation
US5459054A (en) * 1989-12-05 1995-10-17 Neocrin Company Cells encapsulated in alginate containing a high content of a- l- guluronic acid
WO1991009119A1 (fr) * 1989-12-13 1991-06-27 Trancel Corporation Microcapsules d'alginate ameliorees et procedes pour leur fabrication et leur utilisation
US5084350A (en) * 1990-02-16 1992-01-28 The Royal Institution For The Advance Of Learning (Mcgill University) Method for encapsulating biologically active material including cells
DE59107006D1 (de) * 1990-04-25 1996-01-18 Hoechst Ag Pharmakologische Zubereitung, enthaltend Polyelektrolytkomplexe in mikropartikulärer Form und mindestens einen Wirkstoff.
US5227298A (en) * 1990-08-17 1993-07-13 The Trustees Of Columbia University In The City Of New York Method for microencapuslation of cells or tissue
US5462990A (en) * 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5380536A (en) 1990-10-15 1995-01-10 The Board Of Regents, The University Of Texas System Biocompatible microcapsules
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
FR2673122B1 (fr) * 1991-02-25 1994-09-09 Moet & Chandon Gel ionotrope deficient en entite ionique de gelification, procede de preparation d'un tel gel et utilisation de celui-ci notamment dans un procede d'elaboration de vin effervescent.
JP4215273B2 (ja) * 1991-04-25 2009-01-28 ブラウン ユニヴァーシティ リサーチ ファンデーション 選択された治療物質放出用の移植可能で生体適合性の免疫遮断性ビークル
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
WO1994015589A1 (fr) * 1992-12-30 1994-07-21 Clover Consolidated, Limited Systemes de conditionnement de substances biologiquement actives dans des macrocapsules recuperables, biocompatibles et cytoprotectrices
US5545423A (en) * 1991-11-25 1996-08-13 Vivorx, Inc. Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials
AU687728B2 (en) * 1991-11-25 1998-03-05 Vivorx, Inc. Cytoprotective, biocompatible, retrievable macrocapsule containment systems for biologically active materials
US5170744A (en) * 1991-12-13 1992-12-15 Biosys Corporation Long-term storage of infective juvenile nematodes in pseudoplastic layers
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
PT627911E (pt) * 1992-02-28 2001-04-30 Univ Texas Hidrogeis biodegradaveis fotopolimerizaveis como materiais de contacto de tecidos e veiculos de libertacao controlada
US5578442A (en) * 1992-03-23 1996-11-26 Vivorx, Inc. Graft copolymers of polycationic species and water-soluble polymers, and use therefor
US5334640A (en) * 1992-04-08 1994-08-02 Clover Consolidated, Ltd. Ionically covalently crosslinked and crosslinkable biocompatible encapsulation compositions and methods
US5578314A (en) * 1992-05-29 1996-11-26 The Regents Of The University Of California Multiple layer alginate coatings of biological tissue for transplantation
US5429821A (en) * 1992-05-29 1995-07-04 The Regents Of The University Of California Non-fibrogenic high mannuronate alginate coated transplants, processes for their manufacture, and methods for their use
US5521079A (en) * 1994-01-24 1996-05-28 The Regents Of The University Of California Microcapsule generating system containing an air knife and method of encapsulating
US6001387A (en) * 1992-05-29 1999-12-14 The Reguents Of The University Of California Spin disk encapsulation apparatus and method of use
US5643594A (en) * 1992-05-29 1997-07-01 The Regents Of The University Of California Spin encapsulation apparatus and method of use
WO1993024076A1 (fr) * 1992-05-29 1993-12-09 The Regents Of The University Of California Transplant revetu et procede de fabrication correspondant
ATE204470T1 (de) * 1992-05-29 2001-09-15 Vivorx Inc Mikroverkapselung von zellen
WO1994012161A1 (fr) * 1992-11-24 1994-06-09 Clover Consolidated, Limited Macrocapsules cytoprotectrices, biocompatibles et recuperables
DE4312970A1 (de) * 1993-04-21 1994-10-27 Juergen Dr Schrezenmeir Mikrokapsel sowie Verfahren und Vorrichtung zu ihrer Herstellung
DK0663817T3 (da) 1993-08-10 2000-03-13 Gore & Ass Celleindkapslingsindretning
US5965149A (en) * 1993-08-13 1999-10-12 Thermo Trilogy Corporation Granular formulation of biological entities with improved storage stability
USRE39542E1 (en) * 1994-01-13 2007-04-03 The Rogosin Institute Preparation of agarose coated, solid agarose-collagen beads containing secretory cells
ES2260568T3 (es) * 1994-01-13 2006-11-01 The Rogosin Institute Celulas secretoras macroencapsuladas.
