PT73863A - Procede de preparation de derives d'imidazo^1,2-a[pyridine applicables en therapeutique - Google Patents

Procede de preparation de derives d'imidazo^1,2-a[pyridine applicables en therapeutique

Info

Publication number
PT73863A
PT73863A PT73863A PT7386381A PT73863A PT 73863 A PT73863 A PT 73863A PT 73863 A PT73863 A PT 73863A PT 7386381 A PT7386381 A PT 7386381A PT 73863 A PT73863 A PT 73863A
Authority
PT
Portugal
Prior art keywords
imidazo
therapeutically
preparation
pyridine derivatives
pyridine
Prior art date
Application number
PT73863A
Other languages
English (en)
Portuguese (pt)
Other versions
PT73863B (fr
Inventor
Jean Pierre Kaplan
Pascal George
Original Assignee
Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9247171&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT73863(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synthelabo filed Critical Synthelabo
Publication of PT73863A publication Critical patent/PT73863A/fr
Publication of PT73863B publication Critical patent/PT73863B/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
PT73863A 1980-10-22 1981-10-21 Procede de preparation de derives d'imidazo^1,2-a[pyridine applicables en therapeutique PT73863B (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8022537A FR2492382A1 (fr) 1980-10-22 1980-10-22 Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
PT73863A true PT73863A (fr) 1981-11-01
PT73863B PT73863B (fr) 1983-11-07

Family

ID=9247171

Family Applications (1)

Application Number Title Priority Date Filing Date
PT73863A PT73863B (fr) 1980-10-22 1981-10-21 Procede de preparation de derives d'imidazo^1,2-a[pyridine applicables en therapeutique

Country Status (22)

