ES8207537A1 - Procedimiento de preparacion de imidazo (1,2-a)piridinas - Google Patents

Procedimiento de preparacion de imidazo (1,2-a)piridinas

Info

Publication number
ES8207537A1
ES8207537A1 ES506412A ES506412A ES8207537A1 ES 8207537 A1 ES8207537 A1 ES 8207537A1 ES 506412 A ES506412 A ES 506412A ES 506412 A ES506412 A ES 506412A ES 8207537 A1 ES8207537 A1 ES 8207537A1
Authority
ES
Spain
Prior art keywords
hydrogen
radical
image
alkyl radical
halogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES506412A
Other languages
English (en)
Other versions
ES506412A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9247171&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8207537(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of ES506412A0 publication Critical patent/ES506412A0/es
Publication of ES8207537A1 publication Critical patent/ES8207537A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cosmetics (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE IMIDAZO (1,2-A) PIRIDINAS Y Y Z SON LOS MISMOS QUE EN LA FORMULA (I), CON UN ACIDO TAL COMO CLORURO DE HIDROGENO EN ACIDO FORMICO A 15 Y 50 GRADOS CENTIGRADOS PARA OBTENER LA AMIDA,QUE SE SAPONIFICA AL ACIDO EN POTASA ALCOHOLICA A LA TEMPERATURA DE REFLUJO, Y ESTE SE AMIDIFICA POR TRATAMIENTO CON LA AMINA DE FORMULA H R1 R2 EN LA QUE R1 Y R2 SON LOS MISMOS QUE EN LA FORMULA (I). ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS PROPIEDADES ANSIOLITICAS, ANTIANOXICAS, INDUCTORAS DEL SUEÑO, HIPNOTICAS Y ANTICONVUSIVAS.
ES506412A 1980-10-22 1981-10-21 Procedimiento de preparacion de imidazo (1,2-a)piridinas Expired ES8207537A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8022537A FR2492382A1 (fr) 1980-10-22 1980-10-22 Derives d'imidazo (1,2-a) pyridine, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
ES506412A0 ES506412A0 (es) 1982-09-16
ES8207537A1 true ES8207537A1 (es) 1982-09-16

Family

ID=9247171

Family Applications (1)

Application Number Title Priority Date Filing Date
ES506412A Expired ES8207537A1 (es) 1980-10-22 1981-10-21 Procedimiento de preparacion de imidazo (1,2-a)piridinas

Country Status (22)

