JPS5798283A - Imidazopyridine derivative - Google Patents

Imidazopyridine derivative

Info

Publication number
JPS5798283A
JPS5798283A JP56169392A JP16939281A JPS5798283A JP S5798283 A JPS5798283 A JP S5798283A JP 56169392 A JP56169392 A JP 56169392A JP 16939281 A JP16939281 A JP 16939281A JP S5798283 A JPS5798283 A JP S5798283A
Authority
JP
Japan
Prior art keywords
methylthiophenyl
imidazo
pyridine
methyl
dimethyl acetamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP56169392A
Other languages
English (en)
Japanese (ja)
Other versions
JPS637545B2 (enExample
Inventor
Jiyan Pieeru Kapuran
Pasukaru Jiyorujiyu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9247171&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS5798283(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of JPS5798283A publication Critical patent/JPS5798283A/ja
Publication of JPS637545B2 publication Critical patent/JPS637545B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cosmetics (AREA)
JP56169392A 1980-10-22 1981-10-21 Imidazopyridine derivative Granted JPS5798283A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8022537A FR2492382A1 (fr) 1980-10-22 1980-10-22 Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
JPS5798283A true JPS5798283A (en) 1982-06-18
JPS637545B2 JPS637545B2 (enExample) 1988-02-17

Family

ID=9247171

Family Applications (1)

Application Number Title Priority Date Filing Date
JP56169392A Granted JPS5798283A (en) 1980-10-22 1981-10-21 Imidazopyridine derivative

Country Status (22)

Country Link
US (2) US4382938A (enExample)
EP (1) EP0050563B1 (enExample)
JP (1) JPS5798283A (enExample)
AT (1) ATE7393T1 (enExample)
AU (1) AU544345B2 (enExample)
CA (1) CA1157470A (enExample)
DE (1) DE3163524D1 (enExample)
DK (1) DK154429C (enExample)
ES (1) ES506412A0 (enExample)
FI (1) FI71143C (enExample)
FR (1) FR2492382A1 (enExample)
GR (1) GR74701B (enExample)
IE (1) IE51686B1 (enExample)
IL (1) IL64091A (enExample)
LU (1) LU88228I2 (enExample)
MX (1) MX6463E (enExample)
NL (1) NL930044I2 (enExample)
NO (1) NO155664C (enExample)
NZ (1) NZ198722A (enExample)
OA (1) OA07076A (enExample)
PT (1) PT73863B (enExample)
ZA (1) ZA817297B (enExample)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002531499A (ja) * 1998-12-04 2002-09-24 サノフィ−サンテラボ ゾルピデムまたはその塩からなる制御放出剤形
JP2003128038A (ja) * 2001-10-10 2003-05-08 Churu Yan 拡張部が形成された紙カップ
JP2004506633A (ja) * 2000-08-16 2004-03-04 ベーリンガー　インゲルハイム　ファルマ　ゲゼルシャフト　ミット　ベシュレンクテル　ハフツング　ウント　コンパニー　コマンディトゲゼルシャフト 新規β−アミロイド阻害剤、その製造方法及び医薬組成物としての使用
JP2006249105A (ja) * 2000-04-24 2006-09-21 Teva Pharmaceutical Industries Ltd ゾルピデムヘミタートレイト
JP2009522327A (ja) * 2006-01-03 2009-06-11 フエルレル インターナショナル，ソシエダッド アノニマ イミダゾ（１，２−ａ）ピリジン−３−イル−酢酸ヒドラジド、その製造方法及び医薬としての使用
JP2009531384A (ja) * 2006-03-29 2009-09-03 フエルレル インターナショナル，ソシエダッド アノニマ イミダゾ［１，２−ｂ］ピリダジン、その調製方法及びＧＡＢＡ受容体リガンドとしてのその使用
JP2009539863A (ja) * 2006-06-05 2009-11-19 オースペックス・ファーマシューティカルズ・インコーポレイテッド 催眠効果を持つ置換イミダゾピリジン化合物の調製と利用
JP2010501491A (ja) * 2006-08-24 2010-01-21 オーストラリアン ヌークリア サイエンス アンド テクノロジー オーガニゼイション 末梢性ベンゾジアゼピン受容体をターゲッティングするためのフッ化リガンド
WO2016104434A1 (ja) * 2014-12-24 2016-06-30 武田薬品工業株式会社 複素環化合物
US12630509B2 (en) 2019-11-14 2026-05-19 Takeda Pharmaceutical Company Limited Heterocyclic NMDA antagonists

