JPH10511934A - 新規な置換型ｄｔｐａ誘導体、その金属錯体、その錯体を含有する医薬並びに診断及び治療におけるそれら医薬の使用 - Google Patents

新規な置換型ｄｔｐａ誘導体、その金属錯体、その錯体を含有する医薬並びに診断及び治療におけるそれら医薬の使用

Info

Publication number
JPH10511934A
JPH10511934A JP8517148A JP51714895A JPH10511934A JP H10511934 A JPH10511934 A JP H10511934A JP 8517148 A JP8517148 A JP 8517148A JP 51714895 A JP51714895 A JP 51714895A JP H10511934 A JPH10511934 A JP H10511934A
Authority
JP
Japan
Prior art keywords
residue
metal
independently
compound
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP8517148A
Other languages
English (en)
Japanese (ja)
Inventor
マイアー，フランツ−カール
バウアー，ミカエル
クラウセ，ベルナー
スペック，ウルリッヒ
シューマン−ジアンピーリ，ガブリエール
ミューラー，アンドリアス
バルツェル，トーマス
プレス，ウォルフ−リディゲル
Original Assignee
シェーリング アクチェンゲゼルシャフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by シェーリング アクチェンゲゼルシャフト filed Critical シェーリング アクチェンゲゼルシャフト
Publication of JPH10511934A publication Critical patent/JPH10511934A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Pathology (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP8517148A 1994-11-30 1995-11-20 新規な置換型ｄｔｐａ誘導体、その金属錯体、その錯体を含有する医薬並びに診断及び治療におけるそれら医薬の使用 Withdrawn JPH10511934A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US35108694A 1994-11-30 1994-11-30
US08/351,086 1994-11-30
US38740895A 1995-02-13 1995-02-13
US08/387,408 1995-02-13
PCT/EP1995/004548 WO1996016928A1 (de) 1994-11-30 1995-11-20 Neuartig substituierte dtpa-derivate, deren metallkomplexe, diese komplexe enthaltende pharmazeutische mittel und deren verwendung in der diagnostik und therapie

Publications (1)

Publication Number Publication Date
JPH10511934A true JPH10511934A (ja) 1998-11-17

Family

ID=26996938

Family Applications (3)

Application Number Title Priority Date Filing Date
JP8517148A Withdrawn JPH10511934A (ja) 1994-11-30 1995-11-20 新規な置換型ｄｔｐａ誘導体、その金属錯体、その錯体を含有する医薬並びに診断及び治療におけるそれら医薬の使用
JP8518026A Pending JPH11503405A (ja) 1994-11-30 1995-11-20 コンピュータ断層撮影における肝臓及び胆嚢用ｘ線診断薬剤としての金属錯体の使用
JP8517856A Withdrawn JPH10509961A (ja) 1994-11-30 1995-11-20 新規な、多重置換型ｄｔｐａ誘導体及びその金属錯体、その錯体を含有する医薬、診断及び治療におけるその使用、並びに錯体形成剤及び錯体の製造方法並びに医薬の製造方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP8518026A Pending JPH11503405A (ja) 1994-11-30 1995-11-20 コンピュータ断層撮影における肝臓及び胆嚢用ｘ線診断薬剤としての金属錯体の使用
JP8517856A Withdrawn JPH10509961A (ja) 1994-11-30 1995-11-20 新規な、多重置換型ｄｔｐａ誘導体及びその金属錯体、その錯体を含有する医薬、診断及び治療におけるその使用、並びに錯体形成剤及び錯体の製造方法並びに医薬の製造方法

Country Status (15)

