JPS52102293A - Novel oxim derivative of 77 aminothiazolylacetoamide cephalospolanate process for preparing same and pharmaceutical composition - Google Patents

Novel oxim derivative of 77 aminothiazolylacetoamide cephalospolanate process for preparing same and pharmaceutical composition

Info

Publication number
JPS52102293A
JPS52102293A JP504977A JP504977A JPS52102293A JP S52102293 A JPS52102293 A JP S52102293A JP 504977 A JP504977 A JP 504977A JP 504977 A JP504977 A JP 504977A JP S52102293 A JPS52102293 A JP S52102293A
Authority
JP
Japan
Prior art keywords
cephalospolanate
aminothiazolylacetoamide
oxim
derivative
novel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP504977A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6228152B2 (da
Inventor
Eemu Rune
Riyutsutsu Andore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27250574&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPS52102293(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR7601834A external-priority patent/FR2346014A1/fr
Priority claimed from FR7617743A external-priority patent/FR2361893A2/fr
Priority claimed from FR7625051A external-priority patent/FR2361894A2/fr
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of JPS52102293A publication Critical patent/JPS52102293A/ja
Publication of JPS6228152B2 publication Critical patent/JPS6228152B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP504977A 1976-01-23 1977-01-21 Novel oxim derivative of 77 aminothiazolylacetoamide cephalospolanate process for preparing same and pharmaceutical composition Granted JPS52102293A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR7601834A FR2346014A1 (fr) 1976-01-23 1976-01-23 Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR7617743A FR2361893A2 (fr) 1976-01-23 1976-06-11 Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR7625051A FR2361894A2 (fr) 1976-01-23 1976-08-18 Nouvelles oximes derivees de l'acide 7-aminothiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
JPS52102293A true JPS52102293A (en) 1977-08-27
JPS6228152B2 JPS6228152B2 (da) 1987-06-18

Family

ID=27250574

Family Applications (3)

Application Number Title Priority Date Filing Date
JP504977A Granted JPS52102293A (en) 1976-01-23 1977-01-21 Novel oxim derivative of 77 aminothiazolylacetoamide cephalospolanate process for preparing same and pharmaceutical composition
JP2101872A Pending JPH03204868A (ja) 1976-01-23 1990-04-19 アミノチアゾリル酢酸の新規なオキシム誘導体
JP5023427A Pending JPH05247013A (ja) 1976-01-23 1993-01-20 アミノチアゾリル酢酸の新規なオキシム誘導体及びその製造法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2101872A Pending JPH03204868A (ja) 1976-01-23 1990-04-19 アミノチアゾリル酢酸の新規なオキシム誘導体
JP5023427A Pending JPH05247013A (ja) 1976-01-23 1993-01-20 アミノチアゾリル酢酸の新規なオキシム誘導体及びその製造法

Country Status (31)

Country Link
JP (3) JPS52102293A (da)
AR (1) AR231985A1 (da)
AT (2) AT355205B (da)
AU (1) AU511680B2 (da)
BE (1) BE850662A (da)
CA (1) CA1319682C (da)
CH (1) CH622264A5 (da)
CY (1) CY1123A (da)
DD (2) DD128594A5 (da)
DE (3) DE2702501C2 (da)
DK (1) DK161082C (da)
ES (2) ES455089A1 (da)
GB (2) GB1580621A (da)
GE (1) GEP19970783B (da)
GR (1) GR70302B (da)
HK (1) HK50381A (da)
HU (1) HU173110B (da)
IE (1) IE45015B1 (da)
IL (2) IL51192A (da)
IT (1) IT1104601B (da)
KE (1) KE3365A (da)
LU (1) LU76624A1 (da)
MX (1) MX4407E (da)
MY (1) MY8500417A (da)
NL (1) NL7700706A (da)
NZ (1) NZ183150A (da)
PL (1) PL122698B1 (da)
PT (1) PT66099B (da)
SE (2) SE440655B (da)
SU (1) SU822754A3 (da)
YU (3) YU41060B (da)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS549296A (en) * 1977-04-02 1979-01-24 Hoechst Ag Cephem derivative and its preparation
JPS5422392A (en) * 1977-07-19 1979-02-20 Roussel Uclaf Novel oxime derivative of 77aminothiazolylacetoamido cephalosporanic acid*their preparations and their applications as drugs
JPS5444695A (en) * 1977-09-13 1979-04-09 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid and its salt and their preparation
JPS5484595A (en) * 1977-12-05 1979-07-05 Roussel Uclaf Novel oxime derivatives of 33substituted 77aminothiazolyl acetoamide cephalosporanic acid*their manufacture and pharmateutical composition containing them
WO1982003217A1 (en) * 1981-03-16 1982-09-30 Sakano Isao 2-thiazoleamine derivatives,process for their preparation,and medicinal composition containing same
JPS57163386A (en) * 1981-08-13 1982-10-07 Takeda Chem Ind Ltd Cephalosporin derivative and its production
JPS60142971A (ja) * 1977-03-14 1985-07-29 Fujisawa Pharmaceut Co Ltd ７―置換―３―セフェム―４―カルボン酸化合物
JPS6263578A (ja) * 1978-07-31 1987-03-20 Fujisawa Pharmaceut Co Ltd アミノチアゾリル酢酸誘導体
EP0238060A2 (en) 1986-03-19 1987-09-23 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, processes for their preparation and antibacterial agents
JPH03115256A (ja) * 1977-03-14 1991-05-16 Fujisawa Pharmaceut Co Ltd 酢酸誘導体
JPH03135946A (ja) * 1976-04-12 1991-06-10 Fujisawa Pharmaceut Co Ltd 置換酢酸誘導体