Country Link
US (2) US4382938A (fr)
EP (1) EP0050563B1 (fr)
JP (1) JPS5798283A (fr)
AT (1) ATE7393T1 (fr)
AU (1) AU544345B2 (fr)
CA (1) CA1157470A (fr)
DE (1) DE3163524D1 (fr)
DK (1) DK154429C (fr)
ES (1) ES8207537A1 (fr)
FI (1) FI71143C (fr)
FR (1) FR2492382A1 (fr)
GR (1) GR74701B (fr)
IE (1) IE51686B1 (fr)
IL (1) IL64091A (fr)
LU (1) LU88228I2 (fr)
MX (1) MX6463E (fr)
NL (1) NL930044I2 (fr)
NO (1) NO155664C (fr)
NZ (1) NZ198722A (fr)
OA (1) OA07076A (fr)
PT (1) PT73863B (fr)
ZA (1) ZA817297B (fr)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2525601A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Derives d'imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
FR2525602A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
FR2568879B1 (fr) * 1984-08-07 1986-12-12 Synthelabo Imidazo(1,2-a)quinolines, leur preparation et leur application en therapeutique
FR2581646B1 (fr) * 1985-05-07 1987-09-18 Synthelabo Derives d'imidazopyridine, leur preparation et leur application en therapeutique
FR2593179B1 (fr) * 1986-01-22 1988-04-01 Synthelabo Derives d'imidazo(1,2-a)quinoleines, leur preparation et leur application en therapeutique
ES2032455T3 (es) * 1986-01-22 1993-02-16 Synthelabo Procedimiento para preparar derivados de 3-acilaminometil-imidazo (-1,2-a)piridinas.
FR2593817B1 (fr) * 1986-01-31 1988-04-15 Synthelabo Derives de tetrahydro-5,6,7,8 imidazo(1,2-a)pyridine, leur preparation et leur application en therapeutique
FR2599368B1 (fr) * 1986-06-02 1988-08-05 Synthelabo Derives hydroxyles d'imidazopyridines, leur preparation et leur application en therapeutique
FR2600650B1 (fr) * 1986-06-27 1988-09-09 Synthelabo Procede de preparation d'imidazopyridines et composes intermediaires
FR2606409B1 (fr) * 1986-11-07 1989-05-05 Synthelabo Derives d'imidazopyridine, leur preparation et leur application en therapeutique
FR2606411B1 (fr) * 1986-11-07 1989-04-07 Synthelabo Imidazopyridine-acetamides, leur preparation et leur application en therapeutique
FR2606410B1 (fr) * 1986-11-07 1989-02-24 Synthelabo Imidazopyridines, leur preparation et leur application en therapeutique
FR2612928B1 (fr) * 1987-03-27 1989-06-16 Synthelabo Derives hydroxyles d'imidazopyridines, leur preparation et leur application en therapeutique
DE3865073D1 (de) * 1987-03-27 1991-10-31 Synthelabo Imidazopyridinderivate, ihre herstellung und therapeutische verwendung.
FR2612927B1 (fr) * 1987-03-27 1989-06-09 Synthelabo Derives d'imidazopyridines, leur preparation et leur application en therapeutique
US5032595A (en) * 1989-11-24 1991-07-16 Fidia-Georgetown Institute For The Neurosciences Method of stimulating steroidogenesis with alpidem
EP0809642A1 (fr) * 1995-02-15 1997-12-03 PHARMACIA & UPJOHN COMPANY Imidazo 1,2-a]pyridines pour le traitement du snc et de cardiopathologies
IT1276522B1 (it) * 1995-04-07 1997-10-31 Elena Benincasa Uso dello zolpidem per il trattamento terapeudico di sindromi neuropsichiatriche associate a disfunsione e di circuiti neurali dei
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
AUPP278498A0 (en) 1998-04-03 1998-04-30 Australian Nuclear Science & Technology Organisation Peripheral benzodiazepine receptor binding agents
EP1005863A1 (fr) * 1998-12-04 2000-06-07 Synthelabo Formes galeniques a liberation controlee contenant un hypnotique a activite courte ou un sel de ce compose
EP1038875B1 (fr) * 1999-03-25 2003-06-04 Synthon B.V. Dérivés d'imidazopyridine et procédé pour leur préparation
DE60020814T2 (de) * 1999-03-25 2006-05-04 Synthon B.V. Zolpidem salze
US6333345B1 (en) 1999-05-14 2001-12-25 Sepracor, Inc. Methods of using and compositions comprising N-desmethylzolpidem
US6399621B1 (en) 1999-08-10 2002-06-04 American Cyanamid Company N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1, 5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