Country Link
US (4) US5672335A (pt-PT)
EP (3) EP0794939A1 (pt-PT)
JP (3) JPH10511934A (pt-PT)
CN (1) CN1167444A (pt-PT)
AU (3) AU4254696A (pt-PT)
CA (3) CA2206397A1 (pt-PT)
CZ (1) CZ166897A3 (pt-PT)
FI (3) FI972288A0 (pt-PT)
HU (1) HUT77284A (pt-PT)
IL (3) IL116208A0 (pt-PT)
MX (1) MX9703880A (pt-PT)
NO (3) NO972457L (pt-PT)
PL (1) PL320462A1 (pt-PT)
SK (1) SK68997A3 (pt-PT)
WO (3) WO1996016928A1 (pt-PT)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501560D0 (en) 1995-01-26 1995-03-15 Nycomed Imaging As Contrast agents
HUP9900428A2 (hu) * 1995-01-26 1999-06-28 Nycomed Imaging A/S Bizmutvegyületek, ezeket tartalmazó diagnosztikai kontrasztanyag, ennek alkalmazása és ezt tartalmazó gyógyászati készítmény
IT1283650B1 (it) * 1996-08-02 1998-04-23 Bracco Spa Chelati paramagnetici ad alta relassivita' in siero
US6458337B1 (en) 1996-08-02 2002-10-01 Dibra S.P.A Diagnostic imaging contrast agent with improved in serum relaxivity
US6403055B1 (en) 1996-08-02 2002-06-11 Dibra S.P.A. Diagnostic imaging contrast agent with improved in serum relaxivity
IT1290417B1 (it) * 1996-08-02 1998-12-03 Bracco Spa Composti chelanti derivati di acidi poliamminopolicarbossilici, loro chelati con ioni metallici paramagnetici, loro preparazione ed
US7521531B2 (en) 1996-08-28 2009-04-21 Immunomedics, Inc. Methods for the purification of stable radioiodine conjugates
US6558669B1 (en) 1996-08-28 2003-05-06 Immunomedics, Inc. Stable radioiodine conjugates and methods for their synthesis
WO1998028258A1 (en) 1996-12-23 1998-07-02 Bracco Research S.A. Compositions for increasing the mri contrast in visualising the digestive tract of patients
DE19719033C1 (de) * 1997-04-29 1999-01-28 Schering Ag Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
US6153655A (en) 1998-04-17 2000-11-28 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
US6767741B1 (en) 1999-08-27 2004-07-27 Invitrogen Corporation Metal binding compounds and their use in cell culture medium compositions
EP1362053B1 (en) * 2001-02-20 2007-11-14 Enzon, Inc. Terminally-branched polymeric linkers and polymeric conjugates containing the same
DE10127126A1 (de) * 2001-06-05 2002-12-19 Forschungszentrum Juelich Gmbh Geschützte Tyrosinderivate, Verfahren zu deren Herstellung und deren Verwendung zur Herstellung von O-(2-[·18·F]-Fluorethyl)-L-tyrosin
US6627394B2 (en) 2001-07-19 2003-09-30 Common Sense Ltd. Diagnostic pad
EP1805188A4 (en) 2004-09-30 2010-03-03 Mds Analytical Technologies Us COMPLEXES OF LUMINESCENT LANTHANIDES
GB0423506D0 (en) * 2004-10-22 2004-11-24 Univ Belfast Light emitting complex salts
EP2717934A4 (en) * 2011-06-06 2015-01-14 Oregon State X-RAY CONTRACTS FROM WISMUT PARTICLES
CA2873652A1 (en) * 2012-05-18 2013-11-21 Markus Berger Bis azainositol heavy metal complexes for x-ray imaging
BR102013023479B1 (pt) * 2013-09-12 2022-07-26 Uniao Brasileira De Educação E Assistência Processo de síntese de compostos de coordenação à base de lantanídeo
CN109613177B (zh) 2014-07-01 2021-08-20 科蒙森斯公司 用于鉴定羊水的诊断组合物
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
ES2814555T3 (es) 2016-11-28 2021-03-29 Bayer Pharma AG Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética
JP6836471B2 (ja) 2017-07-20 2021-03-03 株式会社神戸製鋼所 流体流通装置
JP7120802B2 (ja) 2017-07-20 2022-08-17 株式会社神戸製鋼所 流体流通装置及びその流通異常検知方法
CN107573291A (zh) * 2017-10-27 2018-01-12 上海司太立制药有限公司 一种钆塞酸二钠配体杂质的制备方法和用途
AU2019382881A1 (en) 2018-11-23 2021-05-20 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof
EP4059925A1 (en) 2021-03-15 2022-09-21 Bayer Aktiengesellschaft New contrast agent for use in magnetic resonance imaging
EP4335462A1 (en) 2022-09-09 2024-03-13 Bayer AG Contrast agents for use in diagnostic computed tomography imaging
EP4335840A1 (en) 2022-09-09 2024-03-13 Bayer Aktiengesellschaft New contrast agents for use in diagnostic imaging

