JPS5913721A - 歯苔形成抑制剤 - Google Patents
歯苔形成抑制剤Info
- Publication number
- JPS5913721A JPS5913721A JP57123260A JP12326082A JPS5913721A JP S5913721 A JPS5913721 A JP S5913721A JP 57123260 A JP57123260 A JP 57123260A JP 12326082 A JP12326082 A JP 12326082A JP S5913721 A JPS5913721 A JP S5913721A
- Authority
- JP
- Japan
- Prior art keywords
- agent
- flavonoid
- adhesion
- activity
- oral cavity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000015572 biosynthetic process Effects 0.000 title claims abstract description 14
- 230000001580 bacterial effect Effects 0.000 title description 8
- 229930003935 flavonoid Natural products 0.000 claims abstract description 13
- 150000002215 flavonoids Chemical class 0.000 claims abstract description 13
- 235000017173 flavonoids Nutrition 0.000 claims abstract description 13
- 208000006558 Dental Calculus Diseases 0.000 claims description 14
- 239000003112 inhibitor Substances 0.000 claims description 5
- 229920001503 Glucan Polymers 0.000 abstract description 9
- 230000002401 inhibitory effect Effects 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 8
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 abstract description 6
- 241000894006 Bacteria Species 0.000 abstract description 5
- 102000000340 Glucosyltransferases Human genes 0.000 abstract description 5
- 108010055629 Glucosyltransferases Proteins 0.000 abstract description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract description 5
- 229930006000 Sucrose Natural products 0.000 abstract description 5
- 210000000214 mouth Anatomy 0.000 abstract description 5
- 239000005720 sucrose Substances 0.000 abstract description 5
- 241000194019 Streptococcus mutans Species 0.000 abstract description 4
- 239000003795 chemical substances by application Substances 0.000 abstract description 4
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 abstract description 4
- MQSZRBPYXNEFHF-UHFFFAOYSA-N rhamnocitrin Chemical compound C=1C(OC)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C=C1 MQSZRBPYXNEFHF-UHFFFAOYSA-N 0.000 abstract description 4
- 238000003786 synthesis reaction Methods 0.000 abstract description 4
- UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 abstract description 3
- 235000008777 kaempferol Nutrition 0.000 abstract description 3
- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 abstract description 3
- 230000001013 cariogenic effect Effects 0.000 abstract description 2
- 208000002925 dental caries Diseases 0.000 abstract description 2
- 239000000284 extract Substances 0.000 abstract description 2
- 238000000338 in vitro Methods 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 abstract description 2
- 239000005357 flat glass Substances 0.000 abstract 1
- 230000007505 plaque formation Effects 0.000 abstract 1
- 235000013311 vegetables Nutrition 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 238000000034 method Methods 0.000 description 6
- 206010044029 Tooth deposit Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000003385 bacteriostatic effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 239000005457 ice water Substances 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000012085 test solution Substances 0.000 description 2
- 229940034610 toothpaste Drugs 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- DQFBYFPFKXHELB-UHFFFAOYSA-N Chalcone Natural products C=1C=CC=CC=1C(=O)C=CC1=CC=CC=C1 DQFBYFPFKXHELB-UHFFFAOYSA-N 0.000 description 1
- IKMDFBPHZNJCSN-UHFFFAOYSA-N Myricetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC(O)=C(O)C(O)=C1 IKMDFBPHZNJCSN-UHFFFAOYSA-N 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 229930002878 anthoxanthin Natural products 0.000 description 1
- 150000004637 anthoxanthins Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 239000006189 buccal tablet Substances 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 150000001789 chalcones Chemical class 0.000 description 1
- 235000005513 chalcones Nutrition 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 229960003333 chlorhexidine gluconate Drugs 0.000 description 1
- YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229930003949 flavanone Natural products 0.000 description 1
- 150000002208 flavanones Chemical class 0.000 description 1
