JPS5912672B2 - ベンゾオキサゾ−ル誘導体の製造法 - Google Patents

ベンゾオキサゾ−ル誘導体の製造法

Info

Publication number
JPS5912672B2
JPS5912672B2 JP48055110A JP5511073A JPS5912672B2 JP S5912672 B2 JPS5912672 B2 JP S5912672B2 JP 48055110 A JP48055110 A JP 48055110A JP 5511073 A JP5511073 A JP 5511073A JP S5912672 B2 JPS5912672 B2 JP S5912672B2
Authority
JP
Japan
Prior art keywords
alkyl
formula
benzoxazolyl
phenyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP48055110A
Other languages
English (en)
Japanese (ja)
Other versions
JPS4954363A (OSRAM
Inventor
エヴアンス デルム
ウイリアム ダンウイル デヴイツト
アラン ヒツクス テレンス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lilly Industries Ltd
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of JPS4954363A publication Critical patent/JPS4954363A/ja
Publication of JPS5912672B2 publication Critical patent/JPS5912672B2/ja
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
JP48055110A 1972-05-18 1973-05-17 ベンゾオキサゾ−ル誘導体の製造法 Expired JPS5912672B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2340972A GB1435721A (en) 1972-05-18 1972-05-18 Benzoxazole derivatives
GB2340972 1972-05-18

Publications (2)

Publication Number Publication Date
JPS4954363A JPS4954363A (OSRAM) 1974-05-27
JPS5912672B2 true JPS5912672B2 (ja) 1984-03-24

Family

ID=10195157

Family Applications (6)

Application Number Title Priority Date Filing Date
JP48055110A Expired JPS5912672B2 (ja) 1972-05-18 1973-05-17 ベンゾオキサゾ−ル誘導体の製造法
JP7212181A Pending JPS56167673A (en) 1972-05-18 1981-05-13 Manufacture of benzoxazole derivative
JP56072123A Expired JPS5929185B2 (ja) 1972-05-18 1981-05-13 フエノ−ル誘導体の製造法
JP7212281A Pending JPS56167674A (en) 1972-05-18 1981-05-13 Manufacture of benzoxazole derivative
JP7212481A Pending JPS56167675A (en) 1972-05-18 1981-05-13 Manufacture of benzoxazole derivative
JP59017637A Expired JPS6021976B2 (ja) 1972-05-18 1984-02-02 フエノール誘導体の製造法

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP7212181A Pending JPS56167673A (en) 1972-05-18 1981-05-13 Manufacture of benzoxazole derivative
JP56072123A Expired JPS5929185B2 (ja) 1972-05-18 1981-05-13 フエノ−ル誘導体の製造法
JP7212281A Pending JPS56167674A (en) 1972-05-18 1981-05-13 Manufacture of benzoxazole derivative
JP7212481A Pending JPS56167675A (en) 1972-05-18 1981-05-13 Manufacture of benzoxazole derivative
JP59017637A Expired JPS6021976B2 (ja) 1972-05-18 1984-02-02 フエノール誘導体の製造法

Country Status (31)