US20030091632A1 (en) * 1999-08-26 2003-05-15 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US6485746B1 (en) 2000-08-25 2002-11-26 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US6384221B1 (en) * 1999-09-02 2002-05-07 Neurocrine Biosciences, Inc. Polymorphs of N-methyl-N-(3-{3-[2-thienylcarbonyl]-pyrazol-[1,5-α]-pyrimidin-7-yl}phenyl)acetamide and compositions and methods related thereto
AU5066101A (en) 2000-04-13 2001-10-30 Synthon B.V. Modified release formulations containing a hypnotic agent
EP1604663A1 (fr) 2000-04-24 2005-12-14 Teva Pharmaceutical Industries Ltd Forme H de Solvat de Zolpidem Hemitartrat
ES2277301T3 (es) * 2000-04-24 2007-07-01 Teva Pharmaceutical Industries Ltd. Solvato de hemitartrato de zolpidem.
US6723332B2 (en) 2000-05-26 2004-04-20 Neurogen Corporation Oxomidazopyridine-carboxamides
US6552037B2 (en) 2000-06-30 2003-04-22 Neurogen Corporation 2-Substituted imidazo[1,2-A]pyridine derivatives
IT1318624B1 (it) * 2000-07-14 2003-08-27 Dinamite Dipharma S P A In For Processo per la preparazione di 2-fenil-imidazo (1,2-a)piridin-3-acetammidi.
DE10040016A1 (de) * 2000-08-16 2002-02-28 Boehringer Ingelheim Pharma Neue beta-Amyloid Inhibitoren, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US6514969B2 (en) * 2000-08-16 2003-02-04 Boehringer Ingelheim Pharma Kg β-amyloid inhibitors, processes for preparing them, and their use in pharmaceutical compositions
AU2000264428A1 (en) * 2000-08-17 2002-02-25 Cilag A.G. Process for the preparation of imidazopyridines
US6921839B2 (en) * 2000-08-29 2005-07-26 Ranbaxy Laboratories Limited Synthesis of N,N-dimethyl-3-(4-methyl) benzoyl propionamide a key intermediate of zolpidem
US6596731B2 (en) 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
DE10117183A1 (de) * 2001-04-05 2002-10-10 Gruenenthal Gmbh Verwendung von substituierten Imidazo[1,2-a]-pyridinverbindungen als Arzneimittel
KR100433502B1 (ko) * 2001-10-10 2004-06-07 철 양 확장부가 형성된 종이컵
DE10247271A1 (de) * 2002-10-10 2004-08-26 Grünenthal GmbH Substituierte C-Imidazo[1,2-a]pyridin-3-yle
US7385056B2 (en) * 2002-12-18 2008-06-10 Mallinckrodt Inc. Synthesis of heteroaryl acetamides
US20040204443A1 (en) * 2003-01-27 2004-10-14 Arthur Zaks Method for inducing pain relief using imidazo[1,2-a]pyridine derivatives
US20040241100A1 (en) * 2003-03-17 2004-12-02 Fabre Kramer Pharmaceutical, Inc. Nasally administrable compositions of zolpidem and methods of use
WO2005010002A1 (fr) * 2003-07-31 2005-02-03 Ranbaxy Laboratories Limited Procede pour la synthese de zolpidem
EP1682549B1 (fr) * 2003-10-28 2010-09-22 Sepracor Inc. Anxiolytiques d'imidazo[1,2-a]pyridine
EP1691811B1 (fr) 2003-12-11 2014-07-23 Sunovion Pharmaceuticals Inc. Combinaison d'un sedatif et d'un modulateur des neurotransmetteurs, et methodes permettant d'ameliorer la qualite du sommeil et de traiter la depression
KR20070030178A (ko) * 2004-02-17 2007-03-15 트랜스오랄 파마슈티칼스, 인코포레이티드 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의사용 방법
DE602005018763D1 (de) 2004-02-18 2010-02-25 Sepracor Inc Dopamin-agonisten-kombinationstherapie mit sedativa zur verbesserung der schlafqualität
US20080262025A1 (en) * 2004-07-16 2008-10-23 Yatendra Kumar Processes for the Preparation of Zolpidem and its Hemitartrate
US20060084806A1 (en) * 2004-07-21 2006-04-20 Ramasubramanian Sridharan Processes for the preparation of imidazo[1,2-a] pyridine derivatives
FR2874611B1 (fr) * 2004-08-31 2006-11-17 Servier Lab Nouveaux derives d'imidazopyridine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20070225322A1 (en) * 2005-05-25 2007-09-27 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the night insomnia
US20060276501A1 (en) * 2005-05-25 2006-12-07 Transoral Pharmaceuticals, Inc. Solid compositions for treating middle-of-the-night insomnia
US20070287740A1 (en) * 2005-05-25 2007-12-13 Transcept Pharmaceuticals, Inc. Compositions and methods of treating middle-of-the night insomnia
US20070020333A1 (en) * 2005-07-20 2007-01-25 Chin-Chih Chiang Controlled release of hypnotic agents
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258359A3 (fr) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenèse par modulation des récepteurs muscariniques avec sabcomeline