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1374979A (en) * 1970-12-21 1974-11-20 Nat Res Dev 3,5-dioxopiperazine derivatives
US3994966A (en) * 1972-09-28 1976-11-30 The Board Of Trustees Of The Leland Stanford Junior University Chelating agents
US4622420A (en) * 1980-03-18 1986-11-11 The Regents Of The University Of California Chelating agents and method
US4339426A (en) * 1980-03-18 1982-07-13 Regents Of The University Of California Bleomycin analog
DE3129906C3 (de) * 1981-07-24 1996-12-19 Schering Ag Paramagnetische Komplexsalze, deren Herstellung und Mittel zur Verwendung bei der NMR-Diagnostik
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4957939A (en) * 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
US4652519A (en) * 1983-02-03 1987-03-24 Yeda Research And Development Company Limited Bifunctional chelating agents and process for their production
DE3324235A1 (de) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner, komplexe und komplexsalze
US4672028A (en) * 1984-05-23 1987-06-09 Icn Micromedic Systems, Inc. Compositions and method for simultaneous multiple array of analytes using radioisotope chelate labels
US4824986A (en) * 1985-04-26 1989-04-25 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Metal chelate protein conjugate
US5250285A (en) * 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US4880008A (en) * 1985-05-08 1989-11-14 The General Hospital Corporation Vivo enhancement of NMR relaxivity
US4899755A (en) * 1985-05-08 1990-02-13 The General Hospital Corporation Hepatobiliary NMR contrast agents
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
IL83966A (en) * 1986-09-26 1992-03-29 Schering Ag Amides of aminopolycarboxylic acids and pharmaceutical compositions containing them
IT1224416B (it) * 1987-12-24 1990-10-04 Bracco Ind Chimica Spa Chelanti macrociclici e loro chelati
US5057302A (en) * 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
DE3710730A1 (de) * 1987-03-31 1988-10-20 Schering Ag Substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US5482700A (en) * 1987-03-31 1996-01-09 Schering Aktiengesellschaft Substituted polyamino, polycarboxy complexing agent dimers for MRI and X-ray contrast
EP0299795B1 (en) * 1987-07-16 1992-03-18 Nycomed As Aminopolycarboxylic acids and derivatives thereof
DE3728525A1 (de) * 1987-08-24 1989-03-16 Schering Ag Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US5399340A (en) * 1987-09-24 1995-03-21 Schering Aktiengesellschaft Use of amide complex compounds
US5137711A (en) * 1988-07-19 1992-08-11 Mallickrodt Medical, Inc. Paramagnetic dtpa and edta alkoxyalkylamide complexes as mri agents
US5334371A (en) * 1988-07-20 1994-08-02 Schering Aktiengesellschaft Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI
IE980697A1 (en) * 1988-10-31 2000-12-13 Dow Chemical Co Chelants possessing ortho ligating functionality and complexes thereof
US5342604A (en) * 1988-10-31 1994-08-30 The Dow Chemical Company Complexes possessing ortho ligating functionality
US5101041A (en) * 1989-04-26 1992-03-31 The Curators Of The University Of Missouri Triamines and their derivatives as bifunctional chelating agents
US5695739A (en) * 1989-06-30 1997-12-09 Schering Aktiengesellschaft Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
DE3922005A1 (de) * 1989-06-30 1991-01-10 Schering Ag Derivatisierte dtpa-komplexe, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
DE4011684A1 (de) * 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
GB9122984D0 (en) * 1991-10-30 1991-12-18 Salutar Inc Contrast media
US5385893A (en) * 1993-05-06 1995-01-31 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
WO1994027644A1 (en) * 1993-06-02 1994-12-08 Bracco S.P.A. Iodinated paramagnetic chelates, and their use as contrast agents
US5358704A (en) * 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
EP0731797B1 (en) * 1993-12-03 1999-09-08 BRACCO S.p.A. Paramagnetic chelates for nuclear magnetic resonance diagnosis

