JPS6018653B2 - 新規な２，６−ジ置換２−フエニルイミノ−イミダゾリジンおよびその酸付加塩の製造方法 - Google Patents

新規な２，６−ジ置換２−フエニルイミノ−イミダゾリジンおよびその酸付加塩の製造方法

Info

Publication number
JPS6018653B2
JPS6018653B2 JP50118196A JP11819675A JPS6018653B2 JP S6018653 B2 JPS6018653 B2 JP S6018653B2 JP 50118196 A JP50118196 A JP 50118196A JP 11819675 A JP11819675 A JP 11819675A JP S6018653 B2 JPS6018653 B2 JP S6018653B2
Authority
JP
Japan
Prior art keywords
formula
group
chloro
acid addition
bromo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP50118196A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5159863A (en
Inventor
シユタ−レ ヘルム−ト
コ−ペ ヘルベルト
クンメル ベルネク
ホエフケ ボルフガンク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
C.H. Boehringer Sohn AG and Co KG
Original Assignee
C.H. Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.H. Boehringer Sohn AG and Co KG filed Critical C.H. Boehringer Sohn AG and Co KG
Publication of JPS5159863A publication Critical patent/JPS5159863A/ja
Publication of JPS6018653B2 publication Critical patent/JPS6018653B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP50118196A 1974-10-01 1975-09-30 新規な２，６−ジ置換２−フエニルイミノ−イミダゾリジンおよびその酸付加塩の製造方法 Expired JPS6018653B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2446758.1 1974-10-01
DE2446758A DE2446758C3 (de) 1974-10-01 1974-10-01 2-(2-Fluor-6-trifluormethylphenylimino)-imidazolidin, dessen Säureadditionssalze, Verfahren zur Herstellung dieser Verbindungen und deren Verwendung bei der Bekämpfung der Hypertonie

Publications (2)

Publication Number Publication Date
JPS5159863A JPS5159863A (en) 1976-05-25
JPS6018653B2 true JPS6018653B2 (ja) 1985-05-11

Family

ID=5927202

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50118196A Expired JPS6018653B2 (ja) 1974-10-01 1975-09-30 新規な２，６−ジ置換２−フエニルイミノ−イミダゾリジンおよびその酸付加塩の製造方法

Country Status (27)

Country Link
JP (1) JPS6018653B2 (enExample)
AT (1) AT344159B (enExample)
BE (1) BE834051A (enExample)
BG (2) BG25220A3 (enExample)
CA (1) CA1056836A (enExample)
CH (5) CH620682A5 (enExample)
CS (1) CS193524B2 (enExample)
DD (1) DD123602A5 (enExample)
DE (1) DE2446758C3 (enExample)
DK (1) DK441875A (enExample)
ES (4) ES441385A1 (enExample)
FI (1) FI61883C (enExample)
FR (1) FR2286649A1 (enExample)
GB (1) GB1515019A (enExample)
HU (1) HU178469B (enExample)
IE (1) IE42130B1 (enExample)
IL (1) IL48214A (enExample)
LU (1) LU73472A1 (enExample)
NL (1) NL7511490A (enExample)
NO (1) NO143459C (enExample)
NZ (1) NZ178810A (enExample)
PH (1) PH13653A (enExample)
PL (2) PL98984B1 (enExample)
SE (1) SE418497B (enExample)
SU (1) SU575026A3 (enExample)
YU (1) YU230281A (enExample)
ZA (1) ZA756185B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2630060C2 (de) * 1976-07-03 1984-04-19 C.H. Boehringer Sohn, 6507 Ingelheim 2-(2-Brom-6-fluor-phenylimino)-imidazolidin, dessen Säureadditionssalze, diese enthaltende Arzneimittel und Verfahren zu deren Herstellung
DE2806775A1 (de) * 1978-02-17 1979-08-30 Boehringer Sohn Ingelheim Neue substituierte 2-phenylimino- imidazolidine deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
DE2806811A1 (de) * 1978-02-17 1979-08-23 Boehringer Sohn Ingelheim Neue substituierte 2-phenylimino- imidazolidine, deren saeureadditionssalze, diese enthaltene arzneimittel und verfahren zur herstellung derselben
ZA801680B (en) * 1979-04-03 1981-03-25 Fujisawa Pharmaceutical Co 2-imidazoline derivatives,process for the preparation thereof and the pharmaceutical composition of the same
HU192986B (en) 1984-05-23 1987-08-28 Egyt Gyogyszervegyeszeti Gyar Process for production of imidasodiline derivatives
JP2009524619A (ja) * 2006-01-27 2009-07-02 エフ．ホフマン−ラ ロシュ アーゲー Ｃｎｓ障害の処置のための２−イミダゾールの使用
CA2675221C (en) 2007-02-02 2016-02-23 F. Hoffmann-La Roche Ag Novel 2-aminooxazolines as taar1 ligands
MX2009008465A (es) 2007-02-15 2009-08-20 Hoffmann La Roche Nuevas 2-aminooxazolinas como ligandos de taar1.
US8242153B2 (en) 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
US8354441B2 (en) 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
RS60825B1 (sr) 2016-03-17 2020-10-30 Hoffmann La Roche Aktivnost derivata 5-etiol-4-metil-pirazol-3-karboksamida kao agonista taar-a

