JPH11510818A - クロピドグレルと抗血栓剤を含む活性成分の新規な組み合わせ - Google Patents
クロピドグレルと抗血栓剤を含む活性成分の新規な組み合わせInfo
- Publication number
- JPH11510818A JPH11510818A JP9529060A JP52906097A JPH11510818A JP H11510818 A JPH11510818 A JP H11510818A JP 9529060 A JP9529060 A JP 9529060A JP 52906097 A JP52906097 A JP 52906097A JP H11510818 A JPH11510818 A JP H11510818A
- Authority
- JP
- Japan
- Prior art keywords
- aspirin
- clopidogrel
- per day
- pharmaceutical composition
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.活性成分の組み合わせを含有する医薬組成物であって、該活性成分がクロ ピドグレルとアスピリンであって、両成分が遊離状態または医薬上許容される塩 の形で存在する医薬組成物。 2.少なくとも1つの賦形剤との組み合わせである請求項1記載の活性成分の 組み合わせを含有する医薬組成物。 3.非経口または経口経路で投与できる形態の請求項1または2記載の医薬組 成物。 4.クロピドグレルとアスピリンが、アスピリン/クロピドグレルのモル比2 .5〜11.5、好ましくは5〜9で存在する上記いずれか1つの請求項記載の医 薬組成物。 5.安定または不安定アンギナを包含する血小板凝集によって誘発される病状 、不安定アンギナ、大脳発作、血管形成術、血管内膜切除術もしくは金属血管内 補綴固定後の再狭窄のようなアテローム性動脈硬化症または糖尿病に伴う血栓塞 栓形成疾患のような心臓血管および脳血管系の疾患、あるいは血栓崩壊後の再血 栓症、梗塞、虚血由来の痴呆、末梢動脈疾患、血液透析もしくは心房性細動に伴 うまたは血管補綴もしくは大動脈−冠動脈バイパス使用の間の血栓塞栓形成疾患 の治療用の上記いずれか1つの請求項記載の医薬組成物。 6.安定または不安定アンギナを包含する血小板凝集によって誘発される病状 、不安定アンギナ、大脳発作、血管形成術、血管内膜切除術もしくは金属血管内 補綴固定後の再狭窄のようなアテローム性動脈硬化症または糖尿病に伴う血栓塞 栓形成疾患のような心臓血管および脳血管系の疾患、あるいは血栓崩壊後の再血 栓症、梗塞、虚血由来の痴呆、末梢動脈疾患、血液透析もしくは心房性細動に伴 うまたは血管補綴もしくは大動脈−冠動脈バイパス使用の間の血栓塞栓形成疾患 の治療用であって、該治療には、ヒトにおいて、クロピドグレルおよびアスピリ ンの遊離形として表現した用量で、1日当たり、1〜500mgのクロピドグレ ルおよび1日当たり、1〜500mgのアスピリンを投与することが含まれる薬 剤製造のための上 記いずれか1つの請求項記載の医薬組成物の使用。 7.治療が、1日当たり、50〜100mgのクロピトグレルおよび1日当た り、100〜500mgのアスピリンの非経口および/または経口経路による投 与を含む請求項6記載の使用。 8.治療が、1日当たり、65〜100mg、好ましくは65〜85mgのク ロピトグレルおよび1日当たり、200〜400mg、好ましくは315〜33 5mgのアスピリンの非経口および/または経口経路による投与を含む請求項6 記載の使用。 9.有効量のクロピドグレルを、有効量のアスピリンと同時に投与することか らなり、クロピドグレルおよびアスピリンを遊離状態または医薬上許容される塩 の形で投与する血小板凝集によって誘発される病状の治療方法。 10.安定または不安定アンギナ、心臓血管もしくは脳血管系の疾患または血 管補綴もしくは大動脈−冠動脈バイパスの使用の間に現れる疾患の治療用である 請求項9記載の方法。 11.アテローム性動脈硬化症、糖尿病、血栓崩壊後の再血栓症、梗塞、虚血 由来の痴呆、末梢動脈疾患、血液透析および心房性細動に伴う血栓塞栓形成疾患 の治療用である請求項10記載の方法。 12.不安定アンギナ、大脳発作、血管形成術、血管内膜切除術および金属血 管内補綴固定後の再狭窄から選ばれるアテローム性動脈硬化症または糖尿病に伴 う血栓塞栓形成疾患治療用である請求項11記載の方法。 13.ヒトにおいて、クロピドグレルおよびアスピリンの遊離形として表現し た用量で、1日当たり、1〜500mgのクロピドグレルおよび1日当たり、1 〜500mgのアスピリンを投与することが含まれる請求項9記載の方法。 14.ヒトにおいて、クロピドグレルおよびアスピリンの遊離形として表現し た用量で、1日当たり、50〜100mgのクロピトグレルおよび1日当たり、 100〜500mgのアスピリンの非経口および/または経口経路による投与を 含む請求項9記載の方法。 15.ヒトにおいて、クロピドグレルおよびアスピリンの遊離形として表現し た 用量で、1日当たり、65〜100mg、好ましくは65〜85mgのクロピト グレルおよび1日当たり、200〜400mg、好ましくは315〜335mg のアスピリンの非経口および/または経口経路による投与を含む請求項9記載の 方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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FR9602027A FR2744918B1 (fr) | 1996-02-19 | 1996-02-19 | Nouvelles associations de principes actifs contenant un derive de thieno(3,2-c)pyridine et un antithrombotique |
FR96/02027 | 1996-02-19 | ||
PCT/FR1997/000296 WO1997029753A1 (fr) | 1996-02-19 | 1997-02-17 | Nouvelles associations de principes actifs contenant du clopidogrel et un antithrombotique |
Publications (2)
Publication Number | Publication Date |
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JPH11510818A true JPH11510818A (ja) | 1999-09-21 |
JP3662028B2 JP3662028B2 (ja) | 2005-06-22 |
Family
ID=9489354
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Application Number | Title | Priority Date | Filing Date |