Country Link
US (2) US4382938A (es)
EP (1) EP0050563B1 (es)
JP (1) JPS5798283A (es)
AT (1) ATE7393T1 (es)
AU (1) AU544345B2 (es)
CA (1) CA1157470A (es)
DE (1) DE3163524D1 (es)
DK (1) DK154429C (es)
ES (1) ES8207537A1 (es)
FI (1) FI71143C (es)
FR (1) FR2492382A1 (es)
GR (1) GR74701B (es)
IE (1) IE51686B1 (es)
IL (1) IL64091A (es)
LU (1) LU88228I2 (es)
MX (1) MX6463E (es)
NL (1) NL930044I2 (es)
NO (1) NO155664C (es)
NZ (1) NZ198722A (es)
OA (1) OA07076A (es)
PT (1) PT73863B (es)
ZA (1) ZA817297B (es)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2525601A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Derives d'imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
FR2525602A1 (fr) * 1982-04-21 1983-10-28 Synthelabo Imidazo(1,2-a)pyridines, leur preparation et leur application en therapeutique
FR2568879B1 (fr) * 1984-08-07 1986-12-12 Synthelabo Imidazo(1,2-a)quinolines, leur preparation et leur application en therapeutique
FR2581646B1 (fr) * 1985-05-07 1987-09-18 Synthelabo Derives d'imidazopyridine, leur preparation et leur application en therapeutique
ATE62687T1 (de) * 1986-01-22 1991-05-15 Synthelabo Acylaminomethylimidazo(1,2-a>pyrimidinderivate, ihre herstellung und therapeutische verwendung.
FR2593179B1 (fr) * 1986-01-22 1988-04-01 Synthelabo Derives d'imidazo(1,2-a)quinoleines, leur preparation et leur application en therapeutique
FR2593817B1 (fr) * 1986-01-31 1988-04-15 Synthelabo Derives de tetrahydro-5,6,7,8 imidazo(1,2-a)pyridine, leur preparation et leur application en therapeutique
FR2599368B1 (fr) * 1986-06-02 1988-08-05 Synthelabo Derives hydroxyles d'imidazopyridines, leur preparation et leur application en therapeutique
FR2600650B1 (fr) * 1986-06-27 1988-09-09 Synthelabo Procede de preparation d'imidazopyridines et composes intermediaires
FR2606410B1 (fr) * 1986-11-07 1989-02-24 Synthelabo Imidazopyridines, leur preparation et leur application en therapeutique
FR2606411B1 (fr) * 1986-11-07 1989-04-07 Synthelabo Imidazopyridine-acetamides, leur preparation et leur application en therapeutique
FR2606409B1 (fr) * 1986-11-07 1989-05-05 Synthelabo Derives d'imidazopyridine, leur preparation et leur application en therapeutique
EP0289371B1 (fr) * 1987-03-27 1991-09-25 Synthelabo Dérivés d'imidazopyridines, leur préparation et leur application en thérapeutique
FR2612927B1 (fr) * 1987-03-27 1989-06-09 Synthelabo Derives d'imidazopyridines, leur preparation et leur application en therapeutique
FR2612928B1 (fr) * 1987-03-27 1989-06-16 Synthelabo Derives hydroxyles d'imidazopyridines, leur preparation et leur application en therapeutique
US5032595A (en) * 1989-11-24 1991-07-16 Fidia-Georgetown Institute For The Neurosciences Method of stimulating steroidogenesis with alpidem
AU4859596A (en) * 1995-02-15 1996-09-04 Pharmacia & Upjohn Company Imidazo{1,2-a}pyridines for the treatment of cns and cardiac diseases
IT1276522B1 (it) * 1995-04-07 1997-10-31 Elena Benincasa Uso dello zolpidem per il trattamento terapeudico di sindromi neuropsichiatriche associate a disfunsione e di circuiti neurali dei
US6013654A (en) * 1997-08-14 2000-01-11 Pharmacia & Upjohn Company Imidazo[1,2-A]pyridines for the treatment of CNS and cardiac diseases
AUPP278498A0 (en) 1998-04-03 1998-04-30 Australian Nuclear Science & Technology Organisation Peripheral benzodiazepine receptor binding agents
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DK1038875T3 (da) 1999-03-25 2003-09-29 Synthon Bv Imidazopyridine- derivativer og fremgangsmåde til fremstilling deraf
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EP1272181A2 (en) 2000-04-13 2003-01-08 Synthon B.V. Modified release formulations containing a hypnotic agent
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EA202092294A1 (ru) * 2018-03-28 2021-01-15 Такеда Фармасьютикал Компани Лимитед Гетероциклическое соединение и его применение
US11434244B2 (en) 2018-05-29 2022-09-06 President And Fellows Of Harvard College Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment
US12077512B2 (en) 2019-03-25 2024-09-03 President And Fellows Of Harvard College Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment
JP2021050161A (ja) 2019-09-25 2021-04-01 武田薬品工業株式会社 複素環化合物及びその用途

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GB1076089A (en) * 1965-11-09 1967-07-19 Selvi & C Lab Bioterapico New derivatives of imidazo [1,2-a]-pyridine and a process for the manufacture thereof

Also Published As

Publication number Publication date
IL64091A (en) 1984-12-31
IE51686B1 (en) 1987-02-04
US4382938A (en) 1983-05-10
ZA817297B (en) 1982-09-29
ATE7393T1 (de) 1984-05-15
PT73863A (fr) 1981-11-01
IE812470L (en) 1982-04-22
AU7668781A (en) 1983-04-28
OA07076A (fr) 1984-01-31
FI813288L (fi) 1982-04-23
LU88228I2 (es) 1994-02-03
NZ198722A (en) 1984-10-19
JPS5798283A (en) 1982-06-18
US4460592A (en) 1984-07-17
EP0050563A1 (fr) 1982-04-28
ES506412A0 (es) 1982-09-16
MX6463E (es) 1985-06-06
DK154429B (da) 1988-11-14
DK154429C (da) 1989-04-17
NO155664C (no) 1987-05-06
DE3163524D1 (en) 1984-06-14
NO155664B (no) 1987-01-26
FR2492382B1 (es) 1983-07-29
DK465181A (da) 1982-04-23
NL930044I2 (nl) 1993-09-16
FI71143B (fi) 1986-08-14
IL64091A0 (en) 1982-01-31
FI71143C (fi) 1986-11-24
AU544345B2 (en) 1985-05-23
NO813551L (no) 1982-04-23
GR74701B (es) 1984-07-04
FR2492382A1 (fr) 1982-04-23
NL930044I1 (nl) 1993-08-02
PT73863B (fr) 1983-11-07
EP0050563B1 (fr) 1984-05-09
JPS637545B2 (es) 1988-02-17
CA1157470A (en) 1983-11-22

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Effective date: 20020307