- 235000011981 flavanones Nutrition 0.000 description 1
- 229930003939 flavanonol Natural products 0.000 description 1
- 150000002210 flavanonols Chemical class 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229930002879 flavonoid pigment Natural products 0.000 description 1
- 150000004638 flavonoid pigments Chemical class 0.000 description 1
- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Natural products O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 description 1
- 150000002216 flavonol derivatives Chemical class 0.000 description 1
- 235000011957 flavonols Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 150000002515 isoflavone derivatives Chemical class 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 239000000401 methanolic extract Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- PCOBUQBNVYZTBU-UHFFFAOYSA-N myricetin Natural products OC1=C(O)C(O)=CC(C=2OC3=CC(O)=C(O)C(O)=C3C(=O)C=2)=C1 PCOBUQBNVYZTBU-UHFFFAOYSA-N 0.000 description 1
- 235000007743 myricetin Nutrition 0.000 description 1
- 229940116852 myricetin Drugs 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000006190 sub-lingual tablet Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57123260A JPS5913721A (ja) | 1982-07-15 | 1982-07-15 | 歯苔形成抑制剤 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57123260A JPS5913721A (ja) | 1982-07-15 | 1982-07-15 | 歯苔形成抑制剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5913721A true JPS5913721A (ja) | 1984-01-24 |
| JPS6310133B2 JPS6310133B2 (enExample) | 1988-03-04 |
Family
ID=14856156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP57123260A Granted JPS5913721A (ja) | 1982-07-15 | 1982-07-15 | 歯苔形成抑制剤 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5913721A (enExample) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04230702A (ja) * | 1990-04-12 | 1992-08-19 | Mckinley Opt Inc | 内視鏡中継レンズ |
| JP2001114694A (ja) * | 1999-10-19 | 2001-04-24 | Maruzen Pharmaceut Co Ltd | う蝕防止剤、口腔用剤および飲食物 |
| KR100368007B1 (ko) * | 2000-04-17 | 2003-01-24 | 국보제약주식회사 | 미노싸이클린 ｈｃｌ을 함유한 치주염 예방 및 치료용구강 조성물 |
| JP2003081847A (ja) * | 2001-09-12 | 2003-03-19 | Maruzen Pharmaceut Co Ltd | う蝕防止剤及び口腔用組成物 |
| KR100417261B1 (ko) * | 2000-04-17 | 2004-02-05 | 국보제약주식회사 | 박테리오신을 함유한 치주병 예방 및 치료용 구강 조성물 |
| KR100417259B1 (ko) * | 2000-04-17 | 2004-02-05 | 국보제약주식회사 | 트리암씨놀론 아세토나이드를 함유한 치은염, 구내염,치주염의 예방 및 치료용 구강 조성물 |
| KR100417260B1 (ko) * | 2000-04-17 | 2004-02-05 | 국보제약주식회사 | 옥수수의 불검화 정량 추출물을 함유한 잇몸질환의 예방및 치료용 구강 조성물 |
| CN102464641A (zh) * | 2010-11-19 | 2012-05-23 | 苏州宝泽堂医药科技有限公司 | 一种从镰形棘豆中制备鼠李柠檬素的方法 |
| CN102652712A (zh) * | 2011-03-04 | 2012-09-05 | 全球生技股份有限公司 | 具抗菌的口腔护理组成物及其制法 |
| KR20160059605A (ko) * | 2014-11-19 | 2016-05-27 | 대한민국(환경부 국립생물자원관장) | 캠페롤을 유효성분으로 함유하는 충치와 치주질환 예방 또는 치료용 조성물 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58213706A (ja) * | 1982-06-08 | 1983-12-12 | Lion Corp | 歯垢形成抑制用剤 |
-
1982
- 1982-07-15 JP JP57123260A patent/JPS5913721A/ja active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58213706A (ja) * | 1982-06-08 | 1983-12-12 | Lion Corp | 歯垢形成抑制用剤 |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04230702A (ja) * | 1990-04-12 | 1992-08-19 | Mckinley Opt Inc | 内視鏡中継レンズ |
| JP2001114694A (ja) * | 1999-10-19 | 2001-04-24 | Maruzen Pharmaceut Co Ltd | う蝕防止剤、口腔用剤および飲食物 |
| KR100368007B1 (ko) * | 2000-04-17 | 2003-01-24 | 국보제약주식회사 | 미노싸이클린 ｈｃｌ을 함유한 치주염 예방 및 치료용구강 조성물 |
| KR100417261B1 (ko) * | 2000-04-17 | 2004-02-05 | 국보제약주식회사 | 박테리오신을 함유한 치주병 예방 및 치료용 구강 조성물 |
| KR100417259B1 (ko) * | 2000-04-17 | 2004-02-05 | 국보제약주식회사 | 트리암씨놀론 아세토나이드를 함유한 치은염, 구내염,치주염의 예방 및 치료용 구강 조성물 |
| KR100417260B1 (ko) * | 2000-04-17 | 2004-02-05 | 국보제약주식회사 | 옥수수의 불검화 정량 추출물을 함유한 잇몸질환의 예방및 치료용 구강 조성물 |
| JP2003081847A (ja) * | 2001-09-12 | 2003-03-19 | Maruzen Pharmaceut Co Ltd | う蝕防止剤及び口腔用組成物 |
| CN102464641A (zh) * | 2010-11-19 | 2012-05-23 | 苏州宝泽堂医药科技有限公司 | 一种从镰形棘豆中制备鼠李柠檬素的方法 |
| CN102652712A (zh) * | 2011-03-04 | 2012-09-05 | 全球生技股份有限公司 | 具抗菌的口腔护理组成物及其制法 |
| KR20160059605A (ko) * | 2014-11-19 | 2016-05-27 | 대한민국(환경부 국립생물자원관장) | 캠페롤을 유효성분으로 함유하는 충치와 치주질환 예방 또는 치료용 조성물 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6310133B2 (enExample) | 1988-03-04 |
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