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JP52906097A Expired - Lifetime JP3662028B2 (ja) | 1996-02-19 | 1997-02-17 | クロピドグレルと抗血栓剤を含む活性成分の新規な組み合わせ |
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US (1) | US5989578A (ja) |
EP (1) | EP0881901B1 (ja) |
JP (1) | JP3662028B2 (ja) |
KR (1) | KR100295345B1 (ja) |
CN (1) | CN1116042C (ja) |
AT (1) | ATE218870T1 (ja) |
AU (1) | AU715655B2 (ja) |
BR (1) | BR9707556A (ja) |
CA (1) | CA2246289C (ja) |
CZ (1) | CZ292363B6 (ja) |
DE (2) | DE69713287T2 (ja) |
DK (1) | DK0881901T3 (ja) |
EE (1) | EE03513B1 (ja) |
ES (1) | ES2176684T3 (ja) |
FR (1) | FR2744918B1 (ja) |
HK (1) | HK1017850A1 (ja) |
HU (1) | HU225036B1 (ja) |
IL (1) | IL125848A (ja) |
IS (1) | IS1892B (ja) |
NO (2) | NO317747B3 (ja) |
NZ (1) | NZ331444A (ja) |
PL (1) | PL187292B1 (ja) |
PT (1) | PT881901E (ja) |
RU (1) | RU2184547C2 (ja) |
SI (1) | SI0881901T1 (ja) |
SK (1) | SK284285B6 (ja) |
TR (1) | TR199801608T2 (ja) |
UA (1) | UA51695C2 (ja) |
WO (1) | WO1997029753A1 (ja) |
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JP2011512406A (ja) * | 2008-02-22 | 2011-04-21 | ハナル バイオファーマ カンパニー リミテッド | 複合製剤 |
JP2011527301A (ja) * | 2008-07-10 | 2011-10-27 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 血小板のインヒビターにより誘発される凝固障害を治療するためのフォン・ヴィレブランド因子または第viii因子およびフォン・ヴィレブランド因子 |
JP2012526849A (ja) * | 2009-05-13 | 2012-11-01 | サイデックス・ファーマシューティカルズ・インコーポレイテッド | プラスグレル及びシクロデキストリン誘導体を含む医薬組成物並びにその製造方法及び使用方法 |
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Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2322824A1 (en) * | 1998-03-13 | 1999-09-16 | Merck & Co., Inc. | Combination therapy and composition for acute coronary ischemic syndrome and related conditions |
WO1999065500A1 (en) | 1998-06-17 | 1999-12-23 | Bristol-Myers Squibb Company | Preventing cerebral infarction through administration of adp-receptor antiplatelet and antihypertensive drugs in combination |
US6509348B1 (en) | 1998-11-03 | 2003-01-21 | Bristol-Myers Squibb Company | Combination of an ADP-receptor blocking antiplatelet drug and a thromboxane A2 receptor antagonist and a method for inhibiting thrombus formation employing such combination |
FR2792836B3 (fr) | 1999-04-30 | 2001-07-27 | Sanofi Sa | Composition pharmaceutique sous forme unitaire contenant de l'aspirine et de l'hydrogenosulfate de clopidogrel |
FR2797400A1 (fr) * | 1999-08-11 | 2001-02-16 | Sanofi Synthelabo | Associations a activite anti-thrombotique constituees de l'hydrogenosulfate de clopidogrel et d'un antagoniste des recepteurs gpiib/iiia et les compositions pharmaceutiques les contenant |
FR2832929A1 (fr) * | 2001-12-05 | 2003-06-06 | Sanofi Synthelabo | Compositions pharmaceutiques contenant un agent antithrombotique et un derive d'amines cycliques |
AU2003270861A1 (en) * | 2002-10-02 | 2004-04-23 | Bristol-Myers Squibb Company | Novel combination of a factor xa inhibitor and clopidogrel |
US20070243632A1 (en) * | 2003-07-08 | 2007-10-18 | Coller Barry S | Methods for measuring platelet reactivity of patients that have received drug eluting stents |
