KR780000234B1 - Preparation of benzoxazole derivatives - Google Patents

Preparation of benzoxazole derivatives

Info

Publication number
KR780000234B1
KR780000234B1 KR7300790A KR730000790A KR780000234B1 KR 780000234 B1 KR780000234 B1 KR 780000234B1 KR 7300790 A KR7300790 A KR 7300790A KR 730000790 A KR730000790 A KR 730000790A KR 780000234 B1 KR780000234 B1 KR 780000234B1
Authority
KR
South Korea
Prior art keywords
preparation
benzoxazole derivatives
derivatives
benzoxazole
cyclising
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR7300790A
Other languages
English (en)
Korean (ko)
Inventor
T A Hicks
D Evans
D W Dunwell
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Application granted granted Critical
Publication of KR780000234B1 publication Critical patent/KR780000234B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
KR7300790A 1972-05-18 1973-05-16 Preparation of benzoxazole derivatives Expired KR780000234B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2340972A GB1435721A (en) 1972-05-18 1972-05-18 Benzoxazole derivatives

Publications (1)

Publication Number Publication Date
KR780000234B1 true KR780000234B1 (en) 1978-07-01

Family

ID=10195157

Family Applications (1)

Application Number Title Priority Date Filing Date
KR7300790A Expired KR780000234B1 (en) 1972-05-18 1973-05-16 Preparation of benzoxazole derivatives

Country Status (31)