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK162391C (da) * 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co Analogifremgangsmaade til fremstilling af syn-isomerer af 3,7-disubstituerede 3-cephem-4-carboxylsyreforbindelser
DE2760484C2 (da) * 1976-04-14 1992-12-03 Takeda Chemical Industries, Ltd., Osaka, Jp
FR2400519A1 (fr) * 1977-08-17 1979-03-16 Roussel Uclaf Forme cristalline du sel de sodium d'un derive oximine de l'acide 7-amino-thiazolyl acetamido cephalosporanique, son procede de preparation et son application comme medicament
JPS5498795A (en) * 1978-01-13 1979-08-03 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
FR2387235A1 (fr) * 1978-01-23 1978-11-10 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3,7-disubstitue-3-cephem-4-carboxylique et nouveaux produits ainsi obtenus, ayant une forte activite antibacterienne
FR2432521A1 (fr) * 1978-03-31 1980-02-29 Roussel Uclaf Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
SE445350B (sv) * 1978-04-14 1986-06-16 Roussel Uclaf Oximderivat av 3-azidometyl-7-amino-tiazolyl-acetamido-cefalosporansyra och dess anvendning som antibiotika
FR2448543A1 (fr) * 1979-02-09 1980-09-05 Roussel Uclaf Nouvelles oximes o-substituees par un radical comportant un ammonium quaternaire et derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2461713A1 (fr) * 1979-07-19 1981-02-06 Roussel Uclaf Nouvelles alcoyloximes substituees derivees de l'acide 7-(2-amino 4-thiazolyl) acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
FR2461712A1 (fr) * 1979-07-23 1981-02-06 Hoechst Ag Procede de preparation de derives de cepheme
FR2506307A1 (fr) * 1981-05-22 1982-11-26 Roussel Uclaf Nouveaux derives substitues de l'acide 2-(2-amino 4-thiazolyl) 2-hydroxyimino acetique et leur procede de preparation
HUT53892A (en) * 1989-04-07 1990-12-28 Technologishen Kom Za Promy Mi Process for producing synaminothiazolyl and synaminooxazolyl derivatives
CN112457271A (zh) * 2020-11-18 2021-03-09 河北合佳医药科技集团股份有限公司 一种氨噻肟酸中间体的连续流合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1399086A (en) * 1971-05-14 1975-06-25 Glaxo Lab Ltd Cephalosporin compounds
GB1536281A (en) * 1975-06-09 1978-12-20 Takeda Chemical Industries Ltd Cephem compounds
DK154939C (da) 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
DE2760123C2 (de) 1976-01-23 1986-04-30 Roussel-Uclaf, Paris 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen
JPS6011713B2 (ja) 1976-09-08 1985-03-27 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03135946A (ja) * 1976-04-12 1991-06-10 Fujisawa Pharmaceut Co Ltd 置換酢酸誘導体
JPH03115256A (ja) * 1977-03-14 1991-05-16 Fujisawa Pharmaceut Co Ltd 酢酸誘導体
JPS60142971A (ja) * 1977-03-14 1985-07-29 Fujisawa Pharmaceut Co Ltd ７―置換―３―セフェム―４―カルボン酸化合物
JPH0254839B2 (da) * 1977-03-14 1990-11-22 Fujisawa Pharmaceutical Co
JPH052666B2 (da) * 1977-03-14 1993-01-13 Fujisawa Pharmaceutical Co
JPS5858354B2 (ja) * 1977-04-02 1983-12-24 ヘキスト・アクチ−エンゲゼルシヤフト セフェム誘導体
JPS549296A (en) * 1977-04-02 1979-01-24 Hoechst Ag Cephem derivative and its preparation
JPS5422392A (en) * 1977-07-19 1979-02-20 Roussel Uclaf Novel oxime derivative of 77aminothiazolylacetoamido cephalosporanic acid*their preparations and their applications as drugs
JPS6259708B2 (da) * 1977-07-19 1987-12-12 Roussel Uclaf
JPS5444695A (en) * 1977-09-13 1979-04-09 Fujisawa Pharmaceut Co Ltd 3,7-disubstituted-3-cephem-4-carboxylic acid and its salt and their preparation
JPS6341914B2 (da) * 1977-09-13 1988-08-19 Fujisawa Pharmaceutical Co
JPS5484595A (en) * 1977-12-05 1979-07-05 Roussel Uclaf Novel oxime derivatives of 33substituted 77aminothiazolyl acetoamide cephalosporanic acid*their manufacture and pharmateutical composition containing them
JPS6360992A (ja) * 1977-12-05 1988-03-17 ルセル・ユクラフ ３−置換７−アミノチアゾリルアセトアミドセフアロスポラン酸の新規なオキシム誘導体
JPS6263578A (ja) * 1978-07-31 1987-03-20 Fujisawa Pharmaceut Co Ltd アミノチアゾリル酢酸誘導体
JPH0333154B2 (da) * 1978-07-31 1991-05-16 Fujisawa Pharmaceutical Co
WO1982003217A1 (en) * 1981-03-16 1982-09-30 Sakano Isao 2-thiazoleamine derivatives,process for their preparation,and medicinal composition containing same
JPS64399B2 (da) * 1981-08-13 1989-01-06 Takeda Chemical Industries Ltd
JPS57163386A (en) * 1981-08-13 1982-10-07 Takeda Chem Ind Ltd Cephalosporin derivative and its production
EP0238060A2 (en) 1986-03-19 1987-09-23 Banyu Pharmaceutical Co., Ltd. Cephalosporin derivatives, processes for their preparation and antibacterial agents