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2525602A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
FR2525601A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Derives d'imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
FR2568879B1 (fr) * 1984-08-07 1986-12-12 Synthelabo Imidazo(1,2-a)quinolines, leur preparation et leur application en therapeutique
FR2581646B1 (fr) * 1985-05-07 1987-09-18 Synthelabo Derives d'imidazopyridine, leur preparation et leur application en therapeutique
ATE62687T1 (de) * 1986-01-22 1991-05-15 Synthelabo Acylaminomethylimidazo(1,2-a>pyrimidinderivate, ihre herstellung und therapeutische verwendung.
FR2593179B1 (fr) * 1986-01-22 1988-04-01 Synthelabo Derives d'imidazo(1,2-a)quinoleines, leur preparation et leur application en therapeutique
FR2593817B1 (fr) * 1986-01-31 1988-04-15 Synthelabo Derives de tetrahydro-5,6,7,8 imidazo(1,2-a)pyridine, leur preparation et leur application en therapeutique
FR2599368B1 (fr) * 1986-06-02 1988-08-05 Synthelabo Derives hydroxyles d'imidazopyridines, leur preparation et leur application en therapeutique
FR2600650B1 (fr) * 1986-06-27 1988-09-09 Synthelabo Procede de preparation d'imidazopyridines et composes intermediaires
FR2606409B1 (fr) * 1986-11-07 1989-05-05 Synthelabo Derives d'imidazopyridine, leur preparation et leur application en therapeutique
FR2606410B1 (fr) * 1986-11-07 1989-02-24 Synthelabo Imidazopyridines, leur preparation et leur application en therapeutique
FR2606411B1 (fr) * 1986-11-07 1989-04-07 Synthelabo Imidazopyridine-acetamides, leur preparation et leur application en therapeutique
FR2612927B1 (fr) * 1987-03-27 1989-06-09 Synthelabo Derives d'imidazopyridines, leur preparation et leur application en therapeutique
FR2612928B1 (fr) * 1987-03-27 1989-06-16 Synthelabo Derives hydroxyles d'imidazopyridines, leur preparation et leur application en therapeutique
DE3865073D1 (de) * 1987-03-27 1991-10-31 Synthelabo Imidazopyridinderivate, ihre herstellung und therapeutische verwendung.
US5032595A (en) * 1989-11-24 1991-07-16 Fidia-Georgetown Institute For The Neurosciences Method of stimulating steroidogenesis with alpidem
US5912246A (en) * 1995-02-15 1999-06-15 Pharmacia & Upjohn Company Imidazo 1,2-a!pyridines for the treatment of CNS and cardiac diseases
IT1276522B1 (it) * 1995-04-07 1997-10-31 Elena Benincasa Uso dello zolpidem per il trattamento terapeudico di sindromi neuropsichiatriche associate a disfunsione e di circuiti neurali dei
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
AUPP278498A0 (en) 1998-04-03 1998-04-30 Australian Nuclear Science & Technology Organisation Peripheral benzodiazepine receptor binding agents
PT1163241E (pt) * 1999-03-25 2005-08-31 Synthon Bv Sais de zolpidem
DK1038875T3 (da) 1999-03-25 2003-09-29 Synthon Bv Imidazopyridine- derivativer og fremgangsmåde til fremstilling deraf
US6333345B1 (en) 1999-05-14 2001-12-25 Sepracor, Inc. Methods of using and compositions comprising N-desmethylzolpidem
US6399621B1 (en) 1999-08-10 2002-06-04 American Cyanamid Company N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
US20030091632A1 (en) * 1999-08-26 2003-05-15 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US6485746B1 (en) 2000-08-25 2002-11-26 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US6384221B1 (en) 1999-09-02 2002-05-07 Neurocrine Biosciences, Inc. Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
WO2001078725A2 (en) * 2000-04-13 2001-10-25 Synthon B.V. Modified release formulations containing a hypnotic agent
EP1475093B1 (en) 2000-04-24 2006-09-06 Teva Pharmaceutical Industries Ltd. Micronized Zolpidem hemitartrate
WO2001092257A1 (en) * 2000-05-26 2001-12-06 Neurogen Corporation Oxo-imidazopyrimidine-carboxamides and their use as gaba brain receptor ligands
US6552037B2 (en) 2000-06-30 2003-04-22 Neurogen Corporation 2-Substituted imidazo[1,2-A]pyridine derivatives
IT1318624B1 (it) 2000-07-14 2003-08-27 Dinamite Dipharma S P A In For Processo per la preparazione di 2-fenil-imidazo (1,2-a)piridin-3-acetammidi.
US6514969B2 (en) * 2000-08-16 2003-02-04 Boehringer Ingelheim Pharma Kg β-amyloid inhibitors, processes for preparing them, and their use in pharmaceutical compositions
WO2002014306A1 (en) * 2000-08-17 2002-02-21 Cilag Ag Process for the preparation of imidazopyridines
AU2001284322A1 (en) * 2000-08-29 2002-03-13 Ranbaxy Laboratories Limited Synthesis of n,n-dimethyl-3-(4-methyl) benzoyl propionamide, a key intermediate of zolpidem
US6596731B2 (en) 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
DE10117183A1 (de) * 2001-04-05 2002-10-10 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]-pyridinverbindungen als Arzneimittel
DE10247271A1 (de) * 2002-10-10 2004-08-26 Grünenthal GmbH Substituierte C-Imidazo[1,2-a]pyridin-3-yle
WO2004058758A1 (en) * 2002-12-18 2004-07-15 Mallinckrodt Inc. Synthesis of heteroaryl acetamides