Country Link
US (1) US3912748A (OSRAM)
JP (6) JPS5912672B2 (OSRAM)
KR (1) KR780000234B1 (OSRAM)
AR (4) AR230991A1 (OSRAM)
AT (1) AT333752B (OSRAM)
BE (1) BE799790A (OSRAM)
BG (1) BG21408A3 (OSRAM)
CA (1) CA1029019A (OSRAM)
CH (5) CH595361A5 (OSRAM)
CS (1) CS200455B2 (OSRAM)
CY (1) CY1016A (OSRAM)
DD (1) DD105229A5 (OSRAM)
DE (1) DE2324443A1 (OSRAM)
DK (1) DK140340B (OSRAM)
ES (1) ES414863A1 (OSRAM)
FR (2) FR2184966B1 (OSRAM)
GB (1) GB1435721A (OSRAM)
HK (1) HK72579A (OSRAM)
HU (1) HU167933B (OSRAM)
IE (2) IE37564B1 (OSRAM)
IL (2) IL42102A (OSRAM)
KE (1) KE2975A (OSRAM)
MY (1) MY8000063A (OSRAM)
NL (1) NL170145C (OSRAM)
PH (3) PH9685A (OSRAM)
PL (3) PL92565B1 (OSRAM)
RO (2) RO66278A (OSRAM)
SE (3) SE386174B (OSRAM)
SU (3) SU574157A3 (OSRAM)
YU (3) YU130473A (OSRAM)
ZA (1) ZA732791B (OSRAM)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495488A (en) * 1976-06-23 1977-12-21 Ippco Int Pharma Patents Co Es Optically active 2-(2-phenyl-5-benzoxazolyl)propionic acids
US4087437A (en) * 1976-09-07 1978-05-02 Eli Lilly And Company 2-Phenyl-5-benzoxazolylalkanoic acid purification process
GB1590587A (en) * 1977-06-28 1981-06-03 Lilly Industries Ltd Benoxaprofen
IT1099589B (it) * 1978-08-04 1985-09-18 Ravizza Spa Processo per la preparazione di derivati dell'acido benzoxazolil propionico
CA1125768A (en) * 1978-10-31 1982-06-15 Hoffmann-La Roche Limited Benzoxazole derivatives
GR75153B (OSRAM) * 1981-03-27 1984-07-13 Lilly Co Eli
IT1157295B (it) * 1982-07-19 1987-02-11 Ravizza Spa Processo perfezionato per la preparazione di derivati dell'acido benzoxazolil propionico
DE3413875A1 (de) * 1984-04-12 1985-10-17 Ludwig Heumann & Co GmbH, 8500 Nürnberg Benzothiazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltendes arzneimittel
IT1177017B (it) * 1984-10-22 1987-08-26 Ravizza Spa Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico
US4873259A (en) * 1987-06-10 1989-10-10 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
US4822809A (en) * 1987-11-13 1989-04-18 Abbott Laboratories Benzazole lipoxygenase inhibiting compounds
IT1233836B (it) * 1988-01-13 1992-04-21 Euroresearch Srl Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato.
UA83620C2 (ru) * 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
AU2003283597A1 (en) * 2002-11-16 2004-06-15 Oxford Glycosciences (Uk) Ltd Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors
AU2004215624B2 (en) * 2003-02-25 2011-06-02 Topotarget Uk Limited Hydroxamic acid compounds comprising a bicyclic heteroaryl group as HDAC inhibitors
PT1856031E (pt) * 2004-12-15 2009-05-14 Dompe Pha R Ma Spa Res & Mfg Derivados de ácidos 2-arilpropiónicos e composições farmacêuticas que os contenham
PL1888548T3 (pl) 2005-05-26 2013-01-31 Neuron Systems Inc Pochodna chinoliny do leczenia schorzeń siatkówki
JP5369854B2 (ja) 2008-04-21 2013-12-18 住友化学株式会社 有害節足動物防除組成物および縮合複素環化合物
CA2782015C (en) 2009-12-11 2020-08-25 Neuron Systems, Inc. Topical ophthalmic compositions and methods for the treatment of macular degeneration
US9687481B2 (en) 2013-01-23 2017-06-27 Aldeyra Therapeutics, Inc. Toxic aldehyde related diseases and treatment
CN105228989A (zh) 2013-01-25 2016-01-06 奥尔德拉医疗公司 黄斑变性治疗中的新颖捕获剂
EP3178810A4 (en) * 2014-08-08 2018-07-04 Kasuma Partners Inc. Condensed heterocyclic compound
EP4400106A1 (en) 2015-08-21 2024-07-17 Aldeyra Therapeutics, Inc. Deuterated compounds and uses thereof
US11129823B2 (en) 2016-05-09 2021-09-28 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
AU2018234919A1 (en) 2017-03-16 2019-09-19 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
CN111356451A (zh) 2017-10-10 2020-06-30 奥尔德拉医疗公司 炎性病症的治疗
US12006298B2 (en) 2018-08-06 2024-06-11 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
US11197821B2 (en) 2018-09-25 2021-12-14 Aldeyra Therapeutics, Inc. Formulations for treatment of dry eye disease
WO2020198064A1 (en) 2019-03-26 2020-10-01 Aldeyra Therapeutics, Inc. Ophthalmic formulations and uses thereof
US12098132B2 (en) 2019-05-02 2024-09-24 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates
JP2022530967A (ja) 2019-05-02 2022-07-05 アルデイラ セラピューティクス， インコーポレイテッド 多形化合物およびその使用
CN115697336A (zh) 2020-05-13 2023-02-03 奥尔德拉医疗公司 药物制剂及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD70860A (OSRAM) *
BE625278A (OSRAM) * 1961-11-27
CH516339A (de) * 1969-03-03 1971-12-15 Ciba Geigy Ag Verwendung von Azolverbindungen als Antioxydantien
DE2118315C3 (de) * 1970-04-20 1975-04-03 Sumitomo Chemical Co., Ltd., Osaka (Japan) 2-(1H)-Chinazolinonderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
IL37633A (en) * 1970-09-10 1975-08-31 Merck & Co Inc 2-(4-(2-benzoxazolyl)phenyl)alkanoic acid derivatives
DE2115926C3 (de) * 1971-04-01 1978-05-03 C.H. Boehringer Sohn, 6507 Ingelheim 1 -(4-Hydroxy-3-dimethylaminosuIfamidophenyI)-2-aminoäthanderivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel
GB1491863A (en) * 1973-10-23 1977-11-16 Lilly Industries Ltd 2,5-or 2,6-disubstituted benzoxazoles
GB1590587A (en) * 1977-06-28 1981-06-03 Lilly Industries Ltd Benoxaprofen

