ATE536889T1 - Kontrollierte thrombozyten-aktivierung zur überwachung der behandlung von adp-antagonisten - Google Patents

Kontrollierte thrombozyten-aktivierung zur überwachung der behandlung von adp-antagonisten

Info

Publication number
ATE536889T1
ATE536889T1 AT04756747T AT04756747T ATE536889T1 AT E536889 T1 ATE536889 T1 AT E536889T1 AT 04756747 T AT04756747 T AT 04756747T AT 04756747 T AT04756747 T AT 04756747T AT E536889 T1 ATE536889 T1 AT E536889T1
Authority
AT
Austria
Prior art keywords
platelet
individual
activation
platembocyte
controlled
Prior art date
Application number
AT04756747T
Other languages
English (en)
Inventor
Barry S Coller
Dennis Durbin
Original Assignee
Accumetrics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Accumetrics Inc filed Critical Accumetrics Inc
Application granted granted Critical
Publication of ATE536889T1 publication Critical patent/ATE536889T1/de

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT04756747T 2003-07-08 2004-07-06 Kontrollierte thrombozyten-aktivierung zur überwachung der behandlung von adp-antagonisten ATE536889T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48570303P 2003-07-08 2003-07-08
PCT/US2004/021785 WO2005007868A2 (en) 2003-07-08 2004-07-06 Controlled platelet activation to monitor therapy of adp antagonists

Publications (1)

Publication Number Publication Date
ATE536889T1 true ATE536889T1 (de) 2011-12-15

Family

ID=34079156

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04756747T ATE536889T1 (de) 2003-07-08 2004-07-06 Kontrollierte thrombozyten-aktivierung zur überwachung der behandlung von adp-antagonisten

Country Status (5)

Country Link
US (4) US7790362B2 (de)
EP (1) EP1641492B1 (de)
AT (1) ATE536889T1 (de)
ES (1) ES2378544T3 (de)
WO (1) WO2005007868A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070243632A1 (en) * 2003-07-08 2007-10-18 Coller Barry S Methods for measuring platelet reactivity of patients that have received drug eluting stents
US7790362B2 (en) 2003-07-08 2010-09-07 Accumetrics, Inc. Controlled platelet activation to monitor therapy of ADP antagonists
US7595169B2 (en) * 2005-04-27 2009-09-29 Accumetrics, Inc. Method for determining percent platelet aggregation
DE102006020386A1 (de) 2006-04-28 2007-10-31 Dade Behring Marburg Gmbh Verfahren zur Bestimmung der Thrombozytenfunktion unter Flussbedingungen
DE102006020385A1 (de) * 2006-04-28 2007-10-31 Dade Behring Marburg Gmbh Verfahren und Vorrichtung zur Bestimmung der Thrombozytenfunktion unter Flussbedingungen
ES2387700T3 (es) * 2007-05-03 2012-09-28 Accumetrics, Inc. Métodos para medir la inhibición de la agregación de plaquetas mediante antagonistas del receptor de trombina
US20120141468A1 (en) 2008-05-13 2012-06-07 Lisa Ruderman Chen Maintenance of platelet inhibition during antiplatelet therapy
WO2009140092A1 (en) 2008-05-13 2009-11-19 The Medicines Company Maintenance of platelet inhibition during antiplatelet therapy
KR20110025819A (ko) * 2008-06-09 2011-03-11 아큐메트릭스, 인크. 폐쇄된 용기 시료 채취 시스템을 위한 허브에 꽂힌 이중 캐뉼러 기기
US8448499B2 (en) 2008-12-23 2013-05-28 C A Casyso Ag Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method
US20110165595A1 (en) * 2009-07-13 2011-07-07 Catanzaro Brian E Apparatus and methods for processing a whole blood sample
JP5768422B2 (ja) * 2011-03-17 2015-08-26 ソニー株式会社 血液凝固系解析方法および血液凝固系解析装置
EP2508892A1 (de) * 2011-04-04 2012-10-10 Siemens Healthcare Diagnostics Products GmbH Kontrollen und Kit für Thrombozytenaktivitätsteste
US9404933B2 (en) * 2011-07-21 2016-08-02 Invitrox, Inc. Methods for determining patient response to anti-platelet aggregation therapy
JP6762876B2 (ja) * 2013-10-29 2020-09-30 ヴァーシティ ブラッド リサーチ インスティチュート ファウンデーション インク ヘパリン誘発性血小板減少症/血栓症を引き起こす血小板活性化抗体を検出する方法
US10539579B2 (en) 2014-09-29 2020-01-21 C A Casyso Gmbh Blood testing system and method
KR101899782B1 (ko) 2016-12-19 2018-09-20 원광대학교산학협력단 페닐알라닌-클로로퀸 유도체 화합물을 유효성분으로 함유하는 말라리아 감염 질환의 예방 또는 치료용 조성물