US20040204443A1 (en) * 2003-01-27 2004-10-14 Arthur Zaks Method for inducing pain relief using imidazo[1,2-a]pyridine derivatives
US20040241100A1 (en) * 2003-03-17 2004-12-02 Fabre Kramer Pharmaceutical, Inc. Nasally administrable compositions of zolpidem and methods of use
EP1660496A1 (en) * 2003-07-31 2006-05-31 Ranbaxy Laboratories Limited Process for the synthesis of zolpidem
US7723324B2 (en) * 2003-10-28 2010-05-25 Sepracor, Inc. Imidazo[1,2-A]pyridine anxiolytics
PT1691811E (pt) 2003-12-11 2014-10-30 Sunovion Pharmaceuticals Inc Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão
KR20070030178A (ko) * 2004-02-17 2007-03-15 트랜스오랄 파마슈티칼스, 인코포레이티드 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의사용 방법
ATE454140T1 (de) 2004-02-18 2010-01-15 Sepracor Inc Dopamin-agonisten-kombinationstherapie mit sedativa zur verbesserung der schlafqualität
US20080262025A1 (en) * 2004-07-16 2008-10-23 Yatendra Kumar Processes for the Preparation of Zolpidem and its Hemitartrate
US20060084806A1 (en) * 2004-07-21 2006-04-20 Ramasubramanian Sridharan Processes for the preparation of imidazo[1,2-a] pyridine derivatives
FR2874611B1 (fr) * 2004-08-31 2006-11-17 Servier Lab Nouveaux derives d'imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20070287740A1 (en) * 2005-05-25 2007-12-13 Transcept Pharmaceuticals, Inc. Compositions and methods of treating middle-of-the night insomnia
US20070225322A1 (en) * 2005-05-25 2007-09-27 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the night insomnia
BRPI0609984A2 (pt) * 2005-05-25 2010-05-18 Transcept Pharmaceuticals Inc uso de zolpidem ou um sal do mesmo
US20070020333A1 (en) * 2005-07-20 2007-01-25 Chin-Chih Chiang Controlled release of hypnotic agents
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP2275096A3 (en) 2005-08-26 2011-07-13 Braincells, Inc. Neurogenesis via modulation of the muscarinic receptors
WO2007047978A2 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
WO2007065559A1 (en) 2005-11-18 2007-06-14 Synthon B.V. Zolpidem tablets
US8309104B2 (en) * 2006-03-02 2012-11-13 Watson Pharmaceuticals, Inc. Oral controlled release formulation for sedative and hypnotic agents
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP2021000A2 (en) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenesis by modulating angiotensin
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20080145425A1 (en) * 2006-12-15 2008-06-19 Pliva Research & Development Limited Pharmaceutical composition of zolpidem
US20090076066A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched zolpidem
TW200918102A (en) * 2007-10-24 2009-05-01 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
US20090169618A1 (en) * 2007-12-26 2009-07-02 Limor Ari-Pardo Zolpidem pharmaceutical compositions
US20110142757A1 (en) * 2008-08-19 2011-06-16 The University Of Sydney Novel compounds and their uses in diagnosis
US10478438B2 (en) 2008-10-16 2019-11-19 David Reed Helton Treatment of organophosphate exposure with ocinaplon
US8555875B2 (en) * 2008-12-23 2013-10-15 Map Pharmaceuticals, Inc. Inhalation devices and related methods for administration of sedative hypnotic compounds
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
WO2010122576A1 (en) 2009-04-20 2010-10-28 Matrix Laboratories Ltd Improved process for the preparation of 6-methyl-2-[4-methyl phenyl] imidazo [1, 2-a] pyridine-3-n, n-dimethyl acetamide.
JP5433508B2 (ja) * 2009-06-25 2014-03-05 高田製薬株式会社 ゾルピデム酒石酸塩含有内用液剤
CN102234275B (zh) * 2010-04-27 2015-12-16 溧阳合誉药物科技有限公司 治疗失眠的氘代咪唑并[1,2-a]吡啶衍生物、制备方法及其应用
US8741888B2 (en) 2010-11-09 2014-06-03 Carl A. Forest Sleep aid composition and method
IN2013MU02428A (enExample) * 2013-07-22 2015-06-19 3A Chemie Private Ltd
EP3468545B1 (en) 2016-06-08 2026-08-05 President and Fellows of Harvard College Methods and compositions for reducing tactile dysfunction and anxiety associated with autism spectrum disorder, rett syndrome, and fragile x syndrome
EP3774800B1 (en) * 2018-03-28 2024-11-13 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
WO2019226808A1 (en) 2018-05-22 2019-11-28 President And Fellows Of Harvard College Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment
EP3801512A4 (en) 2018-05-29 2022-01-19 President and Fellows of Harvard College COMPOSITIONS AND METHODS TO REDUCE TACTILE DYSFUNCTION, ANXIETY AND SOCIAL DISABILITIES
US12637418B2 (en) 2019-01-24 2026-05-26 Takeda Pharmaceutical Company Limited Heterocyclic compounds as antagonist of NMDA
US12077512B2 (en) 2019-03-25 2024-09-03 President And Fellows Of Harvard College Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment
JP2021050161A (ja) 2019-09-25 2021-04-01 武田薬品工業株式会社 複素環化合物及びその用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3336194A (en) * 1963-04-30 1967-08-15 Merck & Co Inc Indolyl acid amides
GB1076089A (en) * 1965-11-09 1967-07-19 Selvi & C Lab Bioterapico New derivatives of imidazo [1,2-a]-pyridine and a process for the manufacture thereof

