JPS59157009A - メラニン生成抑制外用剤 - Google Patents
メラニン生成抑制外用剤Info
- Publication number
- JPS59157009A JPS59157009A JP3037583A JP3037583A JPS59157009A JP S59157009 A JPS59157009 A JP S59157009A JP 3037583 A JP3037583 A JP 3037583A JP 3037583 A JP3037583 A JP 3037583A JP S59157009 A JPS59157009 A JP S59157009A
- Authority
- JP
- Japan
- Prior art keywords
- melanin
- inhibitor
- agent
- adsorbent
- hydroquinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 title claims abstract description 56
- 230000015572 biosynthetic process Effects 0.000 title abstract description 9
- 229940079593 drug Drugs 0.000 title abstract description 5
- 239000003814 drug Substances 0.000 title abstract description 5
- 230000000694 effects Effects 0.000 claims abstract description 18
- 239000003463 adsorbent Substances 0.000 claims abstract description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 10
- 239000001301 oxygen Substances 0.000 claims abstract description 10
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 10
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 8
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims abstract description 7
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 7
- 239000006071 cream Substances 0.000 claims abstract description 7
- 239000003112 inhibitor Substances 0.000 claims abstract description 7
- 239000000049 pigment Substances 0.000 claims abstract description 7
- 238000006116 polymerization reaction Methods 0.000 claims abstract description 6
- 239000002674 ointment Substances 0.000 claims abstract description 5
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000004202 carbamide Substances 0.000 claims abstract description 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract 2
- 229930003268 Vitamin C Natural products 0.000 claims abstract 2
- 230000002255 enzymatic effect Effects 0.000 claims abstract 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000003410 keratolytic agent Substances 0.000 claims abstract 2
- 235000019154 vitamin C Nutrition 0.000 claims abstract 2
- 239000011718 vitamin C Substances 0.000 claims abstract 2
- 239000002253 acid Substances 0.000 claims description 11
- 239000000126 substance Substances 0.000 claims description 8
- 230000009931 harmful effect Effects 0.000 claims description 6
- 230000001603 reducing effect Effects 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 230000002087 whitening effect Effects 0.000 claims description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 abstract description 16
- -1 pyrone compound Chemical class 0.000 abstract description 8
- 239000003638 chemical reducing agent Substances 0.000 abstract description 6
- 238000007254 oxidation reaction Methods 0.000 abstract description 5
- 230000003647 oxidation Effects 0.000 abstract description 3
- FUWUEFKEXZQKKA-UHFFFAOYSA-N beta-thujaplicin Chemical compound CC(C)C=1C=CC=C(O)C(=O)C=1 FUWUEFKEXZQKKA-UHFFFAOYSA-N 0.000 abstract 4
- 208000003351 Melanosis Diseases 0.000 abstract 3
- 229940090972 beta-thujaplicin Drugs 0.000 abstract 3
- 206010008570 Chloasma Diseases 0.000 abstract 2
- 101710147108 Tyrosinase inhibitor Proteins 0.000 abstract 2
- 238000013329 compounding Methods 0.000 abstract 2
- 229930007845 β-thujaplicin Natural products 0.000 abstract 2
- 206010014970 Ephelides Diseases 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 229910000323 aluminium silicate Inorganic materials 0.000 abstract 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 description 12
- 238000005755 formation reaction Methods 0.000 description 8
- 230000008099 melanin synthesis Effects 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 5
- 239000004615 ingredient Substances 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 230000005764 inhibitory process Effects 0.000 description 5
- 230000002195 synergetic effect Effects 0.000 description 5
- AZQWKYJCGOJGHM-UHFFFAOYSA-N 1,4-benzoquinone Chemical compound O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 description 4
- 238000006701 autoxidation reaction Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- ZPSJGADGUYYRKE-UHFFFAOYSA-N 2H-pyran-2-one Chemical class O=C1C=CC=CO1 ZPSJGADGUYYRKE-UHFFFAOYSA-N 0.000 description 3