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
CA2625210A1 (fr) 2005-10-31 2007-05-10 Braincells, Inc. Modulation de la neurogenese dont la mediation est assuree par recepteur gaba
WO2007065559A1 (fr) 2005-11-18 2007-06-14 Synthon B.V. Comprimés de zolpidem
EP1803722A1 (fr) * 2006-01-03 2007-07-04 Ferrer Internacional, S.A. Hydrazides d'acides imidazo[1,2-a]pyridin-3-yl-acétiques, leurs procédés de préparation et leur utilisation comme médicaments
US8309104B2 (en) * 2006-03-02 2012-11-13 Watson Pharmaceuticals, Inc. Oral controlled release formulation for sedative and hypnotic agents
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
EP1845098A1 (fr) * 2006-03-29 2007-10-17 Ferrer Internacional, S.A. Imidazo[1,2-b]pyridazines, leur procédés de préparation et leur utilisation comme ligands du recepteur GABA
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
CN101516879A (zh) * 2006-06-05 2009-08-26 奥斯拜客斯制药有限公司 具有催眠作用的取代的咪唑并吡啶化合物的制备及用途
BRPI0716583A2 (pt) * 2006-08-24 2013-10-01 Australian Nuclear Science Tec ligandos fluorados para marcar recptores de benzodiazepina perifÉricos
EP2068872A1 (fr) 2006-09-08 2009-06-17 Braincells, Inc. Combinaisons contenant un dérivé de 4-acylaminopyridine
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20080145425A1 (en) * 2006-12-15 2008-06-19 Pliva Research & Development Limited Pharmaceutical composition of zolpidem
US20090076066A1 (en) * 2007-09-19 2009-03-19 Protia, Llc Deuterium-enriched zolpidem
KR20100091965A (ko) * 2007-10-24 2010-08-19 니혼 메디피직스 가부시키가이샤 신규 아밀로이드 친화성 화합물
WO2009085310A1 (fr) * 2007-12-26 2009-07-09 Teva Pharmaceutical Industries Ltd. Compositions pharmaceutiques à libération prolongée contenant du zolpidem
AU2009284695A1 (en) * 2008-08-19 2010-02-25 The University Of Sydney Novel compounds and their uses in diagnosis
WO2010045615A2 (fr) 2008-10-16 2010-04-22 Cenomed Biosciences, Llc Traitement d'une exposition à des composés organophosphorés avec de l'ocinaplon
WO2010074753A1 (fr) 2008-12-23 2010-07-01 Map Pharmaceuticals, Inc. Dispositifs d'inhalation et procédés associés pour administration de composés hypnotiques sédatifs
WO2010099217A1 (fr) 2009-02-25 2010-09-02 Braincells, Inc. Modulation de neurogenèse à l'aide de combinaisons de d-cyclosérine
WO2010122576A1 (fr) 2009-04-20 2010-10-28 Matrix Laboratories Ltd Procédé amélioré pour la préparation de 6-méthyl-2-[4-méthyl-phényl] imidazo [1, 2-a ] pyridine-3-n, n-diméthyle acétamide
JP5433508B2 (ja) * 2009-06-25 2014-03-05 高田製薬株式会社 ゾルピデム酒石酸塩含有内用液剤
CN102234275B (zh) * 2010-04-27 2015-12-16 溧阳合誉药物科技有限公司 治疗失眠的氘代咪唑并[1,2-a]吡啶衍生物、制备方法及其应用
US8741888B2 (en) 2010-11-09 2014-06-03 Carl A. Forest Sleep aid composition and method
WO2015011722A2 (fr) * 2013-07-22 2015-01-29 3A Chemie Private Limited Zolpidem, procédé de préparation et intermédiaire à l'intérieur de celui-ci
EP3239150B1 (fr) * 2014-12-24 2020-02-05 Takeda Pharmaceutical Company Limited Composé hétérocyclique
EP3468545A4 (fr) 2016-06-08 2020-07-22 President and Fellows of Harvard College Procédés et compositions pour réduire le dysfonctionnement tactile et l'anxiété associés au trouble du spectre de l'autisme, au syndrome de rett et au syndrome de l'x fragile
TW202003519A (zh) * 2018-03-28 2020-01-16 日商武田藥品工業股份有限公司 雜環化合物及其用途
CA3099791A1 (fr) * 2018-05-29 2019-12-05 President And Fellows Of Harvard College Compositions et methodes pour reduire un dysfonctionnement tactile, l'anxiete et une deficience sociale
US12077512B2 (en) 2019-03-25 2024-09-03 President And Fellows Of Harvard College Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment
JP2021050161A (ja) 2019-09-25 2021-04-01 武田薬品工業株式会社 複素環化合物及びその用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3336194A (en) * 1963-04-30 1967-08-15 Merck & Co Inc Indolyl acid amides
GB1076089A (en) * 1965-11-09 1967-07-19 Selvi & C Lab Bioterapico New derivatives of imidazo [1,2-a]-pyridine and a process for the manufacture thereof