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002531499A (ja) * 1998-12-04 2002-09-24 サノフィ−サンテラボ ゾルピデムまたはその塩からなる制御放出剤形
JP2006249105A (ja) * 2000-04-24 2006-09-21 Teva Pharmaceutical Industries Ltd ゾルピデムヘミタートレイト
JP2004506633A (ja) * 2000-08-16 2004-03-04 ベーリンガー　インゲルハイム　ファルマ　ゲゼルシャフト　ミット　ベシュレンクテル　ハフツング　ウント　コンパニー　コマンディトゲゼルシャフト 新規β−アミロイド阻害剤、その製造方法及び医薬組成物としての使用
JP2003128038A (ja) * 2001-10-10 2003-05-08 Churu Yan 拡張部が形成された紙カップ
JP2009522327A (ja) * 2006-01-03 2009-06-11 フエルレル インターナショナル，ソシエダッド アノニマ イミダゾ（１，２−ａ）ピリジン−３−イル−酢酸ヒドラジド、その製造方法及び医薬としての使用
JP2009531384A (ja) * 2006-03-29 2009-09-03 フエルレル インターナショナル，ソシエダッド アノニマ イミダゾ［１，２−ｂ］ピリダジン、その調製方法及びＧＡＢＡ受容体リガンドとしてのその使用
JP2009539863A (ja) * 2006-06-05 2009-11-19 オースペックス・ファーマシューティカルズ・インコーポレイテッド 催眠効果を持つ置換イミダゾピリジン化合物の調製と利用
JP2010501491A (ja) * 2006-08-24 2010-01-21 オーストラリアン ヌークリア サイエンス アンド テクノロジー オーガニゼイション 末梢性ベンゾジアゼピン受容体をターゲッティングするためのフッ化リガンド
WO2016104434A1 (ja) * 2014-12-24 2016-06-30 武田薬品工業株式会社 複素環化合物
US12630509B2 (en) 2019-11-14 2026-05-19 Takeda Pharmaceutical Company Limited Heterocyclic NMDA antagonists