- 102000003425 Tyrosinase Human genes 0.000 description 3
- 108060008724 Tyrosinase Proteins 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 description 2
- VEYIMQVTPXPUHA-UHFFFAOYSA-N 3-hydroxypyran-4-one Chemical compound OC1=COC=CC1=O VEYIMQVTPXPUHA-UHFFFAOYSA-N 0.000 description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 239000006096 absorbing agent Substances 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 229960002433 cysteine Drugs 0.000 description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
- 235000018417 cysteine Nutrition 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- VJNCICVKUHKIIV-UHFFFAOYSA-N dopachrome Chemical compound O=C1C(=O)C=C2NC(C(=O)O)CC2=C1 VJNCICVKUHKIIV-UHFFFAOYSA-N 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 239000007800 oxidant agent Substances 0.000 description 2
- WQGWDDDVZFFDIG-UHFFFAOYSA-N pyrogallol Chemical compound OC1=CC=CC(O)=C1O WQGWDDDVZFFDIG-UHFFFAOYSA-N 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 229920002554 vinyl polymer Polymers 0.000 description 2
- QIJRTFXNRTXDIP-UHFFFAOYSA-N (1-carboxy-2-sulfanylethyl)azanium;chloride;hydrate Chemical compound O.Cl.SCC(N)C(O)=O QIJRTFXNRTXDIP-UHFFFAOYSA-N 0.000 description 1
- CSTRPYAGFNTOEQ-MGMRMFRLSA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;octadecanoic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O.CCCCCCCCCCCCCCCCCC(O)=O CSTRPYAGFNTOEQ-MGMRMFRLSA-N 0.000 description 1
- CBOJBBMQJBVCMW-BTVCFUMJSA-N (2r,3r,4s,5r)-2-amino-3,4,5,6-tetrahydroxyhexanal;hydrochloride Chemical compound Cl.O=C[C@H](N)[C@@H](O)[C@H](O)[C@H](O)CO CBOJBBMQJBVCMW-BTVCFUMJSA-N 0.000 description 1
- WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
- 101100365729 Drosophila melanogaster Shrm gene Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 description 1
- 241000287127 Passeridae Species 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 206010040829 Skin discolouration Diseases 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 206010064127 Solar lentigo Diseases 0.000 description 1
- 206010047642 Vitiligo Diseases 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229930016911 cinnamic acid Natural products 0.000 description 1
- 235000013985 cinnamic acid Nutrition 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000000736 corneocyte Anatomy 0.000 description 1
- 150000001944 cysteine derivatives Chemical class 0.000 description 1
- 229960001305 cysteine hydrochloride Drugs 0.000 description 1
- MHUWZNTUIIFHAS-CLFAGFIQSA-N dioleoyl phosphatidic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MHUWZNTUIIFHAS-CLFAGFIQSA-N 0.000 description 1
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000004299 exfoliation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 229960001911 glucosamine hydrochloride Drugs 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 229960004502 levodopa Drugs 0.000 description 1
- 229940043353 maltol Drugs 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000003061 melanogenesis Effects 0.000 description 1
- 210000002780 melanosome Anatomy 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 229940096717 pamine Drugs 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008055 phosphate buffer solution Substances 0.000 description 1
- 238000006552 photochemical reaction Methods 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 229940079877 pyrogallol Drugs 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- CXYRUNPLKGGUJF-RAFJPFSSSA-M scopolamine methobromide Chemical compound [Br-].C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3[N+]([C@H](C2)[C@@H]2[C@H]3O2)(C)C)=CC=CC=C1 CXYRUNPLKGGUJF-RAFJPFSSSA-M 0.000 description 1
- 229960004029 silicic acid Drugs 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- MWNQXXOSWHCCOZ-UHFFFAOYSA-L sodium;oxido carbonate Chemical compound [Na+].[O-]OC([O-])=O MWNQXXOSWHCCOZ-UHFFFAOYSA-L 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229940035289 tobi Drugs 0.000 description 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
- 229940100611 topical cream Drugs 0.000 description 1