Also Published As

Publication number Publication date
EP0050563A1 (fr) 1982-04-28
ATE7393T1 (de) 1984-05-15
NL930044I1 (nl) 1993-08-02
AU7668781A (en) 1983-04-28
NL930044I2 (nl) 1993-09-16
JPS5798283A (en) 1982-06-18
NO155664B (no) 1987-01-26
OA07076A (fr) 1984-01-31
FR2492382A1 (fr) 1982-04-23
FR2492382B1 (fr) 1983-07-29
AU544345B2 (en) 1985-05-23
FI813288L (fi) 1982-04-23
US4382938A (en) 1983-05-10
FI71143C (fi) 1986-11-24
NO155664C (no) 1987-05-06
MX6463E (es) 1985-06-06
NO813551L (no) 1982-04-23
NZ198722A (en) 1984-10-19
DK154429B (da) 1988-11-14
IE812470L (en) 1982-04-22
ZA817297B (en) 1982-09-29
ES506412A0 (es) 1982-09-16
CA1157470A (fr) 1983-11-22
US4460592A (en) 1984-07-17
IE51686B1 (en) 1987-02-04
IL64091A0 (en) 1982-01-31
ES8207537A1 (es) 1982-09-16
EP0050563B1 (fr) 1984-05-09
IL64091A (en) 1984-12-31
DK465181A (da) 1982-04-23
DK154429C (da) 1989-04-17
DE3163524D1 (en) 1984-06-14
GR74701B (fr) 1984-07-04
JPS637545B2 (fr) 1988-02-17
FI71143B (fi) 1986-08-14
LU88228I2 (fr) 1994-02-03
PT73863B (fr) 1983-11-07

Similar Documents

Publication Publication Date Title
PT73863B (fr) Procede de preparation de derives d'imidazo^1,2-a[pyridine applicables en therapeutique
AT385036B (de) Verfahren zum herstellen von neuen carboxamidoderivaten von 5h-1,3,4-thiadiazolo(3,2-a)-pyrimidinen und ihren pharmazeutisch unbedenklichen salzen
PT83080A (en) Process for the preparation of biciclic naphthyridine compounds or analogs and their salts soluates hydrates and esters
PT76573B (fr) Procede de preparation de derives d'imidazo <1,2-a> pyridine et de compositions pharmaceutiques les contenant
MA21122A1 (fr) Procede de preparation de derives d'acides aminocarboxyliques bicycliques .
PT74652B (fr) Procede de preparation de derives d'imidazo <1,2-a> pyrimidines et de compositions pharmaceutiques les contenant
DE3160044D1 (en) 2,3-dihydroimidazo (1,2-b) pyridazine derivatives, process for their preparation and their therapeutical use
FR2530246B1 (fr) Nouveaux derives pyrido indoliniques et pirido indoliques et leurs sels, ainsi que le procede de preparation et l'application en therapeutique de ces derives et sels
PT72493A (fr) Procede de preparation de derives benzylideniques avec application en therapeutique
AT362377B (de) Verfahren zur herstellung neuer pyrido(1,2-a) pyrimidin-derivate, deren optisch aktiver isomere und physiologisch vertraeglicher salze
HUT49054A (en) Process for producing pharmaceutical compositions absorbed through the derm and comprising pyrazolo(1,5-a) pyridine derivatives as active ingredient
PT82244A (fr) Procede de preparation de nouveaux derives de la 5-h pyrido<3',4':4,5>pyrrolo<3,2-c>pyridine a activite antitumorale et de compositions pharmaceutiques les contenant
FR2456099B1 (fr) Derives de 9-hydrazono-6,7,8,9-tetrahydro-4h-pyrido-(1,2-a)-pyrimidin-4-one, procede pour leur preparation et application a titre de medicament
FI93448C (fi) Menetelmä terapeuttisesti käyttökelpoisen triatsolo/4,5-c/pyridiinijohdannaisten valmistamiseksi
MA19456A1 (fr) Derives d'imidazo 1,2-a pyridine, leur preparation et leur application en therapeutique
ATA182780A (de) Verfahren zur herstellung neuer pyrido-(1,2-a) pyrimidin-derivate, deren optisch aktiver isomerer und physiologisch vertraeglicher salze
ATA182680A (de) Verfahren zur herstellung neuer pyrido-(1,2-a) pyrimidin-derivate, deren optisch aktiver isomeren und physiologisch vertraeglichen salze
FI93837C (fi) Menetelmä uusien terapeuttisesti käyttökelpoisten 4-okso-4,5-dihydro-imidatso/1,5-a/pyrido/2,3-e/pyratsiinijohdannaisten valmistamiseksi

Legal Events

Date Code Title Description
PC3A Transfer or assignment

Free format text: 20001107 SANOFI-SYNTHELABO FR