Also Published As

Publication number Publication date
FI972286A (fi) 1997-05-29
CZ166897A3 (en) 1997-09-17
HUT77284A (hu) 1998-03-30
US5885548A (en) 1999-03-23
NO972460D0 (no) 1997-05-29
FI972288A (fi) 1997-05-29
WO1996016929A1 (de) 1996-06-06
EP0794799A2 (de) 1997-09-17
CA2206576A1 (en) 1996-06-06
IL116206A0 (en) 1996-01-31
JPH11503405A (ja) 1999-03-26
MX9703880A (es) 1997-08-30
FI972287A0 (fi) 1997-05-29
US5746995A (en) 1998-05-05
NO972457D0 (no) 1997-05-29
JPH10509961A (ja) 1998-09-29
US5853699A (en) 1998-12-29
CA2206397A1 (en) 1996-06-06
US5672335A (en) 1997-09-30
WO1996016928A1 (de) 1996-06-06
AU3922795A (en) 1996-06-19
NO972459D0 (no) 1997-05-29
EP0794938A1 (de) 1997-09-17
SK68997A3 (en) 1997-11-05
AU4299496A (en) 1996-06-19
CA2206522A1 (en) 1996-06-06
NO972457L (no) 1997-07-30
FI972287A (fi) 1997-05-29
EP0794939A1 (de) 1997-09-17
CN1167444A (zh) 1997-12-10
NO972459L (no) 1997-07-29
WO1996016677A3 (de) 1996-09-12
WO1996016677A2 (de) 1996-06-06
FI972288A0 (fi) 1997-05-29
PL320462A1 (en) 1997-09-29
AU4254696A (en) 1996-06-19
FI972286A0 (fi) 1997-05-29
IL116208A0 (en) 1996-01-31
NO972460L (no) 1997-05-29
IL116209A0 (en) 1996-01-31

Similar Documents

Publication Publication Date Title
JPH10511934A (ja) 新規な置換型ｄｔｐａ誘導体、その金属錯体、その錯体を含有する医薬並びに診断及び治療におけるそれら医薬の使用
JP2854159B2 (ja) ジエチレントリアミンペンタ酢酸−モノアミド及びその錯体及び錯塩、その製法、これを含有するｎｍｒ−、レントゲン−及び放射線−診断剤並びに放射線−又は射線療法剤及びその薬剤の製法
TW319763B (pt-PT)
US5182370A (en) Paramagnetic chelates
JP2968367B2 (ja) １，４，７，１０−テトラアザシクロドデカン−ブチルトリオール、そのガドリニウム錯体、これを含有する医薬品及び診断剤、その化合物の製法及び医薬品の製法
JP2603357B2 (ja) 誘導化されたｄｔｐａ―錯体、これを含有する製薬学的薬剤、これを含有するｎｍｒ―及びレントゲン―診断剤及び放射線療法剤、この化合物の製法及び製薬学的薬剤の製法
JP2877844B2 (ja) ５員‐又は６員‐環を有する巨大環状ポリアザ‐化合物、その製法及びこれを含有するｎｍｒ‐、ｘ線‐、放射線‐診断用及び放射能‐及び照射線‐治療用薬剤及びこの薬剤の製法
IE913899A1 (en) Mono-N-substituted 1,4,7,10-tetraazacyclododecane¹derivatives, process for their production and pharmaceutical¹agents containing these derivatives
DE3938992A1 (de) Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
JPH05214096A (ja) 重合体化合物、ｎｍｒ診断およびｘ線診断のための薬剤の製造法、この種の薬剤、製薬学的薬剤、重合体化合物の製造法および製薬学的薬剤の製造法
JP2953670B2 (ja) 複素環式キレート化剤
JP7145156B2 (ja) 二量体造影剤
JPH08510458A (ja) 沃素化された常磁性キレートおよびそれらの造影剤としての使用法
JPH09500115A (ja) イメージング用官能化三脚状配位子類
KR19980701674A (ko) 비스무트 화합물
JPH09501919A (ja) ホスホネート部分と非ホスホネート部分との両者を有するｍｒｉ用のポリアミノ常磁性キレート
US5798089A (en) Chelant moieties linked to an aryl moiety by an interrupted alkylene linker
JPH11501012A (ja) 新規な方法において置換されたｄｔｐａ誘導体、それらの金属錯体、これらの錯体を含有する医薬製剤、診断および治療におけるそれらの使用、ならびに錯体および医薬製剤の製造方法
DE10040858C2 (de) Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung
US5695737A (en) Dimeric DTPA derivatives, their metal complexes and pharmaceutical agents containing these complexes
IE904319A1 (en) 10-(2'-Hydroxy-3'POLYOXAALKYL)-1,4,7-TRISCARBOXYMETHYL-¹1,4,7,10-TETRAAZACYCLODODECANE
JPH08506102A (ja) 誘導体化されたｄｔｐａ錯体、該化合物を含有する薬剤、該化合物の使用及び該化合物の製法
JP2007536295A (ja) 三量体マクロ環式置換ハロ−ベンゼン誘導体
US5616312A (en) Thiol ligands and complexes for X-ray imaging
JP2000136174A (ja) ジポリキレ―ト化剤

Legal Events

Date Code Title Description
A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20040114