US5876742A (en) * 1994-01-24 1999-03-02 The Regents Of The University Of California Biological tissue transplant coated with stabilized multilayer alginate coating suitable for transplantation and method of preparation thereof
US5514377A (en) * 1994-03-08 1996-05-07 The Regents Of The University Of California In situ dissolution of alginate coatings of biological tissue transplants
US5651980A (en) * 1994-04-15 1997-07-29 Biohybrid Technologies, Inc. Methods of use of uncoated gel particles
JPH11501512A (ja) * 1995-03-03 1999-02-09 メタボレックス,インコーポレイティド ゲル化ポリマーによる新規の被包方法
US5916790A (en) * 1995-03-03 1999-06-29 Metabolex, Inc. Encapsulation compositions, and methods
JP3265918B2 (ja) * 1995-06-15 2002-03-18 矢崎総業株式会社 乾燥したゲル被覆種子の復元方法
US6096344A (en) * 1995-07-28 2000-08-01 Advanced Polymer Systems, Inc. Bioerodible porous compositions
WO1997010807A1 (fr) * 1995-09-22 1997-03-27 Gore Hybrid Technologies, Inc. Dispositif ameliore d'encapsulation de cellules
US7041634B2 (en) 1995-09-27 2006-05-09 Emory University Method of inhibiting immune system destruction of transplanted viable cells
US7297331B2 (en) * 1996-04-03 2007-11-20 The Rogosin Institute Beads containing restricted cancer cells producing material suppressing cancer cell proliferation
US5888497A (en) * 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
US6224912B1 (en) 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
DE69738170T2 (de) * 1996-04-03 2008-01-24 The Rogosin Institute Konditioniertes Medium und diffusionsfähiges biologisches Material gewonnen durch Inkubierung von eingeschlossenen Zellen
US6033887A (en) * 1997-05-05 2000-03-07 Champagne Moet & Chandon Dehydrated polysaccharide gel containing microorganisms, a sugar and a polyol for producing fermented drinks
GB2327074B (en) * 1997-07-07 2001-09-12 Norsk Hydro As Improvements in or relating to capsules
US6368612B1 (en) 1997-12-12 2002-04-09 Biohybrid Technologies Llc Devices for cloaking transplanted cells
US6958148B1 (en) 1998-01-20 2005-10-25 Pericor Science, Inc. Linkage of agents to body tissue using microparticles and transglutaminase
US6919076B1 (en) 1998-01-20 2005-07-19 Pericor Science, Inc. Conjugates of agents and transglutaminase substrate linking molecules
US7101575B2 (en) * 1998-03-19 2006-09-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Production of nanocapsules and microcapsules by layer-wise polyelectrolyte self-assembly
ATE228883T1 (de) * 1998-03-19 2002-12-15 Max Planck Gesellschaft Herstellung von mit mehrlagen gestrichenen partikeln und hohlen schalen durch elektrostatische selbstorganisierung von nanokompositmehrlagen auf zersetzbaren schablonen
WO1999047252A2 (fr) * 1998-03-19 1999-09-23 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Production de nanogelules et de microgelules par auto-assemblage stratiforme de polyelectrolytes
WO2000003797A1 (fr) * 1998-07-15 2000-01-27 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Revetement polyelectrolytique de specimens biologiques
WO2000029206A1 (fr) * 1998-11-13 2000-05-25 Sensor Technologies Inc. Preparations monodispersees utiles pour des protheses
US6495161B1 (en) * 1999-03-09 2002-12-17 Vivorx, Inc. Cytoprotective biocompatible containment systems for biologically active materials and methods of making same
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
AU1186401A (en) 1999-06-23 2001-01-22 Sedum Laboratories, Inc. Ionically formulated biomolecule microcarriers
AU2001246440A1 (en) * 2000-02-29 2001-09-12 Rainer Pommersheim Microcapsule, in particular, for immobilizing organic or inorganic solids, liquids and/or gases
AU2001273234A1 (en) * 2000-07-05 2002-01-14 Islet Technology, Inc. Method and system for consistent and effective encapsulation of biological material
US6790455B2 (en) * 2001-09-14 2004-09-14 The Research Foundation At State University Of New York Cell delivery system comprising a fibrous matrix and cells