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3518057A (en) 1966-04-22 1970-06-30 Huron Road Hospital Method and apparatus for thrombus formation time determinations
US3694161A (en) 1971-04-14 1972-09-26 Armour Pharma Method for measuring platelet aggregation
US3817837A (en) * 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US4051236A (en) * 1973-02-15 1977-09-27 E. R. Squibb & Sons, Inc. Inhibition of blood platelet aggregation
FI58700C (fi) 1974-02-21 1981-03-10 Braun Melsungen Ag Foerfarande foer maetning av blodplaettars spontanaaggregation i blodplaettsrik citratplasma
US4529561A (en) * 1978-03-24 1985-07-16 The Regents Of The University Of California Method for producing liposomes in selected size range
JPS5697226A (en) * 1979-12-28 1981-08-05 Mitsubishi Chem Ind Ltd Blood platelet coagulation inhibitor
US4622293A (en) 1983-07-05 1986-11-11 Miles Laboratories, Inc. Iodothyronine immunoassays employing HMS as TBP blocking agent
US4717654A (en) 1984-06-19 1988-01-05 Akzo N.V. Process for solid phase platelet antibody assay
US4634681A (en) * 1984-10-29 1987-01-06 General Electric Company Diagnostic method of determining the presence or absence of select proteins in a liquid sample
US4619904A (en) * 1984-10-29 1986-10-28 General Electric Company Agglutinating immunoassay using protein-coated liquid droplets
US4948961A (en) * 1985-08-05 1990-08-14 Biotrack, Inc. Capillary flow device
CA1284642C (en) * 1986-03-31 1991-06-04 Hikozo Iwakura Prostacyclin (pgi ) analogues
US5114842A (en) * 1987-07-08 1992-05-19 The Scripps Research Institute Peptides and antibodies that inhibit platelet adhesion
US5066592A (en) * 1988-03-08 1991-11-19 Temple University Of The Commonwealth System Of Higher Education Trigramin - a platelet aggregation inhibiting polypeptide
US5023233A (en) * 1989-07-28 1991-06-11 Merck & Co., Inc. Fibrinogen receptor antagonists
JP2635212B2 (ja) * 1990-04-30 1997-07-30 アイシス・ファーマシューティカルス・インコーポレーテッド アラキドン酸代謝のオリゴヌクレオチド変調
US5246832A (en) * 1990-06-20 1993-09-21 University Of Massachusetts Medical Center Platelet analysis in whole blood
US5196309A (en) 1990-11-15 1993-03-23 The Scripps Research Institute Characterization of platelet aggregation disorders
US5242810A (en) * 1990-12-07 1993-09-07 Biogen, Inc. Bifunctional inhibitors of thrombin and platelet activation
US5688768A (en) 1991-02-19 1997-11-18 Cor Therapeutics, Inc. Recombinant thrombin receptor and related pharmaceuticals
US5266462A (en) * 1992-06-03 1993-11-30 Baxter Diagnostics Inc. Measurement of platelet activities
US5427913A (en) * 1992-12-03 1995-06-27 Alberta Cancer Board Methods for determining platelet function
JPH09501910A (ja) 1993-06-18 1997-02-25 ラ ホヤ キャンサー リサーチ ファウンデイション 血栓症処置のための方法および組成物
US5455228A (en) 1993-07-02 1995-10-03 The Research Foundation Of State University Of New York Peptidase resistant thrombin receptor peptide ligand
IL106330A (en) * 1993-07-14 1998-01-04 Univ Ramot Method and instrument for determining the activity of their plaques in the initial coagulation system