Country Link
US (1) US3912748A (OSRAM)
JP (6) JPS5912672B2 (OSRAM)
KR (1) KR780000234B1 (OSRAM)
AR (4) AR230991A1 (OSRAM)
AT (1) AT333752B (OSRAM)
BE (1) BE799790A (OSRAM)
BG (1) BG21408A3 (OSRAM)
CA (1) CA1029019A (OSRAM)
CH (5) CH592071A5 (OSRAM)
CS (1) CS200455B2 (OSRAM)
CY (1) CY1016A (OSRAM)
DD (1) DD105229A5 (OSRAM)
DE (1) DE2324443A1 (OSRAM)
DK (1) DK140340B (OSRAM)
ES (1) ES414863A1 (OSRAM)
FR (2) FR2184966B1 (OSRAM)
GB (1) GB1435721A (OSRAM)
HK (1) HK72579A (OSRAM)
HU (1) HU167933B (OSRAM)
IE (2) IE37564B1 (OSRAM)
IL (2) IL42102A (OSRAM)
KE (1) KE2975A (OSRAM)
MY (1) MY8000063A (OSRAM)
NL (1) NL170145C (OSRAM)
PH (3) PH9685A (OSRAM)
PL (3) PL89247B1 (OSRAM)
RO (2) RO66278A (OSRAM)
SE (3) SE386174B (OSRAM)
SU (3) SU574157A3 (OSRAM)
YU (3) YU130473A (OSRAM)
ZA (1) ZA732791B (OSRAM)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495488A (en) * 1976-06-23 1977-12-21 Ippco Int Pharma Patents Co Es Optically active 2-(2-phenyl-5-benzoxazolyl)propionic acids
US4087437A (en) * 1976-09-07 1978-05-02 Eli Lilly And Company 2-Phenyl-5-benzoxazolylalkanoic acid purification process
GB1590587A (en) * 1977-06-28 1981-06-03 Lilly Industries Ltd Benoxaprofen
IT1099589B (it) * 1978-08-04 1985-09-18 Ravizza Spa Processo per la preparazione di derivati dell'acido benzoxazolil propionico
CA1125768A (en) * 1978-10-31 1982-06-15 Hoffmann-La Roche Limited Benzoxazole derivatives
GR75153B (OSRAM) * 1981-03-27 1984-07-13 Lilly Co Eli
IT1157295B (it) * 1982-07-19 1987-02-11 Ravizza Spa Processo perfezionato per la preparazione di derivati dell'acido benzoxazolil propionico
DE3413875A1 (de) * 1984-04-12 1985-10-17 Ludwig Heumann & Co GmbH, 8500 Nürnberg Benzothiazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltendes arzneimittel
IT1177017B (it) * 1984-10-22 1987-08-26 Ravizza Spa Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico
US4873259A (en) * 1987-06-10 1989-10-10 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
US4822809A (en) * 1987-11-13 1989-04-18 Abbott Laboratories Benzazole lipoxygenase inhibiting compounds
IT1233836B (it) * 1988-01-13 1992-04-21 Euroresearch Srl Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato.
UA83620C2 (ru) * 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
AU2003283597A1 (en) * 2002-11-16 2004-06-15 Oxford Glycosciences (Uk) Ltd Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors
WO2004076386A2 (en) 2003-02-25 2004-09-10 Topotarget Uk Limited Carbamic acid compounds comprising a bicyclic heteroaryl group as hdac inhibitors
NZ555502A (en) * 2004-12-15 2010-12-24 Dompe Pha R Ma Spa Res & Mfg 2-arylpropionic acid derivatives and pharmaceutical compositions containing them
WO2006127945A1 (en) 2005-05-26 2006-11-30 Neuron Systems Compositions and methods of treating retinal disease
JP5369854B2 (ja) 2008-04-21 2013-12-18 住友化学株式会社 有害節足動物防除組成物および縮合複素環化合物
JP5885670B2 (ja) 2009-12-11 2016-03-15 アルデイラ セラピューティクス， インコーポレイテッド 黄斑変性の処置のための組成物および方法
KR102243169B1 (ko) 2013-01-23 2021-04-22 알데이라 테라퓨틱스, 아이엔씨. 독성 알데히드 관련된 질병 및 치료
CN105228989A (zh) 2013-01-25 2016-01-06 奥尔德拉医疗公司 黄斑变性治疗中的新颖捕获剂
CN107001267A (zh) * 2014-08-08 2017-08-01 马合伙人株式会社 稠合杂环化合物
EP3337486B1 (en) 2015-08-21 2024-04-03 Aldeyra Therapeutics, Inc. Deuterated compounds and uses thereof
MX2018013472A (es) 2016-05-09 2019-02-28 Aldeyra Therapeutics Inc Tratamiento de combinacion de trastornos y enfermedades inflamatorios oculares.
MX2019010576A (es) 2017-03-16 2019-10-07 Aldeyra Therapeutics Inc Compuestos polimorficos y usos de los mismos.
EP3694500A4 (en) 2017-10-10 2021-06-30 Aldeyra Therapeutics, Inc. TREATMENT OF INFLAMMATORY DISORDERS
AU2019319740A1 (en) 2018-08-06 2021-03-25 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
JP7505786B2 (ja) 2018-09-25 2024-06-25 アルデイラ セラピューティクス， インコーポレイテッド ドライアイ疾患を処置するための製剤
JP7706758B2 (ja) 2019-03-26 2025-07-14 アルデイラ セラピューティクス， インコーポレイテッド 眼科用製剤およびその使用
US12098132B2 (en) 2019-05-02 2024-09-24 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates
WO2020223685A1 (en) 2019-05-02 2020-11-05 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
JP2023526016A (ja) 2020-05-13 2023-06-20 アルデイラ セラピューティクス， インコーポレイテッド 医薬製剤およびその使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD70860A (OSRAM) *
BE625278A (OSRAM) * 1961-11-27
CH516339A (de) * 1969-03-03 1971-12-15 Ciba Geigy Ag Verwendung von Azolverbindungen als Antioxydantien
DE2118315C3 (de) * 1970-04-20 1975-04-03 Sumitomo Chemical Co., Ltd., Osaka (Japan) 2-(1H)-Chinazolinonderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
IL37633A (en) * 1970-09-10 1975-08-31 Merck & Co Inc 2-(4-(2-benzoxazolyl)phenyl)alkanoic acid derivatives
DE2115926C3 (de) * 1971-04-01 1978-05-03 C.H. Boehringer Sohn, 6507 Ingelheim 1 -(4-Hydroxy-3-dimethylaminosuIfamidophenyI)-2-aminoäthanderivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel
GB1491863A (en) * 1973-10-23 1977-11-16 Lilly Industries Ltd 2,5-or 2,6-disubstituted benzoxazoles
GB1590587A (en) * 1977-06-28 1981-06-03 Lilly Industries Ltd Benoxaprofen

