JPS5946205B2 - ベンゾイル誘導体を有効成分とする消炎鎮痛剤 - Google Patents

ベンゾイル誘導体を有効成分とする消炎鎮痛剤

Info

Publication number
JPS5946205B2
JPS5946205B2 JP51000232A JP23276A JPS5946205B2 JP S5946205 B2 JPS5946205 B2 JP S5946205B2 JP 51000232 A JP51000232 A JP 51000232A JP 23276 A JP23276 A JP 23276A JP S5946205 B2 JPS5946205 B2 JP S5946205B2
Authority
JP
Japan
Prior art keywords
group
compound
mol
active ingredient
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP51000232A
Other languages
English (en)
Japanese (ja)
Other versions
JPS5283937A (en
Inventor
泰彦 浜崎
昭三 河端
俊之 山本
泰夫 白石
明 上野
功治 雨宮
克昌 嵯峨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaken Pharmaceutical Co Ltd
Original Assignee
Kaken Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaken Pharmaceutical Co Ltd filed Critical Kaken Pharmaceutical Co Ltd
Priority to JP51000232A priority Critical patent/JPS5946205B2/ja
Priority to GB51719/76A priority patent/GB1556263A/en
Priority to AU20715/76A priority patent/AU504411B2/en
Priority to FR7638882A priority patent/FR2336923A1/fr
Priority to US05/755,069 priority patent/US4124726A/en
Priority to NL7614567A priority patent/NL7614567A/xx
Priority to DE19762659580 priority patent/DE2659580A1/de
Priority to BE173778A priority patent/BE850024A/xx
Publication of JPS5283937A publication Critical patent/JPS5283937A/ja
Priority to US05/856,919 priority patent/US4145444A/en
Publication of JPS5946205B2 publication Critical patent/JPS5946205B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/28—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/784—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic with all keto groups bound to a non-condensed ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/792—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/794—Ketones containing a keto group bound to a six-membered aromatic ring having unsaturation outside an aromatic ring
    • C07C49/796—Ketones containing a keto group bound to a six-membered aromatic ring having unsaturation outside an aromatic ring polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP51000232A 1976-01-01 1976-01-01 ベンゾイル誘導体を有効成分とする消炎鎮痛剤 Expired JPS5946205B2 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP51000232A JPS5946205B2 (ja) 1976-01-01 1976-01-01 ベンゾイル誘導体を有効成分とする消炎鎮痛剤
GB51719/76A GB1556263A (en) 1976-01-01 1976-12-10 Anti-inflammatory compositions comprising benzophenones
AU20715/76A AU504411B2 (en) 1976-01-01 1976-12-17 Substituted benzophenones
FR7638882A FR2336923A1 (fr) 1976-01-01 1976-12-23 Agent anti-inflammatoire a base d'un derive benzoyle
US05/755,069 US4124726A (en) 1976-01-01 1976-12-28 Anti-inflammatory agent of benzoyl derivative
NL7614567A NL7614567A (nl) 1976-01-01 1976-12-30 Werkwijze ter bereiding van een geneesmiddel en werkwijze ter bereiding van de geneeskrachtige verbinding.
DE19762659580 DE2659580A1 (de) 1976-01-01 1976-12-30 Entzuendungshemmendes mittel
BE173778A BE850024A (fr) 1976-01-01 1976-12-31 Agent anti-inflammatoire a base d'un derive benzoyle
US05/856,919 US4145444A (en) 1976-01-01 1977-12-02 Anti-inflammatory agent of benzoyl derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP51000232A JPS5946205B2 (ja) 1976-01-01 1976-01-01 ベンゾイル誘導体を有効成分とする消炎鎮痛剤

Publications (2)

Publication Number Publication Date
JPS5283937A JPS5283937A (en) 1977-07-13
JPS5946205B2 true JPS5946205B2 (ja) 1984-11-10

Family

ID=11468211

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51000232A Expired JPS5946205B2 (ja) 1976-01-01 1976-01-01 ベンゾイル誘導体を有効成分とする消炎鎮痛剤

Country Status (8)