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3236857A (en) * 1961-10-09 1966-02-22 Boehringer Sohn Ingelheim 2-(phenyl-amino)-1, 3-diazacyclopentene-(2) substitution products
DE1670807A1 (de) * 1967-02-17 1971-03-11 Bayer Ag Verfahren zur Herstellung von cyclischen Guanidinen
DE1670918A1 (de) * 1967-09-07 1971-04-08 Bayer Ag Verfahren zur Herstellung von 2-Aryl-amino-substituierten stickstoffhaltigen Heterocyclen
BE787683A (fr) * 1971-08-20 1973-02-19 Boehringer Sohn Ingelheim 2-phenylimino-imidazolidines, leurs sels d'addition avec des acides et procedes pour les fabriquer

Also Published As

Publication number Publication date
ES444901A1 (es) 1977-04-16
BG25221A3 (bg) 1978-08-10
CH627454A5 (en) 1982-01-15
PL97003B1 (pl) 1978-01-31
NZ178810A (en) 1978-04-03
DD123602A5 (enExample) 1977-01-05
DE2446758A1 (de) 1976-04-22
ES441385A1 (es) 1977-08-01
ES444900A1 (es) 1977-04-16
CH627453A5 (en) 1982-01-15
HU178469B (en) 1982-05-28
NO753314L (enExample) 1976-04-02
NO143459B (no) 1980-11-10
CH626352A5 (en) 1981-11-13
ES444898A1 (es) 1977-05-16
FI61883C (fi) 1982-10-11
LU73472A1 (enExample) 1977-05-16
CA1056836A (en) 1979-06-19
DK441875A (da) 1976-04-02
FR2286649A1 (fr) 1976-04-30
DE2446758C3 (de) 1979-01-04
NO143459C (no) 1981-02-18
SE418497B (sv) 1981-06-09
JPS5159863A (en) 1976-05-25
IL48214A (en) 1979-10-31
CS193524B2 (en) 1979-10-31
SE7511028L (sv) 1976-04-02
PL98984B1 (pl) 1978-06-30
BE834051A (fr) 1976-03-30
YU230281A (en) 1982-02-28
ZA756185B (en) 1977-06-29
CH627452A5 (en) 1982-01-15
NL7511490A (nl) 1976-04-05
SU575026A3 (ru) 1977-09-30
FI752728A7 (enExample) 1976-04-02
AU8529875A (en) 1977-04-07
AT344159B (de) 1978-07-10
GB1515019A (en) 1978-06-21
ATA722875A (de) 1977-11-15
IE42130B1 (en) 1980-06-04
BG25220A3 (bg) 1978-08-10
IL48214A0 (en) 1975-11-25
FI61883B (fi) 1982-06-30
PH13653A (en) 1980-08-21
CH620682A5 (en) 1980-12-15
FR2286649B1 (enExample) 1979-09-14
DE2446758B2 (de) 1978-05-18
IE42130L (en) 1976-04-01

Similar Documents

Publication Publication Date Title
ES2410793T3 (es) Nuevo procedimiento para la preparación de derivados de 2-imino-tiazolidin-4-ona
US4125620A (en) 2-[(2',6'-Disubstituted-phenyl)-imino]-imidazolidines and salts thereof
KR860002034B1 (ko) 벤조티아제핀 유도체의 제조방법
US4174397A (en) Thiazolidine derivatives
JP2012501346A5 (enExample)
JPH0359903B2 (enExample)
CA1056836A (en) 2,6-disubstituted 2-phenylimino-imidazolidines their acid addition salts, pharmaceuticals containing same and processes for their production
JPWO1992002514A1 (ja) 新規なベンゾピラン誘導体
NO136360B (enExample)
JP2707936B2 (ja) β−オキソ−β−ベンゼンプロパンチオアミド誘導体
JPS6351381A (ja) ベンゾチアゼピン誘導体
US3634508A (en) Phenylacetylguanidines
JP2876712B2 (ja) 光学活性ピラノベンゾオキサジアゾール誘導体
US4556739A (en) 3,4-Dialkoxy-2-alkylcarbonyl analino compounds
IE45109B1 (en) An n-2-imidazolidinylidene-benzeneamine and salts thereof
FR2468370A1 (fr) Nouvelles pyridothienotriazines et leur procede de preparation
FI64145B (fi) Foerfarande foer framstaellning av 2-arylamino-2-imidazolinderivat
CN101456862B (zh) 含有吡唑并嘧啶酮的苯基胍衍生物、其药物组合物及其制备方法和用途
US3086972A (en) Aza-thiaxanthene derivatives
US3740413A (en) 2-benzimidazolecarboxamides
HU192501B (en) Process for producing /2-methyl-propoxy/-methyl-n-phenyl-n-/phenyl-methyl/-1-pyrrolidin-ethanamine
JP2579116B2 (ja) 新規な４−メチル−１，３−オキサゾール化合物、それらの調製法およびそれらを含む医薬組成物
JPH0413666A (ja) １―（アルコキシフェニル）―３―（４，５，６，７―テトラヒドロベンズイミダゾリル）ウレア
CA1062267A (en) Process for the preparation of 1-benxoyl-2-(2',6'-dichlorophenylamino)-2-imidazoline and salts thereof
JPS5821634B2 (ja) シンキイミダゾ （１，２−ａ）ｓ− トリアジンルイノセイゾウホウホウ