Also Published As

Publication number Publication date
JPS56167675A (en) 1981-12-23
SE7710602L (sv) 1977-09-21
RO66800A (ro) 1982-03-24
SE434399B (sv) 1984-07-23
SU582762A3 (ru) 1977-11-30
JPS56167674A (en) 1981-12-23
IL48711A0 (en) 1976-02-29
NL7307018A (OSRAM) 1973-11-20
PL94208B1 (OSRAM) 1977-07-30
IE37563B1 (en) 1977-08-17
AR207857A1 (es) 1976-11-08
BE799790A (fr) 1973-11-19
SU574157A3 (ru) 1977-09-25
DK140340B (da) 1979-08-06
IE37564L (en) 1973-11-18
HU167933B (OSRAM) 1976-01-28
CY1016A (en) 1979-11-23
JPS59161346A (ja) 1984-09-12
CH592071A5 (OSRAM) 1977-10-14
AR212010A1 (es) 1978-04-28
AT333752B (de) 1976-12-10
GB1435721A (en) 1976-05-12
MY8000063A (en) 1980-12-31
FR2284592A1 (fr) 1976-04-09
PH10704A (en) 1977-08-24
IE37563L (en) 1973-11-18
FR2184966A1 (OSRAM) 1973-12-28
AR205021A1 (es) 1976-03-31
FR2184966B1 (OSRAM) 1979-01-12
IL42102A0 (en) 1973-06-29
ATA432573A (de) 1976-04-15
FR2284592B1 (OSRAM) 1979-01-05
CH595362A5 (OSRAM) 1978-02-15
CA1029019A (en) 1978-04-04
YU117179A (en) 1981-08-31
PH11718A (en) 1978-05-30
KE2975A (en) 1979-07-20
SE435838B (sv) 1984-10-22
DE2324443A1 (de) 1973-11-29
JPS4954363A (OSRAM) 1974-05-27
HK72579A (en) 1979-10-19
IE37564B1 (en) 1977-08-17
CH587834A5 (OSRAM) 1977-05-13
US3912748A (en) 1975-10-14
AR230991A1 (es) 1984-08-31
BG21408A3 (bg) 1976-05-20
SE386174B (sv) 1976-08-02
NL170145B (nl) 1982-05-03
NL170145C (nl) 1982-10-01
PL89247B1 (OSRAM) 1976-11-30
DK140340C (OSRAM) 1979-12-31
SE7509387L (sv) 1975-08-22
YU117079A (en) 1981-08-31
ES414863A1 (es) 1976-02-01
CH594643A5 (OSRAM) 1978-01-13
JPS5929185B2 (ja) 1984-07-18
ZA732791B (en) 1974-12-24
CH595361A5 (OSRAM) 1978-02-15
PH9685A (en) 1976-02-10
SU580837A3 (ru) 1977-11-15
YU36298B (en) 1982-06-18
JPS6021976B2 (ja) 1985-05-30
JPS56167645A (en) 1981-12-23
YU130473A (en) 1981-08-31
DD105229A5 (OSRAM) 1974-04-12
RO66278A (ro) 1981-06-26
JPS5912672B2 (ja) 1984-03-24
JPS56167673A (en) 1981-12-23
CS200455B2 (en) 1980-09-15
AU5590773A (en) 1974-11-21
IL42102A (en) 1977-07-31
PL92565B1 (OSRAM) 1977-04-30

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Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19730516

PG1605 Publication of application before grant of patent

Comment text: Decision on Publication of Application

Patent event code: PG16051S01I

Patent event date: 19780522

PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 19780905