Country Link
US (1) US4124726A (Direct)
JP (1) JPS5946205B2 (Direct)
AU (1) AU504411B2 (Direct)
BE (1) BE850024A (Direct)
DE (1) DE2659580A1 (Direct)
FR (1) FR2336923A1 (Direct)
GB (1) GB1556263A (Direct)
NL (1) NL7614567A (Direct)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237140A (en) * 1979-05-18 1980-12-02 E. I. Du Pont De Nemours And Company Analgesic mixture of nalbuphine and acetaminophen
US5236952A (en) * 1986-03-11 1993-08-17 Hoffmann-La Roche Inc. Catechol derivatives
DE3643403A1 (de) * 1986-12-19 1988-06-30 Shell Agrar Gmbh & Co Kg Benzophenone und verfahren zu ihrer herstellung
DE68915269T2 (de) * 1988-11-25 1994-09-29 Dainippon Ink & Chemicals Polyvalentes entzündungshemmendes mittel.
JP2664790B2 (ja) * 1990-01-10 1997-10-22 サンスター株式会社 紅斑抑制用の外用抗炎症剤
EP0641301A1 (en) * 1992-05-21 1995-03-08 Research Corporation Technologies, Inc. Stilbene derivatives as anticancer agents
DE59310066D1 (de) * 1992-11-04 2000-08-03 Clariant Gmbh Verfahren zur Herstellung fluorierter Benzile
US5773663A (en) * 1996-05-01 1998-06-30 American Cyanamid Company Fungicidal methods, compounds and compositions containing benzophenones
US5679866A (en) * 1995-01-20 1997-10-21 American Cyanamid Company Fungicidal methods, compounds and compositions containing benzophenones
US5723676A (en) * 1996-07-01 1998-03-03 Alliedsignal Inc. Process for producing benzophenone compounds
US5990056A (en) * 1997-06-04 1999-11-23 Mobil Oil Corporation Compositions containing an organo-substituted benzophenone
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
JP2008539047A (ja) 2005-04-28 2008-11-13 プロテウス バイオメディカル インコーポレイテッド ファーマインフォーマティックスシステム
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
CN102458374A (zh) 2009-05-06 2012-05-16 实验室护肤股份有限公司 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN102775289B (zh) * 2011-05-13 2015-04-22 山东中医药大学 白首乌二苯酮类化合物及其制备方法与用途
CN111393277B (zh) * 2020-03-15 2023-01-03 山西医科大学 4-丁基多羟基二苯甲酮类化合物衍生物及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2671016A (en) * 1951-10-23 1954-03-02 Monsanto Chemicals Herbicidal compositions
US2802032A (en) * 1955-06-22 1957-08-06 Monsanto Chemicals 3, 4-dimethylbenzophenone
US3924002A (en) * 1969-07-17 1975-12-02 Ciba Geigy Ag Method for combatting harmful microorganisms
US3755450A (en) * 1969-07-31 1973-08-28 American Cyanamid Co Free flowing uv absorber compositions with magnesium or zinc salts offatty acids
US3898275A (en) * 1970-11-20 1975-08-05 Sandoz Ag M-Substituted benzophenones
US3983176A (en) * 1971-08-24 1976-09-28 Nippon Kayaku Kabushiki Kaisha Benzophenones as plant growth regulants
DE2256662A1 (de) 1972-11-18 1974-05-22 Basf Ag Verfahren zur herstellung von 3-monochlor-2,4,5-trialkylbenzophenonen und 3,6-dichlor-2,4,5-trialkylbenzophenonen
US3954875A (en) * 1973-12-26 1976-05-04 Rohm And Haas Company Benzophenone herbicides
FR2292467A1 (fr) * 1974-11-28 1976-06-25 Roussel Uclaf Nouveaux derives de la benzophenone, leur procede de preparation et leur application comme medicament

Also Published As

Publication number Publication date
NL7614567A (nl) 1977-07-05
GB1556263A (en) 1979-11-21
US4124726A (en) 1978-11-07
DE2659580A1 (de) 1977-07-14
FR2336923A1 (fr) 1977-07-29
FR2336923B1 (Direct) 1980-04-11
AU504411B2 (en) 1979-10-11
JPS5283937A (en) 1977-07-13
BE850024A (fr) 1977-06-30
AU2071576A (en) 1978-06-22

Similar Documents

Publication Publication Date Title
JPS5946205B2 (ja) ベンゾイル誘導体を有効成分とする消炎鎮痛剤
JPH02268178A (ja) ３―ホルミルアミノ―７―メチルスルホニルアミノ―６―フェノキシ―４ｈ―１―ベンゾピラン―４―オンまたはその塩を含有する抗炎症製剤
JPH02289516A (ja) （＋）―プラノプロフェンを含有する医薬組成物
JPS59101448A (ja) ポリプレニルカルボン酸アミドおよびその製造方法ならびにそれを含有する医薬
JPH0222271A (ja) 共役γ−オキシブテノライド化合物およびこれを有効成分とする抗潰瘍剤
JPS604186A (ja) イミダゾキナゾリン化合物
JPH07506594A (ja) 抗転移剤として有用な生物学的に活性なウレイド誘導体
US3870792A (en) Certain dihydrophthalizines for treating hemorrhage and thrombosis
JPS63145272A (ja) ４，５−ジヒドロ−６−（４−置換フエニル）−３（２ｈ）−ピリダジノン誘導体
KR920001778B1 (ko) 신규의 (-)-2-피라졸린 화합물 및 이것의 광학분할방법
WO2005021481A1 (en) N, n’-dibenzyl ethylenediamine salt pf 2-(alpha-hidroxypentyl) benzoic acid and its preparing process and usage
JPH08239380A (ja) １−オキソ−２−（フェニルスルホニルアミノ）ペンチルピペリジン誘導体、その製造及びその治療上の応用
JPS62283922A (ja) 血小板凝集抑制剤
RU2302863C2 (ru) Лекарственный препарат (варианты)
CN116041418A (zh) 羟脯氨酰基-丝氨酸化合物及其制备方法和应用
JPS63101322A (ja) トロンボキサンａ↓２受容体拮抗剤
JPS60152462A (ja) インド−ル酢酸アミド誘導体の製造方法
JPH01193253A (ja) 置換イミダゾール化合物
JPH01313488A (ja) 新規白金含有化合物および悪性腫瘍治療剤
CN116492363A (zh) 新的核苷氨基磷酸脂化合物的组合物及其制备方法
JPH0643413B2 (ja) ７−オキソ−プロスタサイクリン誘導体、その製法および医薬組成物
CN106946891B (zh) 一种用于治疗类风湿性关节炎的药物
JPS6365644B2 (Direct)
CN106916168B (zh) 一种治疗重症胰腺炎的化合物及其制备方法
JPS635088A (ja) 新規なフラン化合物及びその製造法