Also Published As

Publication number Publication date
YU13777A (en) 1983-04-30
JPH05247013A (ja) 1993-09-24
DE2702501A1 (de) 1977-07-28
ES466539A1 (es) 1978-10-01
AU2157977A (en) 1978-08-03
JPS6228152B2 (da) 1987-06-18
ATA41277A (de) 1979-07-15
DE2759895C2 (de) 1986-01-16
IL57445A0 (en) 1979-09-30
GEP19970783B (en) 1997-01-28
IL51192A (en) 1980-11-30
AT355205B (de) 1980-02-25
NZ183150A (en) 1979-12-11
NL7700706A (nl) 1977-07-26
DK161082B (da) 1991-05-27
KE3365A (en) 1984-02-03
YU1283A (en) 1984-02-29
PL122698B1 (en) 1982-08-31
PT66099A (fr) 1977-02-01
CA1319682C (fr) 1993-06-29
AT373592B (de) 1984-02-10
IE45015L (en) 1977-07-23
SE7614678L (sv) 1977-07-24
PT66099B (fr) 1979-03-09
JPH03204868A (ja) 1991-09-06
DE2702501C2 (de) 1982-11-18
IE45015B1 (en) 1982-06-02
CH622264A5 (en) 1981-03-31
DE2760287C2 (da) 1988-04-14
BE850662A (fr) 1977-07-22
GR70302B (da) 1982-09-06
DD132869A5 (de) 1978-11-15
LU76624A1 (da) 1977-08-12
DK23677A (da) 1977-07-24
MY8500417A (en) 1985-12-31
IL51192A0 (en) 1977-02-28
GB1580623A (en) 1980-12-03
DK161082C (da) 1991-11-04
ES455089A1 (es) 1978-04-16
HK50381A (en) 1981-10-30
HU173110B (hu) 1979-02-28
YU1183A (en) 1984-02-29
PL195504A1 (pl) 1978-03-13
SE440655B (sv) 1985-08-12
SE455307B (sv) 1988-07-04
YU43143B (en) 1989-04-30
IT1104601B (it) 1985-10-21
SE8204893D0 (sv) 1982-08-26
CY1123A (en) 1982-02-19
AR231985A1 (es) 1985-04-30
YU41060B (en) 1986-10-31
SU822754A3 (ru) 1981-04-15
AU511680B2 (en) 1980-08-28
MX4407E (es) 1982-04-27
ATA209479A (de) 1983-06-15
SE8204893L (sv) 1982-08-26
DD128594A5 (de) 1977-11-30
GB1580621A (en) 1980-12-03

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