Also Published As

Publication number Publication date
CA1029019A (en) 1978-04-04
JPS56167674A (en) 1981-12-23
JPS56167675A (en) 1981-12-23
IL48711A0 (en) 1976-02-29
NL170145C (nl) 1982-10-01
YU36298B (en) 1982-06-18
AT333752B (de) 1976-12-10
PL89247B1 (OSRAM) 1976-11-30
HU167933B (OSRAM) 1976-01-28
HK72579A (en) 1979-10-19
CH595362A5 (OSRAM) 1978-02-15
AU5590773A (en) 1974-11-21
JPS4954363A (OSRAM) 1974-05-27
DD105229A5 (OSRAM) 1974-04-12
PL92565B1 (OSRAM) 1977-04-30
SE7710602L (sv) 1977-09-21
AR207857A1 (es) 1976-11-08
SE386174B (sv) 1976-08-02
CS200455B2 (en) 1980-09-15
NL7307018A (OSRAM) 1973-11-20
SU582762A3 (ru) 1977-11-30
US3912748A (en) 1975-10-14
ZA732791B (en) 1974-12-24
KE2975A (en) 1979-07-20
IE37564L (en) 1973-11-18
RO66800A (ro) 1982-03-24
SU574157A3 (ru) 1977-09-25
CH592071A5 (OSRAM) 1977-10-14
FR2184966A1 (OSRAM) 1973-12-28
JPS59161346A (ja) 1984-09-12
JPS5929185B2 (ja) 1984-07-18
NL170145B (nl) 1982-05-03
FR2184966B1 (OSRAM) 1979-01-12
DK140340C (OSRAM) 1979-12-31
AR230991A1 (es) 1984-08-31
GB1435721A (en) 1976-05-12
YU130473A (en) 1981-08-31
BE799790A (fr) 1973-11-19
SU580837A3 (ru) 1977-11-15
CH594643A5 (OSRAM) 1978-01-13
CH595361A5 (OSRAM) 1978-02-15
ATA432573A (de) 1976-04-15
IE37563L (en) 1973-11-18
BG21408A3 (bg) 1976-05-20
FR2284592A1 (fr) 1976-04-09
MY8000063A (en) 1980-12-31
AR205021A1 (es) 1976-03-31
JPS6021976B2 (ja) 1985-05-30
ES414863A1 (es) 1976-02-01
IL42102A0 (en) 1973-06-29
KR780000234B1 (en) 1978-07-01
PH10704A (en) 1977-08-24
CY1016A (en) 1979-11-23
IE37563B1 (en) 1977-08-17
DE2324443A1 (de) 1973-11-29
FR2284592B1 (OSRAM) 1979-01-05
IE37564B1 (en) 1977-08-17
RO66278A (ro) 1981-06-26
DK140340B (da) 1979-08-06
YU117179A (en) 1981-08-31
PL94208B1 (OSRAM) 1977-07-30
SE435838B (sv) 1984-10-22
SE434399B (sv) 1984-07-23
JPS56167645A (en) 1981-12-23
PH9685A (en) 1976-02-10
SE7509387L (sv) 1975-08-22
YU117079A (en) 1981-08-31
CH587834A5 (OSRAM) 1977-05-13
JPS56167673A (en) 1981-12-23
IL42102A (en) 1977-07-31
AR212010A1 (es) 1978-04-28
PH11718A (en) 1978-05-30

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