WO2004075855A2 (fr) * 2003-02-26 2004-09-10 Biomed Solutions, Llc Procede de traitement in vivo de cibles biologiques specifiques dans un fluide corporel
US20050053586A1 (en) 2003-09-04 2005-03-10 Bryan Conn Entrapped stem cells and uses thereof
US20050095174A1 (en) * 2003-10-31 2005-05-05 Wolf David E. Semipermeable sensors for detecting analyte
DE102004013637A1 (de) * 2004-03-19 2005-10-13 Capsulution Nanoscience Ag Verfahren zur Herstellung von CS-Partikeln und Mikrokapseln unter Verwendung poröser Template sowie CS-Partikel und Mikrokapseln
DE102004019241A1 (de) * 2004-04-16 2005-11-03 Cellmed Ag Injizierbare vernetzte und unvernetzte Alginate und ihre Verwendung in der Medizin und in der ästhetischen Chirurgie
EP1595534A1 (fr) * 2004-05-13 2005-11-16 Universiteit Utrecht Holding B.V. Gel composant des polymeres charges
EP1807506B1 (fr) * 2004-10-08 2013-04-17 Georgia Tech Research Corporation Microencapsulation de cellules dans des hydrogels a l'aide de potentiels electrostatiques
DE102004055729A1 (de) * 2004-11-18 2006-05-24 Cellmed Ag Herstellung von zwei-oder mehrschichtig aufgebauten Mikrokapseln
JP5232636B2 (ja) 2005-03-11 2013-07-10 ウエイク・フオレスト・ユニバーシテイ・ヘルス・サイエンシズ 組織の工作された血管
JP2007082485A (ja) * 2005-09-22 2007-04-05 Hitachi Plant Technologies Ltd 包括固定化担体、その製造方法、及び保管・輸送方法
US20090196854A1 (en) * 2008-02-04 2009-08-06 Kytos Biosystems S.A. Methods and compositions for use of crl 5803 cells for expression of biotherapeutics and encapsulated cell-based delivery
US9694055B2 (en) 2008-05-09 2017-07-04 Wake Forest University Health Sciences Renal tissue regeneration
WO2011046609A2 (fr) * 2009-10-15 2011-04-21 Appleton Papers Inc. Encapsulation
EP2680862B1 (fr) 2011-03-04 2016-07-20 Wake Forest University Health Sciences Cellules encapsulées pour hormonothérapie substitutive
MX2013011040A (es) 2011-03-29 2014-08-22 Beta Cell Nv Metodo para productos terapeuticos encapsulados y usos de los mismos.
US20140113138A1 (en) * 2011-06-29 2014-04-24 The University Of Akron Method of encapsulation and immobilization
US11096898B2 (en) 2018-11-16 2021-08-24 GH Care Inc. Alginate microcapsules for cell and molecular therapy that secrete bioactive immune molecules

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD36655A3 (fr) * 1964-06-12 1965-11-05
DE1917738B2 (de) * 1969-04-05 1980-06-26 Bayer Ag, 5090 Leverkusen Verfahren zum Einbetten bzw Umhüllen von festen oder flussigen Substanzen
GB1302275A (fr) * 1970-03-26 1973-01-04
US4352883A (en) * 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4391909A (en) * 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
NO158284C (no) * 1981-03-13 1988-08-17 Damon Biotech Inc Fremgangsmaate for selektiv oppbrytning av en permeabel membran.
US4407957A (en) * 1981-03-13 1983-10-04 Damon Corporation Reversible microencapsulation of a core material
US4439488A (en) * 1982-02-26 1984-03-27 The United States Of America As Represented By The Secretary Of Agriculture Encapsulation by entrapment within polyhydroxy polymer borates
US4582799A (en) * 1983-04-15 1986-04-15 Damon Biotech, Inc. Process for recovering nonsecreted substances produced by cells

Also Published As

Publication number Publication date
CH665137A5 (de) 1988-04-29
GB2153780A (en) 1985-08-29
IT8567142A0 (it) 1985-02-12
IT1184885B (it) 1987-10-28
FR2559502A1 (fr) 1985-08-16
DE3504724A1 (de) 1985-09-05
DK65285D0 (da) 1985-02-12
CA1238273A (fr) 1988-06-21
JPS60190229A (ja) 1985-09-27
AU3857285A (en) 1985-08-22
DE3504724C2 (fr) 1987-03-26
AU572609B2 (en) 1988-05-12
BE901704A (fr) 1985-05-29
DK65285A (da) 1985-08-14
GB2153780B (en) 1987-10-21
IT8567142A1 (it) 1986-08-12
JPH0150454B2 (fr) 1989-10-30
US4663286A (en) 1987-05-05
GB8503247D0 (en) 1985-03-13
NL8500352A (nl) 1985-09-02
NO850535L (no) 1985-08-14
SE8500623D0 (sv) 1985-02-12
SE8500623L (sv) 1985-08-14

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