Also Published As

Publication number Publication date
NO155664C (no) 1987-05-06
NL930044I2 (nl) 1993-09-16
FI813288L (fi) 1982-04-23
US4382938A (en) 1983-05-10
JPS637545B2 (enExample) 1988-02-17
US4460592A (en) 1984-07-17
FR2492382B1 (enExample) 1983-07-29
GR74701B (enExample) 1984-07-04
EP0050563A1 (fr) 1982-04-28
IE51686B1 (en) 1987-02-04
MX6463E (es) 1985-06-06
FI71143B (fi) 1986-08-14
LU88228I2 (enExample) 1994-02-03
AU7668781A (en) 1983-04-28
ES8207537A1 (es) 1982-09-16
DE3163524D1 (en) 1984-06-14
OA07076A (fr) 1984-01-31
NO155664B (no) 1987-01-26
IL64091A0 (en) 1982-01-31
ES506412A0 (es) 1982-09-16
ATE7393T1 (de) 1984-05-15
DK465181A (da) 1982-04-23
EP0050563B1 (fr) 1984-05-09
PT73863A (fr) 1981-11-01
NL930044I1 (nl) 1993-08-02
FR2492382A1 (fr) 1982-04-23
NZ198722A (en) 1984-10-19
IE812470L (en) 1982-04-22
IL64091A (en) 1984-12-31
FI71143C (fi) 1986-11-24
AU544345B2 (en) 1985-05-23
DK154429C (da) 1989-04-17
CA1157470A (en) 1983-11-22
PT73863B (fr) 1983-11-07
DK154429B (da) 1988-11-14
ZA817297B (en) 1982-09-29
NO813551L (no) 1982-04-23

Similar Documents

Publication Publication Date Title
AU544345B2 (en) Imidazo(1,2-a)pyridine derivatives
AU3502289A (en) Method for administering the drug deprenyl so as to minimize the danger of side effects
ATA438383A (de) Verfahren zum herstellen von neuen carboxamidoderivaten von 5h-1,3,4-thiadiazolo(3,2-a)-pyrimidinen und ihren pharmazeutisch unbedenklichen salzen
HUP9900733A3 (en) Use of imidazo[1,2-a]pyridine-3-acetamide derivatives for the therapeutic treatment of neuropsychiatric syndromes associated with difunction of the neural circuits of the basal ganglia
PT83080A (en) Process for the preparation of biciclic naphthyridine compounds or analogs and their salts soluates hydrates and esters
FI922848L (fi) Menetelmä valmistaa terapeuttisesti aktiivisia tetrahydropyrrolo[1,2-a]pyratsiini-4-spiro-3'-pyrrolidiinijohdannaisia
IL92078A0 (en) Use of bicyclic imidazole compounds for the treatment of hyperaldosteronism
PT79220B (en) Process for preparing new pyridoindole derivatives useful as agents for the treatment of diseases of the centrel nervous system
FI892908L (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten imidatso/1,5-a/kinoksaliinijohdannaisten valmistamiseksi
FI890478A7 (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten 4-okso-4H-pyrido/1,2-a/pyrimidiini-3-karboksamidijohdannaisten valmistamiseksi
DE3160044D1 (en) 2,3-dihydroimidazo (1,2-b) pyridazine derivatives, process for their preparation and their therapeutical use
ZA814902B (en) Novel thiazol-2-yl-oxamic acid derivatives,their preparation and therapeutic agents containing these compounds
HUT47579A (en) Process for production of new imidazo /1,2-a/-pirimidins and their salts and medical compositions containing them as active substance
HUT49054A (en) Process for producing pharmaceutical compositions absorbed through the derm and comprising pyrazolo(1,5-a) pyridine derivatives as active ingredient
AT362377B (de) Verfahren zur herstellung neuer pyrido(1,2-a) pyrimidin-derivate, deren optisch aktiver isomere und physiologisch vertraeglicher salze
DK0399653T3 (da) Triazolo(4,5-c)pyridinderivater med antikrampe virkning
PT74009A (en) Amino-penicillin derivative the process for its preparation and therapeutic compounds which contain in it as their active principle
ES498643A0 (es) Procedimiento para la preparacion de imidazo(1,2-a)piridinas
ATA182680A (de) Verfahren zur herstellung neuer pyrido-(1,2-a) pyrimidin-derivate, deren optisch aktiver isomeren und physiologisch vertraeglichen salze
ATA182780A (de) Verfahren zur herstellung neuer pyrido-(1,2-a) pyrimidin-derivate, deren optisch aktiver isomerer und physiologisch vertraeglicher salze

Legal Events

Date Code Title Description
EXPY Cancellation because of completion of term