US5486361A (en) * 1993-10-25 1996-01-23 The United States Of America As Represented By The Department Of Health And Human Services Hybridomas and monoclonal antibodies that speifically bind to GPIB on platelets and inhibit the binding of thrombin to platelets
DE4344919A1 (de) 1993-12-30 1995-07-06 Behringwerke Ag Verfahren zur Bestimmung der Thrombozytenaggregation
WO1995027209A1 (en) 1994-03-31 1995-10-12 The Trustees Of The University Of Pennsylvania Method and kit for detection of thrombin receptor activation of platelets and other cells
WO1996003655A1 (en) 1994-07-23 1996-02-08 Boehringer Mannheim Gmbh Method for the determination of the prethrombotic state
US5763199A (en) * 1994-09-29 1998-06-09 Mount Sinai School Of Medicine Of The City University Of New York Platelet blockade assay
US5952006A (en) * 1995-09-29 1999-09-14 L.A.M. Pharmaceuticals, Llc Drug preparations for treating impotency
FR2744918B1 (fr) * 1996-02-19 1998-05-07 Sanofi Sa Nouvelles associations de principes actifs contenant un derive de thieno(3,2-c)pyridine et un antithrombotique
US5753517A (en) * 1996-03-29 1998-05-19 University Of British Columbia Quantitative immunochromatographic assays
US6221672B1 (en) 1996-04-30 2001-04-24 Medtronic, Inc. Method for determining platelet inhibitor response
US6043871A (en) 1997-03-03 2000-03-28 Brigham Young University System and method for measuring blood platelet function
US5922551A (en) 1997-03-20 1999-07-13 Accumetrics, Inc. Agglutrimetric platelet binding assays in blood
US6010911A (en) * 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
US6016712A (en) 1997-09-18 2000-01-25 Accumetrics Device for receiving and processing a sample
US6210904B1 (en) * 1997-10-14 2001-04-03 Merck & Co., Inc. Anticoagulant test
EP1025842B1 (de) 1997-10-30 2004-07-21 Morishita Jintan Co., Ltd. Doppelschichtige kapsel von ungesättigten fettsäuren oder deren derivate und verfahren zu deren herstellung
US6063847A (en) 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
USD409758S (en) 1998-01-14 1999-05-11 Accumetrics Sample cartridge
JP2002504369A (ja) 1998-02-27 2002-02-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア プロテアーゼ活性化レセプター4およびその使用。
EP0964046B1 (de) 1998-06-03 2003-07-30 Mitsubishi Gas Chemical Company, Inc. Sauerstoffabsorbierende Zusammensetzung, Sauerstoffabsorbierendes Harz und Konservierungsverfahren
US6093370A (en) * 1998-06-11 2000-07-25 Hitachi, Ltd. Polynucleotide separation method and apparatus therefor
JP2002524504A (ja) * 1998-09-11 2002-08-06 イレクサス・ピーティーワイ・リミテッド Fc受容体調節剤およびそれの使用
CA2348612A1 (en) 1998-10-23 2000-05-04 Barry S. Coller Method for determining platelet count
WO2000073792A1 (en) 1999-05-28 2000-12-07 Sendx Medical, Inc. Control for methods for determining platelet count and platelet function
US6585995B1 (en) * 1999-09-21 2003-07-01 Hanson Stephen R Methods and compositions for treating platelet-related disorders