ATE536889T1 (de) | 2003-07-08 | 2011-12-15 | Accumetrics Inc | Kontrollierte thrombozyten-aktivierung zur überwachung der behandlung von adp-antagonisten |
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US8563574B2 (en) | 2009-12-07 | 2013-10-22 | Academic Pharmaceuticals, Inc. | Parenteral formulation of clopidogrel |
CN102389436A (zh) * | 2011-09-09 | 2012-03-28 | 北京阜康仁生物制药科技有限公司 | 一种抗血小板聚集的药物组合物 |
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WO2013133620A1 (en) * | 2012-03-09 | 2013-09-12 | Yuhan Corporation | Pharmaceutical composition comprising clopidogrel and aspirin and process for preparing the same |
CN103720700A (zh) * | 2012-10-10 | 2014-04-16 | 江苏威凯尔医药科技有限公司 | 含有阿斯匹林和维卡格雷的药用组合物 |
EP2796145B1 (en) | 2013-04-22 | 2017-11-01 | CSL Ltd. | A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge |
KR101502588B1 (ko) | 2013-05-01 | 2015-03-16 | 한국유나이티드제약 주식회사 | 클로피도그렐 및 아스피린의 복합제제 |
WO2015015062A1 (fr) * | 2013-08-02 | 2015-02-05 | Sanofi | Comprime pharmaceutique comprenant de l'acide acetylsalicylique et du clopidogrel |
HUP1400294A2 (hu) | 2014-06-13 | 2015-12-28 | Skillpharm Kft | Clopidogrel új alkalmazása |
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RU2745774C1 (ru) * | 2020-08-14 | 2021-03-31 | Алексей Викторович Марочков | Способ лечения пациентов с новой коронавирусной инфекцией (covid-19) |
US20230059869A1 (en) | 2021-08-03 | 2023-02-23 | Liqmeds Worldwide Limited | Oral pharmaceutical solution of clopidogrel |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2307538A1 (fr) * | 1975-04-18 | 1976-11-12 | Centre Etd Ind Pharma | Nouveau medicament anti-agregant plaquettaire |
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1996
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- 1997-02-17 CA CA002246289A patent/CA2246289C/fr not_active Expired - Lifetime
- 1997-02-17 JP JP52906097A patent/JP3662028B2/ja not_active Expired - Lifetime
- 1997-02-17 RU RU98117511/14A patent/RU2184547C2/ru active
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- 1997-02-17 AT AT97905218T patent/ATE218870T1/de active
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8404703B2 (en) | 2000-12-25 | 2013-03-26 | Daiichi Sankyo Company, Limited | Medicinal compositions containing aspirin |
US8569325B2 (en) | 2000-12-25 | 2013-10-29 | Daiichi Sankyo Company, Limited | Method of treatment with coadministration of aspirin and prasugrel |
JP2004532869A (ja) * | 2001-05-31 | 2004-10-28 | アストラゼネカ アクチボラグ | 医薬組成物 |
JP2011512406A (ja) * | 2008-02-22 | 2011-04-21 | ハナル バイオファーマ カンパニー リミテッド | 複合製剤 |
JP2011527301A (ja) * | 2008-07-10 | 2011-10-27 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 血小板のインヒビターにより誘発される凝固障害を治療するためのフォン・ヴィレブランド因子または第viii因子およびフォン・ヴィレブランド因子 |
JP2012526849A (ja) * | 2009-05-13 | 2012-11-01 | サイデックス・ファーマシューティカルズ・インコーポレイテッド | プラスグレル及びシクロデキストリン誘導体を含む医薬組成物並びにその製造方法及び使用方法 |
JP2016026174A (ja) * | 2009-05-13 | 2016-02-12 | サイデックス・ファーマシューティカルズ・インコーポレイテッド | プラスグレル及びシクロデキストリン誘導体を含む医薬組成物並びにその製造方法及び使用方法 |
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