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 1
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000006097 ultraviolet radiation absorber Substances 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3037583A JPS59157009A (ja) | 1983-02-25 | 1983-02-25 | メラニン生成抑制外用剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3037583A JPS59157009A (ja) | 1983-02-25 | 1983-02-25 | メラニン生成抑制外用剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS59157009A true JPS59157009A (ja) | 1984-09-06 |
| JPH042562B2 JPH042562B2 (enrdf_load_stackoverflow) | 1992-01-20 |
Family
ID=12302125
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3037583A Granted JPS59157009A (ja) | 1983-02-25 | 1983-02-25 | メラニン生成抑制外用剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS59157009A (enrdf_load_stackoverflow) |
Cited By (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6178715A (ja) * | 1984-09-26 | 1986-04-22 | Shiseido Co Ltd | 化粧料 |
| FR2584932A1 (fr) * | 1985-07-19 | 1987-01-23 | Hayashibara Ken | Appareil d'electrotherapie pour ionophorese |
| JPS6236306A (ja) * | 1985-08-12 | 1987-02-17 | Taiyo Kagaku Kk | 色白化粧料 |
| JPS63156708A (ja) * | 1986-12-22 | 1988-06-29 | Kishiyouhin Kagaku Kaihou Kenkyusho:Kk | 皮膚美白剤 |
| FR2616325A1 (fr) * | 1987-06-12 | 1988-12-16 | Moet Hennessy Rech | Composition contenant de l'hydroquinone et de l'acide kojique et composition pharmaceutique, notamment dermatologique, a activite depigmentante ou anti-inflammatoire, ou cosmetique comprenant de l'acide kojique et de l'hydroquinone |
| JPS6483010A (en) * | 1987-09-25 | 1989-03-28 | Sansho Seiyaku Kk | Melanization inhibitory drug for external use |
| JPH01100112A (ja) * | 1987-10-12 | 1989-04-18 | Sansho Seiyaku Co Ltd | 皮膚外用剤 |
| JPH03501843A (ja) * | 1987-06-12 | 1991-04-25 | エルブィエムアー リシェルシェ | 桑の抽出物と、薬学的組成物、特に皮膚明色活性または抗炎症活性のある皮膚科学的組成物、または化粧用組成物とからなる水和性脂質ラメラ相またはリポソームに基づいた組成物 |
| US5316767A (en) * | 1990-09-28 | 1994-05-31 | Kyowa Hakko Kogyo Co., Ltd. | Whitening cosmetic composition |
| EP0623342A1 (fr) * | 1993-05-07 | 1994-11-09 | L'oreal | Utilisation d'un alkyle ester de glutathion dans une composition cosmétique ou dermatologique destinée au traitement par voie topique du vieillissement cutané |
| JPH09315960A (ja) * | 1996-05-29 | 1997-12-09 | Nippon Flour Mills Co Ltd | メイラード反応抑制剤、化粧料、食品添加物及び食品 |
| WO1998017247A1 (en) * | 1996-10-23 | 1998-04-30 | The Procter & Gamble Company | Aqueous topical compositions comprising kojic acid, salicylic acid and a water soluble glycol ether |
| FR2787711A1 (fr) * | 1998-12-29 | 2000-06-30 | C3D Sarl | Composition cosmetique a activite depigmentante et son utilisation |
| JP2000302634A (ja) * | 1999-04-27 | 2000-10-31 | Ichimaru Pharcos Co Ltd | 化粧料組成物 |
| WO2001017497A1 (en) * | 1999-09-09 | 2001-03-15 | Carlo Ghisalberti | Depigmenting compositions |
| WO2001017484A3 (en) * | 1999-09-07 | 2001-09-27 | D T R Dermal Therapy Res Inc | Topical urea composition |
| US6497860B1 (en) | 1996-11-04 | 2002-12-24 | Children's Hospital Medical Center | Skin lightening compositions |
| JP2005112760A (ja) * | 2003-10-07 | 2005-04-28 | Ichimaru Pharcos Co Ltd | 美白剤及び美白用皮膚外用剤 |
| JP2011006462A (ja) * | 2010-08-26 | 2011-01-13 | Ichimaru Pharcos Co Ltd | チロシナーゼ活性阻害剤 |
| GB2497985A (en) * | 2011-12-28 | 2013-07-03 | Pangaea Lab Ltd | Stable kojic acid composition to lighten the skin |
| US8772252B2 (en) | 2011-01-27 | 2014-07-08 | New York University | Coumarin compounds as melanogenesis modifiers and uses thereof |
| JP2014198700A (ja) * | 2013-03-29 | 2014-10-23 | 株式会社ピカソ美化学研究所 | 防腐剤および外用組成物、ならびに着色低減方法 |
| WO2014174583A1 (ja) | 2013-04-23 | 2014-10-30 | 株式会社ニチレイバイオサイエンス | 新規美白剤 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS568309A (en) * | 1979-06-29 | 1981-01-28 | Yasuaki Fukuda | White cosmetic |
| JPS5692215A (en) * | 1979-12-25 | 1981-07-25 | Yakurigaku Chuo Kenkyusho:Kk | Germicide and anti-infective for remedying skin disease comprising solid acid or base as main ingredient |
| JPS57207543A (en) * | 1981-06-12 | 1982-12-20 | Yakurigaku Chuo Kenkyusho:Kk | Hydrated aluminum silicate adsorbent deposited with reducing material |
-
1983
- 1983-02-25 JP JP3037583A patent/JPS59157009A/ja active Granted
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS568309A (en) * | 1979-06-29 | 1981-01-28 | Yasuaki Fukuda | White cosmetic |
| JPS5692215A (en) * | 1979-12-25 | 1981-07-25 | Yakurigaku Chuo Kenkyusho:Kk | Germicide and anti-infective for remedying skin disease comprising solid acid or base as main ingredient |
| JPS57207543A (en) * | 1981-06-12 | 1982-12-20 | Yakurigaku Chuo Kenkyusho:Kk | Hydrated aluminum silicate adsorbent deposited with reducing material |
Cited By (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6178715A (ja) * | 1984-09-26 | 1986-04-22 | Shiseido Co Ltd | 化粧料 |
| FR2584932A1 (fr) * | 1985-07-19 | 1987-01-23 | Hayashibara Ken | Appareil d'electrotherapie pour ionophorese |
| JPS6236306A (ja) * | 1985-08-12 | 1987-02-17 | Taiyo Kagaku Kk | 色白化粧料 |
| JPS63156708A (ja) * | 1986-12-22 | 1988-06-29 | Kishiyouhin Kagaku Kaihou Kenkyusho:Kk | 皮膚美白剤 |
| JPH03501843A (ja) * | 1987-06-12 | 1991-04-25 | エルブィエムアー リシェルシェ | 桑の抽出物と、薬学的組成物、特に皮膚明色活性または抗炎症活性のある皮膚科学的組成物、または化粧用組成物とからなる水和性脂質ラメラ相またはリポソームに基づいた組成物 |
| FR2616325A1 (fr) * | 1987-06-12 | 1988-12-16 | Moet Hennessy Rech | Composition contenant de l'hydroquinone et de l'acide kojique et composition pharmaceutique, notamment dermatologique, a activite depigmentante ou anti-inflammatoire, ou cosmetique comprenant de l'acide kojique et de l'hydroquinone |
| JPS6483010A (en) * | 1987-09-25 | 1989-03-28 | Sansho Seiyaku Kk | Melanization inhibitory drug for external use |
| US4919921A (en) * | 1987-09-25 | 1990-04-24 | Sansho Seiyaku Co., Ltd. | Compositions for topical use having melanin synthesis-inhibiting activity |
| JPH01100112A (ja) * | 1987-10-12 | 1989-04-18 | Sansho Seiyaku Co Ltd | 皮膚外用剤 |
| US5316767A (en) * | 1990-09-28 | 1994-05-31 | Kyowa Hakko Kogyo Co., Ltd. | Whitening cosmetic composition |
| EP0623342A1 (fr) * | 1993-05-07 | 1994-11-09 | L'oreal | Utilisation d'un alkyle ester de glutathion dans une composition cosmétique ou dermatologique destinée au traitement par voie topique du vieillissement cutané |
| FR2704754A1 (fr) * | 1993-05-07 | 1994-11-10 | Oreal | Utilisation d'un alkyle ester de glutathion dans une composition cosmétique ou dermatologique destinée au traitement par voie topique du vieillissement cutané. |
| JPH09315960A (ja) * | 1996-05-29 | 1997-12-09 | Nippon Flour Mills Co Ltd | メイラード反応抑制剤、化粧料、食品添加物及び食品 |
| WO1998017247A1 (en) * | 1996-10-23 | 1998-04-30 | The Procter & Gamble Company | Aqueous topical compositions comprising kojic acid, salicylic acid and a water soluble glycol ether |
| US6497860B1 (en) | 1996-11-04 | 2002-12-24 | Children's Hospital Medical Center | Skin lightening compositions |
| FR2787711A1 (fr) * | 1998-12-29 | 2000-06-30 | C3D Sarl | Composition cosmetique a activite depigmentante et son utilisation |
| WO2000038648A1 (fr) * | 1998-12-29 | 2000-07-06 | C3D S.A.R.L. | Composition cosmetique a activite depigmentante et son utilisation |
| JP2000302634A (ja) * | 1999-04-27 | 2000-10-31 | Ichimaru Pharcos Co Ltd | 化粧料組成物 |
| WO2001017484A3 (en) * | 1999-09-07 | 2001-09-27 | D T R Dermal Therapy Res Inc | Topical urea composition |
| WO2001017497A1 (en) * | 1999-09-09 | 2001-03-15 | Carlo Ghisalberti | Depigmenting compositions |
| JP2005112760A (ja) * | 2003-10-07 | 2005-04-28 | Ichimaru Pharcos Co Ltd | 美白剤及び美白用皮膚外用剤 |
| JP2011006462A (ja) * | 2010-08-26 | 2011-01-13 | Ichimaru Pharcos Co Ltd | チロシナーゼ活性阻害剤 |
| US8772252B2 (en) | 2011-01-27 | 2014-07-08 | New York University | Coumarin compounds as melanogenesis modifiers and uses thereof |
| GB2497985A (en) * | 2011-12-28 | 2013-07-03 | Pangaea Lab Ltd | Stable kojic acid composition to lighten the skin |
| GB2497985B (en) * | 2011-12-28 | 2014-03-12 | Pangaea Lab Ltd | A composition to stabilise kojic acid |
| JP2014198700A (ja) * | 2013-03-29 | 2014-10-23 | 株式会社ピカソ美化学研究所 | 防腐剤および外用組成物、ならびに着色低減方法 |
| WO2014174583A1 (ja) | 2013-04-23 | 2014-10-30 | 株式会社ニチレイバイオサイエンス | 新規美白剤 |
| JPWO2014174583A1 (ja) * | 2013-04-23 | 2017-02-23 | 株式会社ニチレイバイオサイエンス | 新規美白剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH042562B2 (enrdf_load_stackoverflow) | 1992-01-20 |
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