US6589992B2 (en) 1999-11-30 2003-07-08 Parker Hughes Institute Inhibiting collagen-induced platelet aggregation
EP1280777B1 (de) * 2000-05-11 2005-11-23 Bristol-Myers Squibb Company Tetrahydroisochinolin-analoga als wachstumshormon-sekretagoga
PT1294714E (pt) 2000-06-15 2007-11-06 Schering Corp Antagonistas do receptor de trombina
US20020077693A1 (en) * 2000-12-19 2002-06-20 Barclay Bruce J. Covered, coiled drug delivery stent and method
EP1420718A4 (de) * 2000-09-29 2005-12-28 Endovasc Ltd Inc Resorbierbare prothese für eine medizinische behandlung
ATE357457T1 (de) 2000-11-01 2007-04-15 Astellas Pharma Inc Verfahren zum screenen eines plättchenhemmers
US6841354B2 (en) * 2000-12-21 2005-01-11 Philadelphia, Health & Education Corporation Screening assay for anti-thrombotic/anti-platelet activity
DE60231608D1 (de) 2001-04-19 2009-04-30 Eisai R&D Man Co Ltd Cyclische amidinderivate
EP1493028A4 (de) * 2001-07-06 2006-06-14 Genentech Inc Im phagen-display präsentierte liganden der pdz-domäne
WO2003033501A1 (en) 2001-10-18 2003-04-24 Schering Corporation Himbacine analogues as thrombin receptor antagonists
US6833536B2 (en) * 2002-05-22 2004-12-21 Applera Corporation Non-contact radiant heating and temperature sensing device for a chemical reaction chamber
US7438925B2 (en) * 2002-08-26 2008-10-21 Biovention Holdings Ltd. Drug eluting coatings for medical implants
WO2004036226A1 (en) 2002-10-15 2004-04-29 The University Of Tennessee Research Foundation Methods for assessment of platelet aggregation
US7125815B2 (en) * 2003-07-07 2006-10-24 Micron Technology, Inc. Methods of forming a phosphorous doped silicon dioxide comprising layer
US7790362B2 (en) * 2003-07-08 2010-09-07 Accumetrics, Inc. Controlled platelet activation to monitor therapy of ADP antagonists
US20070243632A1 (en) 2003-07-08 2007-10-18 Coller Barry S Methods for measuring platelet reactivity of patients that have received drug eluting stents
US7595169B2 (en) 2005-04-27 2009-09-29 Accumetrics, Inc. Method for determining percent platelet aggregation
US7205115B2 (en) 2005-04-28 2007-04-17 Accumetrics, Inc. Method and system for stabilization of arachidonic acid for use in platelet function assay
WO2007007588A1 (ja) 2005-07-08 2007-01-18 Ono Pharmaceutical Co., Ltd. 平面性を有する環状基を母核とする化合物
ES2387700T3 (es) 2007-05-03 2012-09-28 Accumetrics, Inc. Métodos para medir la inhibición de la agregación de plaquetas mediante antagonistas del receptor de trombina
EP2227559B1 (de) 2007-11-30 2018-08-29 QIAGEN Instruments AG Vorrichtung für thermisches cycling

Also Published As

Publication number Publication date
US20110081657A1 (en) 2011-04-07
US8574828B2 (en) 2013-11-05
ES2378544T3 (es) 2012-04-13
US7790362B2 (en) 2010-09-07
EP1641492B1 (de) 2011-12-14
US20140234859A1 (en) 2014-08-21
EP1641492A2 (de) 2006-04-05
US20110065125A1 (en) 2011-03-17
WO2005007868A3 (en) 2005-08-18
US20050031616A1 (en) 2005-02-10
US9341637B2 (en) 2016-05-17
WO2005007868A2 (en) 2005-01-27
EP1641492A4